当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Virion-associated viral fibroblast growth factor stimulates cell motility.

Virion-associated viral fibroblast growth factor stimulates cell motility.

Abstract：

:The Autographa californica M nucleopolyhedrovirus (AcMNPV) viral fibroblast growth factor (vFGF) has functional parallels to cellular FGFs. Deletion of the AcMNPV vfgf has no obvious phenotype in cell culture but delays the time of insect death. Here, we determined vFGF production during virus infection. vFGF was detected at 24 hours post infection and through the remainder of the infection cycle. Since vFGF is thought to be a secreted membrane-binding protein and virions acquire an envelope derived from the cell membrane, we examined virions for the presence of vFGF using microscopy, flow cytometry, and affinity chromatography. We found that vFGF associated with virions. Furthermore, budded virus carrying vFGF had more affinity to heparin than vFGF-deficient budded virus, consistent with the affinity of FGFs for heparan sulfate proteoglycans. Although the function of virion-associated vFGF is not clear, we found that virion-associated vFGF stimulated cell motility and affected virus attachment.

journal_name

Virology

journal_title

Virology

authors

Lehiy CJ,Martinez O,Passarelli AL

doi

10.1016/j.virol.2009.09.011

subject

Has Abstract

pub_date

2009-12-05 00:00:00

pages

152-60

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(09)00559-5

journal_volume

395

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

    abstract：:Following CD4 receptor binding to the HIV-1 envelope spike (Env), the conserved N-heptad repeat (NHR) region of gp41 forms a coiled-coil that is a precursor to the fusion reaction. Although it has been a target of drug and vaccine design, there are few monoclonal antibody (mAb) tools with which to probe the antigenici...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.04.005

    authors： Nelson JD,Kinkead H,Brunel FM,Leaman D,Jensen R,Louis JM,Maruyama T,Bewley CA,Bowdish K,Clore GM,Dawson PE,Frederickson S,Mage RG,Richman DD,Burton DR,Zwick MB

    更新日期：2008-07-20 00:00:00

  • Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon.

    abstract：:We report herein that vesicular stomatitis virus (VSV) induced a concurrent primary Th1 (T helper 1) and Th2 cytokine response detectable ex vivo. Liposome-encapsulated clodronate-mediated elimination of CD8- marginal dendritic cells (DCs) and splenic macrophages (m Phi), but not CD8+ interdigitating DCs, prior to inf...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.07.031

    authors： Ciavarra RP,Taylor L,Greene AR,Yousefieh N,Horeth D,van Rooijen N,Steel C,Gregory B,Birkenbach M,Sekellick M

    更新日期：2005-11-25 00:00:00

  • Changes of the receptor-binding properties of influenza B virus B/Victoria/504/2000 during adaptation in chicken eggs.

    abstract：:Selection of high-growth virus variants of strain B/Victoria/504/2000 by serial passage in eggs resulted in three amino acid substitutions, G141E, R162M, and D196Y, in the vicinity of the receptor-binding pocket of viral hemagglutinin. Virus variants containing the identified amino acid substitutions, individually or ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.08.014

    authors： Lugovtsev VY,Smith DF,Weir JP

    更新日期：2009-11-25 00:00:00

  • Low pH-dependent Sindbis virus-induced fusion of BHK cells: differences between strains correlate with amino acid changes in the E1 glycoprotein.

    abstract：:Expression of alphavirus glycoproteins on the surface of infected cells leads to cell fusion after exposure to acidic pH. Two strains of Sindbis virus, AR339 (SV) and neuroadapted Sindbis virus (NSV), which differ in virulence for weanling mice, were found to differ in pH-dependent fusion. BHK-21 cells infected with S...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90178-5

    authors： Boggs WM,Hahn CS,Strauss EG,Strauss JH,Griffin DE

    更新日期：1989-04-01 00:00:00

  • Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d.

    abstract：:Mouse hepatitis virus strain A59 (MHV-A59) encodes within the 22-kb gene 1 a large polyprotein containing three proteinase domains with proven or predicted cysteine catalytic residues. E64d, a specific, irreversible inhibitor of cysteine (thiol) proteinases, inhibits the processing of the gene 1 polyprotein. Specifica...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1123

    authors： Kim JC,Spence RA,Currier PF,Lu X,Denison MR

    更新日期：1995-04-01 00:00:00

  • Deletion of glycoprotein gE reduces the propagation of pseudorabies virus in the nervous system of mice after intranasal inoculation.

