Abstract:
:The red clover necrotic mosaic dianthovirus capsid protein is expressed in vivo from a subgenomic RNA (sgRNA) identical to the 3'-terminal 1.5 kb of RNA-1. The 5' leader sequence of the capsid protein sgRNA is 62 nucleotides, contains a 14-nucleotide putative promoter sequence homologous to the RNA-1 5' terminus, and exhibits a high level of similarity with the tobacco mosaic virus 5' leader translational enhancer element omega. Analysis of the RNA-1 secondary structure, in the region adjacent to the position where the 5' end of the sgRNA was mapped, predicts a stable stem-loop which includes the putative sgRNA promoter element. It is suggested that this structure is important for recognition of the sgRNA transcriptional initiation from the full-length negative-sense RNA-1.
journal_name
Virologyjournal_title
Virologyauthors
Zavriev SK,Hickey CM,Lommel SAdoi
10.1006/viro.1996.0076subject
Has Abstractpub_date
1996-02-15 00:00:00pages
407-10issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(96)90076-8journal_volume
216pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::Here we completed the whole genome sequence of Cotesia vestalis bracovirus (CvBV) by deep sequencing and compared the genome features of CvBV to those of other polydnaviruses (PDVs). The genome is 540,215 base pairs divided into 35 genomic segments that range from 2.6 to 39.2kb. Comparison of CvBV with other PDVs show...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.03.009
更新日期:2011-05-25 00:00:00
abstract::A system to associate specific genome segments with viral phenotypes and to study factors influencing genome reassortment was developed for tomato spotted wilt Tospovirus (TSWV). Reassortant isolates were generated by co-inoculating a TSWV isolate, TSWV-D, with TSWV-10 or TSWV-MD. The parental origin of each genome se...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9131
更新日期:1998-04-25 00:00:00
abstract::Viral metagenomics coupled to high-throughput sequencing has provided a powerful tool for large-scale detection of known and unknown viruses associated to distinct hosts and environments. Using this approach, known and novel viruses have been characterized from sylvatic and commercial avian hosts, increasing our under...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.05.013
更新日期:2020-09-01 00:00:00
abstract::Cauliflower mosaic virus (CaMV) uses a specialised translation mechanism to bypass the long leader sequence of the 35S RNA. The effect of the CaMV 35S RNA leader sequence on the expression of a downstream beta-glucuronidase (GUS) reporter gene was studied in transgenic tobacco plants. Enzymatic GUS assays of these tra...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9038
更新日期:1998-03-15 00:00:00
abstract::The Hepatitis B virus precore protein is processed in the endoplasmic reticulum (ER) into secreted hepatitis B e antigen (HBeAg), which acts as an immune tolerogen to establish chronic infection. Downregulation of secreted HBeAg should improve clinical outcome, as patients who effectively respond to current treatments...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.12.034
更新日期:2011-03-01 00:00:00
abstract::A clinical feature of Ross River virus disease (RRVD) is the periodic relapse of symptoms months after the initial onset of disease. The underlying mechanisms responsible for this relapse have not been determined. In a long-term (148 days) in vitro study of persistently infected murine macrophages we established that ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2002.1587
更新日期:2002-09-30 00:00:00
abstract::The P670 promoter of HPV16 directs transcription of the virus late genes in the differentiating epithelium. We found that CCAAT/enhancer binding protein beta (C/EBPbeta), a key transcription factor that induces the terminal differentiation of keratinocytes, enhanced the P670-driven transcription in transient reporter ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.10.025
更新日期:2006-03-01 00:00:00
abstract::Two forms of JC virus (JCV) have been isolated from its human host, an archetype found in kidney tissue and urine of nonimmunocompromised individuals and a rearranged type detected in lymphocytes and brain tissue of patients with and without progressive multifocal leukoencephalopathy. To investigate the hypothesis tha...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0037
更新日期:1996-02-01 00:00:00
