JNK phosphorylation, induced during dengue virus infection, is important for viral infection and requires the presence of cholesterol.

abstract：:A map of cleavage sites for the restriction endonucleases EcoRI, HindIII, BamHI, HpaI, and KpnI for a New Zealand strain of orf virus (NZ2) DNA has been deduced. Also, the entire genome, apart from approximately 0.1 kbp at each end, has been cloned into various vectors. The genome is 139 kbp in length and, in common w...

journal_title：Virology

authors： Mercer AA,Fraser K,Barns G,Robinson AJ

更新日期：1987-03-01 00:00:00

abstract：:During capsid assembly of bacteriophage P2 and its satellite phage P4, gpN undergoes proteolytic cleavage with the removal of the first 31 amino acids. The truncated protein gpN* is unable to support formation of viable phages in complementation tests. A c-myc antigenic epitope (EQKLISEEDL) exchanged for eleven amino ...

journal_title：Virology

authors： Bjerve K,Lindqvist BH

更新日期：1996-10-15 00:00:00

abstract：:Transcription of the paramyxovirus RNA genome is thought to involve a sequential stop-start mechanism whereby monocistronic mRNAs are produced by polyadenylation and termination of 3' upstream gene followed by reinitiation at the downstream start site. For a number of paramyxoviruses, transcription across the M-F gene...

journal_title：Virology

authors： Rassa JC,Parks GD

更新日期：1998-08-01 00:00:00

abstract：:Cells infected with a reassortant (113/Ho, H7N2) between A/fowl plague/Rostock/34 (FPV, H7N1) and A/Hong Kong/1/68 (H3N2) carrying RNA segments 1 and 6 of the Hong Kong virus and the residual genes of FPV, synthesized at 40 degrees a neuraminidase (NA) which is enzymatically not active and which is not incorporated in...

journal_title：Virology

authors： Breuning A,Scholtissek C

更新日期：1986-04-15 00:00:00

abstract：:The nucleotide sequence of gene 6 encoding the rotavirus major capsid protein VP6 of EDIM strain (EW) was determined and compared to that of 20 previously reported strains with known subgroup specificities. Multiple alignments of amino acid sequences exhibited a high level of sequence conservation (87 to 99.2%). Site-...

journal_title：Virology

authors： Tang B,Gilbert JM,Matsui SM,Greenberg HB

更新日期：1997-10-13 00:00:00

abstract：:Dengue 2 (DEN 2) virus strains collected from dengue hemorrhagic fever (DHF) patients and Aedes aegypti mosquitoes in Thailand, Burma, and Vietnam over a 25-year period have been analyzed by computer assisted T1-RNase-resistant oligonucleotide fingerprinting. Fifty-seven DEN 2 virus strains of the Thailand topotype we...

journal_title：Virology

authors： Trent DW,Grant JA,Monath TP,Manske CL,Corina M,Fox GE

更新日期：1989-10-01 00:00:00

abstract：:We established the transcription map of early region (E) 3 of bovine adenovirus 3 (BAV-3) by Northern blot, S1 nuclease protection assays, cDNA sequencing, and RT-PCR analysis. Five major classes of mRNAs were identified, which shared the 3' ends. Four classes of mRNAs transcribed from the E3 promoter also shared the ...

journal_title：Virology

authors： Idamakanti N,Reddy PS,Babiuk LA,Tikoo SK

更新日期：1999-04-10 00:00:00

abstract：:Reactivation of latent herpes simplex virus 2 (HSV-2) infections can be characterized by episodic recurrent genital lesions and/or viral shedding. We hypothesize that infected (HSV-2(pos)) asymptomatic individuals have acquired T cell responses to specific HSV-2 antigen(s) that may be an important factor in controllin...

journal_title：Virology

authors： Long D,Skoberne M,Gierahn TM,Larson S,Price JA,Clemens V,Baccari AE,Cohane KP,Garvie D,Siber GR,Flechtner JB

更新日期：2014-09-01 00:00:00

abstract：:The P150 and P90 replicase proteins of rubella virus (RUBV), a plus-strand RNA Togavirus, produce a unique cytoplasmic fiber network resembling microtubules. Pharmacological and mutagenic approaches were used to determine if these fibers functioned in virus replication. The pharmacological approach revealed that micro...

journal_title：Virology

authors： Matthews JD,Tzeng WP,Frey TK

更新日期：2010-10-25 00:00:00

abstract：:The protruding (P) domain of norovirus VP1 is responsible for immune recognition and host receptor interaction. Our previous studies have demonstrated that a modification of the ends of the P domain affects the conformation and/or function of the P protein. An expression of the P domain with or without the hinge, or w...

