当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Mutagenesis occurring following infection with herpes simplex virus does not require virus replication.

Mutagenesis occurring following infection with herpes simplex virus does not require virus replication.

Abstract：

:Infection of eukaryotic cells in culture with herpes simplex virus type-1 (HSV-1) or HSV-2 increased the mutation frequency of the supF gene carried on the shuttle vector pZ189 by around sixfold. The increase was apparent 2 hr postinfection and reached a peak after 8 hr. To investigate this mutagenesis, plasmids pCKRR1 and pCKRR2 were constructed to express the large and small subunits, respectively, of HSV-2 ribonucleotide reductase (RR) under the control of the inducible mouse metallothionein promoter. Expression from these plasmids, either singly or together, had no effect on the mutation frequency of pZ189 under conditions when virus RR activity was detected. The HSV-1 temperature sensitive (ts) mutant viruses ts 1207 and ts 1222, which have ts lesions in the genes encoding R1 and R2, respectively, were as mutagenic as wild-type HSV-1 at both the permissive and nonpermissive temperatures. These results indicate that expression of HSV RR is not mutagenic in this system. Experiments using other HSV-1 mutants and ultraviolet-inactivated virus localized the cause of the increased mutagenic frequency either to a component of the incoming virion or to an effect exerted by the virus DNA itself. The present study confirms previous reports that infection with HSV exerts a mutagenic effect. Further, virus replication and gene expression were not required for the mutagenic effect studied here. This may have implications for a role of HSV in cellular transformation, as a nonproductive infection could mutagenize cellular genes.

journal_name

Virology

journal_title

Virology

authors

Clarke P,Clements JB

doi

10.1016/0042-6822(91)90600-g

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

597-606

issue

2

eissn

0042-6822

issn

1096-0341

journal_volume

182

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Recombinant human parainfluenza virus type 2 with mutations in V that permit cellular interferon signaling are not attenuated in non-human primates.

    abstract：:The HPIV2 V protein inhibits type I interferon (IFN) induction and signaling. To manipulate the V protein, whose coding sequence overlaps that of the polymerase-associated phosphoprotein (P), without altering the P protein, we generated an HPIV2 virus in which P and V are expressed from separate genes (rHPIV2-P+V). rH...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.07.011

    authors： Schaap-Nutt A,D'Angelo C,Amaro-Carambot E,Nolan SM,Davis S,Wise SM,Higgins C,Bradley K,Kim O,Mayor R,Skiadopoulos MH,Collins PL,Murphy BR,Schmidt AC

    更新日期：2010-10-10 00:00:00

  • Biological characteristics and propagation of human rhinovirus-C in differentiated sinus epithelial cells.

    abstract：:Information about the basic biological properties of human rhinovirus-C (HRV-C) viruses is lacking due to difficulties with culturing these viruses. Our objective was to develop a cell culture system to grow HRV-C. Epithelial cells from human sinuses (HSEC) were differentiated at air-liquid interface (ALI). Differenti...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2012.11.002

    authors： Ashraf S,Brockman-Schneider R,Bochkov YA,Pasic TR,Gern JE

    更新日期：2013-02-05 00:00:00

  • Suppression of antigen-specific T cell proliferation by measles virus infection: role of a soluble factor in suppression.

    abstract：:Measles virus infection causes a profound immunosuppression. The basis for this immunosuppression is not known. This immunosuppression could be due to virus acting directly on lymphoid cells, the production of an immunosuppressive viral product, or a lymphoid product. We have developed an antigen-specific T cell syste...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9186

    authors： Sun X,Burns JB,Howell JM,Fujinami RS

    更新日期：1998-06-20 00:00:00

  • Sequence conservation and divergence of hepatitis delta virus RNA.

