Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection.

abstract：:LMP2A deletion and point mutants, with mutations in phosphotyrosine-containing protein-protein interaction motifs, were transiently expressed in 293 cells and their phosphorylation was examined in immune complex kinase assays as well as in vivo. In vitro LMP2A phosphorylation depended on tyrosine 112. In vivo, mutatio...

journal_title：Virology

authors： Scholle F,Longnecker R,Raab-Traub N

更新日期：2001-12-20 00:00:00

abstract：:The Hepatitis B virus Precore protein, present in the secretory pathway as the HBeAg precursor, can associate in the cytoplasm with the Core protein to form heterocapsids, likely to favor viral persistence. Core and Precore proteins share their primary sequence except for ten additional aminoacids at the N-terminus of...

journal_title：Virology

authors： Duriez M,Thouard A,Bressanelli S,Rossignol JM,Sitterlin D

更新日期：2014-08-01 00:00:00

abstract：:Most adenovirus-specific mRNAs expressed late after infection originate from a single transcription unit, the so-called major late transcription unit. All mRNAs expressed from this unit have in common a 201 nucleotide-long spliced tripartite leader segment attached to their 5' ends. Human adenovirus mutants that carry...

journal_title：Virology

authors： Ohman K,Nordqvist K,Akusjärvi G

更新日期：1993-05-01 00:00:00

abstract：:In our in vitro model for HPV16-mediated transformation, HPV16-immortalized human keratinocytes (HKc/HPV16) give rise to differentiation resistant, premalignant cells (HKc/DR). HKc/DR, but not HKc/HPV16, are resistant to growth inhibition by transforming growth factor beta (TGF-β), due to a partial loss of TGF-β recep...

journal_title：Virology

authors： Kowli S,Velidandla R,Creek KE,Pirisi L

更新日期：2013-12-01 00:00:00

abstract：:Tomato golden mosaic virus (TGMV) is a bipartite member of the subgroup III Geminiviridae. Like all geminiviruses, TGMV replicates in the nucleus of susceptible cells by rolling circle replication (RCR). Double-stranded replicative form DNA generated during RCR serves as template for the transcription of viral genes b...

journal_title：Virology

authors： Sunter G,Bisaro DM

更新日期：1997-06-09 00:00:00

abstract：:An arginine-rich RNA-binding motif (ARM) found at the N-proximal region of Brome mosaic virus (BMV) coat protein (CP) adopts alpha-helical conformation and shares homology with CPs of plant and insect RNA viruses, HIV-Rev and Tat proteins, bacterial antiterminators, and ribosomal splicing factors. The ARM of BMV CP, c...

journal_title：Virology

authors： Choi YG,Rao AL

更新日期：2000-09-15 00:00:00

abstract：:Chlorella virus PBCV-1 encodes two putative chitinase genes, a181/182r and a260r, and one chitosanase gene, a292l. The three genes were cloned and expressed in Escherichia coli. The recombinant A181/182R protein has endochitinase activity, recombinant A260R has both endochitinase and exochitinase activities, and recom...

journal_title：Virology

authors： Sun L,Adams B,Gurnon JR,Ye Y,Van Etten JL

更新日期：1999-10-25 00:00:00

abstract：:Infection of eukaryotic cells in culture with herpes simplex virus type-1 (HSV-1) or HSV-2 increased the mutation frequency of the supF gene carried on the shuttle vector pZ189 by around sixfold. The increase was apparent 2 hr postinfection and reached a peak after 8 hr. To investigate this mutagenesis, plasmids pCKRR...

journal_title：Virology

authors： Clarke P,Clements JB

更新日期：1991-06-01 00:00:00

abstract：:Endogenous retroviruses (ERVs) arise from the infection and integration of past retroviruses into animal hosts. We performed large-scale genomic mining of 101 avian genomes for discovery of ERVs having none-avian origin and investigated the cross-species transmission events. Phylogenetic analysis of the reverse transc...

journal_title：Virology

authors： Chen M,Cui J

更新日期：2019-04-01 00:00:00

abstract：:The major late promoter (MLP) of the subgroup C human adenoviruses is a preeminent model for the study of the mechanisms of basal and activated transcription, both in vivo and in vitro. However, while the structure and function of the human virus MLP has been the subject of extensive investigation, the conservation of...

journal_title：Virology

authors： Song B,Hu SL,Darai G,Spindler KR,Young CS

更新日期：1996-06-15 00:00:00

abstract：:Viral infections of the central nervous system and immune responses to these infections cause a variety of neurological diseases. Infection of weanling mice with Sindbis virus causes acute nonfatal encephalomyelitis followed by clearance of infectious virus, but persistence of viral RNA. Infection with a neuroadapted ...

