Identification and analysis of an Autographa californica nuclear polyhedrosis virus structural protein of the occlusion-derived virus envelope: ODV-E56.

abstract：:While the 2009 pandemic H1N1 virus has become established in the human population as a seasonal influenza virus, continued adaptation may alter viral virulence. Here, we passaged a 2009 pandemic H1N1 virus (A/Changchun/01/2009) in mice. Serial passage in mice generated viral variants with increased virulence. Adapted ...

journal_title：Virology

authors： Yu Z,Cheng K,Sun W,Zhang X,Li Y,Wang T,Wang H,Zhang Q,Xin Y,Xue L,Zhang K,Huang J,Yang S,Qin C,Wilker PR,Yue D,Chen H,Gao Y,Xia X

更新日期：2015-12-01 00:00:00

abstract：:The lung-derived dendritic cell (LDC) recruitment following intranasal (i.n.) vaccination of different poxviral vector-based vaccines/adjuvants were evaluated to decipher how these factors influenced CD8(+) T cell avidity. Compared to the standard i.n. recombinant fowlpox virus (FPV)-HIV vaccination, the FPV-HIV IL-13...

journal_title：Virology

authors： Trivedi S,Jackson RJ,Ranasinghe C

更新日期：2014-11-01 00:00:00

abstract：:Although v-src, the oncogene of Rous sarcoma virus, has been shown to be capable of inducing lethal tumors at visceral sites distal to the primary tumor mass, the mechanisms opposing visceral tumor formation remain to be elucidated. In the present study, we show that visceral tumors, many of which represent a metastas...

journal_title：Virology

authors： Halpern MS,Wisner TW,Brown IP,England JM

更新日期：1993-11-01 00:00:00

abstract：:Bovine papillomavirus type 4 (BPV-4) morphologically transforms primary bovine cells in vitro only in the presence of an activated ras gene. The transformed cells are capable of anchorage-independent growth, but are not immortal and are incapable of inducing tumors in nude mice, suggesting that other events are needed...

journal_title：Virology

authors： Pennie WD,Campo MS

更新日期：1992-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) core protein constitutes a viral nucleocapsid and may possess multiple functions. In this study, we demonstrated the homotypic interaction and multimerization of HCV core protein in vitro and in vivo. By using a yeast two-hybrid system, we showed that the amino-terminal hydrophilic portion (ami...

journal_title：Virology

authors： Matsumoto M,Hwang SB,Jeng KS,Zhu N,Lai MM

更新日期：1996-04-01 00:00:00

abstract：:The human papillomavirus type 8 (HPV8) is associated with skin cancer development. The goal of this study was to investigate the effects of HPV8 oncoproteins on cellular gene expression and the identification of key regulators. We performed affymetrix microarray analyses to identify differentially expressed genes and ...

journal_title：Virology

authors： Kirschberg M,Heuser S,Syed AS,Steger G,Majewski S,Hufbauer M,Akgül B

更新日期：2019-09-01 00:00:00

abstract：:Wasting is a sign of various underlying disorders and is a common feature of cancer, sepsis, and AIDS. We have developed an in vivo model to study the various stages of wasting following infection of mice with lymphocytic choriomeningitis virus cl-13. Using this model we have identified four distinct stages of wasting...

journal_title：Virology

authors： Stamm A,Valentine L,Potts R,Premenko-Lanier M

更新日期：2012-04-10 00:00:00

abstract：:Chikungunya virus (CHIKV) represents a pandemic threat with no approved vaccine available. Recently, we described a novel vaccination strategy based on iDNA® infectious clone designed to launch a live-attenuated CHIKV vaccine from plasmid DNA in vitro or in vivo. As a proof of concept, we prepared iDNA plasmid pCHIKV-...

journal_title：Virology

authors： Hidajat R,Nickols B,Forrester N,Tretyakova I,Weaver S,Pushko P

更新日期：2016-03-01 00:00:00

abstract：:For successful penetration of HIV-1, the formation of a fusion pore may be required in order to accumulate critical numbers of fusion-activated gp41 with the help of fluidization of the plasma membrane and viral envelope. An increase in temperature to 40 degrees C after viral adsorption at 25 degrees C enhanced the in...

journal_title：Virology

authors： Harada S,Monde K,Tanaka Y,Kimura T,Maeda Y,Yusa K

更新日期：2008-01-05 00:00:00

abstract：:The growth of vesicular stomatitis virus requires two distinct RNA synthetic events: transcription of messenger RNA molecules and replication of the viral genome RNA. We report the use of a panel of monoclonal antibodies directed against the viral phosphoprotein P in an attempt to assess the role of this protein in RN...

