Increased sensitivity of HIV variants selected by attachment inhibitors to broadly neutralizing antibodies.

abstract：:The requirement to replicate in both vertebrate and invertebrate hosts is thought to limit the introduction of genetic changes into the genome of arboviruses. Serial passage under laboratory conditions will overcome this limitation allowing for genetic changes to be introduced and affecting the virulence of the virus ...

journal_title：Virology

authors： McCurdy K,Joyce J,Hamilton S,Nevins C,Sosna W,Puricelli K,Rayner JO

更新日期：2011-06-20 00:00:00

abstract：:Proviral sequences encoding defective HIV-1 regulatory genes have been detected previously in infected individuals; however, the role of these defective genomes in pathogenesis is unclear. The hypothesis that such replication-defective genomes might induce downregulation of the cellular receptor for HIV-1 (CD4) was te...

journal_title：Virology

authors： Little SJ,Riggs NL,Chowers MY,Fitch NJ,Richman DD,Spina CA,Guatelli JC

更新日期：1994-12-01 00:00:00

abstract：:Foot-and-mouth disease virus protease 3C is essential for the processing of the viral precursor polyprotein. It is shown here to also inhibit gene expression in baby hamster kidney cells after transient expression from transfected cDNA fragments. Protease 3C could not be detected by indirect immunofluorescence in cont...

journal_title：Virology

authors： Tesar M,Marquardt O

更新日期：1990-02-01 00:00:00

abstract：:In this study, we present enzymatic differences found between recombinant RTs derived from feline leukemia virus and feline immunodeficiency virus. Firstly, FIV RT showed low steady state K(m) values for dNTPs compared to FeLV RT. Consistent with this, FIV RT synthesized DNA more efficiently than FeLV RT at low dNTP c...

journal_title：Virology

authors： Operario DJ,Reynolds HM,Kim B

更新日期：2005-04-25 00:00:00

abstract：:Outbreaks of avian influenza virus H5N8 first occurred in 2014, and spread to poultry farms in Korea. Although there was no report of human infection by this subtype, it has the potential to threaten human public health. Therefore, we evaluated the pathogenesis of H5N8 viruses in ferrets. Two representative Korean H5N...

journal_title：Virology

authors： Kim HM,Kim CK,Lee NJ,Chu H,Kang C,Kim K,Lee JY

更新日期：2015-07-01 00:00:00

abstract：:Replication of the nonsegmented, plus-stranded RNA genome of Cucumber necrosis tombusvirus (CNV) requires two essential overlapping viral-coded replication proteins, the p33 replication co-factor and the p92 RNA-dependent RNA polymerase. In this paper, we demonstrate that p33 is phosphorylated in vivo and in vitro by ...

journal_title：Virology

authors： Shapka N,Stork J,Nagy PD

更新日期：2005-12-05 00:00:00

abstract：:Recently, cases of severe respiratory illness in military and civilian populations have been associated with a new genomic variant of adenovirus (Ad) serotype 14, designated Ad14a. Compared to the Ad14 reference strain (de Wit), this new virus had a deletion of two amino acid residues in the fiber protein knob. Here w...

journal_title：Virology

authors： Wang H,Tuve S,Erdman DD,Lieber A

更新日期：2009-05-10 00:00:00

abstract：:Two tick-borne encephalitis (TBE) virus variants were studied: mouse brain-adapted strain EK-328 and its derivate adapted to Hyalomma marginatum ticks. The tick-adapted virus exhibited small-plaque phenotype and slower replication in PEK cells, higher yield in ticks, decreased neuroinvasiveness in mice, increased bind...

journal_title：Virology

authors： Romanova LIu,Gmyl AP,Dzhivanian TI,Bakhmutov DV,Lukashev AN,Gmyl LV,Rumyantsev AA,Burenkova LA,Lashkevich VA,Karganova GG

更新日期：2007-05-25 00:00:00

abstract：:The host-virus interaction during the cellular entry of Japanese encephalitis virus (JEV) is poorly characterized. The ubiquitin-proteasome system (UPS), the major intracellular proteolytic pathway, mediates diverse cellular processes, including endocytosis and signal transduction, which may be involved in the entry o...

journal_title：Virology

authors： Wang S,Liu H,Zu X,Liu Y,Chen L,Zhu X,Zhang L,Zhou Z,Xiao G,Wang W

更新日期：2016-11-01 00:00:00

abstract：:Strong evidence indicates that virions of mammalian reoviruses undergo proteolytic processing by acid-dependent cellular proteinases as an essential step in productive infection. Proteolytic processing takes the form of a series of cleavages of outer-capsid proteins final sigma3 and mu1/mu1C. Previous studies showed a...

