The evolution and characterization of influenza A(H7N9) virus under the selective pressure of peramivir.

abstract：:While several studies have shown a role for autophagy in the replication of dengue virus (DENV), these studies have been performed in directly infected cells. However, in severe cases of DENV infection the critical cell in the disease is believed to be monocytes which are poorly infected directly, but are highly susce...

journal_title：Virology

authors： Panyasrivanit M,Greenwood MP,Murphy D,Isidoro C,Auewarakul P,Smith DR

更新日期：2011-09-15 00:00:00

abstract：:Infection of rhesus macaques with attenuated SIVmac is, at present, the only strategy which confers significant protection from challenge with wild-type SIVmac grown in monkey PBMC. However, initial results suggest that the protective mechanism does not develop until late after "vaccination" (approx 10 months). As par...

journal_title：Virology

authors： Norley S,Beer B,Binninger-Schinzel D,Cosma C,Kurth R

更新日期：1996-05-01 00:00:00

abstract：:The complete nucleotide sequence of the nucleocapsid (N) gene of lettuce necrotic yellows virus (LNYV), the type member of the genus Cytorhabdovirus of plant rhabdoviruses, has been determined from cDNA clones of both the viral genomic and messenger RNAs. The previously identified N gene was adjacent to the 3' leader ...

journal_title：Virology

authors： Wetzel T,Dietzgen RG,Geering AD,Dale JL

更新日期：1994-08-01 00:00:00

abstract：:The mechanism by which lentivirus envelope (Env) glycoproteins are packaged into budding virions is poorly understood. Simian immunodeficiency virus (SIV) contains an Env protein with an unusually long cytoplasmic tail. To investigate the role of this domain in the incorporation of the SIV Env into virions, we generat...

journal_title：Virology

authors： Celma CC,Manrique JM,Affranchino JL,Hunter E,González SA

更新日期：2001-05-10 00:00:00

abstract：:Torque Teno Virus (TTV) has been assigned to the floating genus Anellovirus. TTV ssDNA genomes have a size of 3.6 to 3.8 kb and display up to 30% nucleotide diversity. The pathogenic potential of TTV is under investigation. To address a putative link of pathogenicity with the observed sequence variations, the transcri...

journal_title：Virology

authors： Mueller B,Maerz A,Doberstein K,Finsterbusch T,Mankertz A

更新日期：2008-11-10 00:00:00

abstract：:The genome of the Trichoplusia ni single nucleopolyhedrovirus (TnSNPV), a group II NPV which infects the cabbage looper (T. ni), has been completely sequenced and analyzed. The TnSNPV DNA genome consists of 134,394 bp and has an overall G + C content of 39%. Gene analysis predicted 144 open reading frames (ORFs) of 15...

journal_title：Virology

authors： Willis LG,Seipp R,Stewart TM,Erlandson MA,Theilmann DA

更新日期：2005-08-01 00:00:00

abstract：:Foot-and-mouth disease virus protease 3C is essential for the processing of the viral precursor polyprotein. It is shown here to also inhibit gene expression in baby hamster kidney cells after transient expression from transfected cDNA fragments. Protease 3C could not be detected by indirect immunofluorescence in cont...

journal_title：Virology

authors： Tesar M,Marquardt O

更新日期：1990-02-01 00:00:00

abstract：:In HSV types 1 and 2, gH forms a noncovalent heterodimer with gL. Previous studies demonstrated that the first 323 amino acids of gH1 and the first 161 amino acids of gL1 are sufficient for gH/gL binding. For gL1, substitution of any of its four cysteine (C) residues (all located within the gH/gL binding region) destr...

journal_title：Virology

authors： Cairns TM,Landsburg DJ,Whitbeck JC,Eisenberg RJ,Cohen GH

更新日期：2005-02-20 00:00:00

abstract：:The tobamoviruses, tobacco mosaic virus (TMV) and Odontoglossum ringspot virus (ORSV), differ in the range of plant species that each can systemically infect. Both viruses systemically infect Nicotiana benthamiana similarly, but differ in the ability to systemically infect tobacco (N. tabacum). ORSV is confined to the...

journal_title：Virology

authors： Hilf ME,Dawson WO

更新日期：1993-03-01 00:00:00

abstract：:Several strains of tobacco ringspot virus (TobRV) support the replication and encapsidation of satellite tobacco ringspot virus RNA (STobRV RNA). We have compared the nucleotide sequences of four STobRV RNAs, each initially associated with a different isolate of TobRV. A STobRV RNA from a geranium isolate of TobRV and...

