Abstract:
:The phosphatidylinositol-3-kinase (PI3K)-Akt signaling pathway regulates several key cellular functions including protein synthesis, cell growth, glucose metabolism, and inflammation. Many viruses have evolved mechanisms to manipulate this signaling pathway to ensure successful virus replication. The human herpesviruses undergo both latent and lytic infection, but differ in cell tropism, growth kinetics, and disease manifestations. Herpesviruses express multiple proteins that target the PI3K/Akt cell signaling pathway during the course of their life cycle to facilitate viral infection, replication, latency, and reactivation. Rare human genetic disorders with mutations in either the catalytic or regulatory subunit of PI3K that result in constitutive activation of the protein predispose to severe herpesvirus infections as well as to virus-associated malignancies. Inhibiting the PI3K/Akt pathway or its downstream proteins using drugs already approved for other diseases can block herpesvirus lytic infection and may reduce malignancies associated with latent herpesvirus infections.
journal_name
Virologyjournal_title
Virologyauthors
Liu X,Cohen JIdoi
10.1016/j.virol.2015.02.040subject
Has Abstractpub_date
2015-05-01 00:00:00pages
568-77eissn
0042-6822issn
1096-0341pii
S0042-6822(15)00086-0journal_volume
479-480pub_type
杂志文章,评审相关文献
VIROLOGY文献大全abstract::The nucleoprotein (NP) of the influenza A virus encapsidates the viral RNA and participates in the infectious life cycle of the virus. The aims of this study were to find the degree of conservation of NP among all virus subtypes and hosts and to identify conserved binding sites, which may be utilised as potential drug...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.01.023
更新日期:2014-04-01 00:00:00
abstract::Little is known about the molecular determinants causing and sustaining viral persistent infections at the cellular level. We found that Drosophila cells persistently infected (PI) with Flock House virus (FHV) invariably harbor defective viral RNAs, which are replicated by the FHV RNA-dependent RNA polymerase. Some de...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.08.002
更新日期:2011-10-10 00:00:00
abstract::The complete nucleotide sequence of the RSV cpts-248/404 live attenuated vaccine candidate was determined from cloned cDNA and was compared to that of the RSV A2/HEK7 wild-type, cold-passaged cp-RSV, and cpts-248 virus, which constitute the series of progenitor viruses. RSV cpts-248/404 is more attenuated and more tem...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0618
更新日期:1996-11-15 00:00:00
abstract::Antiviral cytotoxic T-cells are critical for control of lymphocytic choriomeningitis virus (LCMV) infection in mice. In H-2b mice, the antiviral response is directed against three Db-restricted epitopes in the viral nucleoprotein (NP396-404) and glycoprotein (GP276-286 and GP33-41). Our present data revealed a clear h...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8934
更新日期:1998-01-05 00:00:00
abstract::Following a bite from an infected tick, tick-borne flaviviruses cause encephalitis, meningitis and hemorrhagic fever in humans. Although these viruses spend most of their time in the tick, little is known regarding the virus-vector interactions. We developed a simple method for synchronously infecting Ixodes scapulari...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.03.057
更新日期:2007-09-01 00:00:00
abstract::Human noroviruses bind histo-blood group antigens (HBGAs) and this interaction is thought to be important for an infection. We identified two additional fucose-binding pockets (termed fucose-3/4 sites) on a genogroup II human (GII.10) norovirus-protruding (P) dimer using X-ray crystallography. Fucose-3/4 sites were lo...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.04.006
更新日期:2015-09-01 00:00:00
abstract::Using the 5' long terminal repeat (LTR) as its only promoter, the HTLV-1 provirus generates a single RNA transcript that undergoes differential splicing to express the various viral proteins. Examination of sequence near the transcription start site revealed an element resembling a transcriptional initiator (Inr) at p...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0751
更新日期:2001-02-01 00:00:00
abstract::CD8+ T lymphocytes are critical for the control of gammaherpesvirus latency. To determine how memory CD8+ T cells generated during latency differ from those primed during acute or chronic viral infection, we adoptively transferred naive P14 CD8+ T cells into uninfected recipients, and examined surface proteins, cytoki...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2017.06.018
