Abstract:
:A collection of TK+, ACV-resistant mutants of herpes simplex virus type 1 (HSV-1) has been derived using a selection system based on biochemically transformed cells. Evidence is presented suggesting that most of these mutants induce resistant DNA polymerase activities and are thus likely to express variant DNA polymerases. Preliminary data on the pathogenesis of these mutants show that most are similar to wild type virus in the majority of their characteristics, although they may be reduced in their ability to kill mice.
journal_name
Virologyjournal_title
Virologyauthors
Larder BA,Darby Gdoi
10.1016/0042-6822(85)90009-1subject
Has Abstractpub_date
1985-10-30 00:00:00pages
262-71issue
2eissn
0042-6822issn
1096-0341journal_volume
146pub_type
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