    abstract：:A pseudorabies virus (PrV) mutant, deficient in the nonessential glycoprotein E (gE) and expressing the LacZ gene (gE- beta gal+ PrV), and its rescued virus were inoculated intranasally in mice. The median lethal dose of gE- beta gal+ PrV was similar to that of the parental Kaplan strain, but mice survived longer and ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0247

    authors： Babic N,Klupp B,Brack A,Mettenleiter TC,Ugolini G,Flamand A

    更新日期：1996-05-01 00:00:00

  • Molecular cloning and characterization of MSRV-related sequences associated with retrovirus-like particles.

    abstract：:New sequences have been obtained by successive overlapping RT-PCR extensions from the pol region of a retroviral RNA (multiple sclerosis-associated retroviral element, MSRV) amplified in retrovirus-like particles from patients with multiple sclerosis. gag and pol sequences are related to type C oncoviruses, whereas th...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.9792

    authors： Komurian-Pradel F,Paranhos-Baccala G,Bedin F,Ounanian-Paraz A,Sodoyer M,Ott C,Rajoharison A,Garcia E,Mallet F,Mandrand B,Perron H

    更新日期：1999-07-20 00:00:00

  • The gag and pol genes of bovine leukemia virus: nucleotide sequence and analysis.

    abstract：:The DNA sequence of the gag and pol regions of a provirus cloned from a bovine tumor is presented. In order to confirm these results the sequence of portions of a second clone, derived from a virus-producing cell line, was also determined. The gag gene was found to consist of 1179 nucleotides, which probably encode on...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90344-7

    authors： Rice NR,Stephens RM,Burny A,Gilden RV

    更新日期：1985-04-30 00:00:00

  • Cross-reactive CTL recognizing two HLA-A*02-restricted epitopes within the BK virus and JC virus VP1 polypeptides are frequent in immunocompetent individuals.

    abstract：:Two HLA-A*02-restricted epitopes have been identified within the VP1 polypeptide of a human polyomavirus, BK virus, which is associated with polyomavirus-associated nephropathy in kidney transplant patients. Immunization of transgenic mice with recombinant modified vaccinia Ankara expressing BKV VP1 (rMVA-BKV VP1) eli...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.02.040

    authors： Sharma MC,Zhou W,Martinez J,Krymskaya L,Srivastava T,Haq W,Diamond DJ,Lacey SF

    更新日期：2006-06-20 00:00:00

  • The majority of simian immunodeficiency virus/mne circle junctions result from ligation of unintegrated viral DNA ends that are aberrant for integration.

    abstract：:SIV/Mne circle junctions were amplified by the polymerase chain reaction (PCR) and cloned in a bacterial plasmid. Sequence analysis of clones isolated from 11 independent PCRs reveals that the start site for plus DNA synthesis is 5' ACTG. . ., and thus an asymmetric cleavage must occur during viral integration. In add...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1329

    authors： Randolph CA,Champoux JJ

    更新日期：1993-06-01 00:00:00

  • Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells.

    abstract：:We present a case of sexual transmission of HIV-1 predicted to have CXCR4-tropism during male-to-male sexual exposure. Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event. ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2012.09.010

    authors： Gianella S,Mehta SR,Young JA,Vargas MV,Little SJ,Richman DD,Kosakovsky Pond SL,Smith DM

    更新日期：2012-12-05 00:00:00

  • Combination of Adt-O1Manisa and Ad5-boIFNλ3 induces early protective immunity against foot-and-mouth disease in cattle.

    abstract：:Foot-and-mouth-disease (FMD) remains the most infectious livestock disease worldwide. Although commercially available inactivated or adenovirus-vectored-vaccines (Ad5-FMD) are effective, they require 5-7 days to induce protection. Therefore, new control strategies that stimulate rapid immune responses are needed. Expr...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2016.09.027

    authors： Diaz-San Segundo F,Montiel NA,Sturza DF,Perez-Martin E,Hickman D,Ramirez-Medina E,Grubman MJ,de Los Santos T

    更新日期：2016-12-01 00:00:00

  • Characterization of the leader papain-like proteinase of MHV-A59: identification of a new in vitro cleavage site.

    abstract：:Sequence analysis of the mouse hepatitis virus, strain A59 (MHV-A59) genome predicts the presence of two papain-like proteinases encoded within the first open reading frame (ORF 1a) of the replicase gene. The more 5' of these domains, the leader papain-like proteinase, is responsible for the cleavage of the amino term...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1281

    authors： Bonilla PJ,Hughes SA,Piñón JD,Weiss SR

    更新日期：1995-06-01 00:00:00

  • Characterization of the contribution of spliced RNAs of hepatitis B virus to DNA synthesis in transfected cultures of Huh7 and HepG2 cells.