journal_title：Virology

authors： Kothandaraman S,Hebert MC,Raines RT,Nibert ML

更新日期：1998-11-25 00:00:00

abstract：:The immunogenicity of capsomeres of human papillomavirus type 33 was evaluated in a dose-response analysis. Capsomeres were obtained free of capsids by expression of L1 carrying the single point mutation C427S. Neutralizing antibodies were detected using an in vitro pseudoinfection assay. Capsomeres induced type-speci...

journal_title：Virology

authors： Fligge C,Giroglou T,Streeck RE,Sapp M

更新日期：2001-05-10 00:00:00

abstract：:The complete sequence of the genome of the cherry strain of tomato bushy stunt virus (TBSV), a member of the tombusvirus group, was determined. A full-length clone of the genome containing a bacteriophage T7 RNA polymerase promoter was assembled from partial cDNA clones. In vitro transcripts of the genome, either with...

journal_title：Virology

authors： Hearne PQ,Knorr DA,Hillman BI,Morris TJ

更新日期：1990-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) RNA replication requires viral nonstructural proteins as well as cellular factors. Recently, a cellular protein, synaptotagmin-binding, cytoplasmic RNA-interacting protein (SYNCRIP), also known as NSAP1, was found to bind HCV RNA and enhance HCV IRES-dependent translation. We investigate whethe...

journal_title：Virology

authors： Liu HM,Aizaki H,Choi KS,Machida K,Ou JJ,Lai MM

更新日期：2009-04-10 00:00:00

abstract：:The v-erb B protein of avian erythroblastosis virus (AEV) possesses an associated protein kinase activity in vitro. Analysis of temperature-sensitive mutants, and nonconditional host range mutants of AEV demonstrated that there was no simple correlation between this autophosphorylation activity and the transformation ...

journal_title：Virology

authors： Hayman MJ,Kitchener G,Knight J,McMahon J,Watson R,Beug H

更新日期：1986-04-15 00:00:00

abstract：:Infection with Epstein-Barr virus (EBV) usually leads to a latent state in B lymphocytes. The virus can be reactivated through two viral transactivators, Zta and Rta, leading to a cascade of gene expression. An EBV DNA array was generated to analyze the pattern of transcription of the entire EBV genome under various c...

journal_title：Virology

authors： Lu CC,Jeng YY,Tsai CH,Liu MY,Yeh SW,Hsu TY,Chen MR

更新日期：2006-02-20 00:00:00

abstract：:The role of binding kinetics in determining neutralizing potency for antiviral antibodies is poorly understood. While it is believed that increased steady-state affinity correlates positively with increased virus-neutralizing activity, the relationship between association or dissociation rate and neutralization potenc...

journal_title：Virology

authors： Bates JT,Keefer CJ,Slaughter JC,Kulp DW,Schief WR,Crowe JE Jr

更新日期：2014-04-01 00:00:00

abstract：:Fowlpox virus (FPV), type species of the Avipoxvirus genus, causes a slow-spreading pox disease of chickens. Following infection of mammalian cells there is no evidence of productive replication of FPV although cytopathic effects are induced and FPV recombinants have been shown to express foreign genes from vaccinia v...

journal_title：Virology

authors： Somogyi P,Frazier J,Skinner MA

更新日期：1993-11-01 00:00:00

abstract：:The reticuloendotheliosis virus (REV) group of retroviruses and type D simian retroviruses (SRV) belong to the same receptor interference group. The cellular receptor for these viruses has not yet been identified. In order to study the distribution of the receptor and to identify a receptor negative cell line, vector ...

journal_title：Virology

authors： Koo HM,Parthasarathi S,Ron Y,Dougherty JP

更新日期：1994-11-15 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the Gammaherpesvirinae and is causally associated with Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. The KSHV genome encodes over 85 genes; the function of some is entirely unknown. We have characterized the transcriptio...

journal_title：Virology

authors： Masa SR,Lando R,Sarid R

更新日期：2008-02-05 00:00:00

abstract：:Picornavirus infection induces the proliferation and rearrangement of intracellular membranes in response to the synthesis of nonstructural proteins, including 3A. We have previously shown that changes in 3A are associated with the inability of a Taiwanese strain of foot-and-mouth disease virus (FMDV) (OTai) to grow i...

journal_title：Virology

authors： O'Donnell VK,Pacheco JM,Henry TM,Mason PW

更新日期：2001-08-15 00:00:00

abstract：:The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender based sexual violence. Despite significant efforts that resulted in the redu...

