Vaccinia virus-mediated inhibition of host protein synthesis involves neither degradation nor underphosphorylation of components of the cap-binding eukaryotic translation initiation factor complex eIF-4F.

abstract：:The complete DNA sequence of a new lytic T7-like bacteriophage phiKMV is presented. It is the first genome sequence of a member of the Podoviridae that infects Pseudomonas aeruginosa. The linear G + C-rich (62.3%) double-stranded DNA genome of 42,519 bp has direct terminal repeats of 414 bp and contains 48 open readin...

journal_title：Virology

authors： Lavigne R,Burkal'tseva MV,Robben J,Sykilinda NN,Kurochkina LP,Grymonprez B,Jonckx B,Krylov VN,Mesyanzhinov VV,Volckaert G

更新日期：2003-07-20 00:00:00

abstract：:Gene transfer approaches using viruses such human adenovirus (HAdV) may provide an alternative treatment for diseases involving hematopoietic cells. Better understanding of the cellular mechanisms by which the HAdV introduces DNA into these cells should help in vector design. We examined HAdV intracellular delivery in...

journal_title：Virology

authors： Colin M,Renaut L,Mailly L,D'Halluin JC

更新日期：2004-03-01 00:00:00

abstract：:Tobacco mosaic virus (TMV) is widespread in China and causes considerable economic losses to tobacco production. The molecular epidemiology of this virus is, however, poorly understood. In this study, we sequenced the genomes of 51 TMV isolates from five tobacco-producing regions in China and investigated the dispersa...

journal_title：Virology

authors： Gao F,Liu X,Du Z,Hou H,Wang X,Wang F,Yang J

更新日期：2019-02-01 00:00:00

abstract：:HIV-1 Nef is expressed in astrocytes, but a contribution to neuropathogenesis and the development of HIV-associated dementia (HAD) remains uncertain. To determine the neuropathogenic actions of the HIV-1 Nef protein, the brain-derived (YU-2) and blood-derived (NL4-3) Nef proteins were expressed in neural cells using a...

journal_title：Virology

authors： van Marle G,Henry S,Todoruk T,Sullivan A,Silva C,Rourke SB,Holden J,McArthur JC,Gill MJ,Power C

更新日期：2004-11-24 00:00:00

abstract：:The sequences of the 3'-noncoding regions (NCR) of 12 strains of tick-borne encephalitis (TBE) virus were analyzed and found to vary in length from 350 to approximately 750 nucleotides. The size heterogeneity is restricted to a variable region following the stop codon, whereas the most 3'-terminal 350 nucleotides form...

journal_title：Virology

authors： Wallner G,Mandl CW,Kunz C,Heinz FX

更新日期：1995-10-20 00:00:00

abstract：:Old world hantaviruses, causing hemorrhagic fever with renal syndrome (HFRS), still present a public health problem in Asia and Eastern Europe. The majority of cases has been recorded in China. The aim of our study was to generate human recombinant neutralizing antibodies to a hantavirus by phage display technology. T...

journal_title：Virology

authors： Koch J,Liang M,Queitsch I,Kraus AA,Bautz EK

更新日期：2003-03-30 00:00:00

abstract：:To begin to map functional domains of the Sendai P-L RNA polymerase complex we wanted to characterize the P binding site on the Sendai L protein. Analysis of in vitro and in vivo P-L polymerase complex formation with carboxyl-truncations of the L protein showed that the N-terminal half of the protein was required. Sit...

journal_title：Virology

authors： Chandrika R,Horikami SM,Smallwood S,Moyer SA

更新日期：1995-11-10 00:00:00

abstract：:Arabis mosaic virus is a subgroup A nepovirus. The RNA1-encoded polyprotein (P1) contains the domains for the NTP-binding protein (NTB), VPg, proteinase (Pro) and polymerase at its C-terminus. Putative cleavage sites delineating these domains have been proposed. However, the number and location of cleavage sites upstr...

journal_title：Virology

authors： Wetzel T,Chisholm J,Bassler A,Sanfaçon H

更新日期：2008-05-25 00:00:00

abstract：:Human enteric adenovirus Ad41 is associated with children gastroenteritis. To infect gastrointestinal cells, the invading virus must be acid-stable and resistant to inactivation by bile salts and proteases. In addition, it has to cross the mucus barrier before it infects mucosa cells. We show that Ad41 infectivity is ...

journal_title：Virology

authors： Favier AL,Burmeister WP,Chroboczek J

更新日期：2004-04-25 00:00:00

abstract：:Successful encapsidation of hepadnaviral pregenomic RNA requires the orchestrated interaction of the viral capsid and polymerase proteins with each other and with the RNA packaging substrate. The early steps of this process involve binding of the polymerase to the encapsidation signal, epsilon, and are already underst...

