Abstract:
:Nonspecific anti-inflammatory drugs have been purported to reduce the burden of severe influenza disease. We demonstrate that, unlike oseltamivir administration, simvastatin administration did not reduce morbidity, mortality, or viral load of mice infected with H1N1 or H5N1 viruses. No added benefit to the efficacy of oseltamivir therapy was observed when mice were treated in combination with simvastatin. Modest reductions in lung cytokine production in H5N1 but not H1N1 virus-infected simvastatin-treated mice indicate a potential benefit for statin use in mitigating disease following severe virus infection.
journal_name
Virologyjournal_title
Virologyauthors
Belser JA,Szretter KJ,Katz JM,Tumpey TMdoi
10.1016/j.virol.2013.01.017subject
Has Abstractpub_date
2013-04-25 00:00:00pages
42-6issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(13)00063-9journal_volume
439pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::In our in vitro model for HPV16-mediated transformation, HPV16-immortalized human keratinocytes (HKc/HPV16) give rise to differentiation resistant, premalignant cells (HKc/DR). HKc/DR, but not HKc/HPV16, are resistant to growth inhibition by transforming growth factor beta (TGF-β), due to a partial loss of TGF-β recep...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.08.034
更新日期:2013-12-01 00:00:00
abstract::The N-terminal domains of the NS1 protein of influenza B virus (NS1B protein) and the NS1 protein of influenza A virus (NS1A protein) share one function: binding double-stranded RNA (dsRNA). Here we show that the N-terminal domain of the NS1B protein possesses an additional function that is not shared by its NS1A coun...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2002.1663
更新日期:2002-12-20 00:00:00
abstract::Poliovirus procapsids, isolated and partially purified from infected HeLa cells, were found to dissociate into 14 S pentamers following freezing at -20 degrees overnight. Unlike pentameric subunits isolated directly from virus-infected cells or those obtained by alkaline treatment of procapsids, the "freeze-dissociate...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90465-x
更新日期:1987-08-01 00:00:00
abstract::We have characterized capsids made by seven temperature-sensitive (ts) mutants of HSV-1 previously shown to be defective in viral DNA processing and packaging at the nonpermissive temperature (NPT). The empty capsids isolated from mutant-infected cells at the NPT were devoid of DNA, cosedimented in sucrose with wt B c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(88)90288-7
更新日期:1988-04-01 00:00:00
abstract::We investigated the localization of host mRNA during Rift Valley fever virus (RVFV) infection. Fluorescence in situ hybridization revealed that infection with RVFV altered the localization of host mRNA. mRNA accumulated in the nuclei of RVFV-infected but not mock-infected cells. Further, overexpression of the NSS gene...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.09.003
更新日期:2015-12-01 00:00:00
abstract::The role of the nucleocapsid protein of HIV-1 Gag in virus assembly was investigated using Gag truncation mutants, a nucleocapsid deletion mutant, and point mutations in the nucleocapsid region of Gag, in transfected COS cells, and in stable T-cell lines. Consistent with previous investigations, a truncation containin...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9374
更新日期:1998-11-10 00:00:00
abstract::The gene encoding the VP8* trypsin-cleavage product of the VP4 protein of porcine rotavirus strain A34 was sequenced, and the predicted amino acid (aa) sequence was compared to the homologous region of all known P genotypes. The aa sequence of the VP8* of strain A34 shared low identity, ranging from 39% (bovine strain...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(03)00534-8
更新日期:2003-10-25 00:00:00
abstract::Hemorrhagic fever viruses are associated with rapidly progressing severe disease with high case fatality, making them of public health and biothreat importance. Effective antivirals are not available for most of the members of this diverse group of viruses. A broad spectrum strategy for antiviral development would be ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.06.032
更新日期:2009-09-15 00:00:00
abstract::Sulfation is a common post-translational modification of secreted and membrane proteins, with the sulfate attached to tyrosine residues or to glycan side-chains. I have shown that varicella-zoster virus (VZV) envelope glycoproteins gpI, gpII, and gpIII can be labeled with [35S]sulfate. The predominant VZV glycoprotein...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1576
更新日期:1993-11-01 00:00:00
abstract::Human adenovirus type 5 (Ad5) has been the most popular platform for the development of oncolytic Ads. Alternative Ad serotypes with low seroprevalence might allow for improved anticancer efficacy in Ad5-immune patients. We studied the safety and efficacy of rare serotypes Ad6, Ad11 and Ad35. In vitro cytotoxicity of ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.08.038
更新日期:2009-11-25 00:00:00
abstract::Human schlafen11 is a novel restriction factor for HIV-1 based on bias regarding relative synonymous codon usage (RSCU). Here, we report the cloning of equine schlafen11 (eSLFN11) and the characteristics of its role in restricting the production of equine infectious anemia virus (EIAV), a retrovirus similar to HIV-1. ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.04.024
更新日期:2016-08-01 00:00:00
abstract::Eight rhesus macaques inoculated with molecularly cloned SIVmac239 developed viremia and virus-binding antibodies, but only one (macaque 2D) developed neutralizing antibodies to the virus. Viremia persisted in macaque 2D even in the presence of neutralizing antibodies. Neutralizing antibodies in the plasma collected f...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1390
更新日期:1993-08-01 00:00:00
abstract::We have recently described the cloning of a portion of the hepatitis E virus (HEV) and confirmed its etiologic association with enterically transmitted (waterborne, epidemic) non-A, non-B hepatitis. The virus consists of a single-stranded, positive-sense RNA genome of approximately 7.5 kb, with a polyadenylated 3' end...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)90760-9
更新日期:1991-11-01 00:00:00
abstract::To identify new genes affecting Tomato bushy stunt virus (TBSV) replication in yeast model host, we are studying protein families, whose members have been identified during previous high throughput screening. In this paper, we have characterized the WW domain-containing protein family from yeast and plants. We find th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.01.020
