Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus 68.

abstract：:In this study, we investigated the autoimmune response in rabbit ovaries following infection with a recombinant myxoma virus expressing rabbit zona pellucida protein B (MV-ZPB). A specific IgG antibody response to ZPB was elicited in the serum of infected rabbits and the antibody strongly bound to the zona pellucida o...

journal_title：Virology

authors： Gu W,Holland M,Janssens P,Seamark R,Kerr P

更新日期：2004-01-20 00:00:00

abstract：:In benign squamous lesions and in organotypic epithelial cultures, the human papillomavirus (HPV) E6 and E7 genes are transcriptionally up-regulated in differentiated, spinous keratinocytes. We previously identified sequence elements in the enhancer-promoter regions of HPV types 18 and 11 important for this promoter r...

journal_title：Virology

authors： Zhao W,Chow LT,Broker TR

更新日期：1999-01-20 00:00:00

abstract：:Repression of human papillomavirus (HPV) E6 and E7 oncogenes in established cervical carcinoma cell lines causes senescence due to reactivation of cellular tumor suppressor pathways. Here, we determined whether ongoing expression of HPV16 or HPV18 oncogenes is required for the proliferation of primary human cervical c...

journal_title：Virology

authors： Magaldi TG,Almstead LL,Bellone S,Prevatt EG,Santin AD,DiMaio D

更新日期：2012-01-05 00:00:00

abstract：:A system to associate specific genome segments with viral phenotypes and to study factors influencing genome reassortment was developed for tomato spotted wilt Tospovirus (TSWV). Reassortant isolates were generated by co-inoculating a TSWV isolate, TSWV-D, with TSWV-10 or TSWV-MD. The parental origin of each genome se...

journal_title：Virology

authors： Qiu WP,Geske SM,Hickey CM,Moyer JW

更新日期：1998-04-25 00:00:00

abstract：:Phylogenetic analysis of the N8 neuraminidase (NA) genes from 18 influenza A viruses, representing equine and avian hosts in different geographic locations, revealed three major lineages: (i) currently circulating equine 2 viruses; (ii) avian viruses isolated in the Eurasian region, including A/Equine/Jilin/1/89, a re...

journal_title：Virology

authors： Saito T,Kawaoka Y,Webster RG

更新日期：1993-04-01 00:00:00

abstract：:Next generation sequence analyses were used to assess virus-derived small RNA (vsRNA) profiles for Homalodisca coagulata virus-1 (HoCV-1), family Dicistroviridae, and Homalodisca vitripennis reovirus (HoVRV), family Reoviridae, from virus-infected H. vitripennis, the glassy-winged sharpshooter. The vsRNA reads were ma...

journal_title：Virology

authors： Nandety RS,Fofanov VY,Koshinsky H,Stenger DC,Falk BW

更新日期：2013-07-20 00:00:00

abstract：:The M2 protein of influenza A H1N1 strains PR8, WS, and WSN is present in homooligomeric forms in virions grown in the allantoic cavity of embryonated eggs. The bulk of the virion M2 is detected as tetramers and dimers. The oligomeric forms of PR8 virions differ from those of WS and WSN not only in apparent molecular ...

journal_title：Virology

authors： Panayotov PP,Schlesinger RW

更新日期：1992-01-01 00:00:00

abstract：:Mouse hepatitis viruses (MHV) of different virulence for mice were studied with respect to interferon (IFN) sensitivity. The growth of low-virulent MHV-S and intermediately virulent MHV-JHM was significantly suppressed in IFN-treated L cells compared with untreated cells. However, a comparable suppression of the growt...

journal_title：Virology

authors： Taguchi F,Siddell SG

更新日期：1985-11-01 00:00:00

abstract：:The presence of anti-Tax antibody responses in human T cell leukemia virus type I (HTLV-I)-infected individuals has been correlated with increased proviral load, increased risk of transmitting infection, and increased risk of developing tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). In this study...

journal_title：Virology

authors： Lydy SL,Conner ME,Marriott SJ

更新日期：1998-10-10 00:00:00

abstract：:The major DNA-binding protein or infected cell protein 8 (ICP8) encoded by herpes simplex virus exhibits multiple interactions with the cell nucleus in that it interacts with the host cell nuclear matrix and viral DNA molecules as sequential stages in its maturational process (M. P. Quinlan, L. B. Chen, and D. M. Knip...

journal_title：Virology

authors： Gao M,Bouchey J,Curtin K,Knipe DM

更新日期：1988-04-01 00:00:00

abstract：:Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important ...

journal_title：Virology

authors： Carballeda JM,Maroniche G,Lucero MS,Richetta M,Gómez E,Chimeno Zoth S,Berinstein A

