Abstract:
:The gene encoding the VP8* trypsin-cleavage product of the VP4 protein of porcine rotavirus strain A34 was sequenced, and the predicted amino acid (aa) sequence was compared to the homologous region of all known P genotypes. The aa sequence of the VP8* of strain A34 shared low identity, ranging from 39% (bovine strain B223, P8[11]) to 76% (human strain 69M, P4[10]), with the homologous sequences of representative strains of the remaining 21 P genotypes. Phylogenetic relationships showed that the VP8* of strain A34 shares a common evolutionary lineage with those of human 69M (P4[10]) and equine H-2 (P4[12]) strains. Hyperimmune sera raised to strain A34 and to a genetic reassortant strain containing the VP4 gene from strain A34, both with high homologous neutralization titer via VP4, failed to neutralize strains representative of 15 different P genotypes. These results indicate that strain A34 should be considered as prototype of a new P genotype and serotype (P14[23]) and provide further evidence for the vast genetic and antigenic diversity of group A rotaviruses.
journal_name
Virologyjournal_title
Virologyauthors
Liprandi F,Gerder M,Bastidas Z,López JA,Pujol FH,Ludert JE,Joelsson DB,Ciarlet Mdoi
10.1016/s0042-6822(03)00534-8subject
Has Abstractpub_date
2003-10-25 00:00:00pages
373-80issue
2eissn
0042-6822issn
1096-0341pii
S0042682203005348journal_volume
315pub_type
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