Abstract:
:Adenovirus serotype 5 (Ad5) is a common cause of respiratory tract infection, and populations worldwide have high prevalence of anti-Ad5 antibodies, implying extensively prior infection. Ad5 infection potently activates the host innate defense and inflammation, but the molecular mechanisms are not completely clarified. We report here that monocytes from Ad5-seropositive subjects upregulates the expression of scavenger receptor A (SR-A), and the increased SR-A promote the susceptibility of Ad5 entry and subsequent innate signaling activation. SR-A is also known as major receptor for lipid uptake, we therefore observed that monocytes from Ad5-seropositive subjects accumulated the acetylated low-density lipoprotein (acLDL) and had the elevated cellular stress to induce the activation of monocyte/macrophages. These findings demonstrate that SR-A-mediated Ad5 entry, innate signaling activation and acLDL accumulation synergistically trigger the robust antiviral innate and inflammatory responses, which are helpful to our understanding of the pathogenesis of adenovirus infection.
journal_name
Virologyjournal_title
Virologyauthors
Li P,Feng F,Pan E,Fan X,Yang Q,Guan M,Chen L,Sun Cdoi
10.1016/j.virol.2018.04.005subject
Has Abstractpub_date
2018-06-01 00:00:00pages
86-98eissn
0042-6822issn
1096-0341pii
S0042-6822(18)30120-Xjournal_volume
519pub_type
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