abstract::The major capsid protein of HPV, L1, assembles into pentamers that form a T = 7 icosahedral particle, but the location of the co-assembled minor capsid protein, L2, remains controversial. Several researchers have developed useful monoclonal antibodies targeting L2, but most react with linear epitopes toward the N-term...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.08.017
更新日期:2018-11-01 00:00:00
abstract::Avarol is a sesquiterpenoid hydroquinone, which displays no inhibitory potencies on mammalian DNA polymerases alpha, beta, and gamma, on mammalian RNA polymerases I, II, and III, or on reverse transcriptases from Moloney murine leukemia virus (Mo-MuLV) and from HIV. For a further elucidation of the antiviral effect of...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(88)90596-x
更新日期:1988-08-01 00:00:00
abstract::Hantaviruses are enveloped RNA viruses that belong to the family Bunyaviridae. They are the causative agents of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Hantaviruses show a worldwide distribution with specific rodent species as natural hosts. It is known that rodents can tr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2003.09.006
更新日期:2004-01-05 00:00:00
abstract::The baculovirus-insect cell system is used routinely for foreign glycoprotein production, but the precise nature of the N-glycosylation pathway in this system remains unclear. Some studies indicate that these cells cannot process N-linked oligosaccharides to complex forms containing outer-chain galactose and sialic ac...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1508
更新日期:1995-10-01 00:00:00
abstract::The measles virus (MV) vaccine lineage is a promising oncolytic but prior exposure to the measles vaccine or wild-type MV strains limits treatment utility due to the presence of anti-measles antibodies. MV entry can be redirected by displaying a polypeptide ligand on the Hemagglutinin (H) C-terminus. We hypothesized t...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.01.027
更新日期:2014-04-01 00:00:00
abstract::The herpes simplex virus single-stranded DNA-binding protein, ICP8, localizes initially to structures in the nucleus called prereplicative sites. As replication proceeds, these sites mature into large globular structures called replication compartments. The details of what signals or proteins are involved in the redis...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(03)00108-9
更新日期:2003-05-10 00:00:00
abstract::Infected cell protein (ICP) 27 is an essential herpes simplex virus type 1 (HSV-1) phosphoprotein required for optimal viral DNA and early or late gene synthesis. Three slow-migrating immunoreactive species were detected using multiple anti-ICP27 antibodies following HSV-1 infection of HEp-2 and Vero cells in the pres...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.04.011
更新日期:2004-07-01 00:00:00
abstract::Rift Valley fever virus-induced protein synthesis was examined by polyacrylamide gel electrophoresis and fluorography. Five virus-induced polypeptides were detected, the nucleocapsid protein N, the nucleus-associated nonstructural protein NS1, the glycoproteins G1 and G2, and a protein of molecular weight 80K. The N, ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(84)90277-0
更新日期:1984-04-15 00:00:00
abstract::Phage-display methodology has been used to select variant CD4 proteins exhibiting increased binding to the surface envelope glycoprotein, gp120, of Human Immunodeficiency Virus Type-1. To facilitate the selection, a library of mutant CD4 proteins was constructed by cloning a PCR-generated error prone population of the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8651
更新日期:1997-08-04 00:00:00
abstract::In this report, we examined the abilities and requirements of heterologous Gag proteins to functionally complement each other to support viral replication. Two distantly related gammaretroviruses, murine leukemia virus (MLV) and spleen necrosis virus (SNV), were used as a model system because SNV proteins can support ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.10.038
更新日期:2007-04-10 00:00:00
abstract::Two mutant strains of cucumber mosaic virus (CMV) were investigated with respect to virion stability and molecular determinants of aphid vector transmission. The mutant 2A1-MT-60x, derived from the mechanically passaged wild type 2A1-AT, is poorly transmissible by the aphid Aphis gossypii and not transmissible by the ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0569
更新日期:2000-10-25 00:00:00
