Abstract:
:The nucleotide sequence was determined of a 1.6-kb restriction fragment containing the polyhedrin gene of the multicapsid nuclear polyhedrosis virus of Orgyia pseudotsugata (OpMNPV). In addition, both the 5' and 3' termini of the polyhedrin mRNA were located in the flanking sequences using S1 mapping procedures. 5' Leader, 3' flanking, and open reading frame sequences of 50-52, 145-167, and 735 nucleotides, respectively, were determined, for a total mRNA length of about 935 nucleotides. A potential 5' regulatory sequence which included the mRNA initiation site was identified and an open reading frame upstream of the polyhedrin gene was located. In addition to the polyhedrin mRNA, two major transcripts upstream of the polyhedrin gene were identified by transcriptional mapping.
journal_name
Virologyjournal_title
Virologyauthors
Leisy D,Rohrmann G,Beaudreau Gdoi
10.1016/0042-6822(86)90031-0subject
Has Abstractpub_date
1986-09-01 00:00:00pages
280-8issue
2eissn
0042-6822issn
1096-0341journal_volume
153pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::The morbilliviruses are a closely related genus which are very similar in their sequences and share a common receptor, but nevertheless show significant restriction in the host species in which they cause disease. One contribution to this restriction might be the nature of the hosts' responses to infection. We have us...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.09.031
更新日期:2009-12-20 00:00:00
abstract::Infectious bronchitis virus (IBV) infection and associated illness may be dramatically modified by passive transfer of immune T lymphocytes. Lymphocytes collected 10 days postinfection were transferred to naive chicks before challenge with virus. As determined by respiratory illness and viral load, transfer of syngene...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0211
更新日期:2000-03-30 00:00:00
abstract::The objective of this study was to identify porcine reproductive and respiratory syndrome virus (PRRSV)-encoded proteins that are responsible for the inhibition of TNF-α expression and the mechanism(s) involved in this phenomenon. Using a TNF-α promoter reporter system, the non-structural protein 1 (Nsp1) was found to...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.07.016
更新日期:2010-10-25 00:00:00
abstract::An arginine-rich RNA-binding motif (ARM) found at the N-proximal region of Brome mosaic virus (BMV) coat protein (CP) adopts alpha-helical conformation and shares homology with CPs of plant and insect RNA viruses, HIV-Rev and Tat proteins, bacterial antiterminators, and ribosomal splicing factors. The ARM of BMV CP, c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0513
更新日期:2000-09-15 00:00:00
abstract::The rep gene of the defective human parvovirus, adeno-associated virus, (AAV) mediates several trans-acting functions important to virus replication, transcription, and gene expression. At least four overlapping polypeptides are expressed from the rep gene. We have constructed a prokaryotic vector which expressed in E...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90166-8
更新日期:1987-11-01 00:00:00
abstract::The genus Badnavirus is characterized by members that are genetically and serologically heterogeneous which presents challenges for their detection and characterization. The presence of integrated badnavirus-like sequences in some host species further complicates detection using PCR-based protocols. To address these c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.01.013
更新日期:2019-03-01 00:00:00
abstract::Geminiviruses are small, ssDNA-containing plant viruses. Bean golden mosaic virus (BGMV) and tomato golden mosaic virus (TGMV) have bipartite genomes, the components of which are designated A and B. Although they are closely related, BGMV and TGMV nevertheless exhibit distinct host-specific phenotypes, with BGMV being...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9424
更新日期:1998-11-25 00:00:00
abstract::The mechanism of vaccinia virus-induced selective inhibition of host cell protein synthesis was studied in a nonpermissive (Chinese hamster ovary, CHO) and in a permissive mouse cell line ( L cells). Small polyadenylated RNAs obtained from uninfected and infected cells were fractionated into six size classes by polyac...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(90)90135-e
更新日期:1990-12-01 00:00:00