journal_title：Virology

authors： Ziermann R,Ganem D

更新日期：1996-05-15 00:00:00

abstract：:Despite significant contributions of monocytes to HIV persistence, the genomic basis of HIV-infection of monocytes and its association with plasma viremia remain elusive. To understand HIV interactions with monocytes during disease progression, monocytic transcriptomes from long-term non-progressors (LTNP), HIV+ patie...

journal_title：Virology

authors： Wu JQ,Sassé TR,Wolkenstein G,Conceicao V,Saksena MM,Soedjono M,Perera SS,Wang B,Dwyer DE,Saksena NK

更新日期：2013-01-20 00:00:00

abstract：:The porcine lymphotropic herpesvirus 1 (PLHV-1), the first gammaherpesvirus of pigs, has been detected at a high prevalence in healthy pig populations. A porcine gammaherpesvirus has also been detected at high copy numbers in animals suffering from posttransplant lymphoproliferative disease (PTLD). While human PTLD is...

journal_title：Virology

authors： Goltz M,Ericsson T,Patience C,Huang CA,Noack S,Sachs DH,Ehlers B

更新日期：2002-03-15 00:00:00

abstract：:The shuttle vector plasmid pZ189 was used as a target for mutagenesis in COS-1 cells. Complex mutations were analyzed in 5 plasmids that were recovered from noninfected cells and 15 plasmids that were recovered from cells that were infected with herpes simplex virus type-1 (HSV-1). Complex mutations in noninfected cel...

journal_title：Virology

authors： Hwang CB,Shillitoe EJ

更新日期：1991-04-01 00:00:00

abstract：:Serotype 4 rotavirus strains have been classified into two antigenic "subtypes" by a solid phase immune electron microscopy technique in which cross-absorbed animal polyclonal immune sera are used as the source of antibodies. The sequences of the gene encoding the outer capsid glycoprotein VP7 from a single serotype 4...

journal_title：Virology

authors： Green KY,Sarasini A,Qian Y,Gerna G

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:When antiretroviral therapy does not fully suppress HIV replication, suboptimal levels of antiretrovirals can select for antiretroviral resistant variants of HIV. These variants may exhibit reduced replication capacity and result in lower viral loads in blood. Our study evaluated whether antiretroviral resis...

journal_title：Virology

authors： Hightower GK,Letendre SL,Cherner M,Gibson SA,Ellis RJ,Wolfson TJ,Gamst AC,Ignacio CC,Heaton RK,Grant I,Richman DD,Smith DM,HNRC Group.

更新日期：2009-11-25 00:00:00

abstract：:The pr55gag polyprotein of HIV-1 plays a critical role in the formation of immature virus particles in the cell and during the budding process. We investigated the influence of amino acid substitutions in the p24CA- region of the gag polyprotein on the viral assembly process. Deletion of the amino acids 341-352 in the...

journal_title：Virology

authors： von Poblotzki A,Wagner R,Niedrig M,Wanner G,Wolf H,Modrow S

更新日期：1993-04-01 00:00:00

abstract：:The physical stability of virions of Cucumber mosaic virus (CMV) mutants was investigated to determine if relative stability correlated with efficiency of aphid transmission. Virion stability was evaluated by a urea disruption assay and by testing the infectivity of virus following purifications. All viruses were infe...

journal_title：Virology

authors： Ng JC,Josefsson C,Clark AJ,Franz AW,Perry KL

更新日期：2005-02-05 00:00:00

abstract：:Bombyx mori nucleopolyhedrovirus (BmNPV) orf5 (Bm5) is a core gene of lepidopteran baculoviruses and encodes the protein with the conserved amino acid residues (DUF3627) in its C-terminus. Here, we found that Bm5 disruption resulted in lower titers of budded viruses and fewer numbers of occlusion bodies (OBs) in B. mo...

journal_title：Virology

authors： Kokusho R,Koh Y,Fujimoto M,Shimada T,Katsuma S

更新日期：2016-11-01 00:00:00

abstract：:Encephalomyocarditis virus (EMCV) is the prototype member of the cardiovirus genus of picornaviruses. For cardioviruses and the related aphthoviruses, the first protein segment translated from the plus-strand RNA genome is the Leader protein. The aphthovirus Leader (173-201 amino acids) is an autocatalytic papain-like...

journal_title：Virology

authors： Dvorak CM,Hall DJ,Hill M,Riddle M,Pranter A,Dillman J,Deibel M,Palmenberg AC

更新日期：2001-11-25 00:00:00

abstract：:This report describes induction of HIV-1 resistance and synthesis of resistance factors in immortal CD4-positive T lymphocytes. SupT1 cells were infected by NL4-3 attenuated by a defect in the vif gene through coculture with infected primary lymphocytes. Cell lines from this infection, termed R1, expressed CD4 and CXC...