更新日期：2015-09-01 00:00:00

abstract：:The Nef protein of Simian immunodeficiency virus (SIV) associates with multiple T lymphocyte signaling proteins, including the T cell receptor (TCR) zeta chain. We demonstrate here that these interactions are conserved and highly specific. Nefs derived from genetically diverse strains of SIV (SIV(mac)239, SIV(smm)PBj,...

journal_title：Virology

authors： Schaefer TM,Bell I,Pfeifer ME,Ghosh M,Trible RP,Fuller CL,Ashman C,Reinhart TA

更新日期：2002-10-10 00:00:00

abstract：:The human apolipoprotein B mRNA editing enzyme catalytic peptide-like 3 (APOBEC3; A3) family of proteins (A3A-H) are known to restrict various retroviruses and retroelements, but the full complement of rhesus macaque A3 proteins remains unclear. We report the isolation and characterization of the hA3A homologue from r...

journal_title：Virology

authors： Schmitt K,Guo K,Algaier M,Ruiz A,Cheng F,Qiu J,Wissing S,Santiago ML,Stephens EB

更新日期：2011-10-10 00:00:00

abstract：:The causal agent of rhizomania disease, Beet necrotic yellow vein virus (BNYVV), typically produces asymptomatic root-limited infections in sugar beets (Beta vulgaris) carrying the Rz1-allele. Unfortunately, this dominant resistance has been recently overcome. Multiple cDNA clones of the viral pathogenic determinant p...

journal_title：Virology

authors： Acosta-Leal R,Fawley MW,Rush CM

更新日期：2008-06-20 00:00:00

abstract：:A previous study suggested that the genomes of the arenaviruses native to North America are a product of genetic recombination between New World arenaviruses with significantly different phylogenetic histories. The purpose of this study was to extend our knowledge of the principal host relationships and evolutionary h...

journal_title：Virology

authors： Cajimat MN,Milazzo ML,Hess BD,Rood MP,Fulhorst CF

更新日期：2007-10-25 00:00:00

abstract：:A previous study showed that an Autographa californica multicapsid nuclear polyhedrosis virus (AcMNPV) 25K mutant produced less polyhedrin protein than wild-type (Jarvis et al., J. Virol. 66, 6903-6911, 1992). In this study, the role of the 25K gene product (AcMNPV ORF 61) in baculovirus gene expression was further in...

journal_title：Virology

authors： Harrison RL,Jarvis DL,Summers MD

更新日期：1996-12-01 00:00:00

abstract：:Human Cytomegalovirus (HCMV) infection is compromised in cells lacking p53, a transcription factor that mediates cellular stress responses. In this study we have investigated compromised functional virion production in cells with p53 knocked out (p53KOs). Infectious center assays found most p53KOs released functional ...

journal_title：Virology

authors： Kuan MI,O'Dowd JM,Chughtai K,Hayman I,Brown CJ,Fortunato EA

更新日期：2016-10-01 00:00:00

abstract：:Interferon gamma (IFNγ) has complex immunomodulatory and antiviral properties. While IFNγ is detected in the airways in response to infection with the pneumovirus pathogen, pneumonia virus of mice (PVM; Family Paramyxoviridae), its role in promoting disease has not been fully explored. Here, we evaluate PVM infection ...

journal_title：Virology

authors： Glineur SF,Bowen AB,Percopo CM,Garcia-Crespo KE,Dyer KD,Ochkur SI,Lee NA,Lee JJ,Domachowske JB,Rosenberg HF

更新日期：2014-11-01 00:00:00

abstract：:Although lentiviruses like HIV-1 are able to infect non-dividing cells, particular resting cells such as non-stimulated primary peripheral blood mononuclear cells (PBMC) are resistant to infection. In contrast to other lentiviruses, SIVsmmPBj can replicate in non-stimulated PBMC. Moreover, SIVsmmPBj-derived, but not H...

journal_title：Virology

authors： Wolfrum N,Mühlebach MD,Schüle S,Kaiser JK,Kloke BP,Cichutek K,Schweizer M

更新日期：2007-08-01 00:00:00

abstract：:A number of studies examining interactions of dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) with viral pathogens have relied on monocytic transfectants as models for primary DCs. Here we show that the presumed "THP-1" monocytic cells used in these studies are instead Raji B cells. Moreover, we dem...

journal_title：Virology

authors： Wu L,Martin TD,Carrington M,KewalRamani VN

更新日期：2004-01-05 00:00:00

abstract：:Segment 7 (M) of the cold-adapted live influenza A virus vaccine plays a primary role in the ability of this virus to interfere with the replication of wild-type influenza A viruses. This conclusion is based on several lines of evidence. Single gene reassortant viruses derived by crossing influenza A/Ann Arbor/6/60 (H...