journal_title：Virology

authors： Richardson JC,Peluso RW

更新日期：1996-02-01 00:00:00

abstract：:Multiple nucleoside resistance involves specific mutational patterns of the HIV-1 pol gene that are independent of the classic mutations conferring resistance to individual dideoxynucleosides. These include a cluster of five mutations in the reverse-transcriptase (RT) coding region (A62V, V75I, F77L, F116Y, and Q151M)...

journal_title：Virology

authors： Tamalet C,Yahi N,Tourrès C,Colson P,Quinson AM,Poizot-Martin I,Dhiver C,Fantini J

更新日期：2000-05-10 00:00:00

abstract：:Aside from a common gene organization shared with other picornaviruses, hepatitis A virus (HAV) is characterized by its slow-growth phenotype, the inability to shut off host macromolecular synthesis, and, in general, lack of cytopathic (cp) effects in permissive cell cultures. Nevertheless, several cp HAV strains have...

journal_title：Virology

authors： Gosert R,Egger D,Bienz K

更新日期：2000-01-05 00:00:00

abstract：:The satellite RNA of Bamboo mosaic virus (satBaMV) contains on open reading frame for a 20-kDa protein that is flanked by a 5'-untranslated region (UTR) of 159 nucleotides (nt) and a 3'-UTR of 129 nt. A secondary structure was predicted for the 5'-UTR of satBaMV RNA, which folds into a large stem-loop (LSL) and a smal...

journal_title：Virology

authors： Annamalai P,Hsu YH,Liu YP,Tsai CH,Lin NS

更新日期：2003-06-20 00:00:00

abstract：:H7N9 influenza A first caused human infections in early 2013 in China. Virus genetics, histories of patient exposures to poultry, and previous experimental studies suggest the source of the virus is a domestic avian species, such as chickens. In order to better understand the ecology of this H7N9 in chickens, we evalu...

journal_title：Virology

authors： Spackman E,Pantin-Jackwood M,Swayne DE,Suarez DL,Kapczynski DR

更新日期：2015-03-01 00:00:00

abstract：:The pathogenesis of Venezuelan equine encephalitis virus (VEE) was examined in the mouse model using V3000, a virus derived from a molecular clone of the Trinidad donkey strain of VEE. These results were compared in parallel experiments with avirulent mutants of VEE derived by site-directed mutagenesis of the clone. A...

journal_title：Virology

authors： Grieder FB,Davis NL,Aronson JF,Charles PC,Sellon DC,Suzuki K,Johnston RE

更新日期：1995-02-01 00:00:00

abstract：:CD8 T cells are necessary for controlling tumors induced by mouse polyoma virus (PyV), but the effector mechanism(s) responsible have not been determined. We examined the PyV tumorigenicity in C57BL/6 mice mutated in Fas or carrying targeted disruptions in the perforin gene or in both TNF receptor type I and type II g...

journal_title：Virology

authors： Byers AM,Hadley A,Lukacher AE

更新日期：2007-02-20 00:00:00

abstract：:Two types of dengue (DEN) 2 virus mutants were selected either by repeated exposure to acidic pH (acid mutant, AM), or by the addition of ammonium chloride to Aedes albopictus C6/36 cells prior to and during viral infection (fusion mutant, FM). Both mutants grew more slowly than the parent strain and induced smaller p...

journal_title：Virology

authors： Guirakhoo F,Hunt AR,Lewis JG,Roehrig JT

更新日期：1993-05-01 00:00:00

abstract：:GP5, the principal envelope glycoprotein of porcine reproductive and respiratory syndrome virus (PRRSV), contains a hypervariable region within the ectodomain which is responsible for generating diversity in field isolates. The purpose of this study was to gain insight into the possible origin of this diversity by fol...

journal_title：Virology

authors： Rowland RR,Steffen M,Ackerman T,Benfield DA

更新日期：1999-07-05 00:00:00

abstract：:An effective type I interferon (IFN-alpha/beta) response is critical for the control of many viral infections. Using an oncolytic strain of vesicular stomatitis virus, we have examined the cross-talk between virus-induced apoptosis and initiation of innate immune response. The intrinsic apoptotic cascade, specifically...

journal_title：Virology

authors： Sharif-Askari E,Nakhaei P,Oliere S,Tumilasci V,Hernandez E,Wilkinson P,Lin R,Bell J,Hiscott J

更新日期：2007-08-15 00:00:00

abstract：:In order to investigate the global and dynamic host microRNAs (miRNAs)/messenger RNAs (mRNAs) expression alteration during in vitro acute HCV infection, a comprehensive microarray analysis was performed using human hepatoma cells. Totally, 108 human miRNAs and 1247 mRNAs were identified whose expression levels changed...

