Vaccination with live attenuated simian immunodeficiency virus for 21 days protects against superinfection.

abstract：:A new type of retrovirus (Sm-MTV) released by cultured cells of a spontaneous mammary tumor from a house musk shrew, Suncus murinus, is described. The Sm-MTV is distinct morphologically from type C particles. In spite of certain morphological similarities to type B and type D retroviruses, the Sm-MTV is readily distin...

journal_title：Virology

authors： Tsutsui Y,Nagayoshi S,Saga S,Takahashi M,Aoyama A,Malavasi JY,Hayakawa S,Yokoi T,Oda S,Hoshino M

更新日期：1985-07-15 00:00:00

abstract：:The epithelium of the cervix uteri has been reported to be frequently coinfected with both human papillomaviruses (HPV) and helper virus-dependent adenoassociated viruses (AAV). Seroepidemiological data suggest that AAV infection could inhibit cervical cancer that is caused by specific ("high-risk") types of papilloma...

journal_title：Virology

authors： Walz CM,Correa-Ochoa MM,Müller M,Schlehofer JR

更新日期：2002-02-01 00:00:00

abstract：:The biological phenotype of HIV-1 isolates from 21 subjects with primary HIV-1 infection was determined in primary lymphocytes and monocyte-derived macrophages as well as in three T-cell lines (MT-2, HUT78, and C8166). Seven isolates (33%) replicated on at least one cell line and were classified as rapid/high (n = 6) ...

journal_title：Virology

authors： Fiore JR,Björndal A,Peipke KA,Di Stefano M,Angarano G,Pastore G,Gaines H,Fenyö EM,Albert J

更新日期：1994-10-01 00:00:00

abstract：:The pregenomic RNA (pgRNA) of hepadnaviruses serves a dual role: as mRNA for the core (C) and polymerase (P) synthesis and as an RNA template for viral genome replication. A question arises as to how these two roles are regulated. We hypothesized that the P protein could suppress translation of the pgRNA via its inter...

journal_title：Virology

authors： Ryu DK,Kim S,Ryu WS

更新日期：2008-03-30 00:00:00

abstract：:Frog virus 3 (FV3) is the type species member of the genus Ranavirus (family Iridoviridae). To better understand the molecular mechanisms involved in the replication of FV3, including transcription of its highly methylated DNA genome, we have determined the complete nucleotide sequence of the FV3 genome. The FV3 genom...

journal_title：Virology

authors： Tan WG,Barkman TJ,Gregory Chinchar V,Essani K

更新日期：2004-05-20 00:00:00

abstract：:An in-frame gag gene mutant of human immunodeficiency virus type 1, which carries two amino acid substitutions in the center of the p24 coding region, was constructed in vitro, and its replication properties in several cell lines were examined. In CD4-negative SW480 cells transfected with the mutant clone, synthesis a...

journal_title：Virology

authors： Sakuragi J,Sakai H,Kawamura M,Tokunaga K,Ueda S,Adachi A

更新日期：1995-09-10 00:00:00

abstract：:Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analy...

journal_title：Virology

authors： Na H,Huisman W,Ellestad KK,Phillips TR,Power C

更新日期：2010-09-01 00:00:00

abstract：:Genetic studies have been carried out on orbiviruses in the Great Island (GI) antigenic subgroup of the Kemerovo serogroup (Orbivrus, Reoviridae) to elucidate the functions of the 10 genomic double-stranded RNA segments. Such studies have shown that segment 4 is the major genetic determinant of neurovirulence (P.A. Nu...

journal_title：Virology

authors： Nuttall PA,Moss SR,Carey D,Jones LD,Jacobs SC

更新日期：1990-02-01 00:00:00

abstract：:The retroviral cyclin protein (rv-cyclin) of walleye dermal sarcoma virus contains two known functional domains, a cyclin box motif and a carboxy terminal transcription activation domain (AD). The AD contacts TATA-binding protein-associated factor 9 (TAF9), and this action is necessary for both positive and negative r...

journal_title：Virology

authors： Quackenbush SL,Linton A,Brewster CD,Rovnak J

更新日期：2009-03-30 00:00:00

abstract：:Most adenovirus transducing vectors have the cytomegalovirus major immediate-early (CMV) or the Rous sarcoma virus long terminal repeat (RSV) promoter driving expression of the transgene. Both of these promoters are highly active in transfection and transduction assays in 293 cells, in which transducing vectors are co...

journal_title：Virology

authors： Schaack J,Allen B,Orlicky DJ,Bennett ML,Maxwell IH,Smith RL

更新日期：2001-12-05 00:00:00

abstract：:Multiplication of frog virus 3 (FV 3) occurs in mammalian cells provided they are incubated at temperatures lower than 33 degrees. The expression of the viral genome at supraoptimal temperatures was followed by analyzing the polypeptides produced in CHO-infected cells and comparing with those obtained under restrictiv...

