当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Sulfatide inhibits HIV-1 entry into CD4-/CXCR4+ cells.

Sulfatide inhibits HIV-1 entry into CD4-/CXCR4+ cells.

Abstract：

:Sulfatide (3'sulfogalactosylceramide) is the natural sulfated derivative of galactosylceramide (GalCer), a glycosphingolipid receptor allowing HIV-1 infection of CD4-negative cells from neural and intestinal tissues. The incorporation of exogenous sulfatide into the plasma membrane of HT-29 (a CD4-/GalCer+/CXCR4+ human intestinal cell line) or RD (CD4-/GalCer-/ CXCR4+ human rhabdomyosarcoma) resulted in a dose-dependent inhibition of HIV-1 infection. Experiments with luciferase reporter viruses pseudotyped with HIV-1 or amphotropic murine leukemia virus envelopes demonstrated that sulfatide acts at the level of viral entry. Paradoxically, the transfer of sulfatide in the plasma membrane of various CD4- cells resulted in increased binding of HIV-1. Surface pressure measurements were conducted to study the interaction of gp120 with glycosphingolipid monolayers. The data showed that gp120 could penetrate into a monomolecular film of GalCer, confirming the role of this glycosphingolipid as a functional receptor for HIV-1. In contrast, the insertion of gp120 into a monolayer of sulfatide was very limited. Moreover, the incorporation of sulfatide in a monomolecular film of GalCer specifically inhibited the penetration of gp120. In conclusion, these data show that sulfatide mediates gp120 binding but, in marked contrast with GalCer, is not able to initiate the fusion event.

journal_name

Virology

journal_title

Virology

authors

Fantini J,Hammache D,Delézay O,Piéroni G,Tamalet C,Yahi N

doi

10.1006/viro.1998.9216

subject

Has Abstract

pub_date

1998-07-05 00:00:00

pages

211-20

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(98)99216-9

journal_volume

246

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Cloning of the genome of a densovirus and rescue of infectious virions from recombinant plasmid in the insect host Spodoptera littoralis.

    abstract：:We have cloned an infectious genome of the Junonia coenia densonucleosis virus (JcDNV) into the bacterial plasmid pBR322. The viral genome could be rescued from the recombinant plasmid pBRJ by transfection of pBRJ DNA to sensitive Spodoptera littoralis larvae. pBRJ DNA produced a typical viral infection and a comparab...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90308-e

    authors： Jourdan M,Jousset FX,Gervais M,Skory S,Bergoin M,Dumas B

    更新日期：1990-11-01 00:00:00

  • Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins.

    abstract：:Tetherin has been defined as a restriction factor of HIV-1 and several other enveloped viruses. However, the significance of tetherin in viral infection remains to be further addressed. Here, we investigated whether tetherin plays a role in HSV-2 infection. Our study revealed that overexpression of tetherin restricted...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2014.11.005

    authors： Liu Y,Luo S,He S,Zhang M,Wang P,Li C,Huang W,Hu B,Griffin GE,Shattock RJ,Hu Q

    更新日期：2015-01-15 00:00:00

  • The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes.

    abstract：:Productive infection by human immunodeficiency virus type I (HIV-1) in the central nervous system (CNS) involves mainly macrophages and microglial cells. A frequency of less than 10% of human astrocytes is estimated to be infectable with HIV-1. Nonetheless, this relatively low percentage of infected astrocytes, but as...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.03.017

    authors： Fang J,Acheampong E,Dave R,Wang F,Mukhtar M,Pomerantz RJ

    更新日期：2005-06-05 00:00:00

  • Cloning and characterization of antiviral cytotoxic T lymphocytes in channel catfish, Ictalurus punctatus.

    abstract：:To determine the role of piscine anti-viral cytotoxic cells, we analyzed the response of channel catfish to Ictalurid herpesvirus 1, commonly designated channel catfish virus (CCV). Peripheral blood leukocytes (PBL) from catfish immunized with MHC-matched, CCV-infected G14D cells (G14D-CCV) showed marked lysis of G14D...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.11.014

    authors： Taylor EB,Chinchar VG,Quiniou SMA,Wilson M,Bengtén E

    更新日期：2020-01-15 00:00:00

  • Protection from SARS coronavirus conferred by live measles vaccine expressing the spike glycoprotein.

    abstract：:The recent identification of a novel human coronavirus responsible of a SARS-like illness in the Middle-East a decade after the SARS pandemic, demonstrates that reemergence of a SARS-like coronavirus from an animal reservoir remains a credible threat. Because SARS is contracted by aerosolized contamination of the resp...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2014.01.002

    authors： Escriou N,Callendret B,Lorin V,Combredet C,Marianneau P,Février M,Tangy F

