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Identification of a neutralization epitope in the VP1 capsid protein of SV40.

Abstract：

:Three SV40 escape mutants were identified by selection in the presence of monoclonal antibodies with neutralizing activity. The VP1 amino acid alterations in these mutants were: (1) K73-->E (in loop BC); (2) D77-->E (in loop BC); (3) K171-->R (in loop EF); and (4) Q175-->H (in loop EF). These residues are clustered in close proximity to each other on the surface of the native capsid protein, strongly suggesting that they form a conformational epitope directly recognized by the neutralizing antibody. To our knowledge, the present study represents the first experimental mapping of a neutralization epitope of a polyomavirus family member. Structural information regarding the neutralization epitope should be useful for clarifying the extent of cross-reactivity exhibited by the humoral immune response towards related primate polyomaviruses (e.g., SV40, BKV, and JCV).

journal_name

Virology

journal_title

Virology

authors

Murata H,Teferedegne B,Sheng L,Lewis AM Jr,Peden K

doi

10.1016/j.virol.2008.07.032

subject

Has Abstract

pub_date

2008-11-10 00:00:00

pages

116-22

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(08)00479-0

journal_volume

381

pub_type

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