Abstract:
:Computational analysis of human adenovirus type 4 (HAdV-E4), a pathogen that is the only HAdV member of species E, provides insights into its zoonotic origin and molecular adaptation. Its genome encodes a domain of the major capsid protein, hexon, from HAdV-B16 recombined into the genome chassis of a simian adenovirus. Genomes of two recent field strains provide a clue to its adaptation to the new host: recombination of a NF-I binding site motif, which is required for efficient viral replication, from another HAdV genome. This motif is absent in the chimpanzee adenoviruses and the HAdV-E4 prototype, but is conserved amongst other HAdVs. This is the first report of an interspecies recombination event for HAdVs, and the first documentation of a lateral partial gene transfer from a chimpanzee AdV. The potential for such recombination events are important when considering chimpanzee adenoviruses as candidate gene delivery vectors for human patients.
journal_name
Virologyjournal_title
Virologyauthors
Dehghan S,Seto J,Liu EB,Walsh MP,Dyer DW,Chodosh J,Seto Ddoi
10.1016/j.virol.2013.05.014subject
Has Abstractpub_date
2013-09-01 00:00:00pages
197-207issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(13)00294-8journal_volume
443pub_type
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