journal_title：Virology

authors： Cordier O,Tondre L,Aubertin AM,Kirn A

更新日期：1986-07-30 00:00:00

abstract：:To identify ranavirus virulence genes, we engineered Frog Virus 3 (FV3) knockout (KO) mutants defective for a putative viral caspase activation and recruitment domain-containing (CARD) protein (Δ64R-FV3) and a β-hydroxysteroid dehydrogenase homolog (Δ52L-FV3). Compared to wild type (WT) FV3, infection of Xenopus tadpo...

journal_title：Virology

authors： Andino Fde J,Grayfer L,Chen G,Chinchar VG,Edholm ES,Robert J

更新日期：2015-11-01 00:00:00

abstract：:A pseudorabies virus (PrV) mutant, deficient in the nonessential glycoprotein E (gE) and expressing the LacZ gene (gE- beta gal+ PrV), and its rescued virus were inoculated intranasally in mice. The median lethal dose of gE- beta gal+ PrV was similar to that of the parental Kaplan strain, but mice survived longer and ...

journal_title：Virology

authors： Babic N,Klupp B,Brack A,Mettenleiter TC,Ugolini G,Flamand A

更新日期：1996-05-01 00:00:00

abstract：:Transcriptionally targeted MLV-based ProCon vectors allow expression of the transduced gene in a promoter-specific manner by replacement of the viral U3 region with a heterologous promoter. In order to evaluate the effects of sequence elements present in ProCon vectors on transgene expression (enhanced green fluoresce...

journal_title：Virology

authors： Hlavaty J,Portsmouth D,Stracke A,Salmons B,Günzburg WH,Renner M

更新日期：2004-12-05 00:00:00

abstract：:We recently reported the phenomenon of retroviral insertion into a herpesvirus (Isfort et al., (1992) Proc. Natl. Acad. Sci. USA 89, 991-995). We have now isolated Marek's disease virus (MDV) clones that carry retroviral inserts. Retroviral LTR insertion has the potential to activate or inactivate herpesvirus genes le...

journal_title：Virology

authors： Kost R,Jones D,Isfort R,Witter R,Kung HJ

更新日期：1993-01-01 00:00:00

abstract：:LMP2A deletion and point mutants, with mutations in phosphotyrosine-containing protein-protein interaction motifs, were transiently expressed in 293 cells and their phosphorylation was examined in immune complex kinase assays as well as in vivo. In vitro LMP2A phosphorylation depended on tyrosine 112. In vivo, mutatio...

journal_title：Virology

authors： Scholle F,Longnecker R,Raab-Traub N

更新日期：2001-12-20 00:00:00

abstract：:RNase protection analysis of mRNAs for Epstein-Barr virus (EBV) genes activated early in the induction of the productive cycle in Akata cells has confirmed that BZLF1 and BRLF1 behave as immediate early genes. These are likely to be the only virus immediate early genes since analysis of three other transcripts previou...

journal_title：Virology

authors： Packham G,Brimmell M,Cook D,Sinclair AJ,Farrell PJ

更新日期：1993-02-01 00:00:00

abstract：:Nipah virus (NV) and Hendra virus (HV) are recently emergent, related viruses that can cause severe disease in humans and animals. The goal of this study was to investigate the immunogenic and functional properties of the fusion (F) and attachment (G) glycoproteins of NV. Vaccination of mice with recombinant vaccinia ...

journal_title：Virology

authors： Tamin A,Harcourt BH,Ksiazek TG,Rollin PE,Bellini WJ,Rota PA

更新日期：2002-04-25 00:00:00

abstract：:We have compared the deduced envelope (E) protein sequences of two biologically well-characterized yellow fever (YF) virus vaccine strains. The 17DD strain has been produced in Brazil for more than 50 years and used to successfully vaccinate millions of people worldwide. The 17D-213 is a candidate vaccine strain produ...

journal_title：Virology

authors： Post PR,Santos CN,Carvalho R,Cruz AC,Rice CM,Galler R

更新日期：1992-05-01 00:00:00

abstract：:Adenoviruses (Ads) infect hosts from all vertebrate species and have been investigated as vaccine vectors. We report here near-atomic structures of two bovine Ad type 3 (BAd3) intermediates obtained by cryo-electron microscopy. A comparison between the two intermediate structures reveals that the differences are local...

journal_title：Virology

authors： Cheng L,Huang X,Li X,Xiong W,Sun W,Yang C,Zhang K,Wang Y,Liu H,Huang X,Ji G,Sun F,Zheng C,Zhu P

