Large-scale genomic analysis reveals recurrent patterns of intertypic recombination in human enteroviruses.

abstract：:Monoclonal antibodies to the matrix or E1 glycoprotein of mouse hepatitis virus (MHV) were tested for their ability to protect mice from a normally lethal challenge of MHV-4. Four antibodies were tested, and two of these, J.1.3 and J.3.9, were protective. Protection did not correlate with virus neutralization in vitro...

journal_title：Virology

authors： Fleming JO,Shubin RA,Sussman MA,Casteel N,Stohlman SA

更新日期：1989-01-01 00:00:00

abstract：:Posttranslational modification of viral proteins by cellular enzymes is a feature of many virus replication strategies. Here, we report that during infection the multifunctional human influenza A virus NS1 protein is phosphorylated at threonine-215. Substitution of alanine for threonine at this position reduced early ...

journal_title：Virology

authors： Hale BG,Knebel A,Botting CH,Galloway CS,Precious BL,Jackson D,Elliott RM,Randall RE

更新日期：2009-01-05 00:00:00

abstract：:Lysolecithin permeabilization of vaccinia virus-infected cells was employed to prepare extracts that support faithful transcription initiation in vitro on plasmids possessing early, intermediate, and late viral gene promoters. Conditions which optimize transcription from each promoter were defined. The in vitro system...

journal_title：Virology

authors： Condit RC,Lewis JI,Quinn M,Christen LM,Niles EG

更新日期：1996-04-01 00:00:00

abstract：:The human polyomavirus BK virus (BKV) is an important opportunistic pathogen whose disease prevalence continues to increase with the growing immunocompromised population. To date, the major determinant of replication in cell culture has not been formally proven. BKV exists as archetype virus and rearranged variants, w...

journal_title：Virology

authors： Broekema NM,Abend JR,Bennett SM,Butel JS,Vanchiere JA,Imperiale MJ

更新日期：2010-11-25 00:00:00

abstract：:Bipartite geminiviruses are small, plant-infecting viruses with genomes composed of circular, single-stranded DNA molecules, designated A and B. Although they are closely related genetically, individual bipartite geminiviruses frequently exhibit host-specific adaptation. Two such viruses are bean golden mosaic virus (...

journal_title：Virology

authors： Petty IT,Carter SC,Morra MR,Jeffrey JL,Olivey HE

更新日期：2000-11-25 00:00:00

abstract：:Within immunocompromised populations, the JC polyomavirus is the cause of the often-fatal disease Progressive Multifocal Leukoencephalopathy (PML). JC virus encodes a protein, termed T-antigen (T-ag), which is essential for its replication and pathogenicity. Previous studies of JCV T-ag have, in general, used antibodi...

journal_title：Virology

authors： Grubman SA,Shin J,Phelan PJ,Gong A,Can H,Dilworth R,Kini SK,Gagnon D,Archambault J,Meinke G,Bohm A,Jefferson DM,Bullock PA

更新日期：2016-10-01 00:00:00

abstract：:A cDNA encoding the entire amino acid sequence of the G glycoprotein of respiratory syncytial virus (RSV) was inserted into a yeast-Escherichia coli shuttle vector such that expression of the virus gene was regulated by the yeast GAL1 promoter. Transformation of Saccharomyces cerevisiae with the vector led to the form...

journal_title：Virology

authors： Ding MX,Wen DZ,Schlesinger MJ,Wertz GW,Ball LA

更新日期：1987-08-01 00:00:00

abstract：:Herpes simplex virus 1 glycoprotein B (gB) is one of 10 glycoproteins in the virion envelope and in the membranes of infected cells. It is required for infection of cells in culture and functions in penetration of the cell by fusing the virion envelope with the plasma membrane. In studies to map the functional domains...

journal_title：Virology

authors： Navarro D,Paz P,Pereira L

更新日期：1992-01-01 00:00:00

abstract：:The genome of Lelystad virus (LV), a positive-strand RNA virus, is 15 kb in length and contains 8 open reading frames (ORFs) that encode putative viral proteins. ORFs 2 to 7 were cloned in plasmids downstream of the Sp6 RNA polymerase promoter, and the translation of transcripts generated in vitro yielded proteins tha...

journal_title：Virology

authors： Meulenberg JJ,Petersen-den Besten A,De Kluyver EP,Moormann RJ,Schaaper WM,Wensvoort G

更新日期：1995-01-10 00:00:00

abstract：:Adenovirus 12 (Ad12), but not adenovirus 2 or 5, induces metaphase chromosome fragility at four specific loci in humans: RNU1, RNU2, PSU1, and RN5S. As each of these sites corresponds to a tandemly repeated multigene family encoding a small, abundant structural RNA, we proposed that Ad12 hinders metaphase chromatin co...

