Abstract:
:Multibranched peptides (SPCs) derived either from the fusion protein (gp41) sequence or from the cleavage sequence of the human immunodeficiency virus type 1 envelope were chemically synthesized and tested for their ability to inhibit both syncytium formation and HIV production in CD4+ cells. The gp41-derived SPCs had no effect. In contrast, an SPC encompassing the envelope cleavage sites strongly inhibited both HIV Env-induced syncytium formation and viral production.
journal_name
Virologyjournal_title
Virologyauthors
Sabatier JM,Mabrouk K,Moulard M,Rochat H,Van Rietschoten J,Fenouillet Edoi
10.1006/viro.1996.0496subject
Has Abstractpub_date
1996-09-15 00:00:00pages
406-8issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(96)90496-1journal_volume
223pub_type
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