HIV-1 Tat induces biochemical changes in the serum of mice.

abstract：:Human papillomaviruses (HPVs) are epitheliotropic viruses, and their life cycle is intimately linked to the stratification and differentiation state of the host epithelial tissues. Defining a role for the E5 gene product in the differentiation-dependent viral life cycle has been difficult due to the lack of a suitable...

journal_title：Virology

authors： Mayer TJ,Meyers C

更新日期：1998-09-01 00:00:00

abstract：:To accomplish their viral life cycle, lentiviruses such as HIV highjack host proteins, the so-called cellular co-factors of replication. Lens Epithelium-derived Growth factor (LEDGF/p75), a transcriptional co-activator, is a co-factor of HIV-integrase (IN) and is required for the tethering and correct integration of t...

journal_title：Virology

authors： Christ F,Debyser Z

更新日期：2013-01-05 00:00:00

abstract：:The HIV-1 Nef protein causes a decrease in major histocompatibility complex (MHC) class I and CD4 molecule expression on the cell surface. To determine if Nef can affect components of the innate immune response, we assessed the ability of Nef to alter the cell surface expression of human CD1d. In cells co-expressing C...

journal_title：Virology

authors： Cho S,Knox KS,Kohli LM,He JJ,Exley MA,Wilson SB,Brutkiewicz RR

更新日期：2005-07-05 00:00:00

abstract：:It was previously reported that integrins alpha2beta1, alpha4beta1, and alphaXbeta2 are involved in rotavirus cell infection. In this work we studied the role of integrin subunits alpha2, alpha4, and beta2 on the attachment of rotaviruses RRV and nar3 to MA104 cells. Integrin alpha2beta1 was found to serve as the bind...

journal_title：Virology

authors： Zárate S,Espinosa R,Romero P,Guerrero CA,Arias CF,López S

更新日期：2000-12-05 00:00:00

abstract：:Hemorrhagic fever viruses are associated with rapidly progressing severe disease with high case fatality, making them of public health and biothreat importance. Effective antivirals are not available for most of the members of this diverse group of viruses. A broad spectrum strategy for antiviral development would be ...

journal_title：Virology

authors： Spiropoulou CF,Ranjan P,Pearce MB,Sealy TK,Albariño CG,Gangappa S,Fujita T,Rollin PE,Nichol ST,Ksiazek TG,Sambhara S

更新日期：2009-09-15 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Rev is a 19-kDa regulatory protein which binds to unspliced and partially spliced HIV-1 RNAs. Export, splicing, stability, and translation of HIV-1 RNAs are influenced by Rev. To further understand the effect of Rev on HIV-1 RNA splicing, the intranuclear localization of uns...

journal_title：Virology

authors： Favaro JP,Borg KT,Arrigo SJ,Schmidt MG

更新日期：1998-09-30 00:00:00

abstract：:In the absence of an effective vaccine against HIV, it is urgent to develop an effective alternative such as a microbicide. Single and repeated applications of MC1220 microbicide were evaluated in macaques. First, animals were given a single application of 0.5% or 1.5% MC1220-containing liposomal gel. A second group w...

journal_title：Virology

authors： Caron M,Besson G,Etenna SL,Mintsa-Ndong A,Mourtas S,Radaelli A,Morghen Cde G,Loddo R,La Colla P,Antimisiaris SG,Kazanji M

更新日期：2010-09-15 00:00:00

abstract：:Epstein-Barr virus (EBV) is widely spread in the human population. EBV nuclear antigen 1 (EBNA1) is a transcription factor that activates viral genes and is necessary for viral replication and partitioning, which binds the EBV genome cooperatively. We identify similar EBNA1 repeat binding sites in the human genome usi...

journal_title：Virology

authors： d'Hérouël AF,Birgersdotter A,Werner M

更新日期：2010-09-30 00:00:00

abstract：:The complete genomes of 30 Soybean mosaic virus (SMV) isolates and strains were sequenced in this study. Together with fourteen previously reported sequences, we analyzed the genetic structure of the SMV population. Analyses of genetic diversity showed that different genomic regions of SMV are under different evolutio...

journal_title：Virology

authors： Seo JK,Ohshima K,Lee HG,Son M,Choi HS,Lee SH,Sohn SH,Kim KH

更新日期：2009-10-10 00:00:00

abstract：:An SH3-binding domain within the Nef protein of primate lentiviruses has been reported to be important to viral replication and infectivity and dispensable for CD4 downregulation, but its precise role remains unclear. This study investigates the effects of mutations in both the polyproline helix and in the hydrophobic...

