Characterization of antigenic determinants in the core antigen of the hepatitis C virus.

abstract：:The uncoating of tobacco mosaic virus (TMV) particles in protoplasts isolated from leaves of transgenic tobacco plants that express the TMV coat protein gene was investigated. Extracts of these protoplasts collected up to 1 hr after inoculation with TMV contained fewer of the complexes ("striposomes") thought to be in...

journal_title：Virology

authors： Wu XJ,Beachy RN,Wilson TM,Shaw JG

更新日期：1990-12-01 00:00:00

abstract：:The nucleotide sequences of the genomes of two strains of canine adenovirus, type 1 (Glaxo and CLL) have been determined within the region spanning approximately 0.80-0.91 map unit. Homology comparisons with other adenoviral DNAs indicate that this region contains part of the hexon-associated protein (pVIII) precursor...

journal_title：Virology

authors： Dragulev BP,Sira S,Abouhaidar MG,Campbell JB

更新日期：1991-07-01 00:00:00

abstract：:The 3' ends of three genomic RNAs (gRNAs) of cowpea chlorotic mottle virus (CCMV) terminate in a highly conserved tRNA-like structure (3'TLS). To examine the intrinsic role played the 3'TLS in packaging, the competence of each gRNA lacking the 3' TLS (DeltaTLS-gRNA) to interact with dissociated coat protein (CP) subun...

journal_title：Virology

authors： Annamalai P,Rao AL

更新日期：2005-02-20 00:00:00

abstract：:The SARS-coronavirus (SARS-CoV) is the etiological agent of severe acute respiratory syndrome (SARS). The SARS-CoV spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion. To delineate functional domains of the SARS-CoV S glycoprotein, single point mutations, clu...

journal_title：Virology

authors： Petit CM,Melancon JM,Chouljenko VN,Colgrove R,Farzan M,Knipe DM,Kousoulas KG

更新日期：2005-10-25 00:00:00

abstract：:An infectious and full-length molecular clone of genomic human spumaretrovirus (HSRV) DNA was constructed. The infectivity of the pHSRV13 clone was demonstrated after transfection into susceptible cells by passage of HSRV-specific cytopathic effects as a cell-free culture supernatant, by electron microscopy of HSRV pa...

journal_title：Virology

authors： Löchelt M,Zentgraf H,Flügel RM

更新日期：1991-09-01 00:00:00

abstract：:Two temperature-sensitive mutants of herpes simplex virus type 1 in complementation group 1-1 were analyzed to determine if the major DNA-binding protein they produced was thermolabile. Cells infected with these mutants were analyzed for deoxyribonucleoprotein complexes containing the DNA-binding protein. These comple...

journal_title：Virology

authors： Leinbach SS,Casto JF,Pickett TK

更新日期：1984-09-01 00:00:00

abstract：:Feline foamy virus (FeFV) belongs to the group of spumaretroviruses that contain in addition to gag, pol, and env accessory genes collectively called bel genes. Primate FVs have been shown to utilize internal promoters in addition to the 5' LTR promoters. In contrast to other known retroviruses, the FV pol genes are e...

journal_title：Virology

authors： Bodem J,Löchelt M,Delius H,Flügel RM

更新日期：1998-05-10 00:00:00

abstract：:In previous studies, a mutant (cp-RSV) of the RSV A2 strain derived from 52 serial cold passages in bovine embryonic tissue culture was highly attenuated in seropositive adults and children but caused upper respiratory tract disease in seronegative infants. We investigated the genetic basis for this attenuation phenot...

journal_title：Virology

authors： Connors M,Crowe JE Jr,Firestone CY,Murphy BR,Collins PL

更新日期：1995-04-20 00:00:00

abstract：:The complete RNA sequence of Sabin 3 (LED3) used in vaccine in the United States has been determined. The LED3 Sabin 3 sequence contains the attenuating mutations at bases 472 and 2034 but differs from that published by Stanway et al. (Nucleic Acids Res., 11, 5629-5643, 1983) at two other base positions, 2493 and 6061...

journal_title：Virology

authors： Weeks-Levy C,Tatem JM,DiMichele SJ,Waterfield W,Georgiu AF,Mento SJ

更新日期：1991-12-01 00:00:00

abstract：:The transcriptive complex, the nucleocapsid with the viral RNA-synthesizing activity, of Newcastle disease virus (NDV) contains three protein components, the major structural subunit (NP) and two associated proteins (P and L) involved in the RNA synthesis. We studied the pathway of these proteins from synthesis to ass...

