High throughput sequence analysis reveals hitherto unreported recombination in the genus Norovirus.

abstract：:Processing of the transmembrane glycoprotein (GP) of Marburg virus involved the conversion of an endo H-sensitive, ER-specific form into an endo H-resistant, Golgi-specific precursor that was cleaved into GP(1) and GP(2). Cleavage was mediated by furin or another subtilisin-like endoprotease with similar substrate spe...

journal_title：Virology

authors： Volchkov VE,Volchkova VA,Ströher U,Becker S,Dolnik O,Cieplik M,Garten W,Klenk HD,Feldmann H

更新日期：2000-03-01 00:00:00

abstract：:We have examined the expression of duck hepatitis B virus (DHBV)-associated proteins in experimentally infected ducks by an immunoblot (Western) method. The DHBV-related core protein, C protein, was identified at the position of 35,000 Da (P35). Pre-S proteins were recognized as two major bands (P37 and P28), the form...

journal_title：Virology

authors： Yokosuka O,Omata M,Ito Y

更新日期：1988-11-01 00:00:00

abstract：:The location of nucleotide sequences important in determining the extent of cowpea mosaic virus M-RNA accumulation in cowpea protoplasts has been analyzed by deletion mutagenesis of full-length cDNA clones from which infectious transcripts can be produced in vitro. The results suggest that cis-acting sequences which d...

journal_title：Virology

authors： Rohll JB,Holness CL,Lomonossoff GP,Maule AJ

更新日期：1993-04-01 00:00:00

abstract：:The transcripts of the DNA of Abutilon mosaic virus, a geminivirus with a bipartite genome (DNA A and DNA B), were characterized by Northern blot hybridization, S1 nuclease assay, primer extension analysis, and sequencing of the 3' termini of cDNA clones. It was shown that transcription is bidirectional and that the t...

journal_title：Virology

authors： Frischmuth S,Frischmuth T,Jeske H

更新日期：1991-12-01 00:00:00

abstract：:Mouse hepatitis viruses (MHV) of different virulence for mice were studied with respect to interferon (IFN) sensitivity. The growth of low-virulent MHV-S and intermediately virulent MHV-JHM was significantly suppressed in IFN-treated L cells compared with untreated cells. However, a comparable suppression of the growt...

journal_title：Virology

authors： Taguchi F,Siddell SG

更新日期：1985-11-01 00:00:00

abstract：:Dengue virus (DENV) infection can cause a self-limiting disease (dengue fever) or a more severe clinical presentation known as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Furthermore, data from recent dengue epidemics in Brazil indicate that the neurological manifestations are becoming more prevalent. ...

journal_title：Virology

authors： Bordignon J,Probst CM,Mosimann AL,Pavoni DP,Stella V,Buck GA,Satproedprai N,Fawcett P,Zanata SM,de Noronha L,Krieger MA,Duarte Dos Santos CN

更新日期：2008-08-01 00:00:00

abstract：:Bombyx mori nucleopolyhedrovirus (BmNPV) orf5 (Bm5) is a core gene of lepidopteran baculoviruses and encodes the protein with the conserved amino acid residues (DUF3627) in its C-terminus. Here, we found that Bm5 disruption resulted in lower titers of budded viruses and fewer numbers of occlusion bodies (OBs) in B. mo...

journal_title：Virology

authors： Kokusho R,Koh Y,Fujimoto M,Shimada T,Katsuma S

更新日期：2016-11-01 00:00:00

abstract：:We cloned and sequenced the cDNAs against genomic RNAs and mRNAs for phosphoproteins (Ps) of human parainfluenza virus types 4A (PIV-4A) and 4B (PIV-4B). The PIV-4A and -4B P genes were 1535 nucleotides including poly(A) tract and were found to have two small open reading frames, neither of which was apparently large ...

journal_title：Virology

authors： Kondo K,Bando H,Tsurudome M,Kawano M,Nishio M,Ito Y

更新日期：1990-09-01 00:00:00

abstract：:The major capsid protein of HPV, L1, assembles into pentamers that form a T = 7 icosahedral particle, but the location of the co-assembled minor capsid protein, L2, remains controversial. Several researchers have developed useful monoclonal antibodies targeting L2, but most react with linear epitopes toward the N-term...

journal_title：Virology

authors： Bywaters SM,Brendle SA,Biryukov J,Wang JW,Walston J,Milici J,Roden RB,Meyers C,Christensen ND

更新日期：2018-11-01 00:00:00

abstract：:Nipah virus (NV) and Hendra virus (HV) are recently emergent, related viruses that can cause severe disease in humans and animals. The goal of this study was to investigate the immunogenic and functional properties of the fusion (F) and attachment (G) glycoproteins of NV. Vaccination of mice with recombinant vaccinia ...

