Abstract:
:We examined the molecular epidemiology and evolution of Ross River (RR) virus in Australia and the Pacific Islands. Nucleotide sequences of the E2 and E3 genes of five RR virus strains revealed remarkable conservation between 1959 and 1989 with a maximum divergence of only 3.3%. Sequence data from a 505-base pair fragment of the E2 gene from 51 additional strains showed that RR virus has diverged genetically into three separate groups although at least 95% sequence homology was still maintained between all 56 strains. Each genetic type predominates in a particular geographic region of Australia and can be broadly defined as occurring in the western, northeastern, and southeastern regions of Australia. However, some RR virus strains did not follow this pattern of geographic distribution indicating movement of virus by the travel of viremic humans or livestock across the continent. The Pacific Islands isolates all belong to the southeastern genotype. These findings suggest genetic divergence and independent evolution of RR virus within geographically isolated enzootic foci; however, selective pressures maintain high nucleotide conservation in nature.
journal_name
Virologyjournal_title
Virologyauthors
Sammels LM,Coelen RJ,Lindsay MD,Mackenzie JSdoi
10.1006/viro.1995.1449subject
Has Abstractpub_date
1995-09-10 00:00:00pages
20-9issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(85)71449-3journal_volume
212pub_type
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