    abstract：:Hepatitis B virus synthesizes multiple spliced RNAs that can be reverse transcribed into viral DNA. We thoroughly characterized the contribution of spliced RNAs to DNA synthesis in transfected cultures of Huh7 and HepG2 cells. We found that up to 50% of DNA within intracellular capsids is derived from five spliced RNA...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.06.021

    authors： Abraham TM,Lewellyn EB,Haines KM,Loeb DD

    更新日期：2008-09-15 00:00:00

  • Characterization of proteins encoded by ORFs 2 to 7 of Lelystad virus.

    abstract：:The genome of Lelystad virus (LV), a positive-strand RNA virus, is 15 kb in length and contains 8 open reading frames (ORFs) that encode putative viral proteins. ORFs 2 to 7 were cloned in plasmids downstream of the Sp6 RNA polymerase promoter, and the translation of transcripts generated in vitro yielded proteins tha...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/s0042-6822(95)80030-1

    authors： Meulenberg JJ,Petersen-den Besten A,De Kluyver EP,Moormann RJ,Schaaper WM,Wensvoort G

    更新日期：1995-01-10 00:00:00

  • DNA processing in temperature-sensitive morphogenic mutants of HSV-1.

    abstract：:The anatomy of DNA synthesized by five HSV-1 mutants previously shown to accumulate predominantly empty capsids at the nonpermissive temperature (NPT) was analyzed with Bg/II restriction digestion. At the NPT, all five generated DNA lacking termini, indicating that in the absence of packaging, viral DNA is not process...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90214-5

    authors： Sherman G,Bachenheimer SL

    更新日期：1987-06-01 00:00:00

  • Computational analysis of four human adenovirus type 4 genomes reveals molecular evolution through two interspecies recombination events.

    abstract：:Computational analysis of human adenovirus type 4 (HAdV-E4), a pathogen that is the only HAdV member of species E, provides insights into its zoonotic origin and molecular adaptation. Its genome encodes a domain of the major capsid protein, hexon, from HAdV-B16 recombined into the genome chassis of a simian adenovirus...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.05.014

    authors： Dehghan S,Seto J,Liu EB,Walsh MP,Dyer DW,Chodosh J,Seto D

    更新日期：2013-09-01 00:00:00

  • Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis.

    abstract：:Infection of mice with coxsackievirus B4 results within days in a severe acute necrotizing pancreatitis, which resolves completely within weeks. Gelatinase B or matrix metalloproteinase 9 (MMP-9) has previously been shown to be involved in several models of pancreatitis, but its role in virus-induced pancreatitis has ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.08.046

    authors： De Palma AM,Verbeken E,Van Aelst I,Van den Steen PE,Opdenakker G,Neyts J

    更新日期：2008-12-05 00:00:00

  • Characterization of proteinase cleavage sites in the N-terminal region of the RNA1-encoded polyprotein from Arabis mosaic virus (subgroup A nepovirus).

    abstract：:Arabis mosaic virus is a subgroup A nepovirus. The RNA1-encoded polyprotein (P1) contains the domains for the NTP-binding protein (NTB), VPg, proteinase (Pro) and polymerase at its C-terminus. Putative cleavage sites delineating these domains have been proposed. However, the number and location of cleavage sites upstr...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.01.046

    authors： Wetzel T,Chisholm J,Bassler A,Sanfaçon H

    更新日期：2008-05-25 00:00:00

  • Identification of a 17-nucleotide splicing enhancer in HPV-16 L1 that counteracts the effect of multiple hnRNP A1-binding splicing silencers.

    abstract：:Human papillomavirus type 16 (HPV-16) infections can in rare cases persist and cause lesions that may progress to cervical cancer. Cells in the lesions are not permissive for virus production, nor are cervical cancer cells. The intracellular environment is such that it prevents production of the highly immunogenic, vi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.08.002

    authors： Zhao X,Fay J,Lambkin H,Schwartz S

    更新日期：2007-12-20 00:00:00

  • Capsid protein and helper component-proteinase function as potyvirus cell-to-cell movement proteins.

    abstract：:The role of bean common mosaic necrosis potyvirus (BCMNV) and lettuce mosaic potyvirus (LMV) proteins was investigated in terms of their capacity to function as viral movement proteins (MPs). Using Escherichia coli-expressed proteins and microinjection techniques, direct evidence was obtained that both the potyviral c...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8777

    authors： Rojas MR,Zerbini FM,Allison RF,Gilbertson RL,Lucas WJ

    更新日期：1997-10-27 00:00:00

  • Generating and evaluating type I interferon receptor-deficient and feline TMPRSS2-expressing cells for propagating serotype I feline infectious peritonitis virus.