journal_title：Virology

authors： Liao D,Yu A,Weiner AM

更新日期：1999-02-01 00:00:00

abstract：:Avian infectious laryngotracheitis virus (ILTV), a herpesvirus, is a highly contagious pathogen that causes an upper respiratory tract infection in chickens. It is one of the major problems in the poultry industry worldwide. Current vaccines are not satisfactory due to the induction of latent infection. Here we descri...

journal_title：Virology

authors： Guo P,Scholz E,Maloney B,Welniak E

更新日期：1994-08-01 00:00:00

abstract：:Coxsackievirus B4 (CBV4), a member of the Picornavirus genus, has long been implicated in the development of insulin-dependent diabetes mellitus (IDDM), by viral-induced pancreatic cell damage. Although the pancreotropic nature of this virus is well documented, the early stages of CBV4 viral infection that involve the...

journal_title：Virology

authors： Triantafilou K,Triantafilou M

更新日期：2004-08-15 00:00:00

abstract：:Chimeric primate lentiviruses composed of SIV and HIV genes may allow the analysis of the role of these discrete HIV genes in viral pathogenesis in macaque monkeys. We have constructed a chimeric virus in which the env, rev, tat, and vpu genes of HIV-1 Lai replace the env, rev, and tat genes of the SIVmac239 genome. T...

journal_title：Virology

authors： Dunn CS,Beyer C,Kieny MP,Gloeckler L,Schmitt D,Gut JP,Kirn A,Aubertin AM

更新日期：1996-09-15 00:00:00

abstract：:Twelve avian reovirus strain 176 proteins, 10 structural (lambda 1, lambda 2, lambda 3, mu 1, mu 2/mu 2C, sigma 1, sigma 2, sigma 3, and sigma 4), and 2 nonstructural (mu NS and sigma NS) were identified and characterized by electrophoretic analysis of purified virions and infected cell lysates. Three of the identifie...

journal_title：Virology

authors： Ni Y,Ramig RF,Kemp MC

更新日期：1993-03-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV-68) replicates robustly in cell culture, providing a model for studying viral genome replication during de novo infection of tumor-associated herpesviruses. We have previously identified a 1.25-kb origin of lytic replication (oriLyt) for MHV-68. To further investigate the molecular mech...

journal_title：Virology

authors： Gong D,Qi J,Arumugaswami V,Sun R,Deng H

更新日期：2009-05-10 00:00:00

abstract：:Red clover necrotic mosaic virus (RCNMV) encodes N-terminally overlapping proteins of 27 and 88 kDa (p27 and p88) known to be required for replication. Green fluorescent protein (GFP) fusions were used to visualize the location of p27 and p88 within Nicotiana benthamiana cells. GFP:p27 fusions localized to the endopla...

journal_title：Virology

authors： Turner KA,Sit TL,Callaway AS,Allen NS,Lommel SA

更新日期：2004-03-15 00:00:00

abstract：:Alpacas develop diminished disease following bovine viral diarrhea virus (BVDV) infection compared to cattle. We hypothesized that alpaca and bovine cells have differential permissiveness and responses to BVDV infection. To characterize alpaca testicular (AT) and bovine turbinate (BT) cells BVDV infection permissivene...

journal_title：Virology

authors： Samson HC,Topliff CL,Donis RO,Kelling CL

更新日期：2011-04-25 00:00:00

abstract：:Tandemers 2MG, 2MG3, 3MG and 4MG are derivatives of the potent anti-HIV-1 microbicide candidate griffithsin (GRFT). We compared these compounds anti-HIV-1 activity to GRFT using the viruses CAP206.08 and CAAN5342.A2 that have decreased sensitivity to this lectin. The 2MG and 2MG3 tandemers had similar activity to GRFT...

journal_title：Virology

authors： Alexandre K,Malatji K,Mulaudzi T

更新日期：2020-05-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is widely spread in the human population. EBV nuclear antigen 1 (EBNA1) is a transcription factor that activates viral genes and is necessary for viral replication and partitioning, which binds the EBV genome cooperatively. We identify similar EBNA1 repeat binding sites in the human genome usi...

journal_title：Virology

authors： d'Hérouël AF,Birgersdotter A,Werner M

更新日期：2010-09-30 00:00:00

abstract：:The aim of this study was to establish a method that could differentiate antibodies against live and inactivated vaccines of porcine reproductive and respiratory syndrome virus (PRRSV). A blocking ELISA (b-ELISA) was established using the PRRSV non-structural protein, Nsp9, as the antigen and a monoclonal antibody, 2D...

journal_title：Virology

authors： Cong Y,Huang Z,Sun Y,Ran W,Zhu L,Yang G,Ding X,Yang Z,Huang X,Wang C,Ding Z

