Abstract:
:We investigated the localization of host mRNA during Rift Valley fever virus (RVFV) infection. Fluorescence in situ hybridization revealed that infection with RVFV altered the localization of host mRNA. mRNA accumulated in the nuclei of RVFV-infected but not mock-infected cells. Further, overexpression of the NSS gene, but not the N, GN or NSM genes correlated with mRNA nuclear accumulation. Nuclear accumulation of host mRNA was not observed in cells infected with a strain of RVFV lacking the gene encoding NSS, confirming that expression of NSS is likely responsible for this phenomenon.
journal_name
Virologyjournal_title
Virologyauthors
Copeland AM,Van Deusen NM,Schmaljohn CSdoi
10.1016/j.virol.2015.09.003subject
Has Abstractpub_date
2015-12-01 00:00:00pages
88-93eissn
0042-6822issn
1096-0341pii
S0042-6822(15)00394-3journal_volume
486pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::Begomoviruses (family Geminiviridae) are responsible for many economically important crop diseases worldwide. The majority of these diseases are caused by bipartite begomovirus infections, although a rapidly growing number of diseases of the Old World are associated with monopartite begomoviruses. With the exception o...
journal_title:Virology
pub_type: 杂志文章,随机对照试验,评审
doi:10.1016/j.virol.2005.09.042
更新日期:2006-01-05 00:00:00
abstract::Viruses in certain genera in family Caulimoviridae were shown to integrate their genomic sequences into their host genomes and exist as endogenous pararetroviral sequences (EPRV). However, members of the genus Caulimovirus remained to be the exception and are known to exist only as episomal elements in the infected ce...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.03.003
更新日期:2008-07-05 00:00:00
abstract::Long-term non-progressive HIV infection, characterized by low but detectable viral load and stable CD4 counts in the absence of antiviral therapy, is observed in about 5% of HIV-infected patients. Here we identified four therapy naïve individuals who are strongly seropositive for HIV-1 but who lack evidence of detecta...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.06.001
更新日期:2005-08-15 00:00:00
abstract::Sulfolobus turreted icosahedral virus (STIV) infects Sulfolobus species found in the hot springs of Yellowstone National Park. Its 37 open reading frames (ORFs) generally lack sequence similarity to other genes. One exception, however, is ORF B116. While its function is unknown, orthologs are found in three additional...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.01.027
更新日期:2007-07-05 00:00:00
abstract::Central African tropical forests are home to several species of non-human primates (NHPs), infected by Simian Immunodeficiency Virus (SIV). It is well-known that HIV-1 epidemic is due to cross-transmission and adaptation of SIV to humans. The main goal of this work was to investigate if a NHP bite is a risk factor for...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.12.026
更新日期:2017-03-01 00:00:00
abstract::We constructed a sensitive and quantitative assay system to examine human T-cell leukemia virus type I (HTLV-I) envelope (env) glycoprotein-mediated cell fusion in which T7 RNA polymerase in donor cells coexpressing env glycoproteins activates a reporter gene in recipient cells upon cell fusion. An efficient expressio...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9530
更新日期:1999-02-15 00:00:00
abstract::The Autographa californica M nucleopolyhedrovirus (AcMNPV) viral fibroblast growth factor (vFGF) has functional parallels to cellular FGFs. Deletion of the AcMNPV vfgf has no obvious phenotype in cell culture but delays the time of insect death. Here, we determined vFGF production during virus infection. vFGF was dete...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.09.011
更新日期:2009-12-05 00:00:00
abstract::A collection of TK+, ACV-resistant mutants of herpes simplex virus type 1 (HSV-1) has been derived using a selection system based on biochemically transformed cells. Evidence is presented suggesting that most of these mutants induce resistant DNA polymerase activities and are thus likely to express variant DNA polymer...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90009-1
更新日期:1985-10-30 00:00:00
abstract::Cell-mediated immunity plays a key role in the regression of papillomavirus-induced warts and intra-epithelial lesions but the target antigens that induce this response are not clear. Canine oral papillomavirus (COPV) infection of the oral cavity in dogs is a well-characterized model of mucosal papillomavirus infectio...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.07.032
