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RIG-I activation inhibits ebolavirus replication.

Abstract：

:Hemorrhagic fever viruses are associated with rapidly progressing severe disease with high case fatality, making them of public health and biothreat importance. Effective antivirals are not available for most of the members of this diverse group of viruses. A broad spectrum strategy for antiviral development would be very advantageous. Perhaps the most challenging target would be the highly immunosuppressive filoviruses, ebolavirus and marburgvirus, associated with aerosol infectivity and case fatalities in the 80-90% range. Here we report that activation of evolutionarily conserved cytosolic viral nucleic acid sensor, RIG-I can cause severe inhibition of ebolavirus replication. These findings indicate that RIG-I-based therapies may provide an attractive approach for antivirals against Ebola hemorrhagic fever, and possibly other HF viruses.

journal_name

Virology

journal_title

Virology

authors

Spiropoulou CF,Ranjan P,Pearce MB,Sealy TK,Albariño CG,Gangappa S,Fujita T,Rollin PE,Nichol ST,Ksiazek TG,Sambhara S

doi

10.1016/j.virol.2009.06.032

subject

Has Abstract

pub_date

2009-09-15 00:00:00

pages

11-5

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(09)00383-3

journal_volume

392

pub_type

杂志文章

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