journal_title：Virology

authors： Kimura T,Griffin DE

更新日期：2003-06-20 00:00:00

abstract：:Human Adenovirus Type 4 (HAdV-4) is responsible for epidemic outbreaks of Acute Respiratory Disease (especially in military recruits), and is known to cause significant morbidity with several reported cases of mortality. However, we do not understand why this serotype causes such high morbidity, and have little insigh...

journal_title：Virology

authors： Hartman ZC,Appledorn DM,Serra D,Glass O,Mendelson TB,Clay TM,Amalfitano A

更新日期：2008-05-10 00:00:00

abstract：:Tetherin has been defined as a restriction factor of HIV-1 and several other enveloped viruses. However, the significance of tetherin in viral infection remains to be further addressed. Here, we investigated whether tetherin plays a role in HSV-2 infection. Our study revealed that overexpression of tetherin restricted...

journal_title：Virology

authors： Liu Y,Luo S,He S,Zhang M,Wang P,Li C,Huang W,Hu B,Griffin GE,Shattock RJ,Hu Q

更新日期：2015-01-15 00:00:00

abstract：:Previously, we studied the envelope (E) gene of dengue virus and reported that dengue-3 virus is present as a quasispecies. To investigate the extent of intrahost sequence variation of other dengue viral genes, we examined in this study the capsid (C) gene and the nonstructural gene, NS2B, derived directly from plasma...

journal_title：Virology

authors： Wang WK,Sung TL,Lee CN,Lin TY,King CC

更新日期：2002-11-10 00:00:00

abstract：:The complete genome sequence of the Liaoning isolate of the Antheraea pernyi multinucleocapsid nucleopolyhedrovirus (AnpeMNPV) was determined. The viral genome size is 126,246 bp, relatively GC-rich (53.5% G+C), with 145 predicted open reading frames (ORFs) of more than 50 amino acids, accounting for more than 97% of ...

journal_title：Virology

authors： Fan Q,Li S,Wang L,Zhang B,Ye B,Zhao Z,Cui L

更新日期：2007-09-30 00:00:00

abstract：:Rice yellow mottle virus (RYMV) is icosahedral in morphology and known to swell in vitro, but the biological function of swollen particles remains unknown. Anion-exchange chromatography was used to identify three markedly stable forms of RYMV particles from infected plants: (1) an unstable swollen form lacking Ca2+ an...

journal_title：Virology

authors： Brugidou C,Opalka N,Yeager M,Beachy RN,Fauquet C

更新日期：2002-05-25 00:00:00

abstract：:The eukaryotic translation initiation factor eIF4E, the cap-binding protein, seems to play an essential role in the establishment of the host shut-off after viral infection. Infection with adenovirus and influenza virus caused dephosphorylation of eIF4E and an involvement of a viral protein was suggested. In this repo...

journal_title：Virology

authors： Kleijn M,Vrins CL,Voorma HO,Thomas AA

更新日期：1996-03-15 00:00:00

abstract：:West Nile virus (WNV) has become firmly established in northeastern US, reemerging every summer since its introduction into North America in 1999. To determine whether WNV overwinters locally or is reseeded annually, we examined the patterns of viral lineage persistence and replacement in Connecticut over 10 consecuti...

journal_title：Virology

authors： Armstrong PM,Vossbrinck CR,Andreadis TG,Anderson JF,Pesko KN,Newman RM,Lennon NJ,Birren BW,Ebel GD,Henn MR

更新日期：2011-08-15 00:00:00

abstract：:To investigate the mode of gene expression of red clover mottle virus (RCMV) middle component (M) RNA, we have synthesized an oligopeptide corresponding to the predicted carboxy-terminus of the RCMV counterparts of the cowpea mosaic virus (CPMV) 48K and 58K proteins. Using an antiserum raised against this synthetic ol...

journal_title：Virology

authors： Shanks M,Tomenius K,Clapham D,Huskisson NS,Barker PJ,Wilson IG,Maule AJ,Lomonossoff GP

更新日期：1989-12-01 00:00:00

abstract：:Plant virus-based vectors provide valuable tools for expression of foreign proteins in plants and for gene function studies. None of the presently available virus vectors is suitable for use in soybean. In the present study, we produced Bean pod mottle virus (BPMV)-based vectors that are appropriate for gene expressio...