journal_title：Virology

authors： Tamin A,Harcourt BH,Ksiazek TG,Rollin PE,Bellini WJ,Rota PA

更新日期：2002-04-25 00:00:00

abstract：:It was recently proposed that HIV RT mutations that decrease RNase H activity increase zidovudine (AZT) resistance by delaying the degradation of the RNA template, allowing more time for AZTMP excision from the 3' end of the viral DNA. This predicts that suboptimal concentrations of an RNase H Inhibitor (RNHI), which ...

journal_title：Virology

authors： Davis CA,Parniak MA,Hughes SH

更新日期：2011-10-25 00:00:00

abstract：:To better understand the origin of human T-cell leukemia virus type l (HTLV-l) in South America, we conducted a phylogenetic study on 27 new HTLV-ls in Brazil. These were obtained from Brazilians of various ethnic origins, such as Japanese immigrants, whites, blacks and mulattos. We amplified and sequenced proviral DN...

journal_title：Virology

authors： Yamashita M,Veronesi R,Menna-Barreto M,Harrington WJ Jr,Sampio C,Brites C,Badaro R,Andrade-Filho AS,Okhura S,Igarashi T,Takehisa J,Miura T,Chamone D,Bianchini O,Jardim C,Sonoda S,Hayami M

更新日期：1999-08-15 00:00:00

abstract：:Viral metagenomics coupled to high-throughput sequencing has provided a powerful tool for large-scale detection of known and unknown viruses associated to distinct hosts and environments. Using this approach, known and novel viruses have been characterized from sylvatic and commercial avian hosts, increasing our under...

journal_title：Virology

authors： Cibulski S,Weber MN,de Sales Lima FE,Lima DA,Fernandes Dos Santos H,Teixeira TF,Varela APM,Tochetto C,Mayer FQ,Roehe PM

更新日期：2020-09-01 00:00:00

abstract：:We have previously shown that peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists inhibited the inflammatory response of RSV-infected human lung epithelial cells. In this study, we supply evidence that specific PPARgamma agonists (15d-PGJ2, ciglitazone, troglitazone, Fmoc-Leu) efficiently blocked the...

journal_title：Virology

authors： Arnold R,König W

更新日期：2006-07-05 00:00:00

abstract：:ARGONAUTEs (notably AGO1 and AGO2) are effectors of plant antiviral RNA silencing. AGO1 was shown to be required for the temperature-dependent symptom recovery of Nicotiana benthamiana plants infected with tomato ringspot virus (isolate ToRSV-Rasp1) at 27 °C. In this study, we show that symptom recovery from isolate T...

journal_title：Virology

authors： Paudel DB,Ghoshal B,Jossey S,Ludman M,Fatyol K,Sanfaçon H

更新日期：2018-11-01 00:00:00

abstract：:The envelope glycoprotein E2 of hepatitis C virus (HCV) is a major component of the viral envelope. Knowledge of its topologic features and antigenic determinants in virions is crucial in understanding the viral binding sites to cellular receptor(s) and the induction of neutralizing antibodies. The lack of a robust ce...

journal_title：Virology

authors： Triyatni M,Vergalla J,Davis AR,Hadlock KG,Foung SK,Liang TJ

更新日期：2002-06-20 00:00:00

abstract：:The bipartite geminiviruses bean golden mosaic virus (BGMV), cabbage leaf curl virus (CabLCV), and tomato golden mosaic virus (TGMV) exhibit differential tissue tropism in Nicotiana benthamiana. In systemically infected leaves, BGMV remains largely confined to vascular-associated cells (phloem-limited), whereas CabLCV...

journal_title：Virology

authors： Qin Y,Petty IT

更新日期：2001-12-20 00:00:00

abstract：:While the 2009 pandemic H1N1 virus has become established in the human population as a seasonal influenza virus, continued adaptation may alter viral virulence. Here, we passaged a 2009 pandemic H1N1 virus (A/Changchun/01/2009) in mice. Serial passage in mice generated viral variants with increased virulence. Adapted ...

journal_title：Virology

authors： Yu Z,Cheng K,Sun W,Zhang X,Li Y,Wang T,Wang H,Zhang Q,Xin Y,Xue L,Zhang K,Huang J,Yang S,Qin C,Wilker PR,Yue D,Chen H,Gao Y,Xia X

更新日期：2015-12-01 00:00:00

abstract：:Computational analysis of human adenovirus type 4 (HAdV-E4), a pathogen that is the only HAdV member of species E, provides insights into its zoonotic origin and molecular adaptation. Its genome encodes a domain of the major capsid protein, hexon, from HAdV-B16 recombined into the genome chassis of a simian adenovirus...

journal_title：Virology

authors： Dehghan S,Seto J,Liu EB,Walsh MP,Dyer DW,Chodosh J,Seto D

更新日期：2013-09-01 00:00:00

abstract：:We previously demonstrated in trials of a variety of experimental vaccines to equine infectious anemia virus (EIAV) a remarkable spectrum of efficacy ranging from sterilizing protection to severe enhancement of virus replication and disease, depending on the immunization strategy used. This range of vaccine efficacy o...