abstract::As a simian species, the langurs are not known to harbor simian retroviruses, except for one report on a simian Type D endogenous retrovirus from the spectacled langur (Trachypithecus obscurus) from Malaysia. The present report describes for the first time natural infection of the common Hanuman langur (Semnopithecus ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0567
更新日期:2000-11-10 00:00:00
abstract::Simian virus (SV40) T antigen shares many characteristics with adenovirus E1A which is known to induce apoptosis. To verify the potential of SV40 T antigen-mediated apoptosis, we stably expressed T antigen in immortalized human epithelial cells (Z172 and HaCaT). We found that SV40 T antigen could directly cause apopto...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9109
更新日期:1998-05-10 00:00:00
abstract::The initiation of reverse transcription of the human immunodeficiency virus type 1 (HIV-1) genome requires cellular tRNA(Lys,3) as a primer and occurs at a site in the viral RNA genome, designated as the primer binding site (PBS), which is complementary to the 3'-terminal 18 nucleotides of tRNA(Lys,3). We previously d...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0658
更新日期:1996-12-15 00:00:00
abstract::Identification of regulators of p53 expression is a crucial step in understanding the diverse functions of p53 and its role in cellular homeostasis and responsiveness to insult. Several viral proteins inactivate p53 as a modulator of cell cycle progression and apoptosis. Here, we report that a unique leporipoxviral tr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0507
更新日期:1996-10-01 00:00:00
abstract::Mammalian type C retroviruses can be detected by their induction of foci of cell transformation in S+I - cells. We have noted that certain subtypes of the mouse xenotropic type C retrovirus (MuLV) inhibit this cell alteration. This inhibition, associated with intact virions, is irreversible and gives the infected cell...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90044-4
更新日期:1987-09-01 00:00:00
abstract::There are more than 100 known adenovirus serotypes, including 50 human serotypes. They can infect all 5 major vertebrate classes but only Aviadenovirus infecting birds and Mastadenovirus infecting mammals have been well studied. CELO (chicken embryo lethal orphan) adenovirus is responsible for mild respiratory patholo...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.05.011
更新日期:2008-08-15 00:00:00
abstract::Mixed infections of tobacco protoplasts with Cowpea chlorotic mottle virus (CCMV) and brome mosaic virus (BMV) have been studied. Fluorescent antibody staining showed that capsids of both viruses were made in doubly infected protoplasts but only infectious BMV could be recovered, i.e., BMV dominated in mixed infection...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(80)90050-1
更新日期:1980-09-01 00:00:00
abstract::The 50-70 S RNA complex of a clone of Kirsten murine leukemia virus (Ki-MLV), propagated in NIH 3T3 cells, as well as that of a Moloney (Mo)-MLV, propagated in a mouse thymus-bone marrow cell line, contained an approximately 30 S RNA of unknown biological activity in addition to 38 S genomic RNA. The approximately 30 ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(77)90225-2
更新日期:1977-11-01 00:00:00
abstract::Human papillomavirus type 16 (HPV-16) infections can in rare cases persist and cause lesions that may progress to cervical cancer. Cells in the lesions are not permissive for virus production, nor are cervical cancer cells. The intracellular environment is such that it prevents production of the highly immunogenic, vi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.08.002
更新日期:2007-12-20 00:00:00
abstract::Nanogram amounts of the proinflammatory cytokine interleukin-1alpha (IL-1alpha) were detected in uninfected cultures of human corneal epithelial cells (HCEC). Although HSV-1 replicated >10(4)-fold in these cells and caused extensive cytopathic effects, virus infection was not accompanied by significant extracellular r...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9084
更新日期:1998-04-25 00:00:00
abstract::Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, shows strong anti-HIV activity in vitro in both human peripheral blood CD4+ lymphocytes and macrophages, as well as established human cell lines. MPA shows its greatest antiviral effects during the early stages of HIV infection. By limiting ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1437
更新日期:1995-08-20 00:00:00