journal_title：Virology

authors： Buzayan JM,McNinch JS,Schneider IR,Bruening G

更新日期：1987-09-01 00:00:00

abstract：:The 24,000-molecular-weight major internal protein (p24) and the 15,000-molecular-weight nucleic acid binding protein (p15) of human T-cell leukemia virus type II (HTLV-II) were subjected to amino acid composition and amino-terminal amino acid sequence analysis. A comparison of amino acid composition of p24 and p15 of...

journal_title：Virology

authors： Devare SG,Kim Y,Fox JL,Getchell J,Cabradilla C,Kalyanaraman VS

更新日期：1985-04-15 00:00:00

abstract：:Phylogenetic analysis of the N8 neuraminidase (NA) genes from 18 influenza A viruses, representing equine and avian hosts in different geographic locations, revealed three major lineages: (i) currently circulating equine 2 viruses; (ii) avian viruses isolated in the Eurasian region, including A/Equine/Jilin/1/89, a re...

journal_title：Virology

authors： Saito T,Kawaoka Y,Webster RG

更新日期：1993-04-01 00:00:00

abstract：:Geographical separation of host species has shaped the avian influenza A virus gene pool into independently evolving Eurasian and American lineages, although phylogenetic evidence for gene flow and reassortment indicates that these lineages also mix on occasion. While the evolutionary dynamics of the avian influenza g...

journal_title：Virology

authors： Bahl J,Vijaykrishna D,Holmes EC,Smith GJ,Guan Y

更新日期：2009-08-01 00:00:00

abstract：:The regions of the AcMNPV genome represented as cytoplasmic transcripts early after infection of Spodoptera frugiperda cells prior to and encompassing the initiation of DNA replication were mapped. In vivo(32)P pulse-labeled cytoplasmic RNA from infected cells at various times postinfection was used to probe Southern ...

journal_title：Virology

authors： Erlandson MA,Carstens EB

更新日期：1983-04-15 00:00:00

abstract：:We have used field inversion gel electrophoresis to survey EBV strains for the size of the major internal repeat, IR-1, and estimate the number of 3.1-kb repeat units present. The B95-8 strain of EBV was estimated to contain 8.6 repeats. The repeat number varies considerably among naturally occurring isolates around a...

journal_title：Virology

authors： Allan GJ,Rowe DT

更新日期：1989-12-01 00:00:00

abstract：:The paramyxovirus fusion protein (F) promotes fusion of the viral envelope with the plasma membrane of target cells as well as cell-cell fusion. The plasma membrane is closely associated with the actin cytoskeleton, but the role of actin dynamics in paramyxovirus F-mediated membrane fusion is unclear. We examined cell...

journal_title：Virology

authors： Schowalter RM,Wurth MA,Aguilar HC,Lee B,Moncman CL,McCann RO,Dutch RE

更新日期：2006-07-05 00:00:00

abstract：:Members of the genus Mastrevirus (family Geminiviridae) produce a complementary-sense (c-sense) transcription unit with the potential to encode two proteins, RepA and Rep. In the present work, we have studied the DNA-protein complexes formed by the Wheat dwarf virus (WDV) RepA protein within the WDV large intergenic r...

journal_title：Virology

authors： Missich R,Ramirez-Parra E,Gutierrez C

更新日期：2000-07-20 00:00:00

abstract：:In mid-January 2016, an outbreak of H7N8 high-pathogenicity avian influenza virus (HPAIV) in commercial turkeys occurred in Indiana. Surveillance within the 10km control zone identified H7N8 low-pathogenicity avian influenza virus (LPAIV) in nine surrounding turkey flocks but no other HPAIV-affected premises. We seque...

journal_title：Virology

authors： Lee DH,Torchetti MK,Killian ML,Swayne DE

更新日期：2017-07-01 00:00:00

abstract：:Phosphorylation of I kappa Bs--the cytoplasmic inhibitors of the NF-kappa B transcription factors--is the key event which triggers activation of the NF-kappa B cascade. Signal-mediated phosphorylation of I kappa B alpha is mediated by a multiprotein complex, the I kappa B kinase (IKK) complex, which is composed of at ...

journal_title：Virology

authors： Le Page C,Popescu O,Génin P,Lian J,Paquin A,Galipeau J,Hiscott J

更新日期：2001-08-01 00:00:00

abstract：:Nucleotide sequence analysis of the genome of the baculovirus Bombyx mori nuclear polyhedrosis virus (BmNPV) identified 18 homologues of the Autographa californica NPV (AcNPV) lefs (late expression factor genes). These BmNPV lefs showed high (73-98%) amino acid sequence identities to AcNPV lefs and were localized to s...

