Perturbation of differentiated functions during viral infection in vivo. II. Viral reassortants map growth hormone defect to the S RNA of the lymphocytic choriomeningitis virus genome.

abstract：:Cauliflower mosaic virus gene VI product (P6) is an essential protein that forms cytoplasmic, inclusion bodies (IBs). P6 contains four regions involved in self-association, termed D1-D4. D3 binds to D1, along with D4 and contains a spacer region (termed D3b) between two RNA-binding domains. Here we show D3b binds full...

journal_title：Virology

authors： Lutz L,Okenka G,Schoelz J,Leisner S

更新日期：2015-02-01 00:00:00

abstract：:We have previously reported that a virus, MH2-PA200, lacking the ability to transform quail embryo cells, could be isolated from wild type (wt) MH2 stocks passaged on chicken neuroretina cells. We report here the molecular cloning and extensive characterization of this MH2-PA200 provirus. Molecularly cloned MH2-PA200 ...

journal_title：Virology

authors： Martin P,Henry C,Denhez F,Amouyel P,Bechade C,Calothy G,Debuire B,Stehelin D,Saule S

更新日期：1986-09-01 00:00:00

abstract：:We have used field inversion gel electrophoresis to survey EBV strains for the size of the major internal repeat, IR-1, and estimate the number of 3.1-kb repeat units present. The B95-8 strain of EBV was estimated to contain 8.6 repeats. The repeat number varies considerably among naturally occurring isolates around a...

journal_title：Virology

authors： Allan GJ,Rowe DT

更新日期：1989-12-01 00:00:00

abstract：:The presence of a genome-linked protein (VPg) at the RNA 5'-end of the genome is a characteristic of different groups of animal and plant positive-sense single-stranded RNA viruses. These viruses express their structural and functional proteins from polyproteins that are sequentially processed by at least one viral pr...

journal_title：Virology

authors： Margis R,Viry M,Pinck M,Bardonnet N,Pinck L

更新日期：1994-04-01 00:00:00

abstract：:Ts1, a temperature-sensitive mutant of Moloney murine leukemia virus-TB (MoMuLV-TB), causes a progressive hindlimb paralytic disease in susceptible strains of mice. Previously, it has been shown that a single amino acid substitution, Val-25----Ile in gPr80env, is responsible for the temperature sensitivity, inefficien...

journal_title：Virology

authors： Kamps CA,Lin YC,Wong PK

更新日期：1991-10-01 00:00:00

abstract：:Infection of microglial cells by the human immunodeficiency virus (HIV) is supposed to play an important role in the pathogenesis of AIDS-related central nervous system (CNS) complications. So far, however, experimental data about interactions between HIV and ramified microglia from the adult CNS were only occasionall...

journal_title：Virology

authors： Hein A,Martin JP,Koehren F,Bingen A,Dörries R

更新日期：2000-03-15 00:00:00

abstract：:La Crosse (LAC) virions exposed to different pHs (7.3, 6.2, and 5.4) and temperatures (37 degrees, 20 degrees, and 4 degrees) were preserved in thin layers of vitreous ice and observed by electron cryomicroscopy. Our results indicate that, at lower pH, virus particles interact with each other to form aggregates. In so...

journal_title：Virology

authors： Wang GJ,Hewlett M,Chiu W

更新日期：1991-09-01 00:00:00

abstract：:Cucumber seedlings infected with cucumber mosaic virus (CMV) contain a virus-induced RNA-dependent RNA polymerase (RNA replicase) in both soluble and particulate fractions of plant extracts; no such activity is found in uninfected plants. The extensive purification and characterization of the soluble RNA replicase has...

journal_title：Virology

authors： Gill DS,Kumarasamy R,Symons RH

更新日期：1981-08-01 00:00:00

abstract：:Tick-borne flaviviruses are maintained in nature in an enzootic cycle involving a tick vector and a vertebrate host. Thus, the virus replicates in two disparate hosts, each providing selective pressures that can influence virus replication and pathogenicity. To identify viral determinants associated with replication i...

journal_title：Virology

authors： Mitzel DN,Best SM,Masnick MF,Porcella SF,Wolfinbarger JB,Bloom ME

更新日期：2008-11-25 00:00:00

abstract：:About 100 nucleotides of DNA sequence at the 5' noncoding region of the Choristoneura biennis entomopoxvirus spheroidin gene was chemically synthesized and inserted into a vaccinia expression vector, interrupting the vaccinia thymidine kinase gene. When the bacterial beta-galactosidase gene was introduced downstream o...