    abstract：:The complete RNA sequence of the hepatitis delta virus (HDV) obtained from the Nauru Island in the Pacific was determined by cDNA cloning and amplification by polymerase chain reaction (PCR). The sequence showed 14-17% divergence from the two known HDV RNA sequences. There are three highly conserved domains: the regio...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90335-o

    authors： Chao YC,Chang MF,Gust I,Lai MM

    更新日期：1990-10-01 00:00:00

  • Enhanced infectivity of modified bluetongue virus particles for two insect cell lines and for two Culicoides vector species.

    abstract：:Previous studies (Mertens et al., Virology 157, 375-386, 1987) have shown that removal of the outer capsid layer from bluetongue virus (BTV) significantly reduces (approximately x 10(-4)) the infectivity of the resultant core particle for mammalian cells (BHK 21 cells). In contrast, the studies reported here, using a ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0153

    authors： Mertens PP,Burroughs JN,Walton A,Wellby MP,Fu H,O'Hara RS,Brookes SM,Mellor PS

    更新日期：1996-03-15 00:00:00

  • Sequence variability and function of measles virus 3' and 5' ends and intercistronic regions.

    abstract：:Sequences critical for the activity of the measles virus (MV) RNA polymerase in transcription and replication were analyzed using a MV genomic cDNA library containing overlapping clones encompassing the entire MV genome. Clones corresponding to the 3' and 5' ends of the MV genome were identified and sequenced, and the...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90564-8

    authors： Crowley JC,Dowling PC,Menonna J,Silverman JI,Schuback D,Cook SD,Blumberg BM

    更新日期：1988-06-01 00:00:00

  • In hepatocytes infected with duck hepatitis B virus, the template for viral RNA synthesis is amplified by an intracellular pathway.

    abstract：:During the productive phase of chronic hepadnaviral infections, virion DNA synthesis occurs in the cytoplasm of the infected hepatocyte, but viral RNA is synthesized in the nucleus, apparently from a covalently closed, circular (CCC) viral DNA. J. Tuttleman, C. Pourcel, and J. Summers (1986a, Cell 47, 451-460) have sh...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90206-7

    authors： Wu TT,Coates L,Aldrich CE,Summers J,Mason WS

    更新日期：1990-03-01 00:00:00

  • Effect of Ku80 depletion on the preintegrative steps of HIV-1 replication in human cells.

    abstract：:To gain new insights regarding the role of Ku, the DNA-PK DNA-binding component, during lentiviral DNA integration, we have investigated the HIV-1 replication in Ku80-depleted human cells. CEM4fx cells underexpressing the Ku80 factor were selected after transduction by a retroviral vector expressing the Ku80 full-leng...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1515

    authors： Jeanson L,Subra F,Vaganay S,Hervy M,Marangoni E,Bourhis J,Mouscadet JF

    更新日期：2002-08-15 00:00:00

  • Comparison of the genomes of attenuated equine herpesvirus-1 strains with their parent virulent strain.

    abstract：:To elucidate the virulence factors of equine herpesvirus-1 (EHV-1), we compared the genomic architecture of the HH1 strain, a Japanese isolate of EHV-1, with that of its four descendant strains obtained by serial passage in bovine kidney (BK) cells, i.e. BK77, BK161, BK271, and BK343. In preliminary studies high-passa...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1228

    authors： Kirisawa R,Ui S,Takahashi A,Kawakami Y,Iwai H

    更新日期：1994-05-01 00:00:00

  • Transcriptional factor C/EBP binds to and transactivates the enhancer element II of the hepatitis B virus.

    abstract：:The human hepatitis B Virus genome (HBV) contains a liver-specific enhancer upstream of the X ORF which has been studied in detail by several investigators. A second liver-specific enhancer element, designated here as enhancer II, has been relatively recently described in the HBV genome, which is located within the co...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)91019-d

    authors： López-Cabrera M,Letovsky J,Hu KQ,Siddiqui A

    更新日期：1991-08-01 00:00:00

  • Apoptosis correlates with immune activation in intestinal lymphoid tissue from macaques acutely infected by a highly enteropathic simian immunodeficiency virus, SIVsmmPBj14.