journal_title：Virology

authors： Simm M,Miller LS,Durkin HG,Allen M,Chao W,Lesner A,Potash MJ,Volsky DJ

更新日期：2002-03-01 00:00:00

abstract：:The 30K protein of tobacco mosaic virus was recently confirmed to be involved in cell-to-cell movement of the virus. To characterize common structural features of the 30K protein, the nucleotide sequence of the 30K protein gene of cucumber green mottle mosaic virus (CGMMV, a member of the tobamoviruses) RNA has been d...

journal_title：Virology

authors： Saito T,Imai Y,Meshi T,Okada Y

更新日期：1988-12-01 00:00:00

abstract：:The monocytoid tumor cell line U-937 and five derived subclones were infected with the HTLV-IIIB isolate of the human immunodeficiency virus (HIV). Susceptibility to infection and sensitivity to the cytopathic effects correlated with the expression of the T4 antigen on the cell surface. On the basis of these character...

journal_title：Virology

authors： Asjö B,Ivhed I,Gidlund M,Fuerstenberg S,Fenyö EM,Nilsson K,Wigzell H

更新日期：1987-04-01 00:00:00

abstract：:Viral loads were investigated in SIVmnd-1 chronically infected mandrills and the results were compared with those previously observed in other nonpathogenic natural SIV infections. Four naturally and 11 experimentally SIVmnd-1-infected mandrills from a semi-free-ranging colony were studied during the chronic phase of ...

journal_title：Virology

authors： Pandrea I,Onanga R,Kornfeld C,Rouquet P,Bourry O,Clifford S,Telfer PT,Abernethy K,White LT,Ngari P,Müller-Trutwin M,Roques P,Marx PA,Simon F,Apetrei C

更新日期：2003-12-05 00:00:00

abstract：:The post-entry events of HIV-1 infection occur within reverse transcription complexes derived from the viral cores entering the target cell. HIV-1 cores contain host proteins incorporated from virus-producing cells. In this report, we show that MCM5, a subunit of the hexameric minichromosome maintenance (MCM) DNA heli...

journal_title：Virology

authors： Santos S,Obukhov Y,Nekhai S,Pushkarsky T,Brichacek B,Bukrinsky M,Iordanskiy S

更新日期：2016-10-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) is a pH-dependent virus that uses mouse transferrin receptor 1 (TfR1) for entry into cells. Previous studies demonstrated that MMTV could induce pH 5-dependent fusion-from-with of mouse cells. Here we show that the MMTV envelope-mediated cell-cell fusion requires both the entry recepto...

journal_title：Virology

authors： Wang E,Obeng-Adjei N,Ying Q,Meertens L,Dragic T,Davey RA,Ross SR

更新日期：2008-11-25 00:00:00

abstract：:HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed...

journal_title：Virology

authors： Reid W,Abdelwahab S,Sadowska M,Huso D,Neal A,Ahearn A,Bryant J,Gallo RC,Lewis GK,Reitz M

更新日期：2004-03-30 00:00:00

abstract：:During Herpes simplex virus envelopment, capsids, tegument polypeptides, and membrane proteins assemble at the site of budding and a cellular lipid bilayer becomes refashioned into a spherical envelope. Though the molecular interactions driving these events are poorly understood, several lines of evidence suggest that...

journal_title：Virology

authors： Gross ST,Harley CA,Wilson DW

更新日期：2003-12-05 00:00:00

abstract：:An Ad2 capsid component, the penton base, expressed as recombinant protein, was found to be capable of affecting the entire entry pathway of adenovirion in HeLa cells, i.e., cell attachment, endocytosis, vesicular escape, intracytoplasmic movement, and translocation through the nuclear pore complex. Data with pentamer...

journal_title：Virology

authors： Hong SS,Gay B,Karayan L,Dabauvalle MC,Boulanger P

更新日期：1999-09-15 00:00:00

abstract：:HPV16 E6 deregulates G1/S cell cycle progression through p53 degradation preventing transcription of the CDK inhibitor p21(WAF1). However, additional mechanisms independent of p53 inactivation appear to exist. Here, we report that HPV16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1) tr...

journal_title：Virology

authors： Parroche P,Touka M,Mansour M,Bouvard V,Thépot A,Accardi R,Carreira C,Roblot GG,Sylla BS,Hasan U,Tommasino M

更新日期：2011-09-01 00:00:00

abstract：:We examined the molecular epidemiology and evolution of Ross River (RR) virus in Australia and the Pacific Islands. Nucleotide sequences of the E2 and E3 genes of five RR virus strains revealed remarkable conservation between 1959 and 1989 with a maximum divergence of only 3.3%. Sequence data from a 505-base pair frag...

journal_title：Virology

authors： Sammels LM,Coelen RJ,Lindsay MD,Mackenzie JS

更新日期：1995-09-10 00:00:00