当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Subcellular distribution of the foot-and-mouth disease virus 3A protein in cells infected with viruses encoding wild-type and bovine-attenuated forms of 3A.

Subcellular distribution of the foot-and-mouth disease virus 3A protein in cells infected with viruses encoding wild-type and bovine-attenuated forms of 3A.

Abstract：

:Picornavirus infection induces the proliferation and rearrangement of intracellular membranes in response to the synthesis of nonstructural proteins, including 3A. We have previously shown that changes in 3A are associated with the inability of a Taiwanese strain of foot-and-mouth disease virus (FMDV) (OTai) to grow in bovine cells and cause disease in cattle, although the virus grows to high titers in porcine cells and is highly virulent in pigs (C. W. Beard and P. W. Mason, 2000, J. Virol. 74, 987-991). To study if differences in the distribution of 3A could account for the species specificity of OTai, we compared the localization of the OTai 3A with a bovine-virulent 3A (serotype A12) in keratinocytes prepared from the tongues of cattle and pigs. Following either infection of keratinocytes or transfection with 3A we were unable to discern differences in 3A distribution in either species of keratinocyte, independent of the strain of virus (or 3A) utilized. In both cell types, 3A distributed in a pattern that overlapped with an endoplasmic reticulum (ER) marker protein, calreticulin (CRT). Furthermore, although FMDV infection or transfection with 3A did not result in a gross redistribution of CRT, both virus infection and 3A transfection disrupted the Golgi. Other picornaviruses that disrupt Golgi function are sensitive to brefeldin A (BFA), a fungal metabolite that interferes with retrograde transport between the Golgi and the ER. Interestingly, BFA has little effect on FMDV replication, suggesting that FMDV may acquire cellular membranes into its replication complexes in a manner different from that of other picornaviruses.

journal_name

Virology

journal_title

Virology

authors

O'Donnell VK,Pacheco JM,Henry TM,Mason PW

doi

10.1006/viro.2001.1035

subject

Has Abstract

pub_date

2001-08-15 00:00:00

pages

151-62

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(01)91035-9

journal_volume

287

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Selection for gene junction sequences important for VSV transcription.

    abstract：:The heptauridine tract at each gene end and intergenic region (IGR) at the gene junctions of vesicular stomatitis virus (VSV) have effects on synthesis of the downstream mRNA, independent of their respective roles in termination of the upstream mRNA. To investigate the role of the U tract and the IGR in downstream gen...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.08.001

    authors： Hinzman EE,Barr JN,Wertz GW

    更新日期：2008-10-25 00:00:00

  • SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids.

    abstract：:Polyomaviral vectors are generated by transfecting 293T cells with three sets of DNAs: DNA for the expression of simian virus 40 (SV40) T antigen; DNA for the expression of SV40 capsid proteins, and vector DNA harboring a reporter gene expression cassette carrying a SV40 origin. The vector DNA harbors a minimal sequen...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.06.032

    authors： Nakanishi A,Chapellier B,Maekawa N,Hiramoto M,Kuge T,Takahashi RU,Handa H,Imai T

    更新日期：2008-09-15 00:00:00

  • Transforming properties of Felis catus papillomavirus type 2 E6 and E7 putative oncogenes in vitro and their transcriptional activity in feline squamous cell carcinoma in vivo.

    abstract：:Felis catus papillomavirus type 2 (FcaPV2) DNA is found in feline cutaneous squamous cell carcinomas (SCCs); however, its biological properties are still uncharacterized. In this study, we successfully expressed FcaPV2 E6 and E7 putative oncogenes in feline epithelial cells and demonstrated that FcaPV2 E6 binds to p53...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2016.05.017

    authors： Altamura G,Corteggio A,Pacini L,Conte A,Pierantoni GM,Tommasino M,Accardi R,Borzacchiello G

    更新日期：2016-09-01 00:00:00

  • Different HIV pox viral vector-based vaccines and adjuvants can induce unique antigen presenting cells that modulate CD8 T cell avidity.

