Abstract:
:Autophagy is a cellular response against stresses which include the infection of viruses and bacteria. We unravel that Dengue virus-2 (DV2) can trigger autophagic process in various infected cell lines demonstrated by GFP-LC3 dot formation and increased LC3-II formation. Autophagosome formation was also observed under the transmission electron microscope. DV2-induced autophagy further enhances the titers of extracellular and intracellular viruses indicating that autophagy can promote viral replication in the infected cells. Moreover, our data show that ATG5 protein is required to execute DV2-induced autophagy. All together, we are the first to demonstrate that DV can activate autophagic machinery that is favorable for viral replication.
journal_name
Virologyjournal_title
Virologyauthors
Lee YR,Lei HY,Liu MT,Wang JR,Chen SH,Jiang-Shieh YF,Lin YS,Yeh TM,Liu CC,Liu HSdoi
10.1016/j.virol.2008.02.016subject
Has Abstractpub_date
2008-05-10 00:00:00pages
240-8issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(08)00112-8journal_volume
374pub_type
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