Differential utilisation of ceramide during replication of the flaviviruses West Nile and dengue virus.

abstract：:Porcine circovirus 2 (PCV2) has a major impact on the swine industry. Eight PCV2 genotypes (a-h) have been identified using capsid sequence analysis. PCV2d has been designated as the emerging genotype. The cryo-electron microscopy molecular envelope of PCV2d virus-like particles identifies differences between PCV2a, b...

journal_title：Virology

authors： Khayat R,Wen K,Alimova A,Gavrilov B,Katz A,Galarza JM,Gottlieb P

更新日期：2019-11-01 00:00:00

abstract：:We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I). Concurrently, the NRTI mutations T69I and V118I and the NNRTI mutations K1...

journal_title：Virology

authors： Megens S,Vaira D,De Baets G,Dekeersmaeker N,Schrooten Y,Li G,Schymkowitz J,Rousseau F,Vandamme AM,Moutschen M,Van Laethem K

更新日期：2014-05-01 00:00:00

abstract：:Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes. We show that hemagglutination involves selective recognition of the non-human sialic acid N-g...

journal_title：Virology

authors： Löfling J,Lyi SM,Parrish CR,Varki A

更新日期：2013-05-25 00:00:00

abstract：:Viruses of the family Luteoviridae are ssRNA plant viruses that have particles that exhibit icosahedral symmetry. To identify the residues that might be exposed on the surface of the Potato leafroll virus (PLRV; genus Polerovirus, family Luteoviridae) capsid, and therefore involved in biological interactions, we perfo...

journal_title：Virology

authors： Terradot L,Souchet M,Tran V,Giblot Ducray-Bourdin D

更新日期：2001-07-20 00:00:00

abstract：:Replication of the nonsegmented, plus-stranded RNA genome of Cucumber necrosis tombusvirus (CNV) requires two essential overlapping viral-coded replication proteins, the p33 replication co-factor and the p92 RNA-dependent RNA polymerase. In this paper, we demonstrate that p33 is phosphorylated in vivo and in vitro by ...

journal_title：Virology

authors： Shapka N,Stork J,Nagy PD

更新日期：2005-12-05 00:00:00

abstract：:A nonhemagglutinating mutant of a 1978 isolate of canine parvovirus (CPV) was derived after repeated passages in the NLFK feline kidney cell line. The mutant CPV was antigenically indistinguishable from wild-type virus when tested with 82 monoclonal antibodies, and it replicated in cat and dog cell lines in culture. S...

journal_title：Virology

authors： Parrish CR,Burtonboy G,Carmichael LE

更新日期：1988-03-01 00:00:00

abstract：:We mutagenized and characterized a 41-kilobase-pair subgenomic cloned fragment from the unique long (UL) region of pseudorabies virus (PRV). Forty mutant clones, each carrying a single inserted oligonucleotide, were used for cotransfection with overlapping cloned viral DNA fragments. More than half of these transfecti...

journal_title：Virology

authors： De Wind N,Peeters BP,Zuderveld A,Gielkens AL,Berns AJ,Kimman TG

更新日期：1994-05-01 00:00:00

abstract：:In March 2017, a novel highly pathogenic avian influenza A(H7N9) virus was detected at two commercial broiler breeder facilities in Tennessee, United States. In this study, a wild bird low pathogenic avian influenza A virus, A/blue-winged teal/Wyoming/AH0099021/2016(H7N9), was shown to be the probable precursor of the...

journal_title：Virology

authors： Li L,DeLiberto TJ,Killian ML,Torchetti MK,Wan XF

更新日期：2018-12-01 00:00:00

abstract：:We investigated the localization of host mRNA during Rift Valley fever virus (RVFV) infection. Fluorescence in situ hybridization revealed that infection with RVFV altered the localization of host mRNA. mRNA accumulated in the nuclei of RVFV-infected but not mock-infected cells. Further, overexpression of the NSS gene...

journal_title：Virology

authors： Copeland AM,Van Deusen NM,Schmaljohn CS

更新日期：2015-12-01 00:00:00

abstract：:The phosphatidylinositol-3-kinase (PI3K)-Akt signaling pathway regulates several key cellular functions including protein synthesis, cell growth, glucose metabolism, and inflammation. Many viruses have evolved mechanisms to manipulate this signaling pathway to ensure successful virus replication. The human herpesvirus...

journal_title：Virology

authors： Liu X,Cohen JI

更新日期：2015-05-01 00:00:00

abstract：:Langat (LGT) flavivirus, derived from infectious full-length cDNA clone 636, was investigated for its apoptotic activities in mouse neuroblastoma (Neuro-2a) and simian kidney (Vero and LLC-MK(2)) cells. The hallmark of apoptosis, cleavage of cellular DNA, was observed 48 h after infection of Vero, LLC-MK(2), and Neuro...

