Strain variation in Epstein-Barr virus immediate early genes.

abstract：:Genome-linked protein VPg of Potato virus A (PVA; genus Potyvirus) has essential functions in all critical steps of PVA infection, i.e. replication, movement, and virulence. Structural features of the recombinant PVA VPg were investigated with the aim to create an outline for structure-function relationships. Circular...

journal_title：Virology

authors： Rantalainen KI,Uversky VN,Permi P,Kalkkinen N,Dunker AK,Mäkinen K

更新日期：2008-08-01 00:00:00

abstract：:We compared the levels of the Ski oncoprotein, an inhibitor of transforming growth factor-beta (TGF-β) signaling, in normal human keratinocytes (HKc), HPV16 immortalized HKc (HKc/HPV16), and differentiation resistant HKc/HPV16 (HKc/DR) in the absence and presence of TGF-β. Steady-state Ski protein levels increased in ...

journal_title：Virology

authors： Chen Y,Pirisi L,Creek KE

更新日期：2013-09-01 00:00:00

abstract：:We previously demonstrated a high permissiveness of HTLV-II-transformed T lymphocytes (C3) to human immunodeficiency virus (HIV) infection in vitro, and that this infection results in the lysis of cells (D.C. Montefiori and W.M. Mitchell (1986) Virology 155, 726-731). We now show that a small percentage of HIV-infecte...

journal_title：Virology

authors： Montefiori DC,Mitchell WM

更新日期：1987-10-01 00:00:00

abstract：:The recent development of arterivirus full-length cDNA clones makes possible the construction of chimeric arteriviruses for fundamental and applied studies. Using an equine arteritis virus (EAV) infectious cDNA clone, we have engineered chimeras in which the ectodomains of the two major envelope proteins, the glycopro...

journal_title：Virology

authors： Dobbe JC,van der Meer Y,Spaan WJ,Snijder EJ

更新日期：2001-09-30 00:00:00

abstract：:The mature flavivirus capsid protein (virion C) is commonly thought to be free in the cytoplasm of infected cells and to form a nucleocapsid-like complex with genomic RNA in mature virus particles. There is little sequence conservation among flavivirus virion C proteins, but they are similar in size (e.g., 99 amino ac...

journal_title：Virology

authors： Markoff L,Falgout B,Chang A

更新日期：1997-06-23 00:00:00

abstract：:Herpes simplex virus mutant strains that fail to encode a functional ICP27 polypeptide show a reduction in their ability to replicate viral DNA compared to wild-type virus. To define the nature of this defect, we examined the formation of viral DNA replication structures in the nucleus of cells infected with these mut...

journal_title：Virology

authors： Curtin KD,Knipe DM

更新日期：1993-09-01 00:00:00

abstract：:Previous studies indicated that hepatitis C virus core protein influences cellular apoptosis. However, the precise mechanisms of the effects are not fully understood. Therefore, in this study, we examined the mechanisms of the effects on cell apoptosis by core protein, using transiently transfected and magnetically co...

journal_title：Virology

authors： Otsuka M,Kato N,Taniguchi H,Yoshida H,Goto T,Shiratori Y,Omata M

更新日期：2002-04-25 00:00:00

abstract：:We have compared the deduced envelope (E) protein sequences of two biologically well-characterized yellow fever (YF) virus vaccine strains. The 17DD strain has been produced in Brazil for more than 50 years and used to successfully vaccinate millions of people worldwide. The 17D-213 is a candidate vaccine strain produ...

journal_title：Virology

authors： Post PR,Santos CN,Carvalho R,Cruz AC,Rice CM,Galler R

更新日期：1992-05-01 00:00:00

abstract：:While several studies have shown a role for autophagy in the replication of dengue virus (DENV), these studies have been performed in directly infected cells. However, in severe cases of DENV infection the critical cell in the disease is believed to be monocytes which are poorly infected directly, but are highly susce...

journal_title：Virology

authors： Panyasrivanit M,Greenwood MP,Murphy D,Isidoro C,Auewarakul P,Smith DR

更新日期：2011-09-15 00:00:00

abstract：:Expression of alphavirus glycoproteins on the surface of infected cells leads to cell fusion after exposure to acidic pH. Two strains of Sindbis virus, AR339 (SV) and neuroadapted Sindbis virus (NSV), which differ in virulence for weanling mice, were found to differ in pH-dependent fusion. BHK-21 cells infected with S...