journal_title：Virology

authors： Craig HM,Pandori MW,Riggs NL,Richman DD,Guatelli JC

更新日期：1999-09-15 00:00:00

abstract：:The promotion of membrane fusion by the paramyxovirus hemagglutinin-neuraminidase (HN) and fusion (F) proteins requires that they be derived from homologous viruses, suggesting the possibility that the promotion of fusion requires a virus-specific communication between the two glycoprotein spikes. We have evaluated th...

journal_title：Virology

authors： Deng R,Wang Z,Mirza AM,Iorio RM

更新日期：1995-06-01 00:00:00

abstract：:Three SV40 escape mutants were identified by selection in the presence of monoclonal antibodies with neutralizing activity. The VP1 amino acid alterations in these mutants were: (1) K73-->E (in loop BC); (2) D77-->E (in loop BC); (3) K171-->R (in loop EF); and (4) Q175-->H (in loop EF). These residues are clustered in...

journal_title：Virology

authors： Murata H,Teferedegne B,Sheng L,Lewis AM Jr,Peden K

更新日期：2008-11-10 00:00:00

abstract：:The dependence of retroviral replication on cell proliferation was described as early as 1958, although different classes of retroviruses are able to infect non-dividing cells with different efficiencies. For example, the human immunodeficiency virus (HIV) and other lentiviruses infect most non-dividing cells nearly a...

journal_title：Virology

authors： Yamashita M,Emerman M

更新日期：2006-01-05 00:00:00

abstract：:Adenovirus serotype 5 (Ad5) is a common cause of respiratory tract infection, and populations worldwide have high prevalence of anti-Ad5 antibodies, implying extensively prior infection. Ad5 infection potently activates the host innate defense and inflammation, but the molecular mechanisms are not completely clarified...

journal_title：Virology

authors： Li P,Feng F,Pan E,Fan X,Yang Q,Guan M,Chen L,Sun C

更新日期：2018-06-01 00:00:00

abstract：:Cell-free extracts of Drosophila melanogaster cells infected with FHV (Flockhouse virus) have the capacity to synthesize FHV RNA. When such extracts are incubated appropriately, ss and ds FHV RNA 1, -2, and -3 can be detected as synthesis products. Pulse-chase analyses indicate that radioactivity, incorporated into ds...

journal_title：Virology

authors： Wu SX,Kaesberg P

更新日期：1991-07-01 00:00:00

abstract：:Retroperitoneal fibromatosis herpesvirus (RFHV), the macaque homolog of the human rhadinovirus, Kaposi's sarcoma-associated herpesvirus (KSHV), was first identified in retroperitoneal fibromatosis (RF) tumor lesions of macaques with simian AIDS. We cloned and sequenced the ORF73 latency-associated nuclear antigen (LAN...

journal_title：Virology

authors： Burnside KL,Ryan JT,Bielefeldt-Ohmann H,Gregory Bruce A,Thouless ME,Tsai CC,Rose TM

更新日期：2006-10-10 00:00:00

abstract：:Mutations disrupting helicase domain motifs of the Tobacco mosaic virus 126/183-kDa proteins were investigated for their effect on replicase function and assembly. These mutations inhibited virus replication but did not affect 126-kDa induced N gene resistance or RNAi suppression. However, in vivo expressed 126-kDa mo...

journal_title：Virology

authors： Wang X,Kelman Z,Culver JN

更新日期：2010-07-05 00:00:00

abstract：:In the present study, 10 clinical isolates of dengue virus were selected according to their susceptibility to the inhibitory effect of nitric oxide radical, NO. Five of them are nitric oxide-susceptible viruses while the other five are nitric oxide-resistant viruses. These isolates were investigated to identify geneti...

journal_title：Virology

authors： Ubol S,Chareonsirisuthigul T,Kasisith J,Klungthong C

更新日期：2008-07-05 00:00:00

abstract：:Our recent results demonstrated that bile acids facilitate virus escape from the endosomes into the cytoplasm for successful replication of porcine enteric calicivirus (PEC). We report a novel finding that bile acids can be substituted by cold treatment for endosomal escape and virus replication. This endosomal escape...

journal_title：Virology

authors： Shivanna V,Kim Y,Chang KO

更新日期：2015-09-01 00:00:00

abstract：:Loading of most endogenous peptides on major histocompatibility complex class I molecules is conditional on their transport into the endoplasmic reticulum (ER) by the peptide transporter TAP. We describe an HSV-2/1 cross-reactive cytotoxic T-cell (CTL) epitope that is processed in a TAP1-independent manner in vivo fol...

