Abstract:
:We describe here the transduction of murine hematopoietic progenitor cells with the dominant selectable neomycin drug-resistance (Neo) gene using a recombinant adeno-associated virus (AAV) vector. Successful transformation of progenitor cells to drug resistance was determined to be approximately 1.5% by colony formation in the presence of geneticin sulfate (G-418). The value of AAV as an alternative to the retrovirus vector systems is discussed.
journal_name
Virologyjournal_title
Virologyauthors
LaFace D,Hermonat P,Wakeland E,Peck Adoi
10.1016/0042-6822(88)90491-6subject
Has Abstractpub_date
1988-02-01 00:00:00pages
483-6issue
2eissn
0042-6822issn
1096-0341journal_volume
162pub_type
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