Abstract:
:Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area.
journal_name
Virologyjournal_title
Virologyauthors
Hughes TT,Allen AL,Bardin JE,Christian MN,Daimon K,Dozier KD,Hansen CL,Holcomb LM,Ahlander Jdoi
10.1016/j.virol.2011.11.016subject
Has Abstractpub_date
2012-02-05 00:00:00pages
1-5issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(11)00545-9journal_volume
423pub_type
杂志文章,评审相关文献
VIROLOGY文献大全abstract::Guinea-Bissau in West Africa has the highest prevalence of human immunodeficiency virus (HIV)-2 infection in the world, but recently the HIV-1 prevalence increased rapidly with the subsequent appearance of HIV-1 and HIV-2 dual infections. Information about the genetic subtypes of HIV in the region is limited. Therefor...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.9867
更新日期:1999-09-30 00:00:00
abstract::Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding site (CD4bs). In new immunizations, we attempted to improve nAb response...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2017.02.024
更新日期:2017-05-01 00:00:00
abstract::The spread of HIV-1 to the nervous system occurs early during infection in a large number of asymptomatic virus carriers. In order to address the question whether the brain is targeted by a group of HIV-1 variants with increased neurotropic properties we have obtained 20 paired isolates from the blood and cerebrospina...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1503
更新日期:1993-10-01 00:00:00
abstract::The display of foreign proteins on the surface of baculovirus virions has provided a tool for the analysis of protein-protein interactions and for cell-specific targeting in gene transfer applications. To evaluate the baculovirus display system as a vaccine vehicle, we have generated a recombinant baculovirus (AcNPV-C...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2003.08.003
更新日期:2003-11-10 00:00:00
abstract::Marek' disease virus serotype-1, also know as Gallid herpesvirus 2 (GaHV-2), elicits T-cell lymphomas in chickens. The GaHV-2 genome encodes an oncoprotein, Meq, with similarity to the Jun/Fos family of proteins. We have previously shown that Meq homodimers are not sufficient to induce lymphomas in chickens. In this s...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.01.006
更新日期:2010-04-10 00:00:00
abstract::The human immunodeficiency virus (HIV-1) causes various hematopoietic abnormalities, with thrombocytopenia (TP) occurring in 30% of infected individuals. In the present study, we aimed to determine whether HIV-1 in the bone marrow of TP patients can infect primary megakaryocytes in vitro, which may contribute to the d...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0193
更新日期:2000-03-30 00:00:00
abstract::Five revertants of a linker-scanning mutation adjacent to the stem-loop V attenuation determinant (X472) in the 5' noncoding region of poliovirus RNA were independently isolated from neuroblastoma cells and contained RNAs with seven nucleotide changes in the pyrimidine-rich region. Generation of the identical rare sec...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.9981
更新日期:1999-11-25 00:00:00
abstract::The E7 transforming protein of Human Papillomavirus type 16 (HPV16) is expressed in the skin of a line of FVB mice transgenic for the E6 and E7 open reading frames of HPV16 driven from the alpha A crystallin promoter (FVB alpha AcryHPV16E6E7). We have transferred skin from FVB alpha AcryHPV16E6E7 mice to naive or E7-p...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8650
更新日期:1997-08-18 00:00:00
abstract::B-HIV1, an oligoclone of immortalized cells derived from human peripheral B lymphocytes infected in vitro with the TIIIB isolate of HIV-1, produces low levels of replication-competent HIV when propagated in 1% serum, but increases production > or = 5-fold after phorbol myristate acetate (PMA) exposure. Electron micros...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1499
更新日期:1993-10-01 00:00:00
abstract::We produced the putative protease 3C of human rhinovirus 1A (HRV-1A), a minor group rhinovirus, by Escherichia coli expression of a segment of HRV-1A cDNA coding for 3A, 3B, 3C, and parts of 2C and 3D (delta 2C3ABC delta 3D). The protease 3C was expected to be processed by intramolecular Q-G cleavages from the virus-s...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)90429-f
更新日期:1991-10-01 00:00:00
abstract::The mitotic spindle assembly checkpoint (SAC) ensures faithful chromosome segregation during mitosis by censoring kinetochore-microtubule interactions. It is frequently rendered dysfunctional during carcinogenesis causing chromosome missegregation and genomic instability. There are conflicting reports whether the HPV1...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.06.006
更新日期:2012-10-10 00:00:00
abstract::Infectious bronchitis has remained one of the most difficult to control diseases in poultry since it was first described in 1931. Previous studies demonstrated that primary CD8(+) T lymphocytes collected at 10 days post-infection (p.i.) are important in controlling acute infection. To further investigate the role of m...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(02)00059-4
更新日期:2003-02-15 00:00:00
abstract::Within the family of Poxviridae, the entomopoxviruses are the most distant relatives of the more well-known and intensively studied orthopoxviruses (vaccinia and variola). The growth of the entomopoxvirus from Amsacta moorei (AmEPV) has been characterized in cell culture and compared to that of vaccinia virus (VV), th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1428
更新日期:1995-08-20 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) Tat transcriptionally activates expression from a number of viral and cellular promoters. Recent studies demonstrate the ability of Tat to differentially modulate cellular responses to apoptotic signaling. The antiapoptotic effects of Tat appear to correlate with increased e...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.9688
更新日期:1999-05-10 00:00:00
abstract::Replication-deficient adenovirus (Ad) vectors provide an efficient technology for direct DNA delivery to cells both in vitro and in vivo. We have inserted the measles virus nucleoprotein (N) gene under the control of the strong constitutive CMV major IE promoter into an Ad type 5 E1- vector to produce the recombinant ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1362
