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Virological and molecular characterization of a simian human immunodeficiency virus (SHIV) encoding the envelope and reverse transcriptase genes from HIV-1.

Abstract：

:Simian-human immunodeficiency virus encoding both reverse transcriptase (RT) and envelope genes of HIV-1 (RT Env SHIV) is important for evaluating biomedical prevention modalities for HIV/AIDS. We describe virological characterization of a clade B RT Env SHIV following infection of macaques via multiple routes. In vivo passage of the RT Env SHIV through Indian rhesus macaque enhanced infectivity. Expanded virus had minimal envelope heterogeneity and was inhibited by NNRTIs and CCR5 antagonists. Infection of macaques with RT Env SHIV via mucosal or intravenous routes resulted in stable infection accompanied by peak plasma viremia of approximately 5×10(6) copies/ml that was controlled beyond set point. Molecular homogeneity of the virus was maintained following in vivo passage. Inhibition of RT Env SHIV by RT and entry inhibitors and ease of in vivo transmission make it a useful model for testing the efficacy of combinations of entry and RT inhibitors in nonhuman primates.

journal_name

Virology

journal_title

Virology

authors

Pal R,Galmin L,Pereira LE,Li B,Zhang J,Li D,Francis J,McNicholl JM,Weiss DE,Smith JM

doi

10.1016/j.virol.2012.05.034

subject

Has Abstract

pub_date

2012-10-10 00:00:00

pages

173-83

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(12)00285-1

journal_volume

432

pub_type

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