    abstract：:The lung-derived dendritic cell (LDC) recruitment following intranasal (i.n.) vaccination of different poxviral vector-based vaccines/adjuvants were evaluated to decipher how these factors influenced CD8(+) T cell avidity. Compared to the standard i.n. recombinant fowlpox virus (FPV)-HIV vaccination, the FPV-HIV IL-13...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2014.09.004

    authors： Trivedi S,Jackson RJ,Ranasinghe C

    更新日期：2014-11-01 00:00:00

  • Intranasal IgG4/7 antibody responses protect horses against equid herpesvirus-1 (EHV-1) infection including nasal virus shedding and cell-associated viremia.

    abstract：:Equid herpesvirus-1 (EHV-1) outbreaks continue despite widely used vaccination. We demonstrated previously that an ORF1/ORF71 gene deletion mutant of the EHV-1 strain Ab4 (Ab4ΔORF1/71) is less virulent than its parent Ab4 virus. Here, we describe the Ab4 challenge infection evaluating protection induced by the Ab4ΔORF...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.03.014

    authors： Perkins G,Babasyan S,Stout AE,Freer H,Rollins A,Wimer CL,Wagner B

    更新日期：2019-05-01 00:00:00

  • UL5, a protein required for HSV DNA synthesis: genetic analysis, overexpression in Escherichia coli, and generation of polyclonal antibodies.

    abstract：:The mutations in two DNA-negative ts mutants of herpes simplex virus type 1 (HSV-1), tsK13 and tsM19, have been previously mapped to a 2.0-kb fragment (coordinates 0.095-0.108) at the left end of the genome (S. Weller, D. Aschman, W. Sacks, D. Coen, and P. Schaffer, 1983, Virology 130, 290-305). Sequence analysis of t...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90507-7

    authors： Zhu L,Weller SK

    更新日期：1988-10-01 00:00:00

  • Self-inactivating lentiviral vectors with U3 and U5 modifications.

    abstract：:Lentiviral vectors have gained much attention in recent years mainly because they integrate into nondividing host-cell genomes. For clinical applications, a safe and efficient lentiviral vector system is required. Previously, we have established a human immunodeficiency virus type 1 (HIV-1)-derived three-plasmid lenti...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.9850

    authors： Iwakuma T,Cui Y,Chang LJ

    更新日期：1999-08-15 00:00:00

  • Phospholipid molecular species profiles of tectiviruses infecting Gram-negative and Gram-positive hosts.

    abstract：:The phospholipid (PL) molecular species compositions of bacteriophages PRD1 and Bam35 as well as their respective hosts were determined quantitatively using liquid chromatography/electrospray ionization mass-spectrometry (LC-ESI-MS) and backed up by gas-chromatographic/mass-spectrometric (GC-MS) analysis of the total ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.02.009

    authors： Laurinavicius S,Käkelä R,Somerharju P,Bamford DH

    更新日期：2004-05-01 00:00:00

  • TLR3-dependent upregulation of RIG-I leads to enhanced cytokine production from cells infected with the parainfluenza virus SV5.

    abstract：:Here we address the role of RIG-I and TLR3 in differential cytokine responses against Simian Virus 5 (SV5) and two distinct cytokine inducing SV5 mutants. IFN-beta and IL-6 secretion was induced by infection with P/V-CPI-, an SV5 mutant with P/V substitutions, and were reduced by either siRNA-mediated knockdown of RIG...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.11.014

    authors： Manuse MJ,Parks GD

    更新日期：2010-02-05 00:00:00

  • In vivo infection of ramified microglia from adult cat central nervous system by feline immunodeficiency virus.

