Abstract:
:The nucleotide sequence of the env gene of a previously described human provirus (ERV3) has been determined beginning near the 3'-end of the pol gene and continuing through the 3'-LTR. Analysis of the nucleotide sequence revealed the presence of a long open reading frame of 1944 nucleotides that is capable of encoding a polypeptide that has characteristics of other retroviral glycoproteins and transmembrane proteins. These include the presence of seven potential glycosylation sites, a typical glycoprotein-transmembrane protein cleavage sequence, and amino acid homologies to the glycoproteins and transmembrane proteins of other retroviruses. Further, we have isolated an ERV3-specific cDNA clone from a library prepared from liver RNA of a 20-week human fetus. DNA sequence analysis of this clone revealed that it is identical to the ERV3 genomic clone in the 1110 nucleotides that were sequenced.
journal_name
Virologyjournal_title
Virologyauthors
Cohen M,Powers M,O'Connell C,Kato Ndoi
10.1016/0042-6822(85)90147-3subject
Has Abstractpub_date
1985-12-01 00:00:00pages
449-58issue
2eissn
0042-6822issn
1096-0341journal_volume
147pub_type
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