Inhibition of VSV genome RNA replication but not transcription by monoclonal antibodies specific for the viral P protein.

abstract：:Langat (LGT) flavivirus, derived from infectious full-length cDNA clone 636, was investigated for its apoptotic activities in mouse neuroblastoma (Neuro-2a) and simian kidney (Vero and LLC-MK(2)) cells. The hallmark of apoptosis, cleavage of cellular DNA, was observed 48 h after infection of Vero, LLC-MK(2), and Neuro...

journal_title：Virology

authors： Prikhod'ko GG,Prikhod'ko EA,Cohen JI,Pletnev AG

更新日期：2001-08-01 00:00:00

abstract：:The Psu (Polarity suppression) protein of satellite bacteriophage P4 was first characterized as an anti-terminator of transcription termination in Escherichia coli. Psu is also a structural component of mature P4 capsids, where it is present as a decoration protein. Psu is located externally on the capsid surface, and...

journal_title：Virology

authors： Isaksen ML,Dokland T,Lindqvist BH

更新日期：1993-06-01 00:00:00

abstract：:The potential role(s) of cytokines in the reduction of infectious virus and persistent viral infection in the central nervous system was examined by determining the kinetics of cytokine mRNA expression following infection with the neurotropic JHM strain of mouse hepatitis virus. Mice were infected with an antibody esc...

journal_title：Virology

authors： Parra B,Hinton DR,Lin MT,Cua DJ,Stohlman SA

更新日期：1997-07-07 00:00:00

abstract：:Virulence markers to distinguish high from low virulence bovine viral diarrhea virus genotype 2 isolates have not been previously reported. The objective of this study was to identify virulence markers by evaluating the primary and secondary structures of the 5'-untranslated region of low and high virulence bovine vir...

journal_title：Virology

authors： Topliff CL,Kelling CL

更新日期：1998-10-10 00:00:00

abstract：:Virions of southern bean mosaic virus (SBMV) show two distinct sensitivity patterns upon heating. Infectivity loss and capsid denaturation occur concurrently if virions are exposed at 50-55 degrees in 0.1 M sodium phosphate buffer, pH 7.5, or 0.1 M glycine-phosphate buffer, pH 9.0. Contrastingly, virions are inactivat...

journal_title：Virology

authors： Veerisetty V,El-Hassan SA,Sehgal OP

更新日期：1981-01-30 00:00:00

abstract：:The interaction of reovirus with the cytoskeleton was investigated. The soluble components of infected cells were extracted with the nonionic detergent NP-40 in a physiological buffer, and a cytoskeletal extract was prepared from the detergent-insoluble fraction. We observed a selective association of viral-specified ...

journal_title：Virology

authors： Mora M,Partin K,Bhatia M,Partin J,Carter C

更新日期：1987-08-01 00:00:00

abstract：:We describe studies of woodchuck hepatitis virus nucleic acids in liver and other tissues of chronically infected woodchucks, using Southern and Northern blot hybridization techniques. Single-stranded and covalently closed circular replicative DNA molecules were distinguished from partly double-stranded virus genomes....

journal_title：Virology

authors： Ogston CW,Schechter EM,Humes CA,Pranikoff MB

更新日期：1989-03-01 00:00:00

abstract：:The differential symptom determinants of the Holmes' masked (M) and U1 strains of tobacco mosaic virus previously were mapped to the 5'-coterminal open reading frame (ORF) encoding the 126-kDa protein and the N-terminal two-thirds of the 183-kDa protein. Both proteins influence viral RNA accumulation, but the function...

journal_title：Virology

authors： Shintaku MH,Carter SA,Bao Y,Nelson RS

更新日期：1996-07-01 00:00:00

abstract：:The causal agent of rhizomania disease, Beet necrotic yellow vein virus (BNYVV), typically produces asymptomatic root-limited infections in sugar beets (Beta vulgaris) carrying the Rz1-allele. Unfortunately, this dominant resistance has been recently overcome. Multiple cDNA clones of the viral pathogenic determinant p...

journal_title：Virology

authors： Acosta-Leal R,Fawley MW,Rush CM

更新日期：2008-06-20 00:00:00

abstract：:The simian hemorrhagic fever virus (SHFV) genome differs from those of other members of the family Arterivirus in encoding two adjacent sets of four minor structural protein open reading frames (ORFs). A stable, full-length, infectious SHFV-LVR cDNA clone was constructed. Virus produced from this clone had replication...