    abstract：:Infection of microglial cells by the human immunodeficiency virus (HIV) is supposed to play an important role in the pathogenesis of AIDS-related central nervous system (CNS) complications. So far, however, experimental data about interactions between HIV and ramified microglia from the adult CNS were only occasionall...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.0152

    authors： Hein A,Martin JP,Koehren F,Bingen A,Dörries R

    更新日期：2000-03-15 00:00:00

  • Alterations in the hemagglutinin associated with adaptation of influenza B virus to growth in eggs.

    abstract：:In 1943 Burnet reported on changes in the hemagglutinating properties of human influenza virus which occurred during adaptation of the virus to growth in chicken eggs. Only recently has direct evidence been presented that these changes affect the antigenic properties of the virus. Schild et al. (G. C. Schild, J. S. Ox...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90105-9

    authors： Robertson JS,Naeve CW,Webster RG,Bootman JS,Newman R,Schild GC

    更新日期：1985-05-01 00:00:00

  • Rescue of a 7502-nucleotide (49.3% of full-length) synthetic analog of respiratory syncytial virus genomic RNA.

    abstract：:A cDNA was constructed to encode an internally-truncated version of negative-sense genomic RNA (vRNA) of respiratory syncytial virus (RSV) containing (in 3' to 5' order) the 3' vRNA leader region, the complement of the open reading frame for bacterial chloramphenicol acetyl transferase (CAT) under the control of RSV g...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1368

    authors： Collins PL,Mink MA,Hill MG 3rd,Camargo E,Grosfeld H,Stec DS

    更新日期：1993-07-01 00:00:00

  • Inhibition of host cellular ribonucleic acid synthesis by glycoprotein of mumps virus.

    abstract：:After infection with mumps virus, cellular ribonucleic acid synthesis of a murine lymphoma cell line, EL4, was appreciably depressed. The inactivation of viral infectivity by ultraviolet irradiation or the treatment of cells with mouse interferon did not abolish the inhibiting effect, suggesting that virus replication...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90187-9

    authors： Yamada A,Tsurudome M,Hishiyama M,Ito Y

    更新日期：1984-06-01 00:00:00

  • Different recombinant murine leukemia viruses use different cell surface receptors.

    abstract：:Retroviruses can be grouped by viral interference measurements into classes which use common cell surface receptors. We previously tested a large number of isolates of mink cell focus-inducing (MCF) murine leukemia viruses (MuLVs), and reported that all of them share a distinct receptor on NIH/3T3 cells (A. Rein, Viro...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90255-1

    authors： Rein A,Schultz A

    更新日期：1984-07-15 00:00:00

  • Emergence and epidemic occurrence of enterovirus 68 respiratory infections in The Netherlands in 2010.

    abstract：:Following an increase in detection of enterovirus 68 (EV68) in community surveillance of respiratory infections in The Netherlands in 2010, epidemiological and virological analyses were performed to investigate the possible public health impact of EV68 infections. We retrospectively tested specimens collected from acu...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2011.11.021

    authors： Meijer A,van der Sanden S,Snijders BE,Jaramillo-Gutierrez G,Bont L,van der Ent CK,Overduin P,Jenny SL,Jusic E,van der Avoort HG,Smith GJ,Donker GA,Koopmans MP

    更新日期：2012-02-05 00:00:00

  • Polymorphisms of the cytidine deaminase APOBEC3F have different HIV-1 restriction efficiencies.

    abstract：:The APOBEC3 enzyme family are host restriction factors that induce mutagenesis of HIV-1 proviral genomes through the deamination of cytosine to form uracil in nascent single-stranded (-)DNA. HIV-1 suppresses APOBEC3 activity through the HIV-1 protein Vif that induces APOBEC3 degradation. Here we compared two common po...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2018.11.004

    authors： Mohammadzadeh N,Follack TB,Love RP,Stewart K,Sanche S,Chelico L

    更新日期：2019-01-15 00:00:00

  • Human papillomavirus type 16 E7 protein expressed in Escherichia coli and monkey COS-1 cells: immunofluorescence detection of the nuclear E7 protein.