journal_title：Virology

authors： Prikhod'ko GG,Prikhod'ko EA,Cohen JI,Pletnev AG

更新日期：2001-08-01 00:00:00

abstract：:RSV is a major cause of severe lower respiratory infection in infants and young children. With no vaccine yet available, it is important to clarify mechanisms of disease pathogenesis. Since indoleamine-2,3-dioxygenase (IDO) is an immunomodulatory enzyme and is upregulated with RSV infection, we studied it in vivo duri...

journal_title：Virology

authors： Rajan D,Chinnadurai R,O'Keefe EL,Boyoglu-Barnum S,Todd SO,Hartert TV,Galipeau J,Anderson LJ

更新日期：2017-12-01 00:00:00

abstract：:Viruses were recovered from HeLa S3 cells and African green monkey kidney (AGMK) cells transfected with an infectious cDNA clone of poliovirus vaccine Sabin 1 strain. The viruses recovered from the different DNA-transfected cells were tested for the biological characteristics of temperature sensitivity (rct marker), p...

journal_title：Virology

authors： Kohara M,Abe S,Kuge S,Semler BL,Komatsu T,Arita M,Itoh H,Nomoto A

更新日期：1986-05-01 00:00:00

abstract：:Within immunocompromised populations, the JC polyomavirus is the cause of the often-fatal disease Progressive Multifocal Leukoencephalopathy (PML). JC virus encodes a protein, termed T-antigen (T-ag), which is essential for its replication and pathogenicity. Previous studies of JCV T-ag have, in general, used antibodi...

journal_title：Virology

authors： Grubman SA,Shin J,Phelan PJ,Gong A,Can H,Dilworth R,Kini SK,Gagnon D,Archambault J,Meinke G,Bohm A,Jefferson DM,Bullock PA

更新日期：2016-10-01 00:00:00

abstract：:The Gardner (GA) and Snyder-Theilen (ST) isolates of feline sarcoma virus (FeSV) represent genetic recombinants between feline leukemia virus (FeLV) and transformation-specific sequences (v-fes gene) of cat cellular origin. A related transforming gene (v-fps), common to the Fujinami, PRC II, and UR 1 strains of avian ...

journal_title：Virology

authors： Groffen J,Heisterkamp N,Shibuya M,Hanafusa H,Stephenson JR

更新日期：1983-03-01 00:00:00

abstract：:Measles virus transcription generates multiple P/C gene-specific mRNAs by a process which has been termed editing. In one of these mRNAs, the cotranscriptional addition of a single nontemplated G residue allows translational access to the V protein reading frame. The protein translated from this mRNA has been called V...

journal_title：Virology

authors： Liston P,Briedis DJ

更新日期：1994-01-01 00:00:00

abstract：:A mutant (Tbts7) of alfalfa mosaic virus, the coat protein of which is unable to activate the viral genome (the RNA species 1, 2, and 3, which need some coat protein for infectivity) at 30 degrees , can be rescued at this temperature by adding to the inoculum wild-type RNA 3 (the genome part that contains the coat pro...

journal_title：Virology

authors： Smit CH,Jaspars EM

更新日期：1982-02-01 00:00:00

abstract：:Plasmids containing the E1 region of Ad12 DNA can transform certain rodent cells into oncogenic cells. To study the role of the E1a subregion in the process of oncogenic transformation, Ad12 region E1 mutants carrying deletions in the E1a region were constructed. Deletion mutants pR7 and pR8 affect only the 13 S mRNA ...

journal_title：Virology

authors： Bos JL,Jochemsen AG,Bernards R,Schrier PI,van Ormondt H,van der Eb AJ

更新日期：1983-09-01 00:00:00

abstract：:The mutations in two DNA-negative ts mutants of herpes simplex virus type 1 (HSV-1), tsK13 and tsM19, have been previously mapped to a 2.0-kb fragment (coordinates 0.095-0.108) at the left end of the genome (S. Weller, D. Aschman, W. Sacks, D. Coen, and P. Schaffer, 1983, Virology 130, 290-305). Sequence analysis of t...

journal_title：Virology

authors： Zhu L,Weller SK

更新日期：1988-10-01 00:00:00

abstract：:An infectious and full-length molecular clone of genomic human spumaretrovirus (HSRV) DNA was constructed. The infectivity of the pHSRV13 clone was demonstrated after transfection into susceptible cells by passage of HSRV-specific cytopathic effects as a cell-free culture supernatant, by electron microscopy of HSRV pa...

