Resistance and susceptibility of bovine cells expressing herpesviral glycoprotein D homologs to herpesviral infections.

Abstract:

:Bovine cell lines individually expressing two related herpesviral proteins, pseudorabies virus glycoprotein 50 and herpes simplex virus type 1 glycoprotein D, were examined for their susceptibility/resistance to infection with several alphaherpesviruses. Cell lines expressing gp50 or gD-1 resisted plaque formation by the homologous virus more than by the heterologous viruses. Bovine cells expressing bovine herpesvirus 1 glycoprotein IV (gIV) were susceptible to infection with three other bovine herpesviruses: bovine herpesvirus 2, bovine herpesvirus 4 (BHV-4) and alcelaphine herpesvirus 1. One line of gIV-expressing cells was resistant to the formation of BHV-4 plaques, suggesting that a cell-associated factor may be responsible for inhibiting cell-to-cell spread.

journal_name

Virology

journal_title

Virology

authors

Chase CC,Lohff C,Letchworth GJ 3rd

doi

10.1006/viro.1993.1269

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

365-9

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(83)71269-9

journal_volume

194

pub_type

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