journal_title：Virology

authors： Zhang C,Ghabrial SA

更新日期：2006-01-20 00:00:00

abstract：:We test the hypothesis that the translation machinery in cells infected by influenza A virus efficiently translates only mRNAs that possess the influenza viral 5' untranslated region (5'-UTR) by introducing mRNAs directly into the cytoplasm of infected cells. This strategy avoids effects due to the inhibition of the n...

journal_title：Virology

authors： Cassetti MC,Noah DL,Montelione GT,Krug RM

更新日期：2001-10-25 00:00:00

abstract：:We previously provided evidence for a model of herpes simplex virus type 1 (HSV-1) entry by a cascade of interactions between components of the virion envelope and cellular plasma membrane (Fuller and Lee, 1992, J. Virol. 66, 5002-5012). In this report we have determined entry kinetics of wild-type HSV-1 into two high...

journal_title：Virology

authors： McClain DS,Fuller AO

更新日期：1994-02-01 00:00:00

abstract：:Herpes simplex virus 1 glycoprotein B (gB) is one of 10 glycoproteins in the virion envelope and in the membranes of infected cells. It is required for infection of cells in culture and functions in penetration of the cell by fusing the virion envelope with the plasma membrane. In studies to map the functional domains...

journal_title：Virology

authors： Navarro D,Paz P,Pereira L

更新日期：1992-01-01 00:00:00

abstract：:The terminal sequences of both genomic dsRNA segments of different strains of infectious bursal disease virus were determined. Analysis of the linear sequences revealed in the 5'-noncoding region of both segments the presence of a 32-nucleotide sequence with motifs conserved between segments and serotypes. The 3'-nonc...

journal_title：Virology

authors： Mundt E,Müller H

更新日期：1995-05-10 00:00:00

abstract：:By the use of reverse transcription followed by polymerase chain reaction (RT-PCR), we have identified one shorter than full-length, pregenomic viral RNA species in liver samples of woodchucks chronically infected with the woodchuck hepatitis virus (WHV). The spliced WHV RNA of about 2.4 kb in length was cloned and pa...

journal_title：Virology

authors： Hantz O,Baginski I,Fourel I,Chemin I,Trepo C

更新日期：1992-09-01 00:00:00

abstract：:Enterovirus A71 (EV-A71) is a neurotropic enterovirus that uses heparan sulfate as an attachment receptor. The molecular determinants of EV-A71-heparan sulfate interaction are unknown. With In silico heparin docking and mutagenesis of all possible lysine residues in VP1, we identified that K162, K242 and K244 are resp...

journal_title：Virology

authors： Tan CW,Sam IC,Lee VS,Wong HV,Chan YF

更新日期：2017-01-15 00:00:00

abstract：:Previous studies with monoclonal antibodies of the antigenic structure of bovine leukemia virus (BLV) envelope glycoprotein (gp51) have identified three epitopes (F, G, H) directly involved in the infectivity of BLV, F, G, and H lost their reactivity with the respective monoclonal antibodies after treatment with a red...

journal_title：Virology

authors： Portetelle D,Couez D,Bruck C,Kettmann R,Mammerickx M,Van der Maaten M,Brasseur R,Burny A

更新日期：1989-03-01 00:00:00

abstract：:The bipartite genomic RNAs of red clover necrotic mosaic virus (RCNMV) lack a 5' cap and a 3' poly(A) tail. RNA1 encodes viral replication proteins, and RNA2 encodes a movement protein (MP). These proteins are translated in a cap-independent manner. We previously identified two cis-acting RNA elements that cooperative...

journal_title：Virology

authors： Tajima Y,Iwakawa HO,Hyodo K,Kaido M,Mise K,Okuno T

更新日期：2017-09-01 00:00:00

abstract：:The Tat regulatory protein encoded by human immunodeficiency virus type 1 (HIV-1) induces high levels of transcription from the viral long terminal repeat (LTR) promoter element after interacting with a promoter proximal RNA target sequence. In the wild-type HIV-1 LTR, this activation is facilitated by the synergistic...

journal_title：Virology

authors： Madore SJ,Cullen BR

更新日期：1995-02-01 00:00:00

abstract：:The results of a previous study suggested that the poly(A) sequence in barley stripe mosaic virus (BSMV) RNA is intercalated between a 3'-terminal tyrosine-accepting structure and the 5'-terminal coding part of the BSMV genome. Here we show that poly(A)+ and poly(A)- fractions of BSMV RNA can be cleaved into two fragm...

journal_title：Virology

authors： Agranovsky AA,Dolja VV,Atabekov JG

更新日期：1982-05-01 00:00:00