    更新日期：2014-03-01 00:00:00

  • Recurrence of WHV integration in the b3n locus in woodchuck hepatocellular carcinoma.

    abstract：:Frequent occurrence of woodchuck hepatitis virus DNA (WHV DNA) integration into or in proximity to myc oncogenes and in the win locus of cellular genome in woodchuck hepatocellular carcinomas (HCC) has been described by several authors. We report a further cellular locus as a recurrent target for WHV integration in wo...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.9936

    authors： Bruni R,Argentini C,D'Ugo E,Giuseppetti R,Ciccaglione AR,Rapicetta M

    更新日期：1995-12-01 00:00:00

  • Formation of phage T1 concatemers by the RecE recombination pathway of Escherichia coli.

    abstract：:Infections of nonpermissive ( sup0 ) Escherichia coli by T1 phage with amber mutations in either gene 3.5 or gene 4 exhibit a variety of defective phenotypes, including premature arrest of T1 DNA synthesis, failure to make concatemeric DNA, formation of an abnormal DNA replication intermediate, failure to package phag...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90130-2

    authors： Pugh JC,Ritchie DA

    更新日期：1984-05-01 00:00:00

  • Promoter strength in adenovirus transducing vectors: down-regulation of the adenovirus E1A promoter in 293 cells facilitates vector construction.

    abstract：:Most adenovirus transducing vectors have the cytomegalovirus major immediate-early (CMV) or the Rous sarcoma virus long terminal repeat (RSV) promoter driving expression of the transgene. Both of these promoters are highly active in transfection and transduction assays in 293 cells, in which transducing vectors are co...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1211

    authors： Schaack J,Allen B,Orlicky DJ,Bennett ML,Maxwell IH,Smith RL

    更新日期：2001-12-05 00:00:00

  • Ultraviolet absorption spectra and difference spectra of barley stripe mosaic and tobacco mosaic viruses in buffer and sodium dodecyl sulfate.

    abstract：:Ultraviolet absorption spectra and difference spectra were determined for barley stripe mosaic virus (BSMV) virions and protein and for tobacco mosaic virus (TMV) virions and protein in buffer and in sodium dodecyl sulfate (SDS). The absorbance at 260 nm of BSMV virions disrupted in SDS was 92% of that of intact virio...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(79)90526-9

    authors： Brakke MK

    更新日期：1979-10-15 00:00:00

  • Activation of HTLV-I transcription in the presence of Tax is independent of the acetylation of CREB-2 (ATF-4).

    abstract：:We have previously demonstrated that the bZIP transcription factor CREB-2, also called ATF-4, trans-activates, in association with the viral protein Tax, the human T-cell leukemia virus type I (HTLV-I) promoter. In this study, we have examined whether CREB-2 acetylation affects transcriptional activation mediated by T...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1501

    authors： Gachon F,Devaux C,Mesnard JM

    更新日期：2002-08-01 00:00:00

  • A comprehensive proteomics analysis of JC virus Agnoprotein-interacting proteins: Agnoprotein primarily targets the host proteins with coiled-coil motifs.

    abstract：:JC virus (JCV) Agnoprotein (Agno) plays critical roles in successful completion of the viral replication cycle. Understanding its regulatory roles requires a complete map of JCV-host protein interactions. Here, we report the first Agno interactome with host cellular targets utilizing "Two-Strep-Tag" affinity purificat...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.10.005

    authors： Saribas AS,Datta PK,Safak M

    更新日期：2020-01-15 00:00:00

  • Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41.

    abstract：:Natural antibodies to gp41 inhibit HIV-1 replication through the recognition of two different regions, corresponding to the leucine zipper motif in the HR1 alpha-helix and to another motif within HR2 region, hosting 2F5 and 4E10 epitope. This study aimed at reproducing such protective responses through VLP vaccination...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2012.05.005

    authors： Pastori C,Tudor D,Diomede L,Drillet AS,Jegerlehner A,Röhn TA,Bomsel M,Lopalco L

    更新日期：2012-09-15 00:00:00

  • Mapping of the tobacco vein mottling virus VPg cistron.

    abstract：:The location of the cistron encoding the genome-linked protein (VPg) in the potyvirus tobacco vein mottling virus (TVMV) was investigated. Precipitation of 125I-labeled VPg with anti-tobacco etch virus 49K nuclear inclusion protein antiserum (which reacts with the NIa nuclear inclusion protein of TVMV) indicated that ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90307-8

    authors： Shahabuddin M,Shaw JG,Rhoads RE

    更新日期：1988-04-01 00:00:00

  • The role of the PI3K-Akt signal transduction pathway in Autographa californica multiple nucleopolyhedrovirus infection of Spodoptera frugiperda cells.