更新日期:2017-09-01 00:00:00
abstract::The tail sheath protein of giant bacteriophage phiKZ Pseudomonas aeruginosa encoded by gene 29 was identified and its expression system was developed. Localization of the protein on the virion was confirmed by immunoelectron microscopy. Properties of gene product (gp) 29 were studied by electron microscopy, immunoblot...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.09.015
更新日期:2009-12-20 00:00:00
abstract::Despite recent progress in the development of direct-acting antivirals against hepatitis C virus (HCV), chronic HCV infection remains an important health burden worldwide. MicroRNA122 (miR122), a liver-specific microRNA (miRNA), positively regulates HCV replication, and systemic application of antisense oligonucleotid...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.05.024
更新日期:2014-08-01 00:00:00
abstract::The ability of some Sendai virus stocks to strongly activate IFNbeta has long been known to be associated with defective-interfering (DI) genomes. We have compared SeV stocks containing various copyback and internal deletion DI genomes (and those containing only nondefective (ND) genomes) for their ability to activate...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.03.022
更新日期:2006-07-20 00:00:00
abstract::Ovarian cancer is the third most common female cancer, with poor survival in later stages of metastatic spread. We test a chimeric virus consisting of genes from Lassa and vesicular stomatitis viruses, LASV-VSV; the native VSV glycoprotein is replaced by the Lassa glycoprotein, greatly reducing neurotropism. Human ova...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.10.009
更新日期:2020-11-12 00:00:00
abstract::Murine gammaherpesvirus 68 (MHV68) is used as a model to study gammaherpesvirus pathogenesis both in tissue culture systems and in vivo. We used a gene-trapping approach to get insight into cellular factors involved in MHV68 infection. By generating a library of gene-trapped CHO cells, we were able to isolate several ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.12.004
更新日期:2008-04-10 00:00:00
abstract::The genes of the RF strain of bovine rotavirus have been cloned into pBR 322 following the synthesis and hybridization of cDNA transcribed from both strands of in vitro polyadenylated genomic RNA. Cloned rotavirus DNAs were assigned to most of the 11 genomic RNA segments by Northern blot hybridization. The complete se...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(84)90159-4
更新日期:1984-10-15 00:00:00
abstract::ICP27 is an essential herpes simplex virus type 1 (HSV-1) nuclear protein which regulates viral early and late genes during infection. The exact mechanism by which ICP27 modulates viral gene expression is unknown, but considerable evidence suggests that it functions posttranscriptionally. In this study, we have asked ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.9006
更新日期:1998-03-01 00:00:00
abstract::Hepatitis delta antigen (HDAg) of hepatitis delta virus (HDV) typically consists of two related protein species. The small HDAg (S-HDAg) is a 24-kDa protein of 195 amino acids and the large HDAg (L-HDAg) is a 27-kDa protein with an additional 19 amino acids at its C-terminus. These two proteins have distinct functions...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0680
更新日期:2000-12-20 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) establishes lifelong latent infection in sensory neurons of the peripheral nervous system. During HSV latency, the latency-associated transcripts (LATs) are the only viral transcripts abundantly expressed. The most abundant form of LATs is a 2-kb stable intron spliced from a primary...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.03.043
更新日期:2004-07-01 00:00:00
abstract::Virulence markers to distinguish high from low virulence bovine viral diarrhea virus genotype 2 isolates have not been previously reported. The objective of this study was to identify virulence markers by evaluating the primary and secondary structures of the 5'-untranslated region of low and high virulence bovine vir...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9350
更新日期:1998-10-10 00:00:00
abstract::The pe38 gene product of Autographa californica M nucleopolyhedrovirus (AcMNPV) has been shown to be involved in transcriptionally transactivating viral genes and augmenting viral DNA replication in transient assays. To assess the role of pe38 during infection, we generated a knockout virus, Delta pe38-E9/E9, in which...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(03)00143-0
