Conserved amino acids of the human immunodeficiency virus type 2 Vpx nuclear localization signal are critical for nuclear targeting of the viral preintegration complex in non-dividing cells.

abstract：:Porcine circovirus type 2 (PCV2) is the causative agent of an emerging swine disease, postweaning multisystemic wasting syndrome. In this work, the RNAs of PCV2 synthesized during productive infection in porcine kidney cells were characterized. A total of nine RNAs were detected. They include the viral capsid protein ...

journal_title：Virology

authors： Cheung AK

更新日期：2003-01-05 00:00:00

abstract：:This study attempts to isolate and characterize West Nile virus-binding molecules on the plasma membrane of Vero and murine neuroblastoma cells that is responsible for virus entry. Pretreatment of Vero cells with proteases, glycosidases (endoglycosidase H, alpha-mannosidase), and sodium periodate strongly inhibited We...

journal_title：Virology

authors： Chu JJ,Ng ML

更新日期：2003-08-01 00:00:00

abstract：:DI7 is a defective interfering RNA derived from RNA 2 of tobacco rattle tobravirus (TRV) isolate PpK20. Tobacco was transformed with DI7 cDNA fused to the CaMV 35S promoter. Upon infection of the transgenic plants with TRV isolate PpK20 or the serologically unrelated isolate PaY4, the transgenic DI7 RNA started to acc...

journal_title：Virology

authors： Visser PB,Brown DJ,Brederode FT,Bol JF

更新日期：1999-10-10 00:00:00

abstract：:Analogous to transmission of human T-cell leukemia virus type 1 (HTLV-1) in vivo, an in vitro cell-to-cell infection model was established by coculturing MT-2 cells as virus donors and HUT78 cells as recipients. At a donor:recipient ratio of 1:2, cell fusion occurred and a new round of HTLV-1 genome replication was in...

journal_title：Virology

authors： Benovic S,Kok T,Stephenson A,McInnes J,Burrell C,Li P

更新日期：1998-05-10 00:00:00

abstract：:The spike glycoprotein (G protein) of rabies virus (CVS strain) expressed in HeLa cells from cloned cDNA mediated membrane fusion after exposure to pHs of 6.1 or below. Chemical crosslinking showed that the rabies G protein, like the vesicular stomatitis virus (VSV) G protein, could be crosslinked to dimers and trimer...

journal_title：Virology

authors： Whitt MA,Buonocore L,Prehaud C,Rose JK

更新日期：1991-12-01 00:00:00

abstract：:A non-optimal receptor-binding specificity of avian influenza viruses is believed to hamper their replication in humans; however, the magnitude of this restriction remains undefined. Here we generated recombinant viruses, R1 and R2, that differed solely by two amino acids in the receptor-binding site of their hemagglu...

journal_title：Virology

authors： Matrosovich M,Matrosovich T,Uhlendorff J,Garten W,Klenk HD

更新日期：2007-05-10 00:00:00

abstract：:In benign squamous lesions and in organotypic epithelial cultures, the human papillomavirus (HPV) E6 and E7 genes are transcriptionally up-regulated in differentiated, spinous keratinocytes. We previously identified sequence elements in the enhancer-promoter regions of HPV types 18 and 11 important for this promoter r...

journal_title：Virology

authors： Zhao W,Chow LT,Broker TR

更新日期：1999-01-20 00:00:00

abstract：:Flaviviruses are RNA viruses that constitute a worrisome threat to global human and animal health. In Europe, West Nile virus (WNV) outbreaks have dramatically increased in number and severity in recent years, with dozens of human and horse deaths and a high avian mortality across the continent. Besides WNV, the only ...

journal_title：Virology

authors： Blázquez AB,Escribano-Romero E,Martín-Acebes MA,Petrovic T,Saiz JC

更新日期：2015-08-01 00:00:00

abstract：:Differing and sometimes conflicting data have been reported regarding several aspects of vaccinia virus (VV) entry. To address this, we used a beta-galactosidase reporter virus to monitor virus entry into multiple cell types under varying conditions. Entry into HeLa, B78H1 and L cells was strongly inhibited by heparin...

journal_title：Virology

authors： Whitbeck JC,Foo CH,Ponce de Leon M,Eisenberg RJ,Cohen GH

更新日期：2009-03-15 00:00:00

abstract：:The red clover necrotic mosaic dianthovirus capsid protein is expressed in vivo from a subgenomic RNA (sgRNA) identical to the 3'-terminal 1.5 kb of RNA-1. The 5' leader sequence of the capsid protein sgRNA is 62 nucleotides, contains a 14-nucleotide putative promoter sequence homologous to the RNA-1 5' terminus, and ...