    abstract：:Human papillomavirus type 16 E7 protein, expressed in Escherichia coli as fusion protein lac alpha peptide-E7 (lac-E7), was purified by electrophoresis and used to immunize rabbits to raise antisera. The anti-lac-E7 sera recognized another bacterially expressed fusion protein trpE-E7 by the Western blot method. The an...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90386-3

    authors： Sato H,Watanabe S,Furuno A,Yoshiike K

    更新日期：1989-05-01 00:00:00

  • Characterization of monoclonal antibodies to the Autographa californica nuclear polyhedrosis virus.

    abstract：:Mouse hybridomas which produce monoclonal antibodies to the Autographa californica nuclear polyhedrosis virus (AcNPV) have been prepared and the protein to which each is directed has been determined. The antibody produced by clones 3F3 and 5E9 specifically bound polyhedron protein of MW 32,000 when used in immunoadsor...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(82)90241-0

    authors： Roberts PL,Naser W

    更新日期：1982-10-30 00:00:00

  • Inducible system in human hepatoma cell lines for hepatitis C virus production.

    abstract：:We cloned the complete complementary DNA of an isolate of the hepatitis C virus, HCV-S1, into a tetracycline-inducible expression vector and stably transfected it into two human hepatoma cell lines, Huh7 and HepG2. Twenty-six Huh7 and two HepG2-positive clones were obtained after preliminary screening. Two Huh7 (SH-7 ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1687

    authors： Lim SP,Soo HM,Tan YH,Brenner S,Horstmann H,MacKenzie JM,Ng ML,Lim SG,Hong Wj

    更新日期：2002-11-10 00:00:00

  • Complete genome analysis and molecular characterization of Usutu virus that emerged in Austria in 2001: comparison with the South African strain SAAR-1776 and other flaviviruses.

    abstract：:Here we describe the complete genome sequences of two strains of Usutu virus (USUV), a mosquito-borne member of the genus Flavivirus in the Japanese encephalitis virus (JEV) serogroup. USUV was detected in Austria in 2001 causing a high mortality rate in blackbirds; the reference strain (SAAR-1776) was isolated in 195...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.08.005

    authors： Bakonyi T,Gould EA,Kolodziejek J,Weissenböck H,Nowotny N

    更新日期：2004-10-25 00:00:00

  • Nucleotide sequence of gene 6 of avian-like group A rotavirus 993/83.

    abstract：:Two cDNA clones, which hybridized in Northern blots to RNA segment 6 of the homologous avian-like group A rotavirus (RV) 993/83 and pigeon RV PO-13, but not to mammalian group A rotaviruses, were sequenced. The gene 6 sequence contained a single long open reading frame encoding a protein of 397 amino acids (total MW 4...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1437

    authors： Rohwedder A,Irmak H,Werchau H,Brüssow H

    更新日期：1993-08-01 00:00:00

  • Cytotoxic T lymphocyte responses to the envelope proteins of endogenous ecotropic and mink cytopathic focus-forming murine leukemia viruses in H-2b mice.

    abstract：:To study the possible role of immune selection in the in vivo generation of pathogenic recombinant murine leukemia viruses (MuLV), we have constructed recombinant vaccinia viruses (rVV) expressing the envelope genes of three MuLV: AKR623, MCF247, and MCF13. rVV expressing either AKR623 or MCF247 env could prime H-2b m...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1370

    authors： Coppola MA,Green WR

    更新日期：1994-07-01 00:00:00

  • Identification of a neutralization epitope in the VP1 capsid protein of SV40.

    abstract：:Three SV40 escape mutants were identified by selection in the presence of monoclonal antibodies with neutralizing activity. The VP1 amino acid alterations in these mutants were: (1) K73-->E (in loop BC); (2) D77-->E (in loop BC); (3) K171-->R (in loop EF); and (4) Q175-->H (in loop EF). These residues are clustered in...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.07.032

    authors： Murata H,Teferedegne B,Sheng L,Lewis AM Jr,Peden K

    更新日期：2008-11-10 00:00:00

  • Two adenovirus proteins with redundant activities in virus growth facilitates tripartite leader mRNA accumulation.