更新日期:2006-12-05 00:00:00
abstract::We have validated a flexible, high-throughput and relatively inexpensive RT-QPCR array platform for absolute quantification of Epstein-Barr virus transcripts in different latent and lytic infection states. Several novel observations are reported. First, during infection of normal B cells, Wp-initiated latent gene tran...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.10.030
更新日期:2015-01-01 00:00:00
abstract::Replication of the nonsegmented, plus-stranded RNA genome of Cucumber necrosis tombusvirus (CNV) requires two essential overlapping viral-coded replication proteins, the p33 replication co-factor and the p92 RNA-dependent RNA polymerase. In this paper, we demonstrate that p33 is phosphorylated in vivo and in vitro by ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.08.006
更新日期:2005-12-05 00:00:00
abstract::The primary cell types that sustain polyomavirus (Py) replication following intranasal infection as well as the nature of the host cellular response to Py were unknown. As this is an essential and specific site for virus entry, it seems likely that viral gene function must be adapted to these mucosal tissues. Using im...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.0030
更新日期:2000-01-05 00:00:00
abstract::We have studied somatically murine leukemia proviral integrations in primary N-methyl-N-nitrosourea (MNU)-induced thymic lymphomas of AKR/J mice. The majority of MNU-induced lymphomas contain newly acquired murine leukemia proviral sequences. In contrast to spontaneous AKR/J lymphomas which contain multiple integratio...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(88)90638-1
更新日期:1988-05-01 00:00:00
abstract::A novel virus isolated from the feather follicles of cockatoos diagnosed as having psittacine beak and feather disease was characterized by electron microscopy, nucleic acid content, and polypeptide composition. Purified virions displayed an icosahedral symmetry, were nonenveloped, and had a mean diameter of 14 to 16 ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(89)90513-8
更新日期:1989-07-01 00:00:00
abstract::Mutational analyses were carried out to investigate whether the nuclear inclusion protein a (NIa) C-terminal amino acids of turnip mosaic potyvirus play any roles in the cis-cleavage between NIa and NIb. The processing rate of the NIa-NIb junction sequence was decreased significantly by either V240D or Q243A mutation ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8938
更新日期:1998-02-01 00:00:00
abstract::Recently, we reported that PrP(Sc), a surrogate marker for prion disease, is associated with the cellular fraction of blood from scrapie-infected sheep using a ligand-based immunoassay. In the study reported here, we found that a subset of peripheral blood mononuclear cells is most likely to sequester PrP(Sc) during b...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.05.023
更新日期:2010-09-15 00:00:00
abstract::The SARS-coronavirus (SARS-CoV) is the etiological agent of the severe acute respiratory syndrome (SARS). The SARS-CoV spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion. The cytoplasmic portion of the S glycoprotein contains four cysteine-rich amino acid cl...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.10.034
更新日期:2007-04-10 00:00:00
abstract::Soluble RNA-dependent RNA polymerases from healthy and alfalfa mosaic virus (AMV)-infected leaves were purified more than 400-fold from the 100,000g supernatant of leaf homogenates, using ammonium sulfate precipitation, Sephadex G-100 filtration, and chromatography on DEAE Sephadex A25 and P11-phosphocellulose. The DE...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(80)90554-1
更新日期:1980-01-15 00:00:00
abstract::Following a bite from an infected tick, tick-borne flaviviruses cause encephalitis, meningitis and hemorrhagic fever in humans. Although these viruses spend most of their time in the tick, little is known regarding the virus-vector interactions. We developed a simple method for synchronously infecting Ixodes scapulari...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.03.057
更新日期:2007-09-01 00:00:00