journal_title：Virology

authors： Whitaker-Dowling P,Zvolenski R,Youngner JS

更新日期：1991-01-01 00:00:00

abstract：:An effective type I interferon (IFN-alpha/beta) response is critical for the control of many viral infections. Using an oncolytic strain of vesicular stomatitis virus, we have examined the cross-talk between virus-induced apoptosis and initiation of innate immune response. The intrinsic apoptotic cascade, specifically...

journal_title：Virology

authors： Sharif-Askari E,Nakhaei P,Oliere S,Tumilasci V,Hernandez E,Wilkinson P,Lin R,Bell J,Hiscott J

更新日期：2007-08-15 00:00:00

abstract：:The P1 plasmid partition system depends on ParA-ParB proteins acting on centromere-like parS sites for a faithful plasmid segregation during the Escherichia coli cell cycle. In vivo we placed parS into host E. coli chromosome and on a Sop(+) F plasmid and found that the stability of a P1 plasmid deleted for parA-parB ...

journal_title：Virology

authors： Kaur T,Al Abdallah Q,Nafissi N,Wettig S,Funnell BE,Slavcev RA

更新日期：2011-12-20 00:00:00

abstract：:The synthesis of linear duplex replicative structures (monomers, head-to-head, and tail-to-tail dimers) is an important hallmark of the productive phase of the adeno-associated virus (AAV) life cycle. These structures are generated by a strand-displacement replication mechanism and believed to be a reservoir for singl...

journal_title：Virology

authors： Musatov SA,Scully TA,Dudus L,Fisher KJ

更新日期：2000-09-30 00:00:00

abstract：:Recent studies have shown enhanced antitumor efficacy with adenoviruses that either lack E1B-19K or overexpress E3-11.6K (also known as adenoviral death protein). E1B-19K is a well-characterized anti-apoptotic protein, and viruses with E1B-19K deletions show increased cytopathicity. However, the mechanism of cell kill...

journal_title：Virology

authors： Zou A,Atencio I,Huang WM,Horn M,Ramachandra M

更新日期：2004-09-01 00:00:00

abstract：:Circoviruses are relatively novel pathogens with increased importance in canids. In this study, we first screened the presence of dog circovirus (DogCV) by molecular methods from a total number of 389 internal organ samples originating from 277 individuals of domestic dogs and wild animals including wolves, foxes and ...

journal_title：Virology

authors： Zaccaria G,Malatesta D,Scipioni G,Di Felice E,Campolo M,Casaccia C,Savini G,Di Sabatino D,Lorusso A

更新日期：2016-03-01 00:00:00

abstract：:The enteric adenovirus type 40 strain Dugan (Ad40) cannot be passaged in HeLa cells, but will grow in 293 cells, which express Ad5 E1 functions. To determine the reason for this limited host range, KB cell lines expressing Ad2 E1A, E1B, or E1A + E1B (L. E. Babiss, C. S. H. Young, P. B. Fisher, and H. S. Ginsberg, 1983...

journal_title：Virology

authors： Mautner V,Mackay N,Steinthorsdottir V

更新日期：1989-08-01 00:00:00

abstract：:Oral-gastric delivery of vaccines is a preferred route of immunization and is particularly relevant to the development of vaccine-vector systems. We have investigated the ability of a replication deficient (E1-deleted) adenovirus construct (RAd68), which efficiently expresses the measles virus nucleocapsid (N) protein...

journal_title：Virology

authors： Sharpe S,Fooks A,Lee J,Hayes K,Clegg C,Cranage M

更新日期：2002-02-15 00:00:00

abstract：:Frog virus 3 (FV3) is the type species member of the genus Ranavirus (family Iridoviridae). To better understand the molecular mechanisms involved in the replication of FV3, including transcription of its highly methylated DNA genome, we have determined the complete nucleotide sequence of the FV3 genome. The FV3 genom...

journal_title：Virology

authors： Tan WG,Barkman TJ,Gregory Chinchar V,Essani K

更新日期：2004-05-20 00:00:00

abstract：:Lactate dehydrogenase-elevating virus (LDV) is currently classified within the Togaviridae family. In an effort to obtain further information on the characteristics of this virus, we have begun to sequence the viral RNA genome and to map the virion structural protein genes. A sequence of 1064 nucleotides, which repres...

journal_title：Virology

authors： Godeny EK,Speicher DW,Brinton MA

更新日期：1990-08-01 00:00:00