journal_title：Virology

authors： Vatter HA,Di H,Donaldson EF,Baric RS,Brinton MA

更新日期：2014-08-01 00:00:00

abstract：:Neutralizing sites on bluetongue virus serotype 10 (BTV-10) were investigated with a panel of seven neutralizing monoclonal antibodies (MAbs). Each MAb was coupled to agarose beads and tested against the other MAbs and a nonneutralizing control MAb in a competitive immueprecipitation assay. In addition, neutralization...

journal_title：Virology

authors： Heidner HW,Rossitto PV,MacLachlan NJ

更新日期：1990-06-01 00:00:00

abstract：:In a previous paper (G. Winkler, V. B. Randolph, G. R. Cleaves, T. E. Ryan, and V. Stollar, 1988, Virology 162, 187-196) we showed that the newly synthesized dengue-2 virus nonstructural protein, NS1, exists briefly as a monomer and then undergoes dimerization. We demonstrate here that the dimerization of NS1 is assoc...

journal_title：Virology

authors： Winkler G,Maxwell SE,Ruemmler C,Stollar V

更新日期：1989-07-01 00:00:00

abstract：:As porcine endogenous retroviruses (PERV) productively infect human cells in vitro, they pose a serious risk in xenotransplantation and xenogeneic cell therapies. We have analyzed the prevalence of six well-characterized full-length PERV, five of them being replication-competent and four of them being chromosomally as...

journal_title：Virology

authors： Niebert M,Tönjes RR

更新日期：2003-09-01 00:00:00

abstract：:Human papillomavirus type 27 (HPV-27) and HPV-2c are isolates of the same virus as judged by genomic sequence identity. In a 400-bp stretch of the long control region and the E6 and L1 genes no changes were found between HPV-27 and HPV-2c whereas 55 changes were found between HPV-27 and HPV-2a. This justifies the elev...

journal_title：Virology

authors： Chan SY,Tan CH,Delius H,Bernard HU

更新日期：1994-06-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) is a ubiquitous betaherpesvirus that predominantly infects and replicates in CD4(+) T lymphocytes. However, the mechanism of HHV-6 transmission to T cells from the peripheral mucosa is unknown. Here we found that dendritic cells (DCs) can transmit HHV-6 to T cells, resulting in productive i...

journal_title：Virology

authors： Takemoto M,Imasawa T,Yamanishi K,Mori Y

更新日期：2009-03-15 00:00:00

abstract：:Previous studies have shown that the transmembrane (TM) domain of the subtype B Vpu enhances virion release from cells and some studies have shown that this domain may form an oligomeric structure with properties of an ion channel. To date, no studies have been performed to assess the role of this domain in virus path...

journal_title：Virology

authors： Hout DR,Gomez ML,Pacyniak E,Gomez LM,Inbody SH,Mulcahy ER,Culley N,Pinson DM,Powers MF,Wong SW,Stephens EB

更新日期：2005-08-15 00:00:00

abstract：:Two major infectious forms of vaccinia virus (VACV) have been described: the intracellular mature virion (IMV), and the extracellular enveloped virion (EEV). Due to their stability in the environment, IMVs play a predominant role in host-to-host transmission, whereas EEVs play an important role in dissemination within...

journal_title：Virology

authors： Hooper JW,Custer DM,Thompson E

更新日期：2003-02-01 00:00:00

abstract：:Respiratory syncytial virus is a major cause of bronchiolitis in infants and pneumonia virus of mice (PVM) causes similar disease in mice. The impact of PVM infection in BALB/c and C57BL/6 neonates, and upon re-infection as elderly mice, was compared. As previously shown for adult mice, PVM caused more disease in BALB...

journal_title：Virology

authors： Shrivastava P,Atanley E,Sarkar I,Watkiss E,Gomis S,van Drunen Littel-van den Hurk S

更新日期：2015-11-01 00:00:00

abstract：:We have constructed the recombinant baculovirus which expresses the human immunodeficiency virus type 1 negative factor (nef) gene. Spodoptera frugiperda cells infected with the recombinant virus produced a 27-kDa protein which reacted with rabbit antisera raised against a carboxy-terminal synthetic peptide of the Nef...

journal_title：Virology

authors： Matsuura Y,Maekawa M,Hattori S,Ikegami N,Hayashi A,Yamazaki S,Morita C,Takebe Y

更新日期：1991-10-01 00:00:00

abstract：:Since SARS-CoV-2 spreads rapidly around the world, data have been needed on the natural fluctuation of viral load and clinical indicators associated with it. We measured and compared viral loads of SARS-CoV-2 from pharyngeal swab, IgM anti-SARS-CoV-2, CRP and SAA from serum of 114 COVID-19 patients on admission. Posit...

