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Immunogenicity of ORFV-based vectors expressing the rabies virus glycoprotein in livestock species.

Abstract：

:The parapoxvirus Orf virus (ORFV) encodes several immunomodulatory proteins (IMPs) that modulate host-innate and pro-inflammatory responses and has been proposed as a vaccine delivery vector for use in animal species. Here we describe the construction and characterization of two recombinant ORFV vectors expressing the rabies virus (RABV) glycoprotein (G). The RABV-G gene was inserted in the ORFV024 or ORFV121 gene loci, which encode for IMPs that are unique to parapoxviruses and inhibit activation of the NF-κB signaling pathway. The immunogenicity of the resultant recombinant viruses (ORFV∆024RABV-G or ORFV∆121RABV-G, respectively) was evaluated in pigs and cattle. Immunization of the target species with ORFV∆024RABV-G and ORFV∆121RABV-G elicited robust neutralizing antibody responses against RABV. Notably, neutralizing antibody titers induced in ORFV∆121RABV-G-immunized pigs and cattle were significantly higher than those detected in ORFV∆024RABV-G-immunized animals, indicating a higher immunogenicity of ORFVΔ121-based vectors in these animal species.

journal_name

Virology

journal_title

Virology

authors

Martins M,Joshi LR,Rodrigues FS,Anziliero D,Frandoloso R,Kutish GF,Rock DL,Weiblen R,Flores EF,Diel DG

doi

10.1016/j.virol.2017.08.027

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

229-239

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(17)30290-8

journal_volume

511

pub_type

杂志文章

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