更新日期：2014-02-01 00:00:00

abstract：:Polyomavirus (PyV) infection induces protective T-cell-independent (TI) IgM and IgG responses in T-cell-deficient (TCR beta x delta-/-) mice. In this study, we show that PyV is a TI -2 antigen: B cells with a mutated Bruton's tyrosine kinase (Xid mutants) do not respond to PyV with antibody secretion in the absence of...

journal_title：Virology

authors： Szomolanyi-Tsuda E,Brien JD,Dorgan JE,Garcea RL,Woodland RT,Welsh RM

更新日期：2001-02-15 00:00:00

abstract：:We have used a yeast two-hybrid system to identify a baculoviral gene encoding a protein kinase-interacting protein (PKIP). The pkip gene is located at 15.8-16.2 m.u (map units) and represents ORF 24 in the sequence of Ayres et al. (1994) of the Autographa californica nuclear polyhedrosis virus. PKIP is a 19.2-kDa pro...

journal_title：Virology

authors： Fan X,McLachlin JR,Weaver RF

更新日期：1998-01-20 00:00:00

abstract：:Previous reports from our lab had shown that sera obtained from SIV(mac)-infected animals neutralized SIV(mac) infectivity in CD4(+) T cells but failed to protect monkey primary macrophages from infection with the virus. However, the antibodies could inhibit completion of the viral life cycle in the macrophages at the...

journal_title：Virology

authors： Zhuge W,Jia F,Mackay G,Kumar A,Narayan O

更新日期：2001-09-01 00:00:00

abstract：:Our recent results demonstrated that bile acids facilitate virus escape from the endosomes into the cytoplasm for successful replication of porcine enteric calicivirus (PEC). We report a novel finding that bile acids can be substituted by cold treatment for endosomal escape and virus replication. This endosomal escape...

journal_title：Virology

authors： Shivanna V,Kim Y,Chang KO

更新日期：2015-09-01 00:00:00

abstract：:While some neurotropic viruses cause rapid central nervous system (CNS) disease upon entry into the brain parenchyma, other viruses that are cytolytic in the periphery either result in little neuropathology or are associated with a protracted course of CNS disease consistent with persistent infection. One such virus, ...

journal_title：Virology

authors： Daley JK,Gechman LA,Skipworth J,Rall GF

更新日期：2005-09-15 00:00:00

abstract：:Three distinct species of nucleocapsids of equine herpesvirus type-1, designated as either light (L), intermediate (I), or heavy (H) on the basis of their densities in Renografin-76 density gradients (Perdue et al. 1975), were characterized with respect to their amino acid content, DNA content, and role in the maturat...

journal_title：Virology

authors： Perdue ML,Cohen JC,Randall CC,O'Callaghan DJ

更新日期：1976-10-01 00:00:00

abstract：BACKGROUND:When antiretroviral therapy does not fully suppress HIV replication, suboptimal levels of antiretrovirals can select for antiretroviral resistant variants of HIV. These variants may exhibit reduced replication capacity and result in lower viral loads in blood. Our study evaluated whether antiretroviral resis...

journal_title：Virology

authors： Hightower GK,Letendre SL,Cherner M,Gibson SA,Ellis RJ,Wolfson TJ,Gamst AC,Ignacio CC,Heaton RK,Grant I,Richman DD,Smith DM,HNRC Group.

更新日期：2009-11-25 00:00:00

abstract：:Encephalitis is a rare, but serious complication from vaccination against smallpox using replication competent strains of vaccinia virus. In this report we describe mutants of vaccinia virus, containing N-terminal deletions of the vaccinia virus interferon resistance gene, E3L, that are attenuated for neuropathogenesi...

journal_title：Virology

authors： Brandt T,Heck MC,Vijaysri S,Jentarra GM,Cameron JM,Jacobs BL

更新日期：2005-03-15 00:00:00

abstract：:The bipartite geminiviruses bean golden mosaic virus (BGMV), cabbage leaf curl virus (CabLCV), and tomato golden mosaic virus (TGMV) exhibit differential tissue tropism in Nicotiana benthamiana. In systemically infected leaves, BGMV remains largely confined to vascular-associated cells (phloem-limited), whereas CabLCV...

journal_title：Virology

authors： Qin Y,Petty IT

更新日期：2001-12-20 00:00:00

abstract：:Avarol is a sesquiterpenoid hydroquinone, which displays no inhibitory potencies on mammalian DNA polymerases alpha, beta, and gamma, on mammalian RNA polymerases I, II, and III, or on reverse transcriptases from Moloney murine leukemia virus (Mo-MuLV) and from HIV. For a further elucidation of the antiviral effect of...

journal_title：Virology

authors： Kuchino Y,Nishimura S,Schröder HC,Rottmann M,Müller WE

更新日期：1988-08-01 00:00:00