journal_title：Virology

authors： Liu X,Wang T,Wakita T,Yang W

更新日期：2010-03-01 00:00:00

abstract：:Parotid tumor agent was an early name for polyomavirus due to its ability to induce tumors (myoepitheliomas originating from the myoepithelial glandular tissues) in mice inoculated with polyomavirus (Py) as neonates. It has long been thought that these tumors directly follow productive infection by Py in epithelial ce...

journal_title：Virology

authors： Atencio IA,Meraz A,Villarreal LP

更新日期：1994-05-01 00:00:00

abstract：:Syncytia formation has been considered important for cell-to-cell spread and pathogenesis of many viruses. As a syncytium forms, individual nuclei often congregate together, allowing close contact of nuclear membranes and possibly fusion to occur. However, there is currently no reported evidence of nuclear membrane fu...

journal_title：Virology

authors： Wang W,Yang L,Huang X,Fu W,Pan D,Cai L,Ye J,Liu J,Xia N,Cheng T,Zhu H

更新日期：2017-12-01 00:00:00

abstract：:Human rotaviruses (Wa, KUN, MO) showed hemagglutination (HA) only with fixed 1-day-old chicken erythrocytes, and their HA activities were completely destroyed by trypsin activation of virions. Simian SA-11 and bovine NCDV had HA activities not only against fixed erythrocytes but also against fresh erythrocytes from va...

journal_title：Virology

authors： Fukudome K,Yoshie O,Konno T

更新日期：1989-09-01 00:00:00

abstract：:Turnip leaves infected with turnip crinkle virus accumulate a 35-kd polypeptide which comigrates with the major protein from isolated virions. RNA from TCV virions directs the synthesis of a number of polypeptides in vitro including a 35-kd protein which is immunoprecipitable with antiserum to virus particles. Transla...

journal_title：Virology

authors： Altenbach SB,Howell SH

更新日期：1982-04-15 00:00:00

abstract：:Some retroviruses, including HIV-1, regulate the relative amounts of gag and pol gene products by a translational frameshift mechanism. The consequences of altering the ratios of the Gag and Pol proteins were tested using vaccinia virus expression vectors, in which the gag and pol genes were fused by placing them in t...

journal_title：Virology

authors： Karacostas V,Wolffe EJ,Nagashima K,Gonda MA,Moss B

更新日期：1993-04-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV68) is used as a model to study gammaherpesvirus pathogenesis both in tissue culture systems and in vivo. We used a gene-trapping approach to get insight into cellular factors involved in MHV68 infection. By generating a library of gene-trapped CHO cells, we were able to isolate several ...

journal_title：Virology

authors： Jarousse N,Coscoy L

更新日期：2008-04-10 00:00:00

abstract：:We compared the in vitro fidelity of wild-type human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) and the prototype foamy virus (PFV) RT. Both enzymes had similar error rates for single nucleotide substitutions; however, PFV RT did not appear to make errors at specific hotspots, like HIV-1 RT. In a...

journal_title：Virology

authors： Boyer PL,Stenbak CR,Hoberman D,Linial ML,Hughes SH

更新日期：2007-10-25 00:00:00

abstract：:The V3 region of the HIV-1 envelope (Env) glycoprotein gp120 is a key functional domain yet it exhibits distinct mutational patterns across subtypes. Here an invariant residue (Ile 309) was replaced with Leu in 7 subtype C patient-derived Envs from recent infection and 4 related neutralizing antibody escape variants t...

journal_title：Virology

authors： Lynch RM,Rong R,Li B,Shen T,Honnen W,Mulenga J,Allen S,Pinter A,Gnanakaran S,Derdeyn CA

更新日期：2010-08-15 00:00:00

abstract：:The effects of inhibitors, which interfere with oligosaccharide trimming by blocking mannosidases, on the processing and export of the viral glycoproteins of Rous sarcoma virus (RSV), have been studied. 1-Deoxymannojirimycin (DIM) prevents removal of mannose residues from the Man9 (GlcNAc)2 oligosaccharide whereas swa...

journal_title：Virology

authors： Bosch JV,Tlusty A,McDowell W,Legler G,Schwarz RT

更新日期：1985-05-01 00:00:00

abstract：:The genetic structure of the population of Watermelon mosaic virus (WMV) in Spain was analysed by the biological and molecular characterisation of isolates sampled from its main host plant, melon. The population was a highly homogeneous one, built of a single pathotype, and comprising isolates closely related genetica...

journal_title：Virology

authors： Moreno IM,Malpica JM,Díaz-Pendón JA,Moriones E,Fraile A,García-Arenal F

更新日期：2004-01-05 00:00:00