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Enterovirus infections of the central nervous system.

Abstract：

:Enteroviruses (EV) frequently infect the central nervous system (CNS) and induce neurological diseases. Although the CNS is composed of many different cell types, the spectrum of tropism for each EV is considerable. These viruses have the ability to completely shut down host translational machinery and are considered highly cytolytic, thereby causing cytopathic effects. Hence, CNS dysfunction following EV infection of neuronal or glial cells might be expected. Perhaps unexpectedly given their cytolytic nature, EVs may establish a persistent infection within the CNS, and the lasting effects on the host might be significant with unanticipated consequences. This review will describe the clinical aspects of EV-mediated disease, mechanisms of disease, determinants of tropism, immune activation within the CNS, and potential treatment regimes.

journal_name

Virology

journal_title

Virology

authors

Rhoades RE,Tabor-Godwin JM,Tsueng G,Feuer R

doi

10.1016/j.virol.2010.12.014

subject

Has Abstract

pub_date

2011-03-15 00:00:00

pages

288-305

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(10)00768-3

journal_volume

411

pub_type

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