Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope.

abstract：:The elucidation of the antigenic structure of the S glycoprotein of murine coronaviruses will provide further understanding of the complex pathogenicity of these viruses. In order to identify linear antigenic determinants, the primary structure of the S glycoprotein of murine hepatitis virus strain A59 was analyzed wi...

journal_title：Virology

authors： Daniel C,Lacroix M,Talbot PJ

更新日期：1994-08-01 00:00:00

abstract：:Attachment of human adenoviruses (Ads) to host cells is mediated by the interaction of the fiber protein of the capsid with specific cell-surface molecules. For one of the species B adenoviruses, Ad3, the mechanism of binding to cells remains to be defined. Several previous reports have proposed CD46, CD80 or CD86 as ...

journal_title：Virology

authors： Hall K,Blair Zajdel ME,Blair GE

更新日期：2009-09-30 00:00:00

abstract：:Growth of clinical specimens of influenza viruses in eggs can result in the selection of antigenic variants distinct from corresponding viruses grown in mammalian tissue culture. To evaluate the contribution of host cell selection on the antigenic diversity of human influenza isolates, as seen in annual surveillance s...

journal_title：Virology

authors： Meyer WJ,Wood JM,Major D,Robertson JS,Webster RG,Katz JM

更新日期：1993-09-01 00:00:00

abstract：:After intranasal inoculation, mouse hepatitis virus (MHV) gains entry into the central nervous system (CNS) via the olfactory and trigeminal nerves. Under the appropriate conditions, some mice develop clinically apparent demyelinating encephalomyelitis several weeks later, with virus always present in the spinal cord....

journal_title：Virology

authors： Perlman S,Jacobsen G,Olson AL,Afifi A

更新日期：1990-04-01 00:00:00

abstract：:Some retroviruses, including HIV-1, regulate the relative amounts of gag and pol gene products by a translational frameshift mechanism. The consequences of altering the ratios of the Gag and Pol proteins were tested using vaccinia virus expression vectors, in which the gag and pol genes were fused by placing them in t...

journal_title：Virology

authors： Karacostas V,Wolffe EJ,Nagashima K,Gonda MA,Moss B

更新日期：1993-04-01 00:00:00

abstract：:We have studied the assembly of human immunodeficiency virus (HIV-1) Gag-B-galactosidase (Gag-B-gal; GBG) fusion proteins into HIV particles in the presence of HIV Gag proteins. Release of fusion proteins from cells was measured by assay of media versus cellular B-gal activities and was dependent on co-expression of u...

journal_title：Virology

authors： Wang CT,Stegeman-Olsen J,Zhang Y,Barklis E

更新日期：1994-05-01 00:00:00

abstract：:The genomic RNAs of barley stripe mosaic virus (BSMV) were used in experiments involving site-specific cleavage to yield noninfective but functionally active fragments and subsequent restoration of infectious viral RNA by means of religation. The specific fragments were obtained after site-specific cleavage of BSMV RN...

journal_title：Virology

authors： Tyulkina LG,Karpova OV,Rodionova NP,Atabekov JG

更新日期：1987-08-01 00:00:00

abstract：:The nucleotide sequence of the env gene of a previously described human provirus (ERV3) has been determined beginning near the 3'-end of the pol gene and continuing through the 3'-LTR. Analysis of the nucleotide sequence revealed the presence of a long open reading frame of 1944 nucleotides that is capable of encoding...

journal_title：Virology

authors： Cohen M,Powers M,O'Connell C,Kato N

更新日期：1985-12-01 00:00:00

abstract：:Assembly of icosahedral capsids of proper size and symmetry is not understood. Residue F170 in bacteriophage P22 coat protein is critical for conformational switching during assembly. Substitutions at this site cause assembly of tubes of hexamerically arranged coat protein. Intragenic suppressors of the ts phenotype o...

journal_title：Virology

authors： Suhanovsky MM,Teschke CM

更新日期：2011-09-01 00:00:00

abstract：:The specificity of poliovirus encapsidation has been studied using a novel chimeric genome in which the gene encoding firefly luciferase has been substituted for the VP2-VP3-VP1 genes of the poliovirus capsid (P1) gene. Transfection of RNA transcribed in vitro from this genome resulted in a VP4-luciferase fusion prote...

journal_title：Virology

authors： Porter DC,Ansardi DC,Wang J,McPherson S,Moldoveanu Z,Morrow CD

更新日期：1998-03-30 00:00:00

abstract：:We have previously cloned and analyzed the structure of a type 16 human papillomavirus (HPV16) integration in a primary cervical carcinoma tissue, M50 (Choo et al., J. Virol. 62, 1659-1666, 1988). We found that specific nucleotide sequences within the HPV16 genome influenced the genomic organization of the integrated ...