abstract::Central African tropical forests are home to several species of non-human primates (NHPs), infected by Simian Immunodeficiency Virus (SIV). It is well-known that HIV-1 epidemic is due to cross-transmission and adaptation of SIV to humans. The main goal of this work was to investigate if a NHP bite is a risk factor for...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.12.026
更新日期:2017-03-01 00:00:00
abstract::KSHV establishes characteristic latent infections in vitro, while RRV, a related macaque rhadinovirus, establishes characteristic permissive infections with virus replication. We identified cells that are not permissive for RRV replication and recapitulate the latent KSHV infection and reactivation processes. The RRV ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.10.013
更新日期:2014-01-05 00:00:00
abstract::Given dengue virus (DENV) genome austerity, it uses cellular molecules and structures for virion entry, translation and replication of the genome. NS1 is a multifunctional protein key to viral replication and pathogenesis. Identification of cellular proteins that interact with NS1 may help in further understanding the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.05.017
更新日期:2015-10-01 00:00:00
abstract::The 2009 influenza pandemic originated from a swine-origin H1N1 virus, which, although less pathogenic than anticipated, may acquire additional virulence-associated mutations in the future. To estimate the potential risk, we sequentially passaged the isolate A/Hamburg/04/2009 in A549 human lung epithelial cells. After...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.02.002
更新日期:2016-05-01 00:00:00
abstract::The parvovirus-encoded nonstructural (NS) proteins have been implicated in the cytopathogenicity of these agents. Although protein NS-1 of minute virus of mice (MVM) has been shown to be toxic, little is known about the role of NS-2 in this process. In order to determine the contribution of NS-1 and NS-2 to cytotoxici...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1355
更新日期:1993-07-01 00:00:00
abstract::The 130-kDa bovine herpesvirus-1 (BHV-1) glycoprotein GVP 6 was found to cross-react immunologically with the herpes simplex glycoprotein gB. Antibodies in polyclonal serum against gB immunoprecipitated GVP 6 and its cleavage products from a lysate of BHV-1-infected cells. Conversely, polyclonal serum against GVP 6 pr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(88)90525-9
更新日期:1988-10-01 00:00:00
abstract::RSV is a major cause of severe lower respiratory infection in infants and young children. With no vaccine yet available, it is important to clarify mechanisms of disease pathogenesis. Since indoleamine-2,3-dioxygenase (IDO) is an immunomodulatory enzyme and is upregulated with RSV infection, we studied it in vivo duri...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2017.09.007
更新日期:2017-12-01 00:00:00
abstract::The growth of vesicular stomatitis virus requires two distinct RNA synthetic events: transcription of messenger RNA molecules and replication of the viral genome RNA. We report the use of a panel of monoclonal antibodies directed against the viral phosphoprotein P in an attempt to assess the role of this protein in RN...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0031
更新日期:1996-02-01 00:00:00
abstract::Studies attempting to identify reservoirs of HIV-1 latency have documented that the virus persists as both a latent and productive infection in subsets of CD4(+) cells. Reports regarding establishment of a stable HIV-1 infection in quiescent T cells in vitro, however, are controversial. In the present study, we invest...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.01.014
更新日期:2004-04-10 00:00:00
abstract::A plasmid-based transfection system capable of generating infectious porcine circovirus type 2 (PCV2) was established. This system was then used in mutagenesis studies to investigate the involvement of a "conserved" nonanucleotide (which constitutes a portion of the loop sequence) located at the origin of DNA replicat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.03.037
更新日期:2004-06-20 00:00:00
abstract::Immunization with heat-inactivated herpes simplex virus type 1 (HSV-1) 2-5 days before ocular infection reduced the frequency of establishment of latent HSV-1 infection in the trigeminal ganglion (TG); this induction of resistance coincided with reduced expression of IFN-gamma mRNA in the TG. Immunization with unrelat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8738
更新日期:1997-09-29 00:00:00