journal_title：Virology

authors： Alexandre KB,Mufhandu HT,London GM,Chakauya E,Khati M

更新日期：2016-10-01 00:00:00

abstract：:The Nef protein of Simian immunodeficiency virus (SIV) associates with multiple T lymphocyte signaling proteins, including the T cell receptor (TCR) zeta chain. We demonstrate here that these interactions are conserved and highly specific. Nefs derived from genetically diverse strains of SIV (SIV(mac)239, SIV(smm)PBj,...

journal_title：Virology

authors： Schaefer TM,Bell I,Pfeifer ME,Ghosh M,Trible RP,Fuller CL,Ashman C,Reinhart TA

更新日期：2002-10-10 00:00:00

abstract：:Autophagy is a cellular response against stresses which include the infection of viruses and bacteria. We unravel that Dengue virus-2 (DV2) can trigger autophagic process in various infected cell lines demonstrated by GFP-LC3 dot formation and increased LC3-II formation. Autophagosome formation was also observed under...

journal_title：Virology

authors： Lee YR,Lei HY,Liu MT,Wang JR,Chen SH,Jiang-Shieh YF,Lin YS,Yeh TM,Liu CC,Liu HS

更新日期：2008-05-10 00:00:00

abstract：:In this study we report the development and optimization of two minigenome rescue systems for Nipah virus, a member of the Paramyxoviridae family. One is mediated by the T7 RNA polymerase supplied either by a constitutively expressing cell line or by transfection of expression plasmids and is thus independent from inf...

journal_title：Virology

authors： Freiberg A,Dolores LK,Enterlein S,Flick R

更新日期：2008-01-05 00:00:00

abstract：:The subgroup II luteovirus barley yellow dwarf virus-RPV (BYDV-RPV) acts as a helper virus for a satellite RNA (satRPV RNA). The subgroup II luteovirus beet western yellows virus (BWYV) and the ST9-associated RNA (ST9a RNA), a BWYV-associated RNA that encodes a polymerase similar to those of subgroup I luteoviruses, w...

journal_title：Virology

authors： Rasochová L,Passmore BK,Falk BW,Miller WA

更新日期：1997-05-12 00:00:00

abstract：:cDNA clones of the St. Louis encephalitis (SLE) virus genome have been obtained and the nucleotide sequence of 4.7 kb corresponding to the 5' terminal half of the genome determined. The genome contains a 5' noncoding region of 98 nucleotides followed by a single continuous open reading frame that encodes three structu...

journal_title：Virology

authors： Trent DW,Kinney RM,Johnson BJ,Vorndam AV,Grant JA,Deubel V,Rice CM,Hahn C

更新日期：1987-02-01 00:00:00

abstract：:Here we completed the whole genome sequence of Cotesia vestalis bracovirus (CvBV) by deep sequencing and compared the genome features of CvBV to those of other polydnaviruses (PDVs). The genome is 540,215 base pairs divided into 35 genomic segments that range from 2.6 to 39.2kb. Comparison of CvBV with other PDVs show...

journal_title：Virology

authors： Chen YF,Gao F,Ye XQ,Wei SJ,Shi M,Zheng HJ,Chen XX

更新日期：2011-05-25 00:00:00

abstract：:It is well established that +ssRNA viruses manipulate cellular lipid homoeostasis and distribution to facilitate efficient replication. Here, we show that the cellular lipid ceramide is redistributed to the West Nile virus strain Kunjin virus (WNVKUN) replication complex (RC) but not to the dengue virus serotype 2 str...

journal_title：Virology

authors： Aktepe TE,Pham H,Mackenzie JM

更新日期：2015-10-01 00:00:00

abstract：:We present a case of sexual transmission of HIV-1 predicted to have CXCR4-tropism during male-to-male sexual exposure. Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event. ...

journal_title：Virology

authors： Gianella S,Mehta SR,Young JA,Vargas MV,Little SJ,Richman DD,Kosakovsky Pond SL,Smith DM

更新日期：2012-12-05 00:00:00

abstract：:Coronavirus (CoV) envelope (E) protein ion channel activity was determined in channels formed in planar lipid bilayers by peptides representing either the transmembrane domain of severe acute respiratory syndrome CoV (SARS-CoV) E protein, or the full-length E protein. Both of them formed a voltage independent ion cond...

journal_title：Virology

authors： Verdiá-Báguena C,Nieto-Torres JL,Alcaraz A,DeDiego ML,Torres J,Aguilella VM,Enjuanes L

更新日期：2012-10-25 00:00:00