Lipid selection in the assembly of the phospholipid bilayer membrane of the lipid-containing bacteriophage PR4.

Abstract:

:Phage PR4 contains a lipid bilayer within the phage protein capsid. The phospholipids of the bilayer are derived from those of the host. We report that phage morphogenesis selects against the unusually bulky phospholipids synthesized by Escherichia coli grown in the presence of various sugar alcohols. These data indicate that assembly of the PR4 lipid bilayer is a selective process rather than the bulk appropriation of host membrane lipids. We also demonstrates that phage PR4 morphogenesis is compatible with the incorporation of several abnormal lipids, monoacylglycerol, diacylglycerol, and phosphatidylinositol into the phage particle.

journal_name

Virology

journal_title

Virology

authors

Myung H,Cronan JE Jr

doi

10.1006/viro.1994.1004

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

25-30

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(84)71004-X

journal_volume

198

pub_type

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