journal_title：Virology

authors： Shi F,Wu T,Zhu X,Ge Y,Zeng X,Chi Y,Du X,Zhu L,Zhu F,Zhu B,Cui L,Wu B

更新日期：2020-07-01 00:00:00

abstract：:The transmembrane envelope (TM) proteins of retroviruses are used as antigen in diagnostic immunoassays and they represent a conserved target for neutralizing antibodies. To analyze the situation in infections with the feline foamy virus (FFV), its recombinant TM protein was produced and used for ELISA and Western blo...

journal_title：Virology

authors： Mühle M,Bleiholder A,Kolb S,Hübner J,Löchelt M,Denner J

更新日期：2011-04-10 00:00:00

abstract：:Three prophage sequences were identified in the Lactobacillus johnsoni strain NCC533. Prophage Lj965 predicted a gene map very similar to those of pac-site Streptococcus thermophilus phages over its DNA packaging and head and tail morphogenesis modules. Sequence similarity linked the putative DNA packaging and head mo...

journal_title：Virology

authors： Desiere F,Pridmore RD,Brüssow H

更新日期：2000-09-30 00:00:00

abstract：:The P1a protein of the ipomovirus Cucumber vein yellowing virus is one of the self-cleavage serine proteases present in Potyviridae family members. P1a is located at the N-terminal end of the viral polyprotein, and is closely related to potyviral P1 protease. For its proteolytic activity, P1a requires a still unknown ...

journal_title：Virology

authors： Shan H,Pasin F,Valli A,Castillo C,Rajulu C,Carbonell A,Simón-Mateo C,García JA,Rodamilans B

更新日期：2015-02-01 00:00:00

abstract：:Infection with a broad diversity of viruses often activates host cell signaling pathways including the mitogen-activated protein kinase pathway. The present study established that dengue virus infection of human macrophages activates Jun NH(2)-terminal kinase (JNK) and the p38 MAPKs pathways. The activation was observ...

journal_title：Virology

authors： Ceballos-Olvera I,Chávez-Salinas S,Medina F,Ludert JE,del Angel RM

更新日期：2010-01-05 00:00:00

abstract：:Infected cell protein (ICP) 27 is an essential herpes simplex virus type 1 (HSV-1) phosphoprotein required for optimal viral DNA and early or late gene synthesis. Three slow-migrating immunoreactive species were detected using multiple anti-ICP27 antibodies following HSV-1 infection of HEp-2 and Vero cells in the pres...

journal_title：Virology

authors： Sanfilippo CM,Lombardozzi RC,Chirimuuta FN,Blaho JA

更新日期：2004-07-01 00:00:00

abstract：:The natural host of SIVrcm is the red-capped mangabey (Cercocebus torquatus torquatus). Although this virus infects macaques and human PBMCs, its pathogenic potential is unknown. We serially passaged SIVrcm through 9 rhesus macaques to assess its potential for virulence. SIVrcm infected all macaques with peak viremia ...

journal_title：Virology

authors： Ling B,Veazey RS,Marx PA

更新日期：2008-09-15 00:00:00

abstract：:Infectious bronchitis virus (IBV) infection and associated illness may be dramatically modified by passive transfer of immune T lymphocytes. Lymphocytes collected 10 days postinfection were transferred to naive chicks before challenge with virus. As determined by respiratory illness and viral load, transfer of syngene...

journal_title：Virology

authors： Seo SH,Pei J,Briles WE,Dzielawa J,Collisson EW

更新日期：2000-03-30 00:00:00

abstract：:Functions of the six Epstein-Barr virus latent infection nuclear proteins (EBNA-1, -2, -3A, -3B, -3C, or -LP) in maintaining latent infection or cell growth transformation are only partially understood. Using antibodies specific for each EBNA in immunofluorescence microscopy, EBNA-2, -3A, and -3C localized to subnucle...

journal_title：Virology

authors： Petti L,Sample C,Kieff E

更新日期：1990-06-01 00:00:00

abstract：:Red sea bream iridovirus (RSIV) of the Iridoviridae family is a causative agent of lethal infections in many cultured marine fish species in southwestern Japan. RSIV-induced apoptosis was divided as follows: (1). cell shrinkage and rounding at the early apoptotic stage, (2). cell enlargement at the middle apoptotic st...

journal_title：Virology

authors： Imajoh M,Sugiura H,Oshima S

更新日期：2004-05-01 00:00:00

abstract：:In previous studies, a mutant (cp-RSV) of the RSV A2 strain derived from 52 serial cold passages in bovine embryonic tissue culture was highly attenuated in seropositive adults and children but caused upper respiratory tract disease in seronegative infants. We investigated the genetic basis for this attenuation phenot...

journal_title：Virology

authors： Connors M,Crowe JE Jr,Firestone CY,Murphy BR,Collins PL

更新日期：1995-04-20 00:00:00