journal_title：Virology

authors： Pearson A,Richardson C,Yuen L

更新日期：1991-02-01 00:00:00

abstract：:The tegument of herpes simplex virus contains proteins important for the efficient initiation of infection. L-particles are noninfectious virion-related particles that lack the nucleocapsid but do contain tegument and envelope. Their ability to deliver functional proteins into cells was compared to that of virions by ...

journal_title：Virology

authors： McLauchlan J,Addison C,Craigie MC,Rixon FJ

更新日期：1992-10-01 00:00:00

abstract：:Incubation of membrane vesicles from normal and Rous sarcoma virus-transformed chick embryo fibroblasts (CEF) with [gamma-32P]ATP resulted in the phosphorylation of a large number of proteins. The major differences observed between the membrane vesicles of untransformed and transformed cells were: (1) a 5- to 10-fold ...

journal_title：Virology

authors： Garber EA,Krueger JG,Hanafusa H,Goldberg AR

更新日期：1983-04-15 00:00:00

abstract：:The prototype strain of Flanders virus (61-7484) has been adapted to grow in Vero cell cultures and a plaque assay has been developed. Electron micrographs of infected cells revealed rod-shaped virions budding in clusters from the plasma membrane, consistent with the tentative classification of Flanders virus as a mem...

journal_title：Virology

authors： Boyd KR,Whitaker-Dowling P

更新日期：1988-04-01 00:00:00

abstract：:The recent development of in vitro hepatitis C virus (HCV) RNA replication systems has provided useful tools for studying the intracellular anti-HCV activity of ribavirin. Ribavirin has been shown to: (1) induce "error catastrophe" in poliovirus, Proc. Natl. Acad. Sci. USA 98, 6895-6900), (2) be a pseudo-substrate of ...

journal_title：Virology

authors： Zhou S,Liu R,Baroudy BM,Malcolm BA,Reyes GR

更新日期：2003-06-05 00:00:00

abstract：:Multiple RNA species (ASV(1-5)) ranging in size from about 61,000 to 185,000 daltons have been detected in association with sunblotch disease of avocado. The predominant species, ASV(5), with a molecular weight of 61,000 accumulates to concentration approaching 5 S RNA. All RNA species are detected in extracts from sy...

journal_title：Virology

authors： Semancik JS,Desjardins PR

更新日期：1980-07-15 00:00:00

abstract：:Revertants were isolated from the protease activation mutant of Sendai virus, F1-R, which causes a systemic infection in mice. The fusion (F) glycoprotein of F1-R is susceptible to activation cleavage by ubiquitous cellular proteases and is thus responsible for pantropism in mice (Tashiro et al., 1988. Virology 165, 5...

journal_title：Virology

authors： Tashiro M,James I,Karri S,Wahn K,Tobita K,Klenk HD,Rott R,Seto JT

更新日期：1991-09-01 00:00:00

abstract：:Mouse LTK- cells (H-2k) were transfected with a series of recombinant plasmids consisting of the herpes simplex virus type 1 thymidine kinase (TK) gene linked to fragments of SV40 DNA coding for portions of SV40 T antigen in pBR322, and TK+ transformants (LTK+) were selected in HAT medium. The TK+ transformants were a...

journal_title：Virology

authors： Tevethia SS,Tevethia MJ,Lewis AJ,Reddy VB,Weissman SM

更新日期：1983-07-30 00:00:00

abstract：:Alphaherpesviruses comprise closely related viruses of man and animal, including herpes simplex virus, varicella-zoster virus and pseudorabies virus (PRV). Here, using methyl-beta-cyclodextrin and fluorescently tagged PRV, we directly show that depletion of cholesterol from the plasma membrane of host cells significan...

journal_title：Virology

authors： Desplanques AS,Nauwynck HJ,Vercauteren D,Geens T,Favoreel HW

更新日期：2008-07-05 00:00:00

abstract：:This report shows that (S)CARNA 5, the satellite of cucumber mosaic virus (CMV) strain S, directs the synthesis of two small proteins in a wheat germ cell-free translation system. The two proteins are produced by the translation of both (S)CARNA 5 purified from CMV virions and the (+) strand purified from double-stran...

journal_title：Virology

authors： Avila-Rincon MJ,Collmer CW,Kaper JM

更新日期：1986-07-30 00:00:00

abstract：:The RTVL-H family of human endogenous retrovirus-like sequences consists of approximately 1000 "full-length" elements and at least as many solitary RTVL-H related long terminal repeats (LTRs). We have characterized cDNA clones from two human cell libraries (Hep-2 and normal peripheral blood) and have found three clone...