journal_title：Virology

authors： Choo KB,Lee HH,Liew LN,Chong KY,Chou HF

更新日期：1990-10-01 00:00:00

abstract：:We constructed a sensitive and quantitative assay system to examine human T-cell leukemia virus type I (HTLV-I) envelope (env) glycoprotein-mediated cell fusion in which T7 RNA polymerase in donor cells coexpressing env glycoproteins activates a reporter gene in recipient cells upon cell fusion. An efficient expressio...

journal_title：Virology

authors： Okuma K,Nakamura M,Nakano S,Niho Y,Matsuura Y

更新日期：1999-02-15 00:00:00

abstract：:Mapping of the 5' ends of virion-derived hepatitis B virus DNA molecules was carried out after cloning and sequencing linearized genomes made fully double stranded. Of five clones obtained, three of four minus strand termini mapped to the G in position 1826 and one to the T in position 1827. Plus strand 5' ends were m...

journal_title：Virology

authors： Saldanha JA,Qiu H,Thomas HC,Monjardino J

更新日期：1992-05-01 00:00:00

abstract：:A previous study suggested that the genomes of the arenaviruses native to North America are a product of genetic recombination between New World arenaviruses with significantly different phylogenetic histories. The purpose of this study was to extend our knowledge of the principal host relationships and evolutionary h...

journal_title：Virology

authors： Cajimat MN,Milazzo ML,Hess BD,Rood MP,Fulhorst CF

更新日期：2007-10-25 00:00:00

abstract：:Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) vFLIP, a latent gene of KSHV, was first identified as a FLICE-inhibitory protein (FLIP) protecting cells from apoptosis. The vFLIP protein has been shown to activate the NF-κB signaling involved in spindle morphology formation both in HUVECs infected with KSHV and Ka...

journal_title：Virology

authors： Yang Z,Honda T,Ueda K

更新日期：2018-09-01 00:00:00

abstract：:Animal viruses profoundly modify the metabolism of lipids, the synthesis of new membranes, and membrane traffic. These alterations are related to the replication of viral genomes. Addition of oleic acid from the beginning of poliovirus infection inhibits the appearance of virus polypeptides at concentrations that do n...

journal_title：Virology

authors： Guinea R,Carrasco L

更新日期：1991-11-01 00:00:00

abstract：:Lloviu virus (LLOV), a phylogenetically divergent filovirus, is the proposed etiologic agent of die-offs of Schreibers's long-fingered bats (Miniopterus schreibersii) in western Europe. Studies of LLOV remain limited because the infectious agent has not yet been isolated. Here, we generated a recombinant vesicular sto...

journal_title：Virology

authors： Ng M,Ndungo E,Jangra RK,Cai Y,Postnikova E,Radoshitzky SR,Dye JM,Ramírez de Arellano E,Negredo A,Palacios G,Kuhn JH,Chandran K

更新日期：2014-11-01 00:00:00

abstract：:To investigate the mode of gene expression of red clover mottle virus (RCMV) middle component (M) RNA, we have synthesized an oligopeptide corresponding to the predicted carboxy-terminus of the RCMV counterparts of the cowpea mosaic virus (CPMV) 48K and 58K proteins. Using an antiserum raised against this synthetic ol...

journal_title：Virology

authors： Shanks M,Tomenius K,Clapham D,Huskisson NS,Barker PJ,Wilson IG,Maule AJ,Lomonossoff GP

更新日期：1989-12-01 00:00:00

abstract：:HIV-1 Vpu antagonizes the block to particle release mediated by CD317 (BST-2/HM1.24/Tetherin) via incompletely understood mechanisms. Vpu and CD317 partially reside in cholesterol-rich lipid rafts where HIV-1 budding preferentially occurs. Here we find that lipid raft association of ectopically expressed or endogenous...

journal_title：Virology

authors： Fritz JV,Tibroni N,Keppler OT,Fackler OT

更新日期：2012-03-01 00:00:00

abstract：:Like their animal-infecting counterparts, plant bunyaviruses use capped RNA leaders cleaved from host cellular mRNAs to prime viral genome transcription in a process called cap-snatching, but in vivo systems to investigate the details of this process are lacking for them. Here, we report that Rice stripe tenuivirus (R...

journal_title：Virology

authors： Lin W,Wu R,Qiu P,Jing Jin,Yang Y,Wang J,Lin Z,Zhang J,Wu Z,Du Z

更新日期：2020-01-02 00:00:00

abstract：:Five regions on the coat protein of BNYVV which had been shown previously to be involved in the formation of continuous epitopes were further analyzed by means of synthetic overlapping peptides. It was found that at least some of these regions may encompass several overlapping epitopes (or parts thereof). Four monoclo...