    abstract：:The PBj14 isolate of simian immunodeficiency virus, SIVsmmPBj14, induces an acutely lethal disease in experimentally inoculated pigtailed macaques, that is characterized by severe enteropathy and extensive immune activation, particularly within gut-associated lymphoid tissue (GALT). Experiments were conducted to deter...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0571

    authors： Gummuluru S,Novembre FJ,Lewis M,Gelbard HA,Dewhurst S

    更新日期：1996-11-01 00:00:00

  • Subviral agents associated with plant single-stranded DNA viruses.

    abstract：:Begomoviruses (family Geminiviridae) are responsible for many economically important crop diseases worldwide. The majority of these diseases are caused by bipartite begomovirus infections, although a rapidly growing number of diseases of the Old World are associated with monopartite begomoviruses. With the exception o...

    journal_title：Virology

    pub_type： 杂志文章,随机对照试验,评审

    doi：10.1016/j.virol.2005.09.042

    authors： Briddon RW,Stanley J

    更新日期：2006-01-05 00:00:00

  • Analysis of the roles of bluetongue virus outer capsid proteins VP2 and VP5 in determination of virus serotype.

    abstract：:Analyses of reassortant and parental strains of BTV serotypes 3 and 10, in serum neutralization tests, confirmed the major role of outer capsid protein VP2 in determination of virus serotype and its involvement in serum neutralization. However, a reassortant BTV strain (R70), containing protein VP5 derived from BTV 3 ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90447-9

    authors： Mertens PP,Pedley S,Cowley J,Burroughs JN,Corteyn AH,Jeggo MH,Jennings DM,Gorman BM

    更新日期：1989-06-01 00:00:00

  • HIV-1 inactivation by 4-vinylpyridine is enhanced by dissociating Zn(2+) from nucleocapsid protein.

    abstract：:Selective inactivation of critical cysteine residues in human immunodeficiency virus type one (HIV-1) was observed after treatment with 4-vinylpyridine (4-VP), with and without the membrane-permeable metal chelator N,N,N',N'-tetrakis(2-pyridylmethyl)-ethylenediamine (TPEN). Chromatographic analysis showed that cystein...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.01.045

    authors： Morcock DR,Thomas JA,Sowder RC 2nd,Henderson LE,Crise BJ,Gorelick RJ

    更新日期：2008-05-25 00:00:00

  • Identification and analysis of an Autographa californica nuclear polyhedrosis virus structural protein of the occlusion-derived virus envelope: ODV-E56.

    abstract：:An Autographa californica nuclear polyhedrosis virus gene encoding an occlusion-derived virus (ODV) envelope protein of 56 kDa was identified and sequenced. Transcription initiates from a conserved baculovirus late motif (ATAAG) with transcripts detected from 16 through 72 hr p.i. The protein is detected in infected c...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0097

    authors： Braunagel SC,Elton DM,Ma H,Summers MD

    更新日期：1996-03-01 00:00:00

  • Bacteriophage P22 capsid size determination: roles for the coat protein telokin-like domain and the scaffolding protein amino-terminus.

    abstract：:Assembly of icosahedral capsids of proper size and symmetry is not understood. Residue F170 in bacteriophage P22 coat protein is critical for conformational switching during assembly. Substitutions at this site cause assembly of tubes of hexamerically arranged coat protein. Intragenic suppressors of the ts phenotype o...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2011.06.025

    authors： Suhanovsky MM,Teschke CM

    更新日期：2011-09-01 00:00:00

  • The distribution and kinetics of polyomavirus in lungs of intranasally infected newborn mice.