更新日期:2003-06-05 00:00:00
abstract::Rabies continues to poses serious threats to the public health in many countries. The development of novel inexpensive, safe and effective vaccines has become a high priority for rabies control worldwide. We previously generated a novel recombinant rabies vaccine by cloning rabies virus glycoprotein into a chimpanzee ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.07.022
更新日期:2019-10-01 00:00:00
abstract::Studies using transformed human cell lines suggest that most SIV strains use CCR5 as co-receptor. Our analysis of primary rhesus macaque CD4(+) T-cell clones revealed marked differences in susceptibility to SIV(mac)239 infection. We investigated whether different levels of CCR5 expression account for clonal difference...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.10.005
更新日期:2011-01-05 00:00:00
abstract::Ovine pulmonary carcinoma is a contagious neoplastic disease of sheep which can be transmitted experimentally with cell-free filtrate. Products homologous to structural proteins of type D and type B retroviruses are expressed in the tumors, but an infectious retrovirus has yet to be isolated. Retroviral RNA was isolat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1366
更新日期:1994-07-01 00:00:00
abstract::Although a live attenuated HIV vaccine is not currently considered for safety reasons, a strategy inducing both T cells and neutralizing antibodies to native assembled HIV-1 particles expressed by a replicating virus might mimic the advantageous characteristics of live attenuated vaccine. To this aim, we generated a l...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.02.047
更新日期:2009-05-25 00:00:00
abstract::Members of the genus Mastrevirus (family Geminiviridae) produce a complementary-sense (c-sense) transcription unit with the potential to encode two proteins, RepA and Rep. In the present work, we have studied the DNA-protein complexes formed by the Wheat dwarf virus (WDV) RepA protein within the WDV large intergenic r...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0412
更新日期:2000-07-20 00:00:00
abstract::West Nile virus is a mosquito-borne, neurotropic flavivirus that causes encephalitis in humans and animals. Since being introduced into the Western hemisphere in 1999, WNV has spread rapidly across North America, identifying this virus as an important emerging pathogen. In this study, we developed a DNA-launched infec...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.01.021
更新日期:2005-03-30 00:00:00
abstract::A plasmid-based transfection system capable of generating infectious porcine circovirus type 2 (PCV2) was established. This system was then used in mutagenesis studies to investigate the involvement of a "conserved" nonanucleotide (which constitutes a portion of the loop sequence) located at the origin of DNA replicat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.03.037
更新日期:2004-06-20 00:00:00
abstract::The coding region of segment 4 of Thogoto (THO) virus, a tick-borne member of the Orthomyxoviridae, was expressed in a baculovirus system under the control of the polyhedrin promoter. This construct expressed authentic envelope glycoprotein as determined by size and antigenic reactivity with a panel of monoclonal anti...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1566
更新日期:1995-10-20 00:00:00
abstract::Two tick-borne encephalitis (TBE) virus variants were studied: mouse brain-adapted strain EK-328 and its derivate adapted to Hyalomma marginatum ticks. The tick-adapted virus exhibited small-plaque phenotype and slower replication in PEK cells, higher yield in ticks, decreased neuroinvasiveness in mice, increased bind...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.12.013
更新日期:2007-05-25 00:00:00
abstract::We studied experimental canine oral papillomavirus (COPV) infection by in situ hybridization and immunohistochemistry of weekly biopsies. After 4 weeks, viral DNA in rete ridges suggested a keratinocyte stem cell target. Abundant viral DNA was seen in E4-positive cells only. E4 was predominantly cytoplasmic but also n...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2001.0868
更新日期:2001-05-25 00:00:00
abstract::The amino-terminal domain of influenza A virus matrix protein (residues 1-164) was crystallized at pH 7 into a new crystal form in space group P1. This packing of the protein implies that M1(1-164) was monomeric in solution when it crystallized. Otherwise, the structure of the M1 fragment in the pH 7 crystals was the ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0727
更新日期:2001-01-20 00:00:00