journal_title：Virology

authors： Hammond SA,Raabe ML,Issel CJ,Montelaro RC

更新日期：1999-09-30 00:00:00

abstract：:The P150 and P90 replicase proteins of rubella virus (RUBV), a plus-strand RNA Togavirus, produce a unique cytoplasmic fiber network resembling microtubules. Pharmacological and mutagenic approaches were used to determine if these fibers functioned in virus replication. The pharmacological approach revealed that micro...

journal_title：Virology

authors： Matthews JD,Tzeng WP,Frey TK

更新日期：2010-10-25 00:00:00

abstract：:Like their animal-infecting counterparts, plant bunyaviruses use capped RNA leaders cleaved from host cellular mRNAs to prime viral genome transcription in a process called cap-snatching, but in vivo systems to investigate the details of this process are lacking for them. Here, we report that Rice stripe tenuivirus (R...

journal_title：Virology

authors： Lin W,Wu R,Qiu P,Jing Jin,Yang Y,Wang J,Lin Z,Zhang J,Wu Z,Du Z

更新日期：2020-01-02 00:00:00

abstract：:Sequence heterogeneity of hepatitis B virus (HBV) is increasingly recognized to play a role in virus-host interaction. We have used a recently established method for HBV full-length genome amplification to search for novel types of HBV variants and to investigate further the sequence heterogeneity of HBV genome popula...

journal_title：Virology

authors： Sommer G,Günther S,Sterneck M,Otto S,Will H

更新日期：1997-12-22 00:00:00

abstract：:The presence of anti-Tax antibody responses in human T cell leukemia virus type I (HTLV-I)-infected individuals has been correlated with increased proviral load, increased risk of transmitting infection, and increased risk of developing tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). In this study...

journal_title：Virology

authors： Lydy SL,Conner ME,Marriott SJ

更新日期：1998-10-10 00:00:00

abstract：:The Rice stripe virus (RSV) pc4 has been determined as the viral movement protein (MP). In this study, the pc4 gene was cloned into a movement-deficient Tobacco mosaic virus (TMV). The resulting hybrid TMV-pc4, in addition to spreading cell to cell in Nicotiana tabacum, moved systemically and induced foliar necrosis i...

journal_title：Virology

authors： Zhang C,Pei X,Wang Z,Jia S,Guo S,Zhang Y,Li W

更新日期：2012-04-10 00:00:00

abstract：:The protruding (P) domain of norovirus VP1 is responsible for immune recognition and host receptor interaction. Our previous studies have demonstrated that a modification of the ends of the P domain affects the conformation and/or function of the P protein. An expression of the P domain with or without the hinge, or w...

journal_title：Virology

authors： Tan M,Fang PA,Xia M,Chachiyo T,Jiang W,Jiang X

更新日期：2011-02-20 00:00:00

abstract：:In vitro packaging experiments with phage P22 using artificially ligated plasmid concatemers have shown that the pac site is not necessary for DNA packaging although in vivo this initiation signal is indispensable. This indicates that the phage-coded protein gp3 also executes other important functions during phage mat...

journal_title：Virology

authors： Behnisch W,Schmieger H

更新日期：1985-07-30 00:00:00

abstract：:In order to gain a better perspective on the true variability of varicella-zoster virus (VZV) and to catalogue the location and number of differences, 11 new complete genome sequences were compared with those previously in the public domain (18 complete genomes in total). Three of the newly sequenced genomes were deri...

journal_title：Virology

authors： Tyler SD,Peters GA,Grose C,Severini A,Gray MJ,Upton C,Tipples GA

更新日期：2007-03-15 00:00:00

abstract：:Chimeric primate lentiviruses composed of SIV and HIV genes may allow the analysis of the role of these discrete HIV genes in viral pathogenesis in macaque monkeys. We have constructed a chimeric virus in which the env, rev, tat, and vpu genes of HIV-1 Lai replace the env, rev, and tat genes of the SIVmac239 genome. T...

journal_title：Virology

authors： Dunn CS,Beyer C,Kieny MP,Gloeckler L,Schmitt D,Gut JP,Kirn A,Aubertin AM

更新日期：1996-09-15 00:00:00

abstract：:The specificity of poliovirus encapsidation has been studied using a novel chimeric genome in which the gene encoding firefly luciferase has been substituted for the VP2-VP3-VP1 genes of the poliovirus capsid (P1) gene. Transfection of RNA transcribed in vitro from this genome resulted in a VP4-luciferase fusion prote...

journal_title：Virology

authors： Porter DC,Ansardi DC,Wang J,McPherson S,Moldoveanu Z,Morrow CD

更新日期：1998-03-30 00:00:00