    abstract：:The primary cell types that sustain polyomavirus (Py) replication following intranasal infection as well as the nature of the host cellular response to Py were unknown. As this is an essential and specific site for virus entry, it seems likely that viral gene function must be adapted to these mucosal tissues. Using im...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.0030

    authors： Gottlieb K,Villarreal LP

    更新日期：2000-01-05 00:00:00

  • Monoclonal antibodies raised to purified woodchuck hepatitis virus core antigen particles demonstrate X antigen reactivity.

    abstract：:Woodchuck hepatitis core antigen (WHcAg) particles purified from the liver of chronically infected animals were used for monoclonal antibody production. Most of the putative clones demonstrated anti-WHc specificity. However, the supernatants from several putative clones bound X antigen sequences from woodchuck hepatit...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90491-9

    authors： Feitelson MA,Clayton MM,Phimister B

    更新日期：1990-07-01 00:00:00

  • Stability of rice yellow mottle virus and cellular compartmentalization during the infection process in Oryza sativa (L.).

    abstract：:Rice yellow mottle virus (RYMV) is icosahedral in morphology and known to swell in vitro, but the biological function of swollen particles remains unknown. Anion-exchange chromatography was used to identify three markedly stable forms of RYMV particles from infected plants: (1) an unstable swollen form lacking Ca2+ an...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1398

    authors： Brugidou C,Opalka N,Yeager M,Beachy RN,Fauquet C

    更新日期：2002-05-25 00:00:00

  • Genetic analysis of bipartite geminivirus tissue tropism.

    abstract：:The bipartite geminiviruses bean golden mosaic virus (BGMV), cabbage leaf curl virus (CabLCV), and tomato golden mosaic virus (TGMV) exhibit differential tissue tropism in Nicotiana benthamiana. In systemically infected leaves, BGMV remains largely confined to vascular-associated cells (phloem-limited), whereas CabLCV...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1205

    authors： Qin Y,Petty IT

    更新日期：2001-12-20 00:00:00

  • Analysis of mutations in the envelope gene of Moloney murine leukemia virus: separation of infectivity from superinfection resistance.

    abstract：:Six deletion mutations and an insertion were generated in the env gene of cloned copies of Moloney murine leukemia virus DNA. All seven mutants were replication-defective as tested by transformation of NIH/3T3 cells. The mutant DNAs were introduced into NIH/3T3 cells to generate stable producer lines; all released vir...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90983-i

    authors： Granowitz C,Colicelli J,Goff SP

    更新日期：1991-08-01 00:00:00

  • Infection, replication, and cytopathology of human papillomavirus type 31 in trophoblasts.

    abstract：:Human papillomavirus (HPV) DNA is preferentially found in spontaneous abortions, specifically residing in trophoblasts, and transfected HPV-16 DNA replicates and produces progeny in 3A trophoblasts in culture. In this study 3A trophoblasts were shown to display both HPV receptors and infection by HPV-31b and HPV-6 vir...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2003.08.020

    authors： You H,Liu Y,Agrawal N,Prasad CK,Chiriva-Internati M,Lowery CL,Kay HH,Hermonat PL

    更新日期：2003-11-25 00:00:00

  • DNA processing in temperature-sensitive morphogenic mutants of HSV-1.

    abstract：:The anatomy of DNA synthesized by five HSV-1 mutants previously shown to accumulate predominantly empty capsids at the nonpermissive temperature (NPT) was analyzed with Bg/II restriction digestion. At the NPT, all five generated DNA lacking termini, indicating that in the absence of packaging, viral DNA is not process...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90214-5

    authors： Sherman G,Bachenheimer SL

    更新日期：1987-06-01 00:00:00

  • Temporal analysis of reassortment and molecular evolution of Cucumber mosaic virus: Extra clues from its segmented genome.

    abstract：:Cucumber mosaic virus (CMV) is a damaging pathogen of over 200 mono- and dicotyledonous crop species worldwide. It has the broadest known host range of any virus, but the timescale of its evolution is unknown. To investigate the evolutionary history of this virus, we obtained the genomic sequences of 40 CMV isolates f...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2015.09.024

    authors： Ohshima K,Matsumoto K,Yasaka R,Nishiyama M,Soejima K,Korkmaz S,Ho SY,Gibbs AJ,Takeshita M