    abstract：:Most adenovirus-specific mRNAs expressed late after infection originate from a single transcription unit, the so-called major late transcription unit. All mRNAs expressed from this unit have in common a 201 nucleotide-long spliced tripartite leader segment attached to their 5' ends. Human adenovirus mutants that carry...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1234

    authors： Ohman K,Nordqvist K,Akusjärvi G

    更新日期：1993-05-01 00:00:00

  • Structure of the bacteriophage lambda cohesive end site: bent DNA on both sides of the site, cosN, at which terminase introduces nicks during chromosome maturation.

    abstract：:Packaging of lambda DNA is mediated by the phage-encoded enzyme, terminase, which acts at a site termed cos. cos consists of cosB, the site where terminase binds lambda DNA, and cosN, the site where nicks are introduced to generate the cohesive ends of virion DNA. cos contains multiple binding sites for gpNu1, the sma...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90085-6

    authors： Yeo A,Kosturka LD,Feiss M

    更新日期：1990-01-01 00:00:00

  • Sequence analysis of the complete genome of Trichoplusia ni single nucleopolyhedrovirus and the identification of a baculoviral photolyase gene.

    abstract：:The genome of the Trichoplusia ni single nucleopolyhedrovirus (TnSNPV), a group II NPV which infects the cabbage looper (T. ni), has been completely sequenced and analyzed. The TnSNPV DNA genome consists of 134,394 bp and has an overall G + C content of 39%. Gene analysis predicted 144 open reading frames (ORFs) of 15...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.04.041

    authors： Willis LG,Seipp R,Stewart TM,Erlandson MA,Theilmann DA

    更新日期：2005-08-01 00:00:00

  • Characterization of an antigenic site that contains a dominant, type-specific neutralization determinant on the envelope protein domain III (ED3) of dengue 2 virus.

    abstract：:The surface of the mature dengue virus (DENV) particle consists of 90 envelope (E) protein dimers that mediate both receptor binding and fusion. The E protein ectodomain can be divided into three structural domains designated ED1, ED2, and ED3, of which ED3 contains the critical and dominant virus-specific neutralizat...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.05.042

    authors： Gromowski GD,Barrett AD

    更新日期：2007-09-30 00:00:00

  • Rift Valley fever virus NSS gene expression correlates with a defect in nuclear mRNA export.

    abstract：:We investigated the localization of host mRNA during Rift Valley fever virus (RVFV) infection. Fluorescence in situ hybridization revealed that infection with RVFV altered the localization of host mRNA. mRNA accumulated in the nuclei of RVFV-infected but not mock-infected cells. Further, overexpression of the NSS gene...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2015.09.003

    authors： Copeland AM,Van Deusen NM,Schmaljohn CS

    更新日期：2015-12-01 00:00:00

  • Excision of lambda prophage: effects on host survival.

    abstract：:Induction with ultraviolet light of K12 lysogens carrying defective prophages leads to death of the host cell. In order to determine whether the killing accompanying induction was due to diffusible phage products, or was a result of prophage excision itself, the survival of lysogens carrying DNA defective prophages on...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(68)90012-3

    authors： Eisen HA,Siminovitch L,Mohide PT

    更新日期：1968-01-01 00:00:00

  • Development of Bean pod mottle virus-based vectors for stable protein expression and sequence-specific virus-induced gene silencing in soybean.

    abstract：:Plant virus-based vectors provide valuable tools for expression of foreign proteins in plants and for gene function studies. None of the presently available virus vectors is suitable for use in soybean. In the present study, we produced Bean pod mottle virus (BPMV)-based vectors that are appropriate for gene expressio...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.08.046

    authors： Zhang C,Ghabrial SA

    更新日期：2006-01-20 00:00:00