journal_title：Virology

authors： Gomi S,Zhou CE,Yih W,Majima K,Maeda S

更新日期：1997-03-31 00:00:00

abstract：:Nectin-1 is a receptor for herpes simplex virus (HSV), a member of the immunoglobulin superfamily, and a cellular adhesion molecule. To study domains of nectin-1alpha involved in cell fusion, we measured the ability of nectin-1alpha/nectin-2alpha chimeras, nectin-1alpha/CD4 chimeras, and transmembrane domain and cytop...

journal_title：Virology

authors： Subramanian RP,Dunn JE,Geraghty RJ

更新日期：2005-09-01 00:00:00

abstract：:The ability of HIV to match levels of viral mRNA to the activation state of the host cell may play a role in its ability to persist as well as to replicate. This linkage depends on the function of the viral transcriptional regulatory protein, Tat, which increases the efficiency of RNA elongation (transcriptional proce...

journal_title：Virology

authors： Adams M,Wong C,Wang D,Romeo J

更新日期：1999-05-10 00:00:00

abstract：:A full-length cDNA clone of the U1 (common) strain of tobacco mosaic virus (TMV) was constructed, and highly infectious transcripts were produced in vitro using bacteriophage T7 RNA polymerase. Frameshift mutations designed to cause premature termination of translation were introduced into either the 30-kDa movement p...

journal_title：Virology

authors： Holt CA,Beachy RN

更新日期：1991-03-01 00:00:00

abstract：:Five plaque-forming viruses (Pbi viruses) of the unicellular, eukaryotic, exsymbiotic Chlorella-like green alga strain Pbi were isolated from fresh water collected in Germany. The viruses were compared to two previously characterized plaque-forming viruses (NC64A viruses) of Chlorella strain NC64A. The Pbi viruses do ...

journal_title：Virology

authors： Reisser W,Burbank DE,Meints SM,Meints RH,Becker B,Van Etten JL

更新日期：1988-11-01 00:00:00

abstract：:While some neurotropic viruses cause rapid central nervous system (CNS) disease upon entry into the brain parenchyma, other viruses that are cytolytic in the periphery either result in little neuropathology or are associated with a protracted course of CNS disease consistent with persistent infection. One such virus, ...

journal_title：Virology

authors： Daley JK,Gechman LA,Skipworth J,Rall GF

更新日期：2005-09-15 00:00:00

abstract：:The quasispecies structure of nervous necrosis virus (NNV) was determined to investigate an outbreak of viral nervous necrosis disease at a barramundi (Lates calcarifer) hatchery. A traditional epidemiological investigation indicated horizontal transmission of infection between two cohorts of fish. However, variation ...

journal_title：Virology

authors： Hick P,Gore K,Whittington R

更新日期：2013-02-05 00:00:00

abstract：:Thirteen viable insertion mutants of vaccinia virus have been constructed. These mutants, containing coding sequences of the herpes simplex virus thymidine kinase (HSV-TK) gene, were generated by marker transfer via in vivo recombination. The mutants were identified using a replica filter plating technique by in situ ...

journal_title：Virology

authors： Perkus ME,Panicali D,Mercer S,Paoletti E

更新日期：1986-07-30 00:00:00

abstract：:We previously analyzed hybrids of Cucumber mosaic virus (CMV) and Tomato aspermy virus (TAV) that contained CMV RNA2 with the 3'-terminal sequence from TAV RNA2. In this article, we scrutinized the RNA3 molecules in these hybrid viruses by Northern hybridization and RT-PCR and found some recombinant CMV RNA3 molecules...

journal_title：Virology

authors： Suzuki M,Hibi T,Masuta C

更新日期：2003-02-01 00:00:00

abstract：:Intact clones containing partial repeats of the genomic components of African cassava mosaic (ACMV DNAs A and B) are infectious when mechanically coinoculated onto Nicotiana benthamiana. Monomeric genomic components may be generated either by homologous recombination or, when two copies of the origin of replication (o...

journal_title：Virology

authors： Stanley J

更新日期：1995-01-10 00:00:00

abstract：:Progressive reorganization and depolymerization of microtubules corresponded with virus-induced rounding of Autographa californica M nuclear polyhedrosis virus (AcMNPV)-infected Spodoptera frugiperda IPLB-Sf-21 cells, suggesting that microtubules were instrumental in maintaining the normal shape of these cells. Depoly...

journal_title：Virology

authors： Volkman LE,Zaal KJ

更新日期：1990-03-01 00:00:00