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Retroviral infection of non-dividing cells: old and new perspectives.

Abstract：

:The dependence of retroviral replication on cell proliferation was described as early as 1958, although different classes of retroviruses are able to infect non-dividing cells with different efficiencies. For example, the human immunodeficiency virus (HIV) and other lentiviruses infect most non-dividing cells nearly as well as dividing cells, while the gammaretroviruses such as the murine leukemia virus (MLV) cannot infect non-dividing cells, and other retroviruses have intermediate phenotypes. One exception to the ability of HIV to infect non-dividing cells involves resting CD4+ T cells in vitro where there are multiple restrictions. However, recent data show that there is massive infection of non-activated CD4+ T cell during acute infection which suggests that the situation is different in vivo. Finally, much work trying to explain the difference between HIV and MLV in non-dividing cells has focused on describing the ability of HIV to enter the nucleus during interphase. However, we suggest that events in the viral life-cycle other than nuclear import may be more important in determining the ability of a given retrovirus to infect non-dividing cells.

journal_name

Virology

journal_title

Virology

authors

Yamashita M,Emerman M

doi

10.1016/j.virol.2005.09.012

subject

Has Abstract

pub_date

2006-01-05 00:00:00

pages

88-93

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(05)00585-4

journal_volume

344

pub_type

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