Cloning and characterization of antiviral cytotoxic T lymphocytes in channel catfish, Ictalurus punctatus.

abstract：:Gene transfer into human hematopoietic stem cells using Ad5 is inefficient due to lack of the primary receptor CAR and the secondary receptors alphavbeta3 integrin and alphavbeta5 integrin, and due to the high seroprevalence of Ad5 antibodies in most adults, resulting in diminished gene transduction. In the present st...

journal_title：Virology

authors： Mei YF,Segerman A,Lindman K,Hörnsten P,Wahlin A,Wadell G

更新日期：2004-10-25 00:00:00

abstract：:The retroviral nucleocapsid (NC) protein contains highly conserved amino acid sequences (-Cys-X2-Cys-X4-His-X4-Cys-) designated retroviral (CCHC) Zn2+ fingers. The NC protein of murine leukemia viruses contains one NC Zn2+ finger and mutants that were competent in metal binding (CCCC and CCHH) packaged wild-type level...

journal_title：Virology

authors： Gorelick RJ,Gagliardi TD,Bosche WJ,Wiltrout TA,Coren LV,Chabot DJ,Lifson JD,Henderson LE,Arthur LO

更新日期：1999-03-30 00:00:00

abstract：:The quasispecies structure of nervous necrosis virus (NNV) was determined to investigate an outbreak of viral nervous necrosis disease at a barramundi (Lates calcarifer) hatchery. A traditional epidemiological investigation indicated horizontal transmission of infection between two cohorts of fish. However, variation ...

journal_title：Virology

authors： Hick P,Gore K,Whittington R

更新日期：2013-02-05 00:00:00

abstract：:We used Cre/loxP recombination to swap targeting ligands present on the adenoviral capsid protein IX (pIX). A loxP-flanked sequence encoding poly-lysine (pK-binds heparan sulfate proteoglycans) was engineered onto the 3'-terminus of pIX, and the resulting fusion protein allowed for routine virus propagation. Growth of...

journal_title：Virology

authors： Poulin KL,Tong G,Vorobyova O,Pool M,Kothary R,Parks RJ

更新日期：2011-11-25 00:00:00

abstract：:While some neurotropic viruses cause rapid central nervous system (CNS) disease upon entry into the brain parenchyma, other viruses that are cytolytic in the periphery either result in little neuropathology or are associated with a protracted course of CNS disease consistent with persistent infection. One such virus, ...

journal_title：Virology

authors： Daley JK,Gechman LA,Skipworth J,Rall GF

更新日期：2005-09-15 00:00:00

abstract：:Stress granule (SG)-like antiviral granules (AVG) had been found in some vaccinia virus infection conditions and shown to repress translation. Similar RNA granules are also associated with translational inhibition and poxvirus restriction mediated by the host restriction factor SAMD9, but their function is less clear....

journal_title：Virology

authors： Meng X,Xiang Y

更新日期：2019-03-01 00:00:00

abstract：:Aster yellows virus (AYV) was recovered from hemolymph, alimentary canal, salivary glands and ovaries, but not from Malpighian tubules, mycetomes, fat body, testes, or brain of viruliferous leafhoppers, Macrosteles fascifrons (Stål). The presence of virus in the tissues was determined by injecting their extracts into ...

journal_title：Virology

authors： Sinha RC,Chiykowski LN

更新日期：1967-12-01 00:00:00

abstract：:For purposes of gene therapy, the tropism of adenovirus (Ad) serotype 5 vectors can be altered with fibers derived from alternative serotypes. However, there is currently limited information available on the cellular receptors used by the approximately 51 known Ad serotypes. Recently, alpha(2-->3)-linked sialic acid (...

journal_title：Virology

authors： Cashman SM,Morris DJ,Kumar-Singh R

更新日期：2004-06-20 00:00:00

abstract：:In this study, we show how the red spotted grouper nervous necrosis virus (RGNNV) causes loss of mitochondrial membrane potential and promotes host secondary apoptotic necrosis. RGNNV viral proteins such as protein alpha (42 kDa) and protein A (110 kDa) were quickly expressed between 12 h and 24 h postinfection (p.i.)...

journal_title：Virology

authors： Chen SP,Yang HL,Her GM,Lin HY,Jeng MF,Wu JL,Hong JR

更新日期：2006-04-10 00:00:00

abstract：:Tumor-inducing viruses like simian virus 40 or the human adenovirus produce oncoproteins which interfere with the cellular retinoblastoma (Rb) tumor-suppressor protein to create an appropriate molecular environment in the nucleus for viral transcription and replication. Such a strategy has been considered to be restri...

