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Use of a high-affinity peptide that aborts MHC-restricted cytotoxic T lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo.

Abstract：

:Binding of a specific peptide(s) from a viral protein to major histocompatibility complex (MHC) class I molecules is a critical step in the activation of CD8(+) cytotoxic T lymphocytes (CTLs). Once activated, CTLs can cause lethal disease in an infected host, for example, by killing virus-containing ependymal and ventricular cells in the central nervous system or viral protein-expressing beta cells in the pancreatic islets of Langerhans. Here we describe the usage of a designed (not natural) high-affinity peptide to compete with viral peptide(s)-MHC binding. This peptide blocks virus-induced CTL-mediated disease both in the CNS and in the pancreatic islets in vivo. Further, the blocking peptide aborts MHC-restricted killing of target cells by CTLs generated to three separate viruses: lymphocytic choriomeningitis virus, influenza virus, and simian virus 40.

journal_name

Virology

journal_title

Virology

authors

Oldstone MB,von Herrath M,Lewicki H,Hudrisier D,Whitton JL,Gairin JE

doi

10.1006/viro.1998.9593

subject

Has Abstract

pub_date

1999-04-10 00:00:00

pages

246-57

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(98)99593-9

journal_volume

256

pub_type

杂志文章

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