journal_title：Virology

authors： Commandeur U,Koenig R,Manteuffel R,Torrance L,Lüddecke P,Frank R

更新日期：1994-01-01 00:00:00

abstract：:nsP3 is one of four viral nonstructural proteins required for RNA replication of Sindbis virus. In this report, post-translational modifications of nsP3 which occur in both vertebrate and mosquito cell cultures have been examined. In pulse-chase experiments, analyzed by immunoprecipitation and sodium dodecyl sulfate-p...

journal_title：Virology

authors： Li GP,La Starza MW,Hardy WR,Strauss JH,Rice CM

更新日期：1990-11-01 00:00:00

abstract：:A full-size cloned cDNA copy of the rotavirus gene encoding the structural neutralization glycoprotein (VP7) of Nebraska calf diarrhea virus (NCDV), a strain recently shown to be effective as a vaccine in children, has been sequenced. Comparison of the deduced amino acid sequence of NCDV (serotype 6) VP7 with that of ...

journal_title：Virology

authors： Glass RI,Keith J,Nakagomi O,Nakagomi T,Askaa J,Kapikian AZ,Chanock RM,Flores J

更新日期：1985-03-01 00:00:00

abstract：:The P1a protein of the ipomovirus Cucumber vein yellowing virus is one of the self-cleavage serine proteases present in Potyviridae family members. P1a is located at the N-terminal end of the viral polyprotein, and is closely related to potyviral P1 protease. For its proteolytic activity, P1a requires a still unknown ...

journal_title：Virology

authors： Shan H,Pasin F,Valli A,Castillo C,Rajulu C,Carbonell A,Simón-Mateo C,García JA,Rodamilans B

更新日期：2015-02-01 00:00:00

abstract：:A method was devised which allows the easy detection of mutations within the ner gene of Mu DNA. This method is based upon the observation that a transcriptional gene A-galK fusion containing the complete ner gene and the cts62 allele does not express the galK gene in an Escherichia coli strain lacking functional inte...

journal_title：Virology

authors： König U,Kirschner P,Schumann W

更新日期：1988-05-01 00:00:00

abstract：:Treatment with HIV attachment inhibitors (AIs) can select for escape mutants throughout the viral envelope. We report on three such mutations: F423Y (gp120 CD4 binding pocket) and I595F and K655E (gp41 ectodomain). Each displayed decreased sensitivity to the AI BMS-488043 and earlier generation AIs, along with increas...

journal_title：Virology

authors： Zhou N,Fan L,Ho HT,Nowicka-Sans B,Sun Y,Zhu Y,Hu Y,McAuliffe B,Rose B,Fang H,Wang T,Kadow J,Krystal M,Alexander L,Colonno R,Lin PF

更新日期：2010-07-05 00:00:00

abstract：:A new type of retrovirus (Sm-MTV) released by cultured cells of a spontaneous mammary tumor from a house musk shrew, Suncus murinus, is described. The Sm-MTV is distinct morphologically from type C particles. In spite of certain morphological similarities to type B and type D retroviruses, the Sm-MTV is readily distin...

journal_title：Virology

authors： Tsutsui Y,Nagayoshi S,Saga S,Takahashi M,Aoyama A,Malavasi JY,Hayakawa S,Yokoi T,Oda S,Hoshino M

更新日期：1985-07-15 00:00:00

abstract：:Cytoplasmic poly(A)-containing RNA from parainfluenza virus 3-infected cells was used as template to construct a cDNA library that was cloned into the EcoRV site of the plasmid pMG5. The resulting clones were screened with [32P]-labeled cDNA probes made from infected and mock-infected cell mRNAs. The virus specificity...

journal_title：Virology

authors： Sánchez A,Banerjee AK

更新日期：1985-11-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) is a pH-dependent virus that uses mouse transferrin receptor 1 (TfR1) for entry into cells. Previous studies demonstrated that MMTV could induce pH 5-dependent fusion-from-with of mouse cells. Here we show that the MMTV envelope-mediated cell-cell fusion requires both the entry recepto...

journal_title：Virology

authors： Wang E,Obeng-Adjei N,Ying Q,Meertens L,Dragic T,Davey RA,Ross SR

更新日期：2008-11-25 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the Gammaherpesvirinae and is causally associated with Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. The KSHV genome encodes over 85 genes; the function of some is entirely unknown. We have characterized the transcriptio...

journal_title：Virology

authors： Masa SR,Lando R,Sarid R

更新日期：2008-02-05 00:00:00