journal_title：Virology

authors： Boggs WM,Hahn CS,Strauss EG,Strauss JH,Griffin DE

更新日期：1989-04-01 00:00:00

abstract：:Like human adenovirus type 5 (HAV5), bovine adenovirus type 3 (BAV3) early region 1 (E1) consists of E1A and E1B transcriptional units. In order to characterize BAV3 E1 proteins and to isolate a cell line of bovine origin that expresses BAV3 E1, polyclonal antibodies specific to E1A, E1B-157R, and E1B-420R were raised...

journal_title：Virology

authors： van Olphen AL,Tikoo SK,Mittal SK

更新日期：2002-03-30 00:00:00

abstract：:We have previously demonstrated that the bZIP transcription factor CREB-2, also called ATF-4, trans-activates, in association with the viral protein Tax, the human T-cell leukemia virus type I (HTLV-I) promoter. In this study, we have examined whether CREB-2 acetylation affects transcriptional activation mediated by T...

journal_title：Virology

authors： Gachon F,Devaux C,Mesnard JM

更新日期：2002-08-01 00:00:00

abstract：:The monoclonal antibody 2D5 neutralized vaccinia virus by preventing penetration of the virus and reacting with VP23-29K. The conformation of the VP23-29K was maintained by a disulfide bond(s), and the 2D5mAb reacted stronger with the nonreduced 23-kDa form than with the reduced 29-kDa form. We selected several escape...

journal_title：Virology

authors： Ichihashi Y,Oie M

更新日期：1996-06-15 00:00:00

abstract：:Seven envelope regions from two series of patient isolates have been molecularly cloned and analyzed for replication phenotypes and immunogenicity. Growth potential was analyzed for env sequences substituted into an HIV-1-NL4-3 backbone (NL4-3/env recombinants). Immunogenicity studies were conducted on secreted monome...

journal_title：Virology

authors： Mustafa F,Richmond JF,Fernandez-Larsson R,Lu S,Fredriksson R,Fenyö EM,O'Connell M,Johnson E,Weng J,Santoro JC,Robinson HL

更新日期：1997-03-03 00:00:00

abstract：:A full-size cloned cDNA copy of the rotavirus gene encoding the structural neutralization glycoprotein (VP7) of Nebraska calf diarrhea virus (NCDV), a strain recently shown to be effective as a vaccine in children, has been sequenced. Comparison of the deduced amino acid sequence of NCDV (serotype 6) VP7 with that of ...

journal_title：Virology

authors： Glass RI,Keith J,Nakagomi O,Nakagomi T,Askaa J,Kapikian AZ,Chanock RM,Flores J

更新日期：1985-03-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) Gag proteins are assembled into virus particles and then cleaved by the virion-associated HIV protease. Concomitant with Gag processing, doughnut-like HIV particles (the immature form) are converted to particles containing condensed cores (the mature form). Here we describe the in vi...

journal_title：Virology

authors： Morikawa Y,Shibuya M,Goto T,Sano K

更新日期：2000-07-05 00:00:00

abstract：:A combinatorial, phage-display library of human Fab antibody fragments was generated from IgG heavy chain (HC) and light chain (LC) genes cloned from the lymphocytes of a vaccinia virus (VACV)-immune donor. To ascertain the complexity of the library, nucleotide sequences of the variable regions of the HC and LC genes ...

journal_title：Virology

authors： Schmaljohn C,Cui Y,Kerby S,Pennock D,Spik K

更新日期：1999-05-25 00:00:00

abstract：:Recombinants of Moloney murine leukemia virus (MoMuLV) with either an amphotropic (MoAmphoV) or 10A1-tropic host range (Mo10A1V) induce a spongiform neurodegenerative disease in susceptible mice. To test whether MoMuLV -derived sequences are required for induction of neuropathology, mice were inoculated with either th...

journal_title：Virology

authors： Münk C,Prassolov V,Rodenburg M,Kalinin V,Löhler J,Stocking C

更新日期：2003-08-15 00:00:00

abstract：:HPV-16 is the major causes of cervical cancer. Persistence of infection is a necessary event for progression of the infection to cancer. Among other factors, virus persistence is due the viral proteins fighting the immune response. HPV-16 E5 down-regulates MHC/HLA class I, which is much reduced on the cell surface and...

journal_title：Virology

authors： Campo MS,Graham SV,Cortese MS,Ashrafi GH,Araibi EH,Dornan ES,Miners K,Nunes C,Man S

更新日期：2010-11-10 00:00:00

abstract：:Primary strains of human immunodeficiency virus type 1 (HIV-1) are known to adapt to replication in cell lines in vitro by becoming sensitive to soluble CD4 (sCD4) and neutralizing antibodies (NAb). T-cell lines favor isolation of variants that use CXCR4 as a co-receptor, while primary isolates predominantly use CCR5....