journal_title：Virology

authors： Löchelt M,Zentgraf H,Flügel RM

更新日期：1991-09-01 00:00:00

abstract：:An immunological relationship was detected between the coat protein of the common (U1) strain of tobacco mosaic virus (TMV) and the large subunit of the ubiquitous CO2-fixing host enzyme, ribulose-1,5-biphosphate carboxylase (RuBisCo). When assayed by Western immunoblotting or indirect ELISA, polyclonal antisera to TM...

journal_title：Virology

authors： Dietzgen RG,Zaitlin M

更新日期：1986-11-01 00:00:00

abstract：:The HPV16 E7 oncoprotein and 17β-estradiol are important factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. Here, we assessed the global gene expression profiles induced by the HPV16 E7 oncoprotein and/or 17...

journal_title：Virology

authors： Cortés-Malagón EM,Bonilla-Delgado J,Díaz-Chávez J,Hidalgo-Miranda A,Romero-Cordoba S,Uren A,Celik H,McCormick M,Munguía-Moreno JA,Ibarra-Sierra E,Escobar-Herrera J,Lambert PF,Mendoza-Villanueva D,Bermudez-Cruz RM,Gariglio P

更新日期：2013-12-01 00:00:00

abstract：:Red clover necrotic mosaic virus (RCNMV) encodes N-terminally overlapping proteins of 27 and 88 kDa (p27 and p88) known to be required for replication. Green fluorescent protein (GFP) fusions were used to visualize the location of p27 and p88 within Nicotiana benthamiana cells. GFP:p27 fusions localized to the endopla...

journal_title：Virology

authors： Turner KA,Sit TL,Callaway AS,Allen NS,Lommel SA

更新日期：2004-03-15 00:00:00

abstract：:Friend murine leukemia virus (Fr-MLV) produces unspliced mRNAs, as well as singly-spliced mRNAs by which the Env protein is generated. We investigated the role of the intron within the Fr-MLV gene in Env expression using vectors with serially truncated introns. The up-regulatory regions, the 361-878 and the 5135-5399 ...

journal_title：Virology

authors： Yamamoto N,Takase-Yoden S

更新日期：2009-03-01 00:00:00

abstract：:Nipah virus (NiV) causes severe encephalitis in humans, with high mortality. NiV nonstructural C protein (NiV-C) is essential for its pathogenicity, but its functions are unclear. In this study, we focused on NiV-C trafficking in cells and found that it localizes predominantly in the cytoplasm but partly in the nucleu...

journal_title：Virology

authors： Horie R,Yoneda M,Uchida S,Sato H,Kai C

更新日期：2016-10-01 00:00:00

abstract：:Rice tungro bacilliform virus (RTBV) replication intermediates have been studied in rice plants infected with the virus. Unencapsidated virus-specific molecules were identified which had open circular, linear, supercoiled (SC), strong-stop, single-stranded, linear double-stranded hairpin, and double-stranded with sing...

journal_title：Virology

authors： Bao Y,Hull R

更新日期：1994-11-01 00:00:00

abstract：:Soluble RNA-dependent RNA polymerases from healthy and alfalfa mosaic virus (AMV)-infected leaves were purified more than 400-fold from the 100,000g supernatant of leaf homogenates, using ammonium sulfate precipitation, Sephadex G-100 filtration, and chromatography on DEAE Sephadex A25 and P11-phosphocellulose. The DE...

journal_title：Virology

authors： Chifflot S,Sommer P,Hartmann D,Stussi-Garaud C,Hirth L

更新日期：1980-01-15 00:00:00

abstract：:The nucleotide and deduced amino acid sequence of the gene 4 of murine rotavirus strain Eb were determined. The gene is 2359 nucleotides in length and encodes for a protein of 775 amino acids. Comparison of the VP4 amino acid sequence of the Eb strain with several human and animal rotavirus strains which represent all...

journal_title：Virology

authors： Sereno MM,Gorziglia MI

更新日期：1994-03-01 00:00:00

abstract：:Broad bean mottle bromovirus (BBMV) was shown to accumulate RNA2-derived defective interfering (DI) RNAs [Romero et al., Virology 194, 576-584 (1993); Pogany et al., Virology 212, 574-586 (1995)]. In this work, we utilize three sets of BBMV RNA2-derived artificial DI RNA constructs to determine factors that affect the...

journal_title：Virology

authors： Pogany J,Romero J,Bujarski JJ

更新日期：1997-02-17 00:00:00

abstract：:We reported earlier that variable expression of the Epstein-Barr virus (EBV) encoded membrane protein LMP 1 in nasopharyngeal carcinoma and the host-cell-phenotype-dependent activity of the BCR2 promoter (one of the possible initiator sites for transcripts of Epstein-Barr nuclear antigens) in Burkitt's lymphoma (BL) l...

journal_title：Virology

authors： Minarovits J,Hu LF,Minarovits-Kormuta S,Klein G,Ernberg I

更新日期：1994-05-01 00:00:00