journal_title：Virology

authors： Zavriev SK,Hickey CM,Lommel SA

更新日期：1996-02-15 00:00:00

abstract：:Mutations disrupting helicase domain motifs of the Tobacco mosaic virus 126/183-kDa proteins were investigated for their effect on replicase function and assembly. These mutations inhibited virus replication but did not affect 126-kDa induced N gene resistance or RNAi suppression. However, in vivo expressed 126-kDa mo...

journal_title：Virology

authors： Wang X,Kelman Z,Culver JN

更新日期：2010-07-05 00:00:00

abstract：:Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression o...

journal_title：Virology

authors： Campoy S,Hervàs A,Busquets N,Erill I,Teixidó L,Barbé J

更新日期：2006-08-01 00:00:00

abstract：:The induction of autoimmunity by viruses has been hypothesized to occur by a number of mechanisms. Coxsackievirus B4 (CB4) induces hyperglycemia in SJL mice resembling diabetes in humans. While virus is effectively cleared within 2 weeks, hyperglycemia does not appear until about 8-12 weeks postinfection at a time whe...

journal_title：Virology

authors： Horwitz MS,Ilic A,Fine C,Rodriguez E,Sarvetnick N

更新日期：2003-09-30 00:00:00

abstract：:The APOBEC3 enzyme family are host restriction factors that induce mutagenesis of HIV-1 proviral genomes through the deamination of cytosine to form uracil in nascent single-stranded (-)DNA. HIV-1 suppresses APOBEC3 activity through the HIV-1 protein Vif that induces APOBEC3 degradation. Here we compared two common po...

journal_title：Virology

authors： Mohammadzadeh N,Follack TB,Love RP,Stewart K,Sanche S,Chelico L

更新日期：2019-01-15 00:00:00

abstract：:HIV-1 transcytosis has been proposed as a potential mechanism allowing the virus to cross the epithelium during mucosal transmission. Epitopes of the HIV-1 envelope involved in this process have not been identified yet. Here, we assessed a large panel of HIV neutralizing antibodies recognizing well-characterized epito...

journal_title：Virology

authors： Chomont N,Hocini H,Gody JC,Bouhlal H,Becquart P,Krief-Bouillet C,Kazatchkine M,Bélec L

更新日期：2008-01-20 00:00:00

abstract：:Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) is an orphan nuclear receptor that represses transcription of many genes. In adenovirus type 12 (Ad12) transformed cells, a high level of binding activity of COUP-TF to the major histocompatibility complex (MHC) class I enhancer correlates with the dow...

journal_title：Virology

authors： Smirnov DA,Hou S,Ricciardi RP

更新日期：2000-03-15 00:00:00

abstract：:We used Cre/loxP recombination to swap targeting ligands present on the adenoviral capsid protein IX (pIX). A loxP-flanked sequence encoding poly-lysine (pK-binds heparan sulfate proteoglycans) was engineered onto the 3'-terminus of pIX, and the resulting fusion protein allowed for routine virus propagation. Growth of...

journal_title：Virology

authors： Poulin KL,Tong G,Vorobyova O,Pool M,Kothary R,Parks RJ

更新日期：2011-11-25 00:00:00

abstract：:Recently, cases of severe respiratory illness in military and civilian populations have been associated with a new genomic variant of adenovirus (Ad) serotype 14, designated Ad14a. Compared to the Ad14 reference strain (de Wit), this new virus had a deletion of two amino acid residues in the fiber protein knob. Here w...

journal_title：Virology

authors： Wang H,Tuve S,Erdman DD,Lieber A

更新日期：2009-05-10 00:00:00

abstract：:Urine and breast milk represent the main routes of human cytomegalovirus (HCMV) transmission but the contribution of renal and mammary epithelial cells to viral excretion remains unclear. We observed that kidney and mammary epithelial cells were permissive to HCMV infection and expressed immediate early, early and lat...

journal_title：Virology

authors： Twite N,Andrei G,Kummert C,Donner C,Perez-Morga D,De Vos R,Snoeck R,Marchant A

更新日期：2014-07-01 00:00:00

abstract：:Sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for human hepatitis B virus (HBV) and its satellite virus Hepatitis D virus (HDV). Physiologically, NTCP is responsible for the majority of sodium-dependent bile acids uptake by hepatocytes. The p.Ser267Phe (S267F) variant of NTCP is a sing...