    更新日期：2016-01-01 00:00:00

  • Mutation and replacement of the 16-kDa protein gene in RNA-1 of tobacco rattle virus.

    abstract：:The function of the 16-kDa protein encoded by tobacco rattle virus (TRV) RNA-1 was investigated by a mutational analysis of the 16-kDa protein gene. Transcripts of TRV RNA-1 produced from a full-length cDNA clone of TRV RNA-1 (SYM strain) remained infectious when the 16-kDa protein gene was disrupted by premature term...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90601-7

    authors： Guilford PJ,Ziegler-Graff V,Baulcombe DC

    更新日期：1991-06-01 00:00:00

  • Natural controlled HIV infection: preserved HIV-specific immunity despite undetectable replication competent virus.

    abstract：:Long-term non-progressive HIV infection, characterized by low but detectable viral load and stable CD4 counts in the absence of antiviral therapy, is observed in about 5% of HIV-infected patients. Here we identified four therapy naïve individuals who are strongly seropositive for HIV-1 but who lack evidence of detecta...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.06.001

    authors： Kloosterboer N,Groeneveld PH,Jansen CA,van der Vorst TJ,Koning F,Winkel CN,Duits AJ,Miedema F,van Baarle D,van Rij RP,Brinkman K,Schuitemaker H

    更新日期：2005-08-15 00:00:00

  • Monoclonal antibody mapping of the envelope glycoprotein of the dengue 2 virus, Jamaica.

    abstract：:Although dengue (DEN) virus is the etiologic agent of dengue fever, the most prevalent vector-borne viral disease in the world, precise information on the antigenic structure of the dengue virion is limited. We have prepared a set of murine monoclonal antibodies (MAbs) specific for the envelope (E) glycoprotein of DEN...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9200

    authors： Roehrig JT,Bolin RA,Kelly RG

    更新日期：1998-07-05 00:00:00

  • Antigenic variation in the hemagglutinin-neuraminidase protein of human parainfluenza type 3 virus.

    abstract：:Sixteen monoclonal antibodies directed to the hemagglutinin-neuraminidase (HN) protein of a 1957 isolate of parainfluenza type 3 virus (PIV3) were produced and used to examine antigenic variation in clinical strains. Analysis of hemagglutination-inhibition reactivity patterns of antigenic variants selected in vitro in...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90395-2

    authors： van Wyke Coelingh KL,Winter C,Murphy BR

    更新日期：1985-06-01 00:00:00

  • Chicken mannose binding lectin has antiviral activity towards infectious bronchitis virus.

    abstract：:Mannose binding lectin (MBL) is a collagenous C-type lectin, which plays an important role in innate immunity. It can bind to carbohydrates on the surface of a wide range of pathogens, including viruses. Here we studied the antiviral effect of recombinant chicken (rc)MBL against Infectious Bronchitis Virus (IBV), a hi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2017.06.028

    authors： Zhang W,Bouwman KM,van Beurden SJ,Ordonez SR,van Eijk M,Haagsman HP,Verheije MH,Veldhuizen EJA

    更新日期：2017-09-01 00:00:00

  • Inhibition of uncoating of tobacco mosaic virus particles in protoplasts from transgenic tobacco plants that express the viral coat protein gene.

    abstract：:The uncoating of tobacco mosaic virus (TMV) particles in protoplasts isolated from leaves of transgenic tobacco plants that express the TMV coat protein gene was investigated. Extracts of these protoplasts collected up to 1 hr after inoculation with TMV contained fewer of the complexes ("striposomes") thought to be in...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90163-l

    authors： Wu XJ,Beachy RN,Wilson TM,Shaw JG

    更新日期：1990-12-01 00:00:00