journal_title：Virology

authors： Hamaguchi M,Nishikawa K,Toyoda T,Yoshida T,Hanaichi T,Nagai Y

更新日期：1985-12-01 00:00:00

abstract：:Infectious bronchitis has remained one of the most difficult to control diseases in poultry since it was first described in 1931. Previous studies demonstrated that primary CD8(+) T lymphocytes collected at 10 days post-infection (p.i.) are important in controlling acute infection. To further investigate the role of m...

journal_title：Virology

authors： Pei J,Briles WE,Collisson EW

更新日期：2003-02-15 00:00:00

abstract：:The coding region of segment 4 of Thogoto (THO) virus, a tick-borne member of the Orthomyxoviridae, was expressed in a baculovirus system under the control of the polyhedrin promoter. This construct expressed authentic envelope glycoprotein as determined by size and antigenic reactivity with a panel of monoclonal anti...

journal_title：Virology

authors： Jones LD,Morse MA,Marriott AC,Nuttall PA

更新日期：1995-10-20 00:00:00

abstract：:Recently, we identified TT virus (TTV) isolates from nonhuman primates and named them simian TTV (s-TTV). To characterize the genomic structure of these isolates in more detail, the full-length nucleotide sequence of the s-TTV isolate (designated s-TTV CH65-1), recovered from a chimpanzee born in West Africa, was ampl...

journal_title：Virology

authors： Inami T,Obara T,Moriyama M,Arakawa Y,Abe K

更新日期：2000-11-25 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Rev is a 19-kDa regulatory protein which binds to unspliced and partially spliced HIV-1 RNAs. Export, splicing, stability, and translation of HIV-1 RNAs are influenced by Rev. To further understand the effect of Rev on HIV-1 RNA splicing, the intranuclear localization of uns...

journal_title：Virology

authors： Favaro JP,Borg KT,Arrigo SJ,Schmidt MG

更新日期：1998-09-30 00:00:00

abstract：:We have proposed that chronic infection of keratinocytes by HPV modifies the expression of potentially important cytokines by interfering with the NF-kappaB signal pathway. We evaluated the constitutive and IL-1beta-induced expression of GM-CSF and TNF-alpha and the expression/activity of NF-kappaB in HPV+ and HPV- ce...

journal_title：Virology

authors： Havard L,Delvenne P,Fraré P,Boniver J,Giannini SL

更新日期：2002-07-05 00:00:00

abstract：:HAV particles isolated from infected cells banded at buoyant densities of 1.42, 1.32, and 1.20 g/ml, and distinctive protein patterns were established by gel electrophoresis and reverse phase high performance liquid chromatography. The relatively higher amounts of p30 in particles with lower buoyant densities suggest ...

journal_title：Virology

authors： Gauss-Müller V,Lottspeich F,Deinhardt F

更新日期：1986-12-01 00:00:00

abstract：:Previously, we showed that the transmembrane (M) and surface (S) glycoproteins were recognized by splenic CD4 T lymphocytes harvested from mice infected intraperitoneally with mouse hepatitis virus, strain JHM (MHV-JHM), whereas only the S protein was recognized by splenocytes derived from mice with MHV-induced chroni...

journal_title：Virology

authors： Xue S,Perlman S

更新日期：1997-11-10 00:00:00

abstract：:We have used mRNA differential display to search for cellular genes whose expression is modulated in SV40-transformed cells. We identified a gene, the alpha1 subunit of type XI procollagen (alpha1(XI)), whose mRNA level is reduced in most F111 rat cell lines that express either wild-type SV40 T antigen or an amino-ter...

journal_title：Virology

authors： Sompayrac L,Jane S,Danna KJ

更新日期：1996-04-15 00:00:00

abstract：:Although herpesviruses have a wide host range and their genomes vary substantially in size, the nucleocapsid appears to be a conservative element of viral design. The capsid shell is icosahedrally symmetric (T = 16), and 125 nm in diameter and 15nm thick in the case of herpes simplex virus 1 (HSV-1). Channel catfish v...

journal_title：Virology

authors： Booy FP,Trus BL,Davison AJ,Steven AC

更新日期：1996-01-15 00:00:00

abstract：:Cardioviruses cause diseases in many animals including, in rare cases, humans. Although they share common features with all picornaviruses, cardioviruses have unique properties that distinguish them from other family members, including enteroviruses. One feature shared by all picornaviruses is the covalent attachment ...