journal_title：Virology

authors： Tan M,Fang PA,Xia M,Chachiyo T,Jiang W,Jiang X

更新日期：2011-02-20 00:00:00

abstract：:Simian cells permissive for influenza A virus infection were stably transformed with a full-length cloned influenza A nucleoprotein gene under the control of an inducible metallothionein promoter and linked to a dihydrofolate reductase gene to facilitate cell selection. Transformed cells synthesized a virus-specific n...

journal_title：Virology

authors： Ryan KW,Mackow ER,Chanock RM,Lai CJ

更新日期：1986-10-15 00:00:00

abstract：:The mutations in two DNA-negative ts mutants of herpes simplex virus type 1 (HSV-1), tsK13 and tsM19, have been previously mapped to a 2.0-kb fragment (coordinates 0.095-0.108) at the left end of the genome (S. Weller, D. Aschman, W. Sacks, D. Coen, and P. Schaffer, 1983, Virology 130, 290-305). Sequence analysis of t...

journal_title：Virology

authors： Zhu L,Weller SK

更新日期：1988-10-01 00:00:00

abstract：:How the H7N9 avian influenza virus gained the distinct ability to infect humans is unclear. Pigs are an important host in influenza virus ecology because they are susceptible to infection with both avian and human influenza viruses and are often involved in interspecies transmission. Here, we passaged one avian isolat...

journal_title：Virology

authors： Xu L,Bao L,Deng W,Zhu H,Li F,Chen T,Lv Q,Yuan J,Xu Y,Li Y,Yao Y,Gu S,Yu P,Chen H,Qin C

更新日期：2014-03-01 00:00:00

abstract：:Three prophage sequences were identified in the Lactobacillus johnsoni strain NCC533. Prophage Lj965 predicted a gene map very similar to those of pac-site Streptococcus thermophilus phages over its DNA packaging and head and tail morphogenesis modules. Sequence similarity linked the putative DNA packaging and head mo...

journal_title：Virology

authors： Desiere F,Pridmore RD,Brüssow H

更新日期：2000-09-30 00:00:00

abstract：:Circoviruses are relatively novel pathogens with increased importance in canids. In this study, we first screened the presence of dog circovirus (DogCV) by molecular methods from a total number of 389 internal organ samples originating from 277 individuals of domestic dogs and wild animals including wolves, foxes and ...

journal_title：Virology

authors： Zaccaria G,Malatesta D,Scipioni G,Di Felice E,Campolo M,Casaccia C,Savini G,Di Sabatino D,Lorusso A

更新日期：2016-03-01 00:00:00

abstract：:Virus-host interactions essential for alphavirus pathogenesis are poorly understood. To address this shortcoming, we coupled retrovirus insertional mutagenesis and a cell survival selection strategy to generate clonal cell lines broadly resistant to Sindbis virus (SINV) and other alphaviruses. Resistant cells had sign...

journal_title：Virology

authors： Kolokoltsova OA,Domina AM,Kolokoltsov AA,Davey RA,Weaver SC,Watowich SJ

更新日期：2008-07-20 00:00:00

abstract：:The hemagglutinin of the 2009 pandemic H1N1 influenza virus is a derivative of and is antigenically related to classical swine but not to seasonal human H1N1 viruses. We compared the A/California/7/2009 (CA/7/09) virus recommended by the WHO as the reference virus for vaccine development, with two classical swine infl...

journal_title：Virology

authors： Min JY,Chen GL,Santos C,Lamirande EW,Matsuoka Y,Subbarao K

更新日期：2010-12-05 00:00:00

abstract：:The envelope glycoprotein (Env) of Moloney murine leukemia virus (MoMuLV) is proteolytically processed and transported to the cell surface where it can be incorporated into budding virions. Cell surface Env is frequently detected using an indirect immunofluorescence assay and fluorescence-activated cell sorting (FACS)...

journal_title：Virology

authors： Yu H,Empig C,Xia J,Anderson WF

更新日期：1998-04-10 00:00:00

abstract：:Recently, the product of equine herpesvirus type 1 (EHV-1) ORF1, a homolog to HSV-1 pUL56, was shown to modulate MHC-I expression and innate immunity. Here, we investigated modulation of respiratory epithelial immunity by EHV-1 pUL56 and compared responses to those of PBMCs, which are important target cells that allow...

journal_title：Virology

authors： Soboll Hussey G,Ashton LV,Quintana AM,Van de Walle GR,Osterrieder N,Lunn DP