journal_title：Virology

authors： Liu C,Xu G,Gao Z,Zhou Z,Guo G,Li D,Jing Z,Sui J,Li W

更新日期：2018-09-01 00:00:00

abstract：:Polyribosomal RNA from tobacco infected with sonchus yellow net virus (SYNV) contained sequences which hybridized to 125I-labeled SYNV RNA and which were complementary to 80 to 100% of the viral RNA genome. The poly(A)-containing RNA from polyribosomes was complementary to over 90% of the viral genome but the polyribo...

journal_title：Virology

authors： Milner JJ,Jackson AO

更新日期：1979-08-01 00:00:00

abstract：:A critical feature of highly pathogenic avian influenza viruses (H5N1 and H7N7) is the efficient intracellular cleavage of the hemagglutinin (HA) protein. H7N7 viruses also exist in equine species, and a unique feature of the equine H7N7 HA is the presence of an eleven amino acid insertion directly N-terminal to a tet...

journal_title：Virology

authors： Hamilton BS,Sun X,Chung C,Whittaker GR

更新日期：2012-12-05 00:00:00

abstract：:The genetic diversity of group M HIV-1 is highest in west central Africa. Blood samples from four locations in Cameroon were collected to determine the molecular epidemiology of HIV-1. The C2-V5 region of envelope was sequenced from 39 of the 40 samples collected, and 7 samples were sequenced across the genome. All st...

journal_title：Virology

authors： Carr JK,Torimiro JN,Wolfe ND,Eitel MN,Kim B,Sanders-Buell E,Jagodzinski LL,Gotte D,Burke DS,Birx DL,McCutchan FE

更新日期：2001-07-20 00:00:00

abstract：:The baculovirus-insect cell system is used routinely for foreign glycoprotein production, but the precise nature of the N-glycosylation pathway in this system remains unclear. Some studies indicate that these cells cannot process N-linked oligosaccharides to complex forms containing outer-chain galactose and sialic ac...

journal_title：Virology

authors： Jarvis DL,Finn EE

更新日期：1995-10-01 00:00:00

abstract：:The identification of mechanisms that prevent infection with human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) would facilitate the development of an effective AIDS vaccine. In time-course experiments, protection against detectable superinfection with homologous wild-type SIV was achieved withi...

journal_title：Virology

authors： Stebbings R,Berry N,Stott J,Hull R,Walker B,Lines J,Elsley W,Brown S,Wade-Evans A,Davis G,Cowie J,Sethi M,Almond N

更新日期：2004-12-05 00:00:00

abstract：:A dodecapeptide containing the sequence of the C terminus of the nonstructural polyprotein of Sindbis virus has been synthesized and used to immunize rabbits. The antisera obtained precipitated polypeptides from cells infected with the HR strains of Sindbis or with temperature-sensitive mutants ts11 or ts18. Four diff...

journal_title：Virology

authors： Lopez S,Bell JR,Strauss EG,Strauss JH

更新日期：1985-03-01 00:00:00

abstract：:Two novel halophilic archaebacterial bacteriophages, HF1 and HF2, were isolated from an Australian solar saltern. They were morphologically identical with icosahedral-shaped heads (diameter 58 nm) and contractile tails (length 94 nm). Other similarities included sensitivity to reduced ionic conditions, similar protein...

journal_title：Virology

authors： Nuttall SD,Dyall-Smith ML

更新日期：1993-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) lytic DNA replication is initiated at the cis-acting oriLyt region and requires six core replication proteins along with UL84 and IE2. Although UL84 is thought to be the replication initiator protein, little is known about its interaction with oriLyt. We have now performed chromatin immuno...

journal_title：Virology

authors： Kagele D,Gao Y,Smallenburg K,Pari GS

更新日期：2009-09-15 00:00:00

abstract：:The mechanism of vaccinia virus-induced selective inhibition of host cell protein synthesis was studied in a nonpermissive (Chinese hamster ovary, CHO) and in a permissive mouse cell line ( L cells). Small polyadenylated RNAs obtained from uninfected and infected cells were fractionated into six size classes by polyac...

journal_title：Virology

authors： Su MJ,Bablanian R

更新日期：1990-12-01 00:00:00

abstract：:An H5N6 highly pathogenic avian influenza virus (HPAIV) outbreak occurred in poultry in Japan during January 2018, and H5N6 HPAIVs killed several wild birds in 3 prefectures during Winter 2017-2018. Time-measured phylogenetic analyses demonstrated that the Hemagglutinin (HA) and internal genes of these isolates were g...

journal_title：Virology

authors： Mine J,Uchida Y,Nakayama M,Tanikawa T,Tsunekuni R,Sharshov K,Takemae N,Sobolev I,Shestpalov A,Saito T

更新日期：2019-07-01 00:00:00