更新日期:2012-05-10 00:00:00
abstract::We describe the in vitro selection and characterisation of virus derived from B/Beijing/1/87 passaged in the presence of zanamivir. During zanamivir passage, the phenotype of virus isolates was either drug dependent or drug resistant in plaque reduction assays. The susceptibility of the neuraminidase of the drug-depen...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.0058
更新日期:1999-12-20 00:00:00
abstract::Molluscum contagiosum virus (MCV) is a human poxvirus that produces small, benign skin tumors primarily in young children and encodes proteins that modulate the host immune response. The MC51L, MC53L, and MC54L open reading frames of MCV have significant amino acid sequence similarities and related proteins are encode...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.9676
更新日期:1999-05-10 00:00:00
abstract::Specific binding sites for Epstein-Barr virus (EBV) nuclear antigen (EBNA-1), isolated and semipurified from EBV-transformed nonproductive Raji cells, were visualized on the molecule of EBV DNA by electron microscopy and mapped. Two measures had to be applied to counteract the limited purity of the EBNA-1 preparation:...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90025-0
更新日期:1987-10-01 00:00:00
abstract::The influenza A virus nucleoprotein previously expressed in Escherichia coli after fusion to 32 heterologous amino acids has now been purified and tested for its ability to form complexes with RNA in vitro. By using a simple filter binding assay, we show that ribonucleoprotein (RNP) complexes form readily with single-...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90419-3
更新日期:1987-02-01 00:00:00
abstract::The presence of anti-Tax antibody responses in human T cell leukemia virus type I (HTLV-I)-infected individuals has been correlated with increased proviral load, increased risk of transmitting infection, and increased risk of developing tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). In this study...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9378
更新日期:1998-10-10 00:00:00
abstract::Viral functions essential for the establishment of latent infection in murine sensory neurons in vivo were investigated by employing a herpes simplex virus type 1 (HSV-1) variant (KD6/B11) deleted for expression of the ICP4 gene and therefore unable to replicate. Since the viral DNA persisted in these cells, the laten...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1089
更新日期:1993-02-01 00:00:00
abstract::The existence and genetic make-up of most primate retroviruses was revealed by studies of bushmeat and fecal samples from unhabituated primate communities. For these, detailed data on intra- and within-species contact rates are generally missing, which makes identification of factors influencing transmission a challen...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.05.012
更新日期:2014-07-01 00:00:00
abstract::Callitrichid hepatitis (CH) is a highly fatal, rodent-borne zoonosis of New World primates (family Callitrichidae) caused by lymphocytic choriomeningitis virus (LCMV). It is unclear whether virulence in Callitrichidae is associated with specific genetic or phylogenetic markers of the virus as only a partial S RNA sequ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2001.0909
更新日期:2001-06-05 00:00:00
abstract::Cytoplasmic poly(A)-containing RNA from parainfluenza virus 3-infected cells was used as template to construct a cDNA library that was cloned into the EcoRV site of the plasmid pMG5. The resulting clones were screened with [32P]-labeled cDNA probes made from infected and mock-infected cell mRNAs. The virus specificity...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90237-5
更新日期:1985-11-01 00:00:00
abstract::Human infection with H7N9 virus has provoked global public health concern due to the substantial morbidity and mortality. Neuraminidase inhibitors (NAIs) are used as first-line drugs to treat the infection. However, virus quasispecies can evolve rapidly under drug pressure, which may alter various biological character...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.08.004
更新日期:2019-10-01 00:00:00
abstract::Antigenic variation among influenza B viruses is different from that of influenza A in several ways. Antigenic shift has not been observed, distinct antigenic variants of influenza B cocirculate, and antigenically similar viruses have been isolated many years apart. To study the mechanism of antigenic drift in influen...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(84)90384-2
更新日期:1984-12-01 00:00:00
abstract::Infectious bronchitis has remained one of the most difficult to control diseases in poultry since it was first described in 1931. Previous studies demonstrated that primary CD8(+) T lymphocytes collected at 10 days post-infection (p.i.) are important in controlling acute infection. To further investigate the role of m...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(02)00059-4
更新日期:2003-02-15 00:00:00
abstract::The virulence factor of Melon necrotic spot virus (MNSV), a virus that induces systemic necrotic spot disease on melon plants, was investigated. When the replication protein p29 was expressed in N. benthamiana using a Cucumber mosaic virus vector, necrotic spots appeared on the leaf tissue. Transmission electron micro...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.05.012
更新日期:2009-08-01 00:00:00
abstract::Retroviruses can be grouped by viral interference measurements into classes which use common cell surface receptors. We previously tested a large number of isolates of mink cell focus-inducing (MCF) murine leukemia viruses (MuLVs), and reported that all of them share a distinct receptor on NIH/3T3 cells (A. Rein, Viro...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(84)90255-1
更新日期:1984-07-15 00:00:00
abstract::We have used field inversion gel electrophoresis to survey EBV strains for the size of the major internal repeat, IR-1, and estimate the number of 3.1-kb repeat units present. The B95-8 strain of EBV was estimated to contain 8.6 repeats. The repeat number varies considerably among naturally occurring isolates around a...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(89)90561-8
更新日期:1989-12-01 00:00:00
abstract::In reporter-based transient expression systems, we characterized simian immunodeficiency virus from a chimpanzee (SIVCPZ), with special reference to the human immunodeficiency virus type 1 (HIV-1). SIVCPZ was not equally activated by tat and rev transactivators derived from representative primate lentiviruses. HIV-1 a...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(92)90715-2
更新日期:1992-07-01 00:00:00