abstract::L83V-related variants of human papillomavirus (HPV) 16 E6, exemplified by the Asian-American variant Q14H/H78Y/L83V, were shown to be more prevalent than E6 prototype in progressing lesions and cervical cancer. We evaluated functions relevant to carcinogenesis for the E6 variants L83V, R10/L83V and Q14H/H78Y/L83V as w...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.09.036
更新日期:2009-01-05 00:00:00
abstract::Cytotoxic T-lymphocyte (CTL) epitopes within the HIV genome are subject to negative and positive selective pressures, the balance of which influences CTL escape at a given epitope. We investigated whether viral fitness requirements dictate conservation of the HLA-A2 restricted immunodominant epitope SLYNTVATL (SL9). V...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.03.003
更新日期:2009-05-25 00:00:00
abstract::Tetherin has been defined as a restriction factor of HIV-1 and several other enveloped viruses. However, the significance of tetherin in viral infection remains to be further addressed. Here, we investigated whether tetherin plays a role in HSV-2 infection. Our study revealed that overexpression of tetherin restricted...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.11.005
更新日期:2015-01-15 00:00:00
abstract::The cowpea strain of Southern bean mosaic virus (SBMV-C), a T = 3 icosahedral RNA virus, was dissociated to yield a ribonucleoprotein complex (RNPC) composed of the viral RNA and coat protein subunits. To determine if the coat protein subunits were bound to a specific site on the viral RNA, the RNPC was treated with r...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1117
更新日期:1995-03-10 00:00:00
abstract::Human hepatitis B virus (HBV) envelopes contain three distinct glycoproteins called L, M, and S HBsAg. Each is posttranslationally modified to contain N-linked oligosaccharides. N-linked oligosaccharides, after attachment to a polypeptide backbone, are processed by enzymes within the endoplasmic reticulum (ER). There ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.0038
更新日期:1995-11-10 00:00:00
abstract::It has been suggested that, in addition to viral proteins, host proteins are involved in RNA virus replication. In this study the RNA helicase domain of the Tobacco mosaic virus (TMV) replicase proteins was used as bait in the yeast two-hybrid system to identify tobacco proteins with a putative role in TMV replication...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2002.1332
更新日期:2002-04-10 00:00:00
abstract::The budded form of Autographa californica nuclear polyhedrosis virus functionally enters cells by adsorptive endocytosis. During the period of virus uptake into Spodoptera frugiperda IPLB Sf21 cells (1 to 4 hr postinfection), filamentous F-actin cables, visualized by fluorescence microscopy, were formed within the cyt...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1585
更新日期:1993-11-01 00:00:00
abstract::Our recent results demonstrated that bile acids facilitate virus escape from the endosomes into the cytoplasm for successful replication of porcine enteric calicivirus (PEC). We report a novel finding that bile acids can be substituted by cold treatment for endosomal escape and virus replication. This endosomal escape...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.04.022
更新日期:2015-09-01 00:00:00
abstract::Human papillomaviruses (HPVs) are epitheliotropic viruses, and their life cycle is intimately linked to the stratification and differentiation state of the host epithelial tissues. Defining a role for the E5 gene product in the differentiation-dependent viral life cycle has been difficult due to the lack of a suitable...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9262
更新日期:1998-09-01 00:00:00
abstract::Two novel halophilic archaebacterial bacteriophages, HF1 and HF2, were isolated from an Australian solar saltern. They were morphologically identical with icosahedral-shaped heads (diameter 58 nm) and contractile tails (length 94 nm). Other similarities included sensitivity to reduced ionic conditions, similar protein...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1643
更新日期:1993-12-01 00:00:00
abstract::Myeloid differential primary response protein (MyD88) is a critical component in the signaling cascade through Toll-like receptors (TLRs) and is induced by alpha interferon (IFN-alpha). To examine the role of MyD88 in the antiviral activity of IFN-alpha against hepatitis B virus (HBV), we established MyD88 stably expr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2003.11.005
更新日期:2004-02-20 00:00:00