journal_title：Virology

authors： Collin S,Fernández-Lobato M,Gooding PS,Mullineaux PM,Fenoll C

更新日期：1996-05-01 00:00:00

abstract：:Glycoprotein C (gC) of pseudorabies virus, a swine herpesvirus, initiates virus attachment by binding to heparan sulfate (HS) linked to proteoglycans (HSPGs) on the cell surface. This interaction facilitates a required step in virus entry, the binding to a non-HS coreceptor, likely by another viral glycoprotein, gD. W...

journal_title：Virology

authors： Rue CA,Ryan P

更新日期：2003-03-01 00:00:00

abstract：:The porcine lymphotropic herpesviruses (PLHV) are discussed as possible risk factors in xenotransplantation because of the high prevalence of PLHV-1, PLHV-2 and PLHV-3 in pig populations world-wide and the fact that PLHV-1 has been found to be associated with porcine post-transplant lymphoproliferative disease. To pro...

journal_title：Virology

authors： Lindner I,Ehlers B,Noack S,Dural G,Yasmum N,Bauer C,Goltz M

更新日期：2007-01-20 00:00:00

abstract：:Hepatitis C virus (HCV) is efficient in the establishment of persistent infection. We have previously shown that HCV core protein inhibits T cell proliferation through its interaction with the complement receptor, gC1qR. Here we show that HCV core-induced inhibition of T cell proliferation involves a G(0)/G(1) cell cy...

journal_title：Virology

authors： Yao ZQ,Eisen-Vandervelde A,Ray S,Hahn YS

更新日期：2003-09-15 00:00:00

abstract：:Friend murine leukemia virus (Fr-MLV) produces unspliced mRNAs, as well as singly-spliced mRNAs by which the Env protein is generated. We investigated the role of the intron within the Fr-MLV gene in Env expression using vectors with serially truncated introns. The up-regulatory regions, the 361-878 and the 5135-5399 ...

journal_title：Virology

authors： Yamamoto N,Takase-Yoden S

更新日期：2009-03-01 00:00:00

abstract：:Recombinant human immunodeficiency virus type-1 (HIV-1)-like gag-env particles produced in mammalian cells were inoculated into two New Zealand white rabbits. In parallel, two control rabbits were inoculated with the homologous HIV-1 virions inactivated by ultra violet light (uv) and psoralen treatments. The humoral a...

journal_title：Virology

authors： Haffar OK,Smithgall MD,Moran PA,Travis BM,Zarling JM,Hu SL

更新日期：1991-08-01 00:00:00

abstract：:Human parainfluenza virus type 2 phosphoprotein (P) is an essential component of viral polymerase. The P gene encodes both P and accessory V proteins by a specific gene editing mechanism. Therefore, the N-terminal 164 amino acids of P protein are common to V protein. Interestingly, while P protein is located in the cy...

journal_title：Virology

authors： Ohtsuka J,Matsumoto Y,Ohta K,Fukumura M,Tsurudome M,Nosaka T,Nishio M

更新日期：2019-02-01 00:00:00

abstract：:The herpes simplex virus single-stranded DNA-binding protein, ICP8, localizes initially to structures in the nucleus called prereplicative sites. As replication proceeds, these sites mature into large globular structures called replication compartments. The details of what signals or proteins are involved in the redis...

journal_title：Virology

authors： Taylor TJ,Knipe DM

更新日期：2003-05-10 00:00:00

abstract：:Following CD4 receptor binding to the HIV-1 envelope spike (Env), the conserved N-heptad repeat (NHR) region of gp41 forms a coiled-coil that is a precursor to the fusion reaction. Although it has been a target of drug and vaccine design, there are few monoclonal antibody (mAb) tools with which to probe the antigenici...

journal_title：Virology

authors： Nelson JD,Kinkead H,Brunel FM,Leaman D,Jensen R,Louis JM,Maruyama T,Bewley CA,Bowdish K,Clore GM,Dawson PE,Frederickson S,Mage RG,Richman DD,Burton DR,Zwick MB

更新日期：2008-07-20 00:00:00

abstract：:The amino acid sequence of BMV (brome mosaic virus) coat protein is presented and compared with the sequence derived from RNA structure. Apart from removal of the N-terminal methionine residue and acetylation of the following serine residue, no post-translational modifications occur. ...

journal_title：Virology

authors： Moosic JP,McKean DJ,Shih DS,Kaesberg P

更新日期：1983-09-01 00:00:00

abstract：:Coinfection of tobacco plants with potato virus X (PVX) and any of several members of the potyvirus group causes a synergistic disease characterized by a dramatic increase in symptom severity correlated with a 3- to 10-fold increase in the accumulation of PVX in the first systemically infected leaves. We have recently...

