Gene transfer into hematopoietic progenitor cells mediated by an adeno-associated virus vector.

Abstract:

:We describe here the transduction of murine hematopoietic progenitor cells with the dominant selectable neomycin drug-resistance (Neo) gene using a recombinant adeno-associated virus (AAV) vector. Successful transformation of progenitor cells to drug resistance was determined to be approximately 1.5% by colony formation in the presence of geneticin sulfate (G-418). The value of AAV as an alternative to the retrovirus vector systems is discussed.

journal_name

Virology

journal_title

Virology

authors

LaFace D,Hermonat P,Wakeland E,Peck A

doi

10.1016/0042-6822(88)90491-6

subject

Has Abstract

pub_date

1988-02-01 00:00:00

pages

483-6

issue

2

eissn

0042-6822

issn

1096-0341

journal_volume

162

pub_type

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