更新日期：2014-09-01 00:00:00

abstract：:HIV-1 entry into cells requires the interaction of both HIV-1 envelope proteins and membrane lipids. We investigated the mechanism of neutralization of HIV-1 infection of primary monocyte-derived macrophages (MDM) by a murine monoclonal antibody (mAb) WR321. WR321 specifically binds phosphatidylinositol-4-phosphate an...

journal_title：Virology

authors： Jobe O,Peachman KK,Matyas GR,Asher LV,Alving CR,Rao M

更新日期：2012-09-01 00:00:00

abstract：:To examine whether there are HBV variants not yet described which cannot express HBe due to a mutation in the pre-C region, and, if they exist, whether they cause a particular course of infection and disease, we analyzed the HBV genomes of a HBs/anti-HBe positive chronic carrier who had several episodes of acute reexa...

journal_title：Virology

authors： Raimondo G,Schneider R,Stemler M,Smedile V,Rodino G,Will H

更新日期：1990-11-01 00:00:00

abstract：:Immunoelectron microscopy using an anti-VP2 monoclonal antibody complexed to colloidal gold has been used to study the mechanism of bluetongue virus (BTV) release from infected cells. Examination of the BTV-infected cell surface revealed that viruses are released both as enveloped particles, by budding through the pla...

journal_title：Virology

authors： Hyatt AD,Eaton BT,Brookes SM

更新日期：1989-11-01 00:00:00

abstract：:Structure-guided approaches to HIV-1 vaccine design depend on knowledge of the presentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAb b12. Here, we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their b12-bound conformation, ...

journal_title：Virology

authors： Sterjovski J,Churchill MJ,Ellett A,Wesselingh SL,Ramsland PA,Gorry PR

更新日期：2012-10-25 00:00:00

abstract：:In this study, we present enzymatic differences found between recombinant RTs derived from feline leukemia virus and feline immunodeficiency virus. Firstly, FIV RT showed low steady state K(m) values for dNTPs compared to FeLV RT. Consistent with this, FIV RT synthesized DNA more efficiently than FeLV RT at low dNTP c...

journal_title：Virology

authors： Operario DJ,Reynolds HM,Kim B

更新日期：2005-04-25 00:00:00

abstract：:The transcription/replication activity of ribonucleoproteins derived from influenza A primary isolates of human (A/Paris/908/97) or avian origin (A/Mallard/Marquenterre/MZ237/83, A/Hong Kong/156/97) was compared upon reconstitution in mammalian or avian cells, using viral-like reporter RNAs synthesized under the contr...

journal_title：Virology

authors： Labadie K,Dos Santos Afonso E,Rameix-Welti MA,van der Werf S,Naffakh N

更新日期：2007-06-05 00:00:00

abstract：:The HIV-2 viral accessory protein Vpx is related to, but distinct from the Vpr protein of HIV-1. Vpx is packaged into virions and as a component of the viral preintegration complex (PIC) is required for efficient virus replication in non-dividing cells. We have previously reported that the minimal transferable region ...

journal_title：Virology

authors： Belshan M,Mahnke LA,Ratner L

更新日期：2006-03-01 00:00:00

abstract：:To comprehensively understand the endocytosis of Sapelovirus A (PSV) entry into PK-15 cells, we studied PSV infection in the context of cell perturbations through drug inhibition, siRNA silencing and overexpression of dominant negative (DN) mutants. We showed here that PSV infection of PK-15 cells was unaffected by pr...

journal_title：Virology

authors： Zhao T,Cui L,Yu X,Zhang Z,Shen X,Hua X

更新日期：2019-03-01 00:00:00

abstract：:The spike glycoprotein (G protein) of rabies virus (CVS strain) expressed in HeLa cells from cloned cDNA mediated membrane fusion after exposure to pHs of 6.1 or below. Chemical crosslinking showed that the rabies G protein, like the vesicular stomatitis virus (VSV) G protein, could be crosslinked to dimers and trimer...

journal_title：Virology

authors： Whitt MA,Buonocore L,Prehaud C,Rose JK

更新日期：1991-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is widely spread in the human population. EBV nuclear antigen 1 (EBNA1) is a transcription factor that activates viral genes and is necessary for viral replication and partitioning, which binds the EBV genome cooperatively. We identify similar EBNA1 repeat binding sites in the human genome usi...

journal_title：Virology

authors： d'Hérouël AF,Birgersdotter A,Werner M

更新日期：2010-09-30 00:00:00

abstract：:Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes. We show that hemagglutination involves selective recognition of the non-human sialic acid N-g...

journal_title：Virology

authors： Löfling J,Lyi SM,Parrish CR,Varki A

更新日期：2013-05-25 00:00:00