    abstract：:Many viruses activate the phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway, thereby modulating diverse downstream signaling pathways associated with antiapoptosis, proliferation, cell cycling, protein synthesis and glucose metabolism, in order to augment their replication. To date, the role of the PI3K-Akt p...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.06.007

    authors： Xiao W,Yang Y,Weng Q,Lin T,Yuan M,Yang K,Pang Y

    更新日期：2009-08-15 00:00:00

  • Potato virus X coat protein: a glycoprotein.

    abstract：:The coat protein (CP) genes of all the strains of potato virus X (PVX) code for a protein of 25 kDa. Analysis of the CP by SDS-PAGE shows a migration mobility of 27 to 29 kDa, depending of the strain. Amino acid identity between some strains is too high to explain such abnormal migration by differences in primary stru...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1386

    authors： Tozzini AC,Ek B,Palva ET,Hopp HE

    更新日期：1994-08-01 00:00:00

  • The secretory cells of mouse salivary glands are nonpermissive for polyomavirus replication.

    abstract：:Parotid tumor agent was an early name for polyomavirus due to its ability to induce tumors (myoepitheliomas originating from the myoepithelial glandular tissues) in mice inoculated with polyomavirus (Py) as neonates. It has long been thought that these tumors directly follow productive infection by Py in epithelial ce...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1254

    authors： Atencio IA,Meraz A,Villarreal LP

    更新日期：1994-05-01 00:00:00

  • Treatment with PTEN-Long protein inhibits hepatitis C virus replication.

    abstract：:Hepatitis C virus (HCV) infection is a confirmed risk factor for hepatocellular carcinoma (HCC). Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) possesses tumor suppression function that is frequently defective in HCC tumors. PTEN-Long, a translation isoform of PTEN, functions in a cell non-autonomous m...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2017.08.002

    authors： Wu Q,Li Z,Liu Q

    更新日期：2017-11-01 00:00:00

  • HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells.

    abstract：:HPV-16 is the major causes of cervical cancer. Persistence of infection is a necessary event for progression of the infection to cancer. Among other factors, virus persistence is due the viral proteins fighting the immune response. HPV-16 E5 down-regulates MHC/HLA class I, which is much reduced on the cell surface and...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.07.044

    authors： Campo MS,Graham SV,Cortese MS,Ashrafi GH,Araibi EH,Dornan ES,Miners K,Nunes C,Man S

    更新日期：2010-11-10 00:00:00

  • In vitro synthesis and characterization of DNA complementary to potato spindle tuber viroid.

    abstract：:When DNase-digested calf thymus DNA is used as primer, the RNA-directed DNA polymerase of avian myeloblastosis virus will accept potato spindle tuber viroid (PSTV) as a template for DNA synthesis. The DNA obtained hybridizes specifically to PSTV and low molecular weight RNA isolated from PSTV-infected plants; no hybri...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(78)90180-0

    authors： Owens RA

    更新日期：1978-09-01 00:00:00

  • Selective integration of avian leukosis virus in different hematopoietic tissues.

    abstract：:Hematopoietic tissues obtained from avian leukosis virus (ALV)-infected Hyline SC chickens were analyzed for the presence of integrated viral DNA sequences. Cells were prepared from bone marrow, bursa, spleen, thymus, and peripheral blood. Following the removal of erythrocytes, cellular DNAs from each of these tissues...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90216-3

    authors： Baba TW,Humphries EH

    更新日期：1986-12-01 00:00:00

  • Functional similarities between HIV-1 Tat and DNA sequence-specific transcriptional activators.

    abstract：:The Tat regulatory protein encoded by human immunodeficiency virus type 1 (HIV-1) induces high levels of transcription from the viral long terminal repeat (LTR) promoter element after interacting with a promoter proximal RNA target sequence. In the wild-type HIV-1 LTR, this activation is facilitated by the synergistic...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1041

    authors： Madore SJ,Cullen BR

    更新日期：1995-02-01 00:00:00

  • A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase.

    abstract：:Hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) has acquired a unique beta-hairpin in the thumb subdomain which protrudes toward the active site. We report here that this beta-hairpin plays an important role in positioning the 3' terminus of the viral RNA genome for correct ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.0948

    authors： Hong Z,Cameron CE,Walker MP,Castro C,Yao N,Lau JY,Zhong W

    更新日期：2001-06-20 00:00:00

  • Human recombinant neutralizing antibodies against hantaan virus G2 protein.

