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Sequences of the N and M genes of the sigma virus of Drosophila and evolutionary comparison.

Abstract：

:The genome of the sigma rhabdovirus of Drosophila melanogaster consists of six genes in the order 3' N-2-3-4-G-L 5'. The nucleotide sequences of the N and of the fourth genes were determined from cDNA clones. Each gene contained a single long open reading frame encoding polypeptides with predicted MW of 50 and 25 kDa, respectively. Evidence that these genes encode the nucleocapsid N and the matrix M proteins were obtained using antibodies raised against recombinant proteins derived from the cloned genes and expressed in Escherichia coli. The M and N predicted amino acid sequences were compared with those of other rhabdoviruses. The M protein of sigma virus shared a similar domain arrangement to the other M proteins, but it showed very little sequence conservation. The N protein of sigma virus showed no significant homology with its counterpart in SYNV or IHNV and VSHV; it did, however, show sequence homology with the N of four vesiculoviruses and two lyssaviruses. The extent of amino acid identity suggests that sigma virus occupies an intermediate evolutionary position between these two genera. Some conserved motifs in the M and N proteins were deduced from the comparisons.

journal_name

Virology

journal_title

Virology

authors

Bras F,Teninges D,Dezelee S

doi

10.1006/viro.1994.1177

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

189-99

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(84)71177-9

journal_volume

200

pub_type

杂志文章

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