更新日期:1995-07-10 00:00:00
abstract::To accomplish their viral life cycle, lentiviruses such as HIV highjack host proteins, the so-called cellular co-factors of replication. Lens Epithelium-derived Growth factor (LEDGF/p75), a transcriptional co-activator, is a co-factor of HIV-integrase (IN) and is required for the tethering and correct integration of t...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2012.09.033
更新日期:2013-01-05 00:00:00
abstract::The presence of anti-Tax antibody responses in human T cell leukemia virus type I (HTLV-I)-infected individuals has been correlated with increased proviral load, increased risk of transmitting infection, and increased risk of developing tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). In this study...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9378
更新日期:1998-10-10 00:00:00
abstract::The M2 protein of influenza A H1N1 strains PR8, WS, and WSN is present in homooligomeric forms in virions grown in the allantoic cavity of embryonated eggs. The bulk of the virion M2 is detected as tetramers and dimers. The oligomeric forms of PR8 virions differ from those of WS and WSN not only in apparent molecular ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(92)90096-8
更新日期:1992-01-01 00:00:00
abstract::The 5' end of the subgenomic RNA of rubella virus was determined by primer extension. The Maxam-Gilbert sequence ladder of the primer extension product contained a determinable sequence which was colinear with the complement of the sequence of the genomic RNA through nucleotide 3325 from the 3' end of the genomic RNA ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(89)90422-4
更新日期:1989-01-01 00:00:00
abstract::The primary cell types that sustain polyomavirus (Py) replication following intranasal infection as well as the nature of the host cellular response to Py were unknown. As this is an essential and specific site for virus entry, it seems likely that viral gene function must be adapted to these mucosal tissues. Using im...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.0030
更新日期:2000-01-05 00:00:00
abstract::The nucleotide sequence of a highly pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) was determined. Transfection of MARC-145 cells with capped in vitro transcripts derived from a full-length cDNA clone of the viral genome resulted in infectious PRRSV with growth characteristics similar to that o...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.04.046
更新日期:2004-08-01 00:00:00
abstract::The avian hematopoietic system has long been an invaluable model to study the mechanisms of cell growth and differentiation. We have developed six MAbs against either chicken embryonic hematopoietic precursor cells or retrovirus-transformed cells. MAbs Mo1, Mo2, and Mo3 recognized transformation-associated markers exp...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(92)90581-9
更新日期:1992-08-01 00:00:00
abstract::The physical structure of the genome of feline herpesvirus-1, a major upper respiratory tract pathogen of cats, was studied. Purified FHV-1 DNA was analyzed by restriction endonuclease and gamma 5' exonuclease digestion, blot hybridization, and electron microscopy. To facilitate further studies, nine bacteriophage clo...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(86)90439-3
更新日期:1986-10-15 00:00:00
abstract::Woodchuck hepatitis core antigen (WHcAg) particles purified from the liver of chronically infected animals were used for monoclonal antibody production. Most of the putative clones demonstrated anti-WHc specificity. However, the supernatants from several putative clones bound X antigen sequences from woodchuck hepatit...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(90)90491-9
更新日期:1990-07-01 00:00:00
abstract::We previously analyzed hybrids of Cucumber mosaic virus (CMV) and Tomato aspermy virus (TAV) that contained CMV RNA2 with the 3'-terminal sequence from TAV RNA2. In this article, we scrutinized the RNA3 molecules in these hybrid viruses by Northern hybridization and RT-PCR and found some recombinant CMV RNA3 molecules...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(02)00050-8
更新日期:2003-02-01 00:00:00
abstract::Antibodies to the hepatitis C virus (HCV) core protein are present in the majority of patients with chronic HCV infection. To characterize the corresponding determinants, synthetic peptides and various deletion clones of the core gene expressed in Escherichia coli were used to test human anti-core positive sera or rab...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1666
更新日期:1994-12-01 00:00:00
abstract::The influenza RNA polymerase is known to be important in pathogenicity and adaptation of avian influenza viruses to mammalian hosts. However, the molecular mechanisms responsible are only partly understood. Here we investigated the role of the polymerase in two different, closely related, H5N1 influenza viruses - a hi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.01.036
更新日期:2010-05-25 00:00:00
abstract::The nucleoprotein (NP) of the influenza A virus encapsidates the viral RNA and participates in the infectious life cycle of the virus. The aims of this study were to find the degree of conservation of NP among all virus subtypes and hosts and to identify conserved binding sites, which may be utilised as potential drug...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.01.023
更新日期:2014-04-01 00:00:00
abstract::The oncogenic potential of human papillomavirus type 18 which is found in a significant number of cervical and penile cancer biopsies was tested in primary human keratinocytes derived from neonatal foreskin. Viral DNA and a gene for resistance to neomycin were introduced into these cells by calcium phosphate transfect...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(89)90247-x
更新日期:1989-11-01 00:00:00
abstract::Metagenomic analysis of whole mosquitoes allows the genetic characterization of all associated viruses, including arboviruses and insect-specific viruses, plus those in their diet or infecting their parasites. We describe here the virome in mosquitoes, primarily Culex pipiens complex, Cx. tarsalis and Cx. erythrothora...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.07.029
更新日期:2018-10-01 00:00:00