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Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins.

Abstract：

:Tetherin has been defined as a restriction factor of HIV-1 and several other enveloped viruses. However, the significance of tetherin in viral infection remains to be further addressed. Here, we investigated whether tetherin plays a role in HSV-2 infection. Our study revealed that overexpression of tetherin restricted the release of HSV-2 into the extracellular medium, while knockdown of tetherin by siRNA enhanced its release. We further demonstrated that HSV-2 infection and viral glycoproteins gB, gD, gH and gL but not gM significantly downregulated the endogenous expression of tetherin. Additional study indicated that tetherin likely physically interacted with gB, gD, gH and gL. This is the first time that tetherin has been shown to be counteracted by multiple viral components of a virus. Our findings inform the complexity of HSV-2-host interactions, providing basis for understanding the role of tetherin as a viral restriction factor and the mechanisms underlying viral countermeasures.

journal_name

Virology

journal_title

Virology

authors

Liu Y,Luo S,He S,Zhang M,Wang P,Li C,Huang W,Hu B,Griffin GE,Shattock RJ,Hu Q

doi

10.1016/j.virol.2014.11.005

subject

Has Abstract

pub_date

2015-01-15 00:00:00

pages

96-109

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(14)00499-1

journal_volume

475

pub_type

杂志文章

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