journal_title：Virology

authors： Shi XM,Miller H,Verchot J,Carrington JC,Vance VB

更新日期：1997-04-28 00:00:00

abstract：:Packaging of lambda DNA is mediated by the phage-encoded enzyme, terminase, which acts at a site termed cos. cos consists of cosB, the site where terminase binds lambda DNA, and cosN, the site where nicks are introduced to generate the cohesive ends of virion DNA. cos contains multiple binding sites for gpNu1, the sma...

journal_title：Virology

authors： Yeo A,Kosturka LD,Feiss M

更新日期：1990-01-01 00:00:00

abstract：:A new mutation designated sur was isolated as a suppressor of a mutation in the uvsX gene of T4 phage. Unlike the other suppressors of mutations in genes involved in DNA repair and recombination, sur has a wide range, suppressing both DNA repair and replication defects in mutations in genes uvsX, uvsY, 46, 47, and 59....

journal_title：Virology

authors： Wakem LP,Ebisuzaki K

更新日期：1984-09-01 00:00:00

abstract：:Both the brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) RNA-dependent RNA polymerases (RdRps) were found to recognize the BMV core subgenomic promoter in the same manner, requiring specific functional groups at positions -17, -14, -13, and -11 relative to the subgenomic initiation site (+1). For CCM...

journal_title：Virology

authors： Adkins S,Kao CC

更新日期：1998-12-05 00:00:00

abstract：:The nonstructural rotavirus receptor glycoprotein NS28 is 175 amino acids long and oriented in the RER membrane with the NH2 terminus on the luminal side and approximately 131 amino acids accessible from the cytoplasmic side. Au et al. (1988) have demonstrated that NS28 is able to interact with rotavirus single-shelle...

journal_title：Virology

authors： Meyer JC,Bergmann CC,Bellamy AR

更新日期：1989-07-01 00:00:00

abstract：:All lepidopteran baculovirus genomes sequenced to date encode a viral fibroblast growth factor homolog (vfgf), suggesting that vfgf may play an important role in the infection cycle of lepidopteran baculoviruses. Here, we describe the characterization of a Bombyx mori nucleopolyhedrovirus (BmNPV) mutant lacking functi...

journal_title：Virology

authors： Katsuma S,Horie S,Daimon T,Iwanaga M,Shimada T

更新日期：2006-11-10 00:00:00

abstract：:Three cDNA clones that express viral gene products in Escherichia coli JM83 were derived from a watermelon mosaic virus-1 strain of papaya ringspot virus (PRSV-W). DNAs complementary to portions of the viral RNA were inserted into the pUC8 and pUC9 plasmids, and the expressed polypeptides were fusion products with the...

journal_title：Virology

authors： Nagel J,Hiebert E

更新日期：1985-06-01 00:00:00

abstract：:A non-plaque-forming vaccine strain of NDV (NDV-B1) interferes with the infection of cultured chick embryo cells by the virulent plaque-forming NDV-L strain. The level of interference increases when the concentration of interfering virus is increased or when the time between infection and superinfection is increased. ...

journal_title：Virology

authors： Bratt MA,Rubin H

更新日期：1967-12-01 00:00:00

abstract：:The caprine arthritis-encephalitis (CAEV) and ovine maedi-visna (MVV) viruses are resistant to antibody neutralization, a feature shared with all other lentiviruses. Whether the CAEV gp135 receptor binding site(s) (RBS) in the functional surface envelope glycoprotein (Env) is protected from antibody binding, allowing ...

journal_title：Virology

authors： Hötzel I,Cheevers WP

更新日期：2005-09-01 00:00:00

abstract：:An antiserum was raised against a synthetic peptide corresponding to the 18 C-terminal amino acids of a putative 16K protein encoded by the 3'-terminal open reading frame of tobacco rattle virus (TRV) RNA-1. This antiserum was used to demonstrate expression of the 16K cistron in vivo. TRV-infected tobacco protoplasts ...

journal_title：Virology

authors： Angenent GC,Verbeek HB,Bol JF

更新日期：1989-04-01 00:00:00

abstract：:For successful penetration of HIV-1, the formation of a fusion pore may be required in order to accumulate critical numbers of fusion-activated gp41 with the help of fluidization of the plasma membrane and viral envelope. An increase in temperature to 40 degrees C after viral adsorption at 25 degrees C enhanced the in...

journal_title：Virology

authors： Harada S,Monde K,Tanaka Y,Kimura T,Maeda Y,Yusa K

更新日期：2008-01-05 00:00:00