journal_title：Virology

authors： Paliard X,Doe B,Selby MJ,Hartog K,Lee AY,Burke RL,Walker CM

更新日期：2001-03-30 00:00:00

abstract：:Human parainfluenza virus type 1 (hPIV1) and type 3 (hPIV3) initiate infection by sialic acid binding. Here, we investigated sialic acid linkage specificities for binding and infection of hPIV1 and hPIV3 by using sialic acid linkage-modified cells treated with sialidases or sialyltransferases. The hPIV1 is bound to on...

journal_title：Virology

authors： Fukushima K,Takahashi T,Ito S,Takaguchi M,Takano M,Kurebayashi Y,Oishi K,Minami A,Kato T,Park EY,Nishimura H,Takimoto T,Suzuki T

更新日期：2014-09-01 00:00:00

abstract：:Very fast sedimenting DNA (VFS DNA) of T4 phage, which is formed by infection with a mutant in gene 49, was examined by electron microscopy after mild treatment with DNase I. It showed Y-shaped, branched strands in addition to linear strands. Each branch contained a single-stranded interruption about 60 nucleotides lo...

journal_title：Virology

authors： Minagawa T,Murakami A,Ryo Y,Yamagishi H

更新日期：1983-04-15 00:00:00

abstract：:The lentivirus caprine arthritis-encephalitis virus (CAEV) is closely related by nucleotide sequence homology to visna virus and other sheep lentiviruses and shows less similarity to the other animal and human lentiviruses. The genomic organization of CAEV is very similar to that of visna virus and the South African o...

journal_title：Virology

authors： Saltarelli M,Querat G,Konings DA,Vigne R,Clements JE

更新日期：1990-11-01 00:00:00

abstract：:Nectin-1 is a receptor for herpes simplex virus (HSV), a member of the immunoglobulin superfamily, and a cellular adhesion molecule. To study domains of nectin-1alpha involved in cell fusion, we measured the ability of nectin-1alpha/nectin-2alpha chimeras, nectin-1alpha/CD4 chimeras, and transmembrane domain and cytop...

journal_title：Virology

authors： Subramanian RP,Dunn JE,Geraghty RJ

更新日期：2005-09-01 00:00:00

abstract：:Avian influenza A viruses of the H5 and H7 subtypes periodically cause severe outbreaks of disease in poultry. The question we wished to address in this study is whether these highly pathogenic strains constitute unique lineages or whether they and related nonpathogenic viruses are derived from common ancestors in the...

journal_title：Virology

authors： Röhm C,Horimoto T,Kawaoka Y,Süss J,Webster RG

更新日期：1995-06-01 00:00:00

abstract：:HPV16 E6 deregulates G1/S cell cycle progression through p53 degradation preventing transcription of the CDK inhibitor p21(WAF1). However, additional mechanisms independent of p53 inactivation appear to exist. Here, we report that HPV16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1) tr...

journal_title：Virology

authors： Parroche P,Touka M,Mansour M,Bouvard V,Thépot A,Accardi R,Carreira C,Roblot GG,Sylla BS,Hasan U,Tommasino M

更新日期：2011-09-01 00:00:00

abstract：:We have constructed a recombinant baculovirus expressing high levels of the herpes simplex virus type 1 (HSV-1) glycoprotein E (gE) in Sf9 cells. The expressed gE migrated on gels as a double band with apparent molecular weights of 68 and 70 kDa. The recombinant gE was glycosylated based on its susceptibility to tunic...

journal_title：Virology

authors： Ghiasi H,Kaiwar R,Nesburn AB,Slanina S,Wechsler SL

更新日期：1992-06-01 00:00:00

abstract：:Lymphoid cell lines were derived from three avian leukosis virus (ALV)-induced lymphomas. These cell lines contained proviral DNA sequences integrated upstream from the c-myc proto-oncogene, expressed increased levels of c-myc RNA, and were tumorigenic in syngeneic animals. While cell surface immunoglobulin (IgM) was ...

journal_title：Virology

authors： Baba TW,Giroir BP,Humphries EH

更新日期：1985-07-15 00:00:00

abstract：:Glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) plays a key role in multiple events during infection including virus entry, cell-to-cell spread, and virus-induced syncytia formation. Here, we provide evidence that an arginine/lysine cluster located at the transmembrane-cytoplasm interface of gD critically c...

journal_title：Virology

authors： Carmichael JC,Starkey J,Zhang D,Sarfo A,Chadha P,Wills JW,Han J

更新日期：2019-01-15 00:00:00

abstract：:The measles virus (MV) phosphoprotein (P) gene encodes three proteins, P, C, and V. The V protein is synthesized by pseudo-templated transcription, also designated as RNA editing: during P gene transcription one G residue is inserted at a defined position in about 50% of the mRNAs. To study the importance of sequence ...

journal_title：Virology

authors： Schneider H,Kaelin K,Billeter MA

更新日期：1997-01-20 00:00:00