更新日期：2013-09-01 00:00:00

abstract：:Temperate coliphage P2 integrates its genome into the host chromosome upon lysogenization via a site-specific recombination event mediated by an integrase belonging to the complex family of tyrosine recombinases. The host integration site attB (BOB') is localized in the end of the cyaR gene and shares 27 nucleotides w...

journal_title：Virology

authors： Sylwan L,Frumerie C,Haggård-Ljungquist E

更新日期：2010-09-01 00:00:00

abstract：:To be incorporated into progeny virions, the viral genome must be transported to the inner leaflet of the plasma membrane (PM) and accumulate there. Some viruses utilize lipid components to assemble at the PM. For example, simian virus 40 (SV40) targets the ganglioside GM1 and human immunodeficiency virus type 1 (HIV-...

journal_title：Virology

authors： Kakisaka M,Yamada K,Yamaji-Hasegawa A,Kobayashi T,Aida Y

更新日期：2016-09-01 00:00:00

abstract：:Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) vFLIP, a latent gene of KSHV, was first identified as a FLICE-inhibitory protein (FLIP) protecting cells from apoptosis. The vFLIP protein has been shown to activate the NF-κB signaling involved in spindle morphology formation both in HUVECs infected with KSHV and Ka...

journal_title：Virology

authors： Yang Z,Honda T,Ueda K

更新日期：2018-09-01 00:00:00

abstract：:HIV-1 Nef is expressed in astrocytes, but a contribution to neuropathogenesis and the development of HIV-associated dementia (HAD) remains uncertain. To determine the neuropathogenic actions of the HIV-1 Nef protein, the brain-derived (YU-2) and blood-derived (NL4-3) Nef proteins were expressed in neural cells using a...

journal_title：Virology

authors： van Marle G,Henry S,Todoruk T,Sullivan A,Silva C,Rourke SB,Holden J,McArthur JC,Gill MJ,Power C

更新日期：2004-11-24 00:00:00

abstract：:Transmissible gastroenteritis virus (TGEV) causes severe diarrhea and high mortality in newborn piglets. It is well established that porcine intestinal epithelium is the target of the TGEV infection, however the mechanism that TGEV invades the host epithelium remains largely unknown. Aminopeptidase N (APN) is a known ...

journal_title：Virology

authors： Hu W,Zhang S,Shen Y,Yang Q

更新日期：2018-08-01 00:00:00

abstract：:Little is known about the neutralization properties of HIV-1 in India to optimally design and test vaccines. For this reason, a functional Env clone was obtained from each of ten newly acquired, heterosexually transmitted HIV-1 infections in Pune, Maharashtra. These clones formed a phylogenetically distinct genetic li...

journal_title：Virology

authors： Kulkarni SS,Lapedes A,Tang H,Gnanakaran S,Daniels MG,Zhang M,Bhattacharya T,Li M,Polonis VR,McCutchan FE,Morris L,Ellenberger D,Butera ST,Bollinger RC,Korber BT,Paranjape RS,Montefiori DC

更新日期：2009-03-15 00:00:00

abstract：:The liver has been suspected to be one of the major targets of dengue virus infection. Here, we detected increasing secretion of the chemokine RANTES (regulated upon activation, normal T cell expressed and secreted), which functions to recruit the immune cells, in dengue-virus-infected liver cells and patients. Three ...

journal_title：Virology

authors： Lin YL,Liu CC,Chuang JI,Lei HY,Yeh TM,Lin YS,Huang YH,Liu HS

更新日期：2000-10-10 00:00:00

abstract：:Although a live attenuated HIV vaccine is not currently considered for safety reasons, a strategy inducing both T cells and neutralizing antibodies to native assembled HIV-1 particles expressed by a replicating virus might mimic the advantageous characteristics of live attenuated vaccine. To this aim, we generated a l...

journal_title：Virology

authors： Guerbois M,Moris A,Combredet C,Najburg V,Ruffié C,Février M,Cayet N,Brandler S,Schwartz O,Tangy F

更新日期：2009-05-25 00:00:00

abstract：:Polyribosomal RNA from tobacco infected with sonchus yellow net virus (SYNV) contained sequences which hybridized to 125I-labeled SYNV RNA and which were complementary to 80 to 100% of the viral RNA genome. The poly(A)-containing RNA from polyribosomes was complementary to over 90% of the viral genome but the polyribo...

journal_title：Virology

authors： Milner JJ,Jackson AO

更新日期：1979-08-01 00:00:00

abstract：:Recently, we identified TT virus (TTV) isolates from nonhuman primates and named them simian TTV (s-TTV). To characterize the genomic structure of these isolates in more detail, the full-length nucleotide sequence of the s-TTV isolate (designated s-TTV CH65-1), recovered from a chimpanzee born in West Africa, was ampl...

journal_title：Virology

authors： Inami T,Obara T,Moriyama M,Arakawa Y,Abe K

更新日期：2000-11-25 00:00:00