journal_title：Virology

authors： Pugach P,Kuhmann SE,Taylor J,Marozsan AJ,Snyder A,Ketas T,Wolinsky SM,Korber BT,Moore JP

更新日期：2004-03-30 00:00:00

abstract：:To determine whether infection with HIV-1 strains of different tropisms would influence expression of the mucosa-associated integrins alpha 4 beta 7 and alpha E beta 7 or the lymph node homing receptor L-selectin on peripheral T lymphocytes, cells were infected with the CXCR4-tropic (X4)/syncytium-inducing (SI) HIV-1(...

journal_title：Virology

authors： Cummins JE Jr,Bunn WJ,Hall SD,Donze HH,Mestecky J,Jackson S

更新日期：2001-02-15 00:00:00

abstract：:Human cytomegalovirus (HCMV) can be isolated from peripheral blood leukocytes; however, in vitro, only abortive infection of monocytes, lymphocytes, and granulocytes has been detected. These studies demonstrate that freshly isolated monocytes can be infected with HCMV. Infection of monocytes was not associated with lo...

journal_title：Virology

authors： Maciejewski JP,Bruening EE,Donahue RE,Sellers SE,Carter C,Young NS,St Jeor S

更新日期：1993-08-01 00:00:00

abstract：:Highly pathogenic alphaviruses display complex glycans on their surface. These glycans play a crucial role in viral pathogenesis by facilitating glycan-host interaction during viral entry which can be targeted. Various studies have reported antiviral activity of lectins that bind to the glycans present on the surface ...

journal_title：Virology

authors： Kaur R,Neetu,Mudgal R,Jose J,Kumar P,Tomar S

更新日期：2019-01-02 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) is a ubiquitous betaherpesvirus that predominantly infects and replicates in CD4(+) T lymphocytes. However, the mechanism of HHV-6 transmission to T cells from the peripheral mucosa is unknown. Here we found that dendritic cells (DCs) can transmit HHV-6 to T cells, resulting in productive i...

journal_title：Virology

authors： Takemoto M,Imasawa T,Yamanishi K,Mori Y

更新日期：2009-03-15 00:00:00

abstract：:Studies attempting to identify reservoirs of HIV-1 latency have documented that the virus persists as both a latent and productive infection in subsets of CD4(+) cells. Reports regarding establishment of a stable HIV-1 infection in quiescent T cells in vitro, however, are controversial. In the present study, we invest...

journal_title：Virology

authors： Joshi A,Vahlenkamp TW,Garg H,Tompkins WA,Tompkins MB

更新日期：2004-04-10 00:00:00

abstract：:We have characterized capsids made by seven temperature-sensitive (ts) mutants of HSV-1 previously shown to be defective in viral DNA processing and packaging at the nonpermissive temperature (NPT). The empty capsids isolated from mutant-infected cells at the NPT were devoid of DNA, cosedimented in sucrose with wt B c...

journal_title：Virology

authors： Sherman G,Bachenheimer SL

更新日期：1988-04-01 00:00:00

abstract：:The role of oxygen tension level is a well-known phenomenon that has been studied in oncology and radiotherapy since about 60 years. Oxygen tension may inhibit or stimulate propagation of viruses in vitro as well as in vivo. In turn modulating oxygen metabolism may constitute a novel approach to treat viral infections...

journal_title：Virology

authors： Morinet F,Casetti L,François JH,Capron C,Pillet S

更新日期：2013-09-01 00:00:00

abstract：:The DNA of a rat cytomegalovirus (RCMV) isolate from England is cleaved by HindIII into 25 fragments, 20 of which have been cloned into recombinant plasmids. Twenty-two of thirty KpnI fragments were similarly cloned which, together with the HindIII clones, resulted in cloning of 93% of the viral genome. Terminal fragm...

journal_title：Virology

authors： Burns WH,Barbour GM,Sandford GR

更新日期：1988-09-01 00:00:00

abstract：:Tetherin (ST2/CD317) is a cellular protein that restricts the release from cells of some enveloped viruses including HIV-1. To examine if influenza virus is affected by tetherin, MDCK cells constitutively expressing human tetherin and control MDCK cells were infected with influenza virus. No difference was observed in...

journal_title：Virology

authors： Watanabe R,Leser GP,Lamb RA

更新日期：2011-08-15 00:00:00

abstract：:Recent reports indicated that vaccinia virus late mRNAs contain a unique 5' poly(A) leader sequence and that the in vitro translation of these mRNAs may be relatively cap-independent. These observations led us to examine the possibility that the mechanism of inhibition of host protein synthesis by vaccinia virus, like...

journal_title：Virology

authors： Schnierle BS,Moss B

更新日期：1992-06-01 00:00:00