    abstract：:Old world hantaviruses, causing hemorrhagic fever with renal syndrome (HFRS), still present a public health problem in Asia and Eastern Europe. The majority of cases has been recorded in China. The aim of our study was to generate human recombinant neutralizing antibodies to a hantavirus by phage display technology. T...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/s0042-6822(02)00094-6

    authors： Koch J,Liang M,Queitsch I,Kraus AA,Bautz EK

    更新日期：2003-03-30 00:00:00

  • The virion N protein of infectious bronchitis virus is more phosphorylated than the N protein from infected cell lysates.

    abstract：:Because phosphorylation of the infectious bronchitis virus (IBV) nucleocapsid protein (N) may regulate its multiple roles in viral replication, the dynamics of N phosphorylation were examined. 32P-orthophosphate labeling and Western blot analyses confirmed that N was the only viral protein that was phosphorylated. Pul...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.04.029

    authors： Jayaram J,Youn S,Collisson EW

    更新日期：2005-08-15 00:00:00

  • Characterization of a human astrovirus serotype 2 structural protein (VP26) that contains an epitope involved in virus neutralization.

    abstract：:An improved purification procedure for human astrovirus serotype 2 (H-Ast2) has facilitated the isolation of a neutralizing monoclonal antibody (PL-2) directed against one of the major structural proteins (VP26) of H-Ast2. A minor component (VP29) of the virus particles is also recognized by PL-2 antibody. Immunofluor...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1296

    authors： Sanchez-Fauquier A,Carrascosa AL,Carrascosa JL,Otero A,Glass RI,Lopez JA,San Martin C,Melero JA

    更新日期：1994-06-01 00:00:00

  • Recombinant human parainfluenza virus type 2 with mutations in V that permit cellular interferon signaling are not attenuated in non-human primates.

    abstract：:The HPIV2 V protein inhibits type I interferon (IFN) induction and signaling. To manipulate the V protein, whose coding sequence overlaps that of the polymerase-associated phosphoprotein (P), without altering the P protein, we generated an HPIV2 virus in which P and V are expressed from separate genes (rHPIV2-P+V). rH...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.07.011

    authors： Schaap-Nutt A,D'Angelo C,Amaro-Carambot E,Nolan SM,Davis S,Wise SM,Higgins C,Bradley K,Kim O,Mayor R,Skiadopoulos MH,Collins PL,Murphy BR,Schmidt AC

    更新日期：2010-10-10 00:00:00

  • Ceramide formation mediated by acid sphingomyelinase facilitates endosomal escape of caliciviruses.

    abstract：:Our recent results demonstrated that bile acids facilitate virus escape from the endosomes into the cytoplasm for successful replication of porcine enteric calicivirus (PEC). We report a novel finding that bile acids can be substituted by cold treatment for endosomal escape and virus replication. This endosomal escape...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2015.04.022

    authors： Shivanna V,Kim Y,Chang KO

    更新日期：2015-09-01 00:00:00

  • High prevalence of hypervariable region 1-specific and -cross-reactive CD4(+) T cells in HCV-infected individuals responsive to IFN-alpha treatment.

    abstract：:The hypervariable region 1 (HVR1) of the putative envelope 2 protein of the hepatitis C virus (HCV) is the most variable part of the whole HCV polyprotein. Anti-HVR1 antibodies have been shown to protect against HCV infection, indicating that this region contains an important neutralization determinant. Recently we an...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0238

    authors： Del Porto P,Puntoriero G,Scottà C,Nicosia A,Piccolella E

    更新日期：2000-04-10 00:00:00

  • Differential expression of the HHV-8 vGCR cellular homolog gene in AIDS-associated and classic Kaposi's sarcoma: potential role of HIV-1 Tat.

    abstract：:Human herpesvirus 8 (HHV-8) has been causally linked to Kaposi's sarcoma (KS). There is significant homology between some HHV-8 genes and cellular genes including D-type cyclin (vCYC), G protein coupled receptor (vGCR), macrophage inflammatory proteins (vMIP-I, vMIP-II), bcl-2 (vBCL2), interferon regulatory factor-1 (...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.0125

    authors： Yen-Moore A,Hudnall SD,Rady PL,Wagner RF Jr,Moore TO,Memar O,Hughes TK,Tyring SK

    更新日期：2000-02-15 00:00:00

  • Differential requirements for Tombusvirus coat protein and P19 in plants following leaf versus root inoculation.

    abstract：:Traditional virus inoculation of plants involves mechanical rubbing of leaves, whereas in nature viruses like Tomato bushy stunt virus (TBSV) are often infected via the roots. A method was adapted to compare leaf versus root inoculation of Nicotiana benthamiana and tomato with transcripts of wild-type TBSV (wtTBSV), a...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.01.011

    authors： Manabayeva SA,Shamekova M,Park JW,Ding XS,Nelson RS,Hsieh YC,Omarov RT,Scholthof HB

    更新日期：2013-05-10 00:00:00