journal_title：Virology

authors： Maciejewski S,Ullmer W,Semler BL

更新日期：2018-03-01 00:00:00

abstract：:Chemokines play critical roles in HIV-1 infection, serving both to modulate viral replication and to recruit target cells to sites of infection. Interferon-gamma-inducible protein 10 (IP-10/CXCL10) is a C-X-C chemokine that acts specifically upon activated T cells and macrophages and attracts T cells into the cerebros...

journal_title：Virology

authors： Lane BR,King SR,Bock PJ,Strieter RM,Coffey MJ,Markovitz DM

更新日期：2003-03-01 00:00:00

abstract：:Transient expression studies using a Nicotiana benthamiana suspension cell-derived protoplast system have identified a minimal sequence that is necessary and sufficient for activation of the tomato golden mosaic virus coat protein (CP) promoter by the viral TrAP protein (also called AL2). The sequence has a bipartite ...

journal_title：Virology

authors： Sunter G,Bisaro DM

更新日期：2003-01-20 00:00:00

abstract：:Granulin and polyhedrin proteins were purified by preparative sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis from the baculoviruses Autographa californica, Rachiplusia ou, Heliothis zea, Heliothis armigera, Trichoplusia ni, and Spodoptera frugiperda. Antisera were raised against Autographa californica...

journal_title：Virology

authors： Summers MD,Hoops P

更新日期：1980-05-01 00:00:00

abstract：:The human immunodeficiency virus (HIV-1) causes various hematopoietic abnormalities, with thrombocytopenia (TP) occurring in 30% of infected individuals. In the present study, we aimed to determine whether HIV-1 in the bone marrow of TP patients can infect primary megakaryocytes in vitro, which may contribute to the d...

journal_title：Virology

authors： Voulgaropoulou F,Pontow SE,Ratner L

更新日期：2000-03-30 00:00:00

abstract：:Coronavirus (CoV) envelope (E) protein ion channel activity was determined in channels formed in planar lipid bilayers by peptides representing either the transmembrane domain of severe acute respiratory syndrome CoV (SARS-CoV) E protein, or the full-length E protein. Both of them formed a voltage independent ion cond...

journal_title：Virology

authors： Verdiá-Báguena C,Nieto-Torres JL,Alcaraz A,DeDiego ML,Torres J,Aguilella VM,Enjuanes L

更新日期：2012-10-25 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear antigen EBNA-1 is essential for viral genome maintenance in vitro and may be the only EBV protein expressed by the majority of latently infected cells in vivo. EBNA-1 may therefore be critical to the evasion of host immunity which allows persistent infection. EBNA-1 includes a poly...

journal_title：Virology

authors： Wrightham MN,Stewart JP,Janjua NJ,Pepper SD,Sample C,Rooney CM,Arrand JR

更新日期：1995-04-20 00:00:00

abstract：:The Autographa californica M nucleopolyhedrovirus (AcMNPV) viral fibroblast growth factor (vFGF) has functional parallels to cellular FGFs. Deletion of the AcMNPV vfgf has no obvious phenotype in cell culture but delays the time of insect death. Here, we determined vFGF production during virus infection. vFGF was dete...

journal_title：Virology

authors： Lehiy CJ,Martinez O,Passarelli AL

更新日期：2009-12-05 00:00:00

abstract：:Proviruses were cloned directly from a cat that developed neurological disorders approximately 28 months after inoculation with a molecularly cloned, minimally pathogenic subgroup A feline leukemia virus (FeLV-A). In addition to FeLV-A proviruses that were nearly identical to the inoculated virus, we detected a subgro...

journal_title：Virology

authors： Boomer S,Gasper P,Whalen LR,Overbaugh J

更新日期：1994-11-01 00:00:00

abstract：:Feline calicivirus depends on host-cell proteins for its replication. We previously showed that knockdown of nucleolin (NCL), a phosphoprotein involved in ribosome biogenesis, resulted in the reduction of FCV protein synthesis and virus yield. Here, we found that NCL may not be involved in FCV binding and entry into c...

journal_title：Virology

authors： Hernández BA,Sandoval-Jaime C,Sosnovtsev SV,Green KY,Gutiérrez-Escolano AL

更新日期：2016-02-01 00:00:00

abstract：:The cellular protein Cyclophilin A (Cyp A) is packaged into human immunodeficiency virus type 1 (HIV-1) particles through a specific interaction with the capsid domain of the Gag polyprotein. Inhibition of Cyp A incorporation by mutagenesis or cyclosporin treatment severely affects infectivity of all HIV-1 M subtypes ...

journal_title：Virology

authors： Wiegers K,Kräusslich HG

更新日期：2002-03-15 00:00:00