journal_title：Virology

authors： Mager DL

更新日期：1989-12-01 00:00:00

abstract：:Five plaque-forming viruses (Pbi viruses) of the unicellular, eukaryotic, exsymbiotic Chlorella-like green alga strain Pbi were isolated from fresh water collected in Germany. The viruses were compared to two previously characterized plaque-forming viruses (NC64A viruses) of Chlorella strain NC64A. The Pbi viruses do ...

journal_title：Virology

authors： Reisser W,Burbank DE,Meints SM,Meints RH,Becker B,Van Etten JL

更新日期：1988-11-01 00:00:00

abstract：:Cytotoxic T-lymphocyte (CTL) epitopes within the HIV genome are subject to negative and positive selective pressures, the balance of which influences CTL escape at a given epitope. We investigated whether viral fitness requirements dictate conservation of the HLA-A2 restricted immunodominant epitope SLYNTVATL (SL9). V...

journal_title：Virology

authors： Christie NM,Willer DO,Lobritz MA,Chan JK,Arts EJ,Ostrowski MA,Cochrane A,Luscher MA,MacDonald KS

更新日期：2009-05-25 00:00:00

abstract：:Expansion of CHIKV outbreaks with appearance of novel mutations are reported from many parts of the world. Two novel mutations viz. E1:K211E and E2:V264A in background of E1:226A are recently identified from Aedes aegypti dominated areas of India. In this study, the role of these mutations in modulation of infectivity...

journal_title：Virology

authors： Agarwal A,Sharma AK,Sukumaran D,Parida M,Dash PK

更新日期：2016-10-01 00:00:00

abstract：:The nucleotide sequence of the env gene of a previously described human provirus (ERV3) has been determined beginning near the 3'-end of the pol gene and continuing through the 3'-LTR. Analysis of the nucleotide sequence revealed the presence of a long open reading frame of 1944 nucleotides that is capable of encoding...

journal_title：Virology

authors： Cohen M,Powers M,O'Connell C,Kato N

更新日期：1985-12-01 00:00:00

abstract：:We recently showed that E6 protein of human papillomavirus (HPV) 16, a mucosal high-risk α-PV type, can potentiate Wnt/β-catenin/TCF signaling. Here we investigated the transcriptional activities of E6 proteins of cutaneous HPV types from the β and α genera. Results from reporter-gene assays showed that similar to HPV...

journal_title：Virology

authors： Sominsky S,Shterzer N,Jackman A,Shapiro B,Yaniv A,Sherman L

更新日期：2017-09-01 00:00:00

abstract：:The bacteriophage T4 e gene encodes lysozyme (e-lysozyme), which releases progeny phage after normal infection of Escherichia coli cells. A mutation in the spackle gene suppresses the defect in e-lysozyme (Emrich, 1968). The spackle gene was mapped between genes 41 and 61, but its precise location has not previously b...

journal_title：Virology

authors： Kai T,Ueno H,Otsuka Y,Morimoto W,Yonesaki T

更新日期：1999-08-01 00:00:00

abstract：:Fowlpox virus (FPV), type species of the Avipoxvirus genus, causes a slow-spreading pox disease of chickens. Following infection of mammalian cells there is no evidence of productive replication of FPV although cytopathic effects are induced and FPV recombinants have been shown to express foreign genes from vaccinia v...

journal_title：Virology

authors： Somogyi P,Frazier J,Skinner MA

更新日期：1993-11-01 00:00:00

abstract：:The objective of this study was to identify porcine reproductive and respiratory syndrome virus (PRRSV)-encoded proteins that are responsible for the inhibition of TNF-α expression and the mechanism(s) involved in this phenomenon. Using a TNF-α promoter reporter system, the non-structural protein 1 (Nsp1) was found to...

journal_title：Virology

authors： Subramaniam S,Kwon B,Beura LK,Kuszynski CA,Pattnaik AK,Osorio FA

更新日期：2010-10-25 00:00:00

abstract：:HIV CRF07 B'/C is a strain circulating mainly in northwest region of China. The gp41 region of CRF07 is derived from a clade C virus. In order to compare the difference of CRF07 gp41 with that of typical clade B virus, we solved the crystal structure of the core region of CRF07 gp41. Compared with clade B gp41, CRF07 ...

journal_title：Virology

authors： Du J,Xue H,Ma J,Liu F,Zhou J,Shao Y,Qiao W,Liu X

更新日期：2013-11-01 00:00:00

abstract：:HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervic...

journal_title：Virology

authors： Hang D,Yin Y,Han J,Jiang J,Ma H,Xie S,Feng X,Zhang K,Hu Z,Shen H,Clifford GM,Dai M,Li N

更新日期：2016-01-15 00:00:00