abstract::In order to investigate the global and dynamic host microRNAs (miRNAs)/messenger RNAs (mRNAs) expression alteration during in vitro acute HCV infection, a comprehensive microarray analysis was performed using human hepatoma cells. Totally, 108 human miRNAs and 1247 mRNAs were identified whose expression levels changed...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.11.036
更新日期:2010-03-01 00:00:00
abstract::The genes encoding the nucleoprotein, PB1, PB2, and PA proteins of the influenza virus strain B/Panamá/45/90 have been cloned under control of the T7 RNA polymerase promoter of plasmid pGEM-3. Transfection of the recombinant plasmids obtained into mammalian cells, which had been infected with a vaccinia virus encoding...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8682
更新日期:1997-09-01 00:00:00
abstract::While the 2009 pandemic H1N1 virus has become established in the human population as a seasonal influenza virus, continued adaptation may alter viral virulence. Here, we passaged a 2009 pandemic H1N1 virus (A/Changchun/01/2009) in mice. Serial passage in mice generated viral variants with increased virulence. Adapted ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.09.014
更新日期:2015-12-01 00:00:00
abstract::We have examined the host range of AIDS-associated retroviruses (ARV) that are known to infect human T cells of the helper subset. We have observed that the virus cannot infect fibroblast and epithelial cell lines of many different animal species. It is infectious and replicates efficiently in peripheral mononuclear c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90146-1
更新日期:1985-12-01 00:00:00
abstract::A cDNA clone containing all of the 26 S mRNA coding region of the RNA genome of Venezuelan equine encephalitis (VEE) virus, virulent strain Trinidad donkey (TRD), has been constructed and sequenced. The nucleotide and deduced amino acid sequences of the 26 S RNA of VEE virus conform to the general organization of the ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(86)90142-x
更新日期:1986-07-30 00:00:00
abstract::Tick-borne flaviviruses are maintained in nature in an enzootic cycle involving a tick vector and a vertebrate host. Thus, the virus replicates in two disparate hosts, each providing selective pressures that can influence virus replication and pathogenicity. To identify viral determinants associated with replication i...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.08.030
更新日期:2008-11-25 00:00:00
abstract::The DNAs of the Cas-Br-E MuLV-induced leukemias always contain somatically acquired mink cell focus-forming (MCF) recombinant proviruses. MCF recombinants could be involved during leukemogenesis at both preleukemic times and in late-stage tumors. Among the Cas-Br-E-induced non-T-, non-B-cell leukemias, viral integrati...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(92)90241-g
更新日期:1992-12-01 00:00:00
abstract::African Swine fever virus (ASFV) genome is a large (170-190 kb) double-stranded DNA molecule with structural features similar to those of Poxviruses. Prominent among those features are the presence of a hairpin loop structure at the end of the DNA molecule and terminal-inverted repeats (TIR). The TIRs have been previo...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1277
更新日期:1994-05-15 00:00:00
abstract::Propagation of human influenza viruses in embryonated chicken eggs (CE) results in the selection of variants with amino acid substitutions near the receptor-binding site of the hemagglutinin (HA) molecule. To evaluate the mechanisms by which these substitutions enable human virus growth in CE, we studied the binding o...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.9732
更新日期:1999-06-05 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) establishes lifelong latent infection in sensory neurons of the peripheral nervous system. During HSV latency, the latency-associated transcripts (LATs) are the only viral transcripts abundantly expressed. The most abundant form of LATs is a 2-kb stable intron spliced from a primary...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.03.043
更新日期:2004-07-01 00:00:00
abstract::In HSV types 1 and 2, gH forms a noncovalent heterodimer with gL. Previous studies demonstrated that the first 323 amino acids of gH1 and the first 161 amino acids of gL1 are sufficient for gH/gL binding. For gL1, substitution of any of its four cysteine (C) residues (all located within the gH/gL binding region) destr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.12.006
更新日期:2005-02-20 00:00:00