Abstract:
:The M2 protein of influenza A H1N1 strains PR8, WS, and WSN is present in homooligomeric forms in virions grown in the allantoic cavity of embryonated eggs. The bulk of the virion M2 is detected as tetramers and dimers. The oligomeric forms of PR8 virions differ from those of WS and WSN not only in apparent molecular weight (MW) but also in that they seem to be composed of two types of monomers differing in MW by approximately 1.5 kDa. Evidence from monoclonal antibody binding (or lack of it) and from in vitro trypsin digestion suggests that, in ovo, the external NH2 region of some PR8 M2 monomers is proteolytically trimmed, resulting in heterogeneous oligomers composed of cleaved and uncleaved monomers in different proportions.
journal_name
Virologyjournal_title
Virologyauthors
Panayotov PP,Schlesinger RWdoi
10.1016/0042-6822(92)90096-8subject
Has Abstractpub_date
1992-01-01 00:00:00pages
352-5issue
1eissn
0042-6822issn
1096-0341journal_volume
186pub_type
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