    abstract：:Feline coronavirus infection can progress to a fatal infectious peritonitis, which is a widespread feline disease without an effective vaccine. Generating feline cells with reduced ability to respond to interferon (IFN) is an essential step facilitating isolation of new candidate vaccine strains. Here, we describe the...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.08.030

    authors： Mettelman RC,O'Brien A,Whittaker GR,Baker SC

    更新日期：2019-11-01 00:00:00

  • Analysis of a type D retroviral capsid gene expressed in ovine pulmonary carcinoma and present in both affected and unaffected sheep genomes.

    abstract：:Ovine pulmonary carcinoma is a contagious neoplastic disease of sheep which can be transmitted experimentally with cell-free filtrate. Products homologous to structural proteins of type D and type B retroviruses are expressed in the tumors, but an infectious retrovirus has yet to be isolated. Retroviral RNA was isolat...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1366

    authors： Hecht SJ,Carlson JO,DeMartin JC

    更新日期：1994-07-01 00:00:00

  • Detection of visna virus antigens and RNA in glial cells in foci of demyelination.

    abstract：:Visna is a slow virus infection of sheep in which the characteristic pathological change is demyelination in foci of inflammation. The latter is thought to be the result of an immunopathological process directed against cellular and antigenic targets that have been difficult to define because of restricted viral gene ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90264-8

    authors： Stowring L,Haase AT,Petursson G,Georgsson G,Palsson P,Lutley R,Roos R,Szuchet S

    更新日期：1985-03-01 00:00:00

  • Localization of a VP3 epitope of infectious bursal disease virus.

    abstract：:An immunodominant region of VP3, one of the two structural proteins of infectious bursal disease virus (IBDV strain 002-73), has been mapped by restriction site-specific deletion analysis and subcloning in Escherichia coli, followed by immunoblot analysis of the synthesized products. The epitope located within 58 amin...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90457-m

    authors： Jagadish MN,Azad AA

    更新日期：1991-10-01 00:00:00

  • Assessment and optimization of rolling circle amplification protocols for the detection and characterization of badnaviruses.

    abstract：:The genus Badnavirus is characterized by members that are genetically and serologically heterogeneous which presents challenges for their detection and characterization. The presence of integrated badnavirus-like sequences in some host species further complicates detection using PCR-based protocols. To address these c...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.01.013

    authors： Sukal AC,Kidanemariam DB,Dale JL,Harding RM,James AP

    更新日期：2019-03-01 00:00:00

  • Murine leukemia virus recombinants that use phosphate transporters for cell entry induce similar spongiform encephalomyelopathies in newborn mice.

    abstract：:Amphotropic Moloney-murine leukemia virus recombinants (Mo-AmphoV) induce a severe spongiform encephalomyelopathy in newborn mice. We show here that a coisogenic recombinant with a 10A1-MuLV host range (Mo-10A1V) also induces a neurodegenerative disease, clinically characterized by mild tremor and ataxia. Spongiform l...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9476

    authors： Münk C,Thomsen S,Stocking C,Löhler J

    更新日期：1998-12-20 00:00:00

  • Rice dwarf phytoreovirus segment S11 encodes a nucleic acid binding protein.

    abstract：:The function of rice dwarf virus segment 11 and the corresponding segments of other phytoreoviruses is not yet determined. The amino acid sequence of Pns11, encoded by segment 11, contains a putative zinc finger and five flanking basic regions at the C-terminus. The full-length Pns11 protein and three truncated deriva...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8945

    authors： Xu H,Li Y,Mao Z,Li Y,Wu Z,Qu L,An C,Ming X,Schiemann J,Casper R,Chen Z

    更新日期：1998-01-20 00:00:00

  • Modeling-based characterization of the elicitor function of amino acid 461 of Cucumber mosaic virus 1a protein in the hypersensitive response.

    abstract：:The Ns strain of Cucumber mosaic virus (CMV) induces hypersensitive response (HR) on Nicotiana tabacum cv. Xanthi-nc and on Nicotiana glutinosa. The genetic determinant of the HR induction was localized earlier to amino acid 461 of the 1a protein. The 3D structure of the 1a protein is still unknown and building a homo...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.08.014

    authors： Salánki K,Gellért A,Náray-Szabó G,Balázs E

    更新日期：2007-02-05 00:00:00

  • Immune response in rabbit ovaries following infection of a recombinant myxoma virus expressing rabbit zona pellucida protein B.

    abstract：:In this study, we investigated the autoimmune response in rabbit ovaries following infection with a recombinant myxoma virus expressing rabbit zona pellucida protein B (MV-ZPB). A specific IgG antibody response to ZPB was elicited in the serum of infected rabbits and the antibody strongly bound to the zona pellucida o...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2003.10.021

    authors： Gu W,Holland M,